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Conferences > FiO > 2003 > TuG > TuG2

In-vivo optical contrast agent dynamics in tumors with MRI co-registration

David J. Cuccia, Fred Bevilacqua, Anthony J. Durkin, Bruce J. Tromberg, Gultekin Gulsen, Hon Yu, Jun Wang, and Orhan Nalcioglu

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Abstract

The dynamics of optical contrast agents are measured in an adenocarcinoma rat tumor model using a combined frequency-domain and steady-state optical technique. Compartmental modeling of contrast agent dynamics allows quantification of physiologic parameters such as capillary permeability and blood flow. Optically-derived parameters are compared to those measured by contrast-enhanced MRI.

© 2003 Optical Society of America

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