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Conferences > COSI > 2019 > CTh4A > CTh4A.4

Single-Molecule Super-Resolution Imaging of Molecular Orientation using a Tri-Spot Point Spread Function

Hesam Mazidi, Eshan S. King, Oumeng Zhang, Arye Nehorai, and Matthew D. Lew

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Abstract

We demonstrate the use of an engineered Tri-spot point-spread function and a joint sparse deconvolution algorithm for imaging the positions and 3D orientations of single molecules. Our images reveal nanoscale order and disorder in DNA strands.

© 2019 The Author(s)

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