Unexpectedly Stalled: Two-Photon Microscopy Reveals White Blood Cell Adhesion in Capillaries Causes Reduced Brain Blood Flow In Alzheimer’s Disease

C.B. Schaffer

doi:10.1364/CLEO_AT.2017.ATu1B.1

Conference on Lasers and Electro-Optics
OSA Technical Digest (online) (Optica Publishing Group, 2017),
paper ATu1B.1
•https://doi.org/10.1364/CLEO_AT.2017.ATu1B.1

Unexpectedly Stalled: Two-Photon Microscopy Reveals White Blood Cell Adhesion in Capillaries Causes Reduced Brain Blood Flow In Alzheimer’s Disease

C.B. Schaffer

CLEO: Applications and Technology 2017

San Jose, California United States
14–19 May 2017
ISBN: 978-1-943580-27-9

From the session
A&T Topical Review on Neurophotonics I (ATu1B)

Open Access

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C. B. Schaffer, "Unexpectedly Stalled: Two-Photon Microscopy Reveals White Blood Cell Adhesion in Capillaries Causes Reduced Brain Blood Flow In Alzheimer’s Disease," in Conference on Lasers and Electro-Optics, OSA Technical Digest (online) (Optica Publishing Group, 2017), paper ATu1B.1.

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Abstract

About 2% of brain capillaries were occluded by leukocytes adhered to the vessel wall in mouse models of Alzheimer’s. When this adhesion was blocked, brain blood flow immediately increased by ~30% and spatial memory performance improved.

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