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THz Signatures of Nucleic Acids in Nanochannels and Estimates of Detectable Molar Amount

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Abstract

High-resolution, frequency-domain THz spectroscopy is combined with nanofluidic-chip technology to detect absorption signatures in nucleic-acid solutions between 800 and 1100 GHz. Two species are investigated, si- RNA and Lambda DNA, and clearly detected with ~4.2×10−15 and ~1.0×10−16 mol, respectively, in the nanochannels.

© 2013 Optical Society of America

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