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Optica Publishing Group
  • Frontiers in Optics 2008/Laser Science XXIV/Plasmonics and Metamaterials/Optical Fabrication and Testing
  • OSA Technical Digest (CD) (Optica Publishing Group, 2008),
  • paper FTuE5
  • https://doi.org/10.1364/FIO.2008.FTuE5

Ultra-short Laser Pulses as a Tool to Measure as Well as Perturb Neurovascular Activity in the Rodent Brain

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Abstract

The ability to image and perturb brain tissue that lies deep to the surface of cortex has facilitated the solution of old problems in blood flow dynamics and has begun to provide new insights into neurovascular coupling. We summarize the use of ultra-short laser pulses to probe the structure and function of vasodynamics through two-photon laser scanning microscopy in junction with fluorescent labels of blood serum and tissue. We next describe the emerging use of amplified ultra-short laser pulses for plasma-assisted ablation as a means to perturb either blood flow or neuronal activity deep to the surface. Lastly, we discuss the use of these same tools for high- throughput block-face imaging of histological issue, in particular, the complete reconstruction of cortical vasculature.

© 2008 Optical Society of America

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