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Mechanisms of the hematoporphyrin-derivative (HpD)-induced photodamage of neoplastic cells: fluorescence studies

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Abstract

This work reports on studies of spectral properties and fluorescence decay times of HpD. The dependence of these parameters on physicochemical and biological conditions has been studied in solution, cells, and a culture medium. Particular attention was devoted to the presence of a HpD emission band in the 570-590-nm range. This band does not naturally occur in fresh HpD solution and seems more likely in tumor than in normal HpD-treated cells.

© 1984 Optical Society of America

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