Abstract

We have developed an optothermal model for the interaction of laser light and the tissue of arterial walls and have checked its validity with animal experiments. The mathematical model consists of a laser diffusing tip positioned intraluminally in a cylindrical artery, in which the diffused laser light is incident on a blood–tissue interface at a distance from the tip. A temperature profile throughout the interface is obtained by considering the optical interaction and the thermal conduction and convection of the blood and tissue. The distribution of light in the media is determined using both Beer’s law and the Kubelka-Munk two-flux theory in cylindrical coordinates. For experimental in vivo verification, a diffusing tip was inserted in canine arteries and the temperature profile varied by restricting the volume of blood; this simulated degrees of occlusion to determine the influence of blood flow on heat transport. The measured temperature profiles compared favorably to the theoretical results. Temperature profiles are also predicted for a water-filled lumen. The theoretical model will be useful in predicting the depth of ablation and extent of normal tissue damage during laser angioplasty treatment of atherosclerosis.

© 1989 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Model for laser Doppler measurements of blood flow in tissue

R. Bonner and R. Nossal
Appl. Opt. 20(12) 2097-2107 (1981)

Experimental evaluation of mathematical models for predicting the thermal response of tissue to laser irradiation

Jorge H. Torres, Massoud Motamedi, John A. Pearce, and A. J. Welch
Appl. Opt. 32(4) 597-606 (1993)

Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI

Guoqiang Yu, Thomas F. Floyd, Turgut Durduran, Chao Zhou, Jiongjiong Wang, John A. Detre, and Arjun G. Yodh
Opt. Express 15(3) 1064-1075 (2007)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (9)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (37)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription