Abstract

We demonstrate the ability of a multimode fiber probe to provide two-photon fluorescence (TPF) imaging feedback that guides the femtosecond laser ablation (FLA) in biological samples for highly selective modifications. We implement the system through the propagation of high power femtosecond pulses through a graded-index (GRIN) multimode fiber and we investigate the limitations posed by the high laser peak intensities required for laser ablation. We demonstrate that the GRIN fiber probe can deliver laser intensities up to 1.5x1013 W/cm2, sufficient for the ablation of a wide range of materials, including biological samples. Wavefront shaping through an ultrathin probe of around 400 μm in diameter is used for diffraction limited focusing and digital scanning of the focus spot. Selective FLA of cochlear hair cells is performed based on the TPF images obtained through the same multimode fiber probe.

© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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References

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2018 (3)

2017 (3)

2016 (6)

D. B. Conkey, N. Stasio, E. E. Morales-Delgado, M. Romito, C. Moser, and D. Psaltis, “Lensless two-photon imaging through a multicore fiber with coherence-gated digital phase conjugation,” J. Biomed. Opt. 21(4), 45002 (2016).
[Crossref] [PubMed]

S. C. Warren, Y. Kim, J. M. Stone, C. Mitchell, J. C. Knight, M. A. A. Neil, C. Paterson, P. M. W. French, and C. Dunsby, “Adaptive multiphoton endomicroscopy through a dynamically deformed multicore optical fiber using proximal detection,” Opt. Express 24(19), 21474–21484 (2016).
[Crossref] [PubMed]

L. V. Amitonova, A. Descloux, J. Petschulat, M. H. Frosz, G. Ahmed, F. Babic, X. Jiang, A. P. Mosk, P. S. J. Russell, and P. W. H. Pinkse, “High-resolution wavefront shaping with a photonic crystal fiber for multimode fiber imaging,” Opt. Lett. 41(3), 497–500 (2016).
[Crossref] [PubMed]

K. Subramanian, I. Gabay, O. Ferhanoğlu, A. Shadfan, M. Pawlowski, Y. Wang, T. Tkaczyk, and A. Ben-Yakar, “Kagome fiber based ultrafast laser microsurgery probe delivering micro-Joule pulse energies,” Biomed. Opt. Express 7(11), 4639–4653 (2016).
[Crossref] [PubMed]

S. Sivankutty, E. R. Andresen, R. Cossart, G. Bouwmans, S. Monneret, and H. Rigneault, “Ultra-thin rigid endoscope: two-photon imaging through a graded-index multi-mode fiber,” Opt. Express 24(2), 825–841 (2016).
[Crossref] [PubMed]

A. Descloux, L. V. Amitonova, and P. W. H. Pinkse, “Aberrations of the point spread function of a multimode fiber due to partial mode excitation,” Opt. Express 24(16), 18501–18512 (2016).
[Crossref] [PubMed]

2015 (6)

2014 (1)

2013 (4)

Y. Wang, M. Alharbi, T. D. Bradley, C. Fourcade-Dutin, B. Debord, B. Beaudou, F. Gerôme, and F. Benabid, “Hollow-core photonic crystal fibre for high power laser beam delivery,” High Power Laser Science and Engineering 1(01), 17–28 (2013).
[Crossref]

E. R. Andresen, G. Bouwmans, S. Monneret, and H. Rigneault, “Two-photon lensless endoscope,” Opt. Express 21(18), 20713–20721 (2013).
[Crossref] [PubMed]

J. Qiu, J. Neev, T. Wang, and T. E. Milner, “Deep subsurface cavities in skin utilizing mechanical optical clearing and femtosecond laser ablation,” Lasers Surg. Med. 45(6), 383–390 (2013).
[Crossref] [PubMed]

I. N. Papadopoulos, S. Farahi, C. Moser, and D. Psaltis, “High-resolution, lensless endoscope based on digital scanning through a multimode optical fiber,” Biomed. Opt. Express 4(2), 260–270 (2013).
[Crossref] [PubMed]

2012 (3)

2011 (2)

D. J. McCabe, A. Tajalli, D. R. Austin, P. Bondareff, I. A. Walmsley, S. Gigan, and B. Chatel, “Spatio-temporal focusing of an ultrafast pulse through a multiply scattering medium,” Nat. Commun. 2(1), 447 (2011).
[Crossref] [PubMed]

R. Di Leonardo and S. Bianchi, “Hologram transmission through multi-mode optical fibers,” Opt. Express 19(1), 247–254 (2011).
[Crossref] [PubMed]

2010 (1)

L. He, K. Sheehy, and W. Culbertson, “Femtosecond laser-assisted cataract surgery,” Curr. Opin. Ophthalmol. 22, 43 (2010).
[Crossref] [PubMed]

2008 (1)

2007 (3)

2006 (1)

2005 (1)

F. Helmchen and W. Denk, “Deep tissue two-photon microscopy,” Nat. Methods 2(12), 932–940 (2005).
[Crossref] [PubMed]

2003 (3)

P. J. Campagnola and L. M. Loew, “Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms,” Nat. Biotechnol. 21(11), 1356–1360 (2003).
[Crossref] [PubMed]

A. Vogel and V. Venugopalan, “Mechanisms of pulsed laser ablation of biological tissues,” Chem. Rev. 103(2), 577–644 (2003).
[Crossref] [PubMed]

P. Russell, “Photonic crystal fibers,” Science 299(5605), 358–362 (2003).
[Crossref] [PubMed]

2002 (1)

J. Serbin, T. Bauer, C. Fallnich, A. Kasenbacher, and W. H. Arnold, “Femtosecond lasers as novel tool in dental surgery,” Appl. Surf. Sci. 197–198, 737–740 (2002).
[Crossref]

Adachi, H.

K. Nakamura, Y. Sora, H. Y. Yoshikawa, Y. Hosokawa, R. Murai, H. Adachi, Y. Mori, T. Sasaki, and H. Masuhara, “Femtosecond laser-induced crystallization of protein in gel medium,” Appl. Surf. Sci. 253(15), 6425–6429 (2007).
[Crossref]

Ahmed, G.

Alharbi, M.

B. Debord, M. Alharbi, L. Vincetti, A. Husakou, C. Fourcade-Dutin, C. Hoenninger, E. Mottay, F. Gérôme, and F. Benabid, “Multi-meter fiber-delivery and pulse self-compression of milli-Joule femtosecond laser and fiber-aided laser-micromachining,” Opt. Express 22(9), 10735–10746 (2014).
[Crossref] [PubMed]

Y. Wang, M. Alharbi, T. D. Bradley, C. Fourcade-Dutin, B. Debord, B. Beaudou, F. Gerôme, and F. Benabid, “Hollow-core photonic crystal fibre for high power laser beam delivery,” High Power Laser Science and Engineering 1(01), 17–28 (2013).
[Crossref]

Amitonova, L. V.

Andresen, E. R.

Arnold, W. H.

J. Serbin, T. Bauer, C. Fallnich, A. Kasenbacher, and W. H. Arnold, “Femtosecond lasers as novel tool in dental surgery,” Appl. Surf. Sci. 197–198, 737–740 (2002).
[Crossref]

Austin, D. R.

D. J. McCabe, A. Tajalli, D. R. Austin, P. Bondareff, I. A. Walmsley, S. Gigan, and B. Chatel, “Spatio-temporal focusing of an ultrafast pulse through a multiply scattering medium,” Nat. Commun. 2(1), 447 (2011).
[Crossref] [PubMed]

Babic, F.

Bardet, S. M.

Barton-Owen, T.

M. Plöschner, V. Kollárová, Z. Dostál, J. Nylk, T. Barton-Owen, D. E. K. Ferrier, R. Chmelík, K. Dholakia, and T. Čižmár, “Multimode fibre: Light-sheet microscopy at the tip of a needle,” Sci. Rep. 5(1), 18050 (2015).
[Crossref] [PubMed]

Bauer, T.

J. Serbin, T. Bauer, C. Fallnich, A. Kasenbacher, and W. H. Arnold, “Femtosecond lasers as novel tool in dental surgery,” Appl. Surf. Sci. 197–198, 737–740 (2002).
[Crossref]

Beaudou, B.

Y. Wang, M. Alharbi, T. D. Bradley, C. Fourcade-Dutin, B. Debord, B. Beaudou, F. Gerôme, and F. Benabid, “Hollow-core photonic crystal fibre for high power laser beam delivery,” High Power Laser Science and Engineering 1(01), 17–28 (2013).
[Crossref]

Benabid, F.

B. Debord, M. Alharbi, L. Vincetti, A. Husakou, C. Fourcade-Dutin, C. Hoenninger, E. Mottay, F. Gérôme, and F. Benabid, “Multi-meter fiber-delivery and pulse self-compression of milli-Joule femtosecond laser and fiber-aided laser-micromachining,” Opt. Express 22(9), 10735–10746 (2014).
[Crossref] [PubMed]

Y. Wang, M. Alharbi, T. D. Bradley, C. Fourcade-Dutin, B. Debord, B. Beaudou, F. Gerôme, and F. Benabid, “Hollow-core photonic crystal fibre for high power laser beam delivery,” High Power Laser Science and Engineering 1(01), 17–28 (2013).
[Crossref]

Ben-Yakar, A.

Bianchi, S.

Bondareff, P.

D. J. McCabe, A. Tajalli, D. R. Austin, P. Bondareff, I. A. Walmsley, S. Gigan, and B. Chatel, “Spatio-temporal focusing of an ultrafast pulse through a multiply scattering medium,” Nat. Commun. 2(1), 447 (2011).
[Crossref] [PubMed]

Bouwmans, G.

Bradley, T. D.

Y. Wang, M. Alharbi, T. D. Bradley, C. Fourcade-Dutin, B. Debord, B. Beaudou, F. Gerôme, and F. Benabid, “Hollow-core photonic crystal fibre for high power laser beam delivery,” High Power Laser Science and Engineering 1(01), 17–28 (2013).
[Crossref]

Brown, E. B.

S. W. Perry, R. M. Burke, and E. B. Brown, “Two-photon and second harmonic microscopy in clinical and translational cancer research,” Ann. Biomed. Eng. 40(2), 277–291 (2012).
[Crossref] [PubMed]

Burke, R. M.

S. W. Perry, R. M. Burke, and E. B. Brown, “Two-photon and second harmonic microscopy in clinical and translational cancer research,” Ann. Biomed. Eng. 40(2), 277–291 (2012).
[Crossref] [PubMed]

Campagnola, P. J.

P. J. Campagnola and L. M. Loew, “Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms,” Nat. Biotechnol. 21(11), 1356–1360 (2003).
[Crossref] [PubMed]

Capitaine, E.

Caravaca-Aguirre, A. M.

O. Tzang, A. M. Caravaca-Aguirre, K. Wagner, and R. Piestun, “Adaptive wavefront shaping for controlling nonlinear multimode interactions in optical fibres,” Nat. Photonics 12(6), 368–374 (2018).
[Crossref]

Chatel, B.

D. J. McCabe, A. Tajalli, D. R. Austin, P. Bondareff, I. A. Walmsley, S. Gigan, and B. Chatel, “Spatio-temporal focusing of an ultrafast pulse through a multiply scattering medium,” Nat. Commun. 2(1), 447 (2011).
[Crossref] [PubMed]

Chen, X.

Chen, Y.

Chen, Z.

Chmelík, R.

M. Plöschner, V. Kollárová, Z. Dostál, J. Nylk, T. Barton-Owen, D. E. K. Ferrier, R. Chmelík, K. Dholakia, and T. Čižmár, “Multimode fibre: Light-sheet microscopy at the tip of a needle,” Sci. Rep. 5(1), 18050 (2015).
[Crossref] [PubMed]

Cižmár, T.

M. Plöschner, V. Kollárová, Z. Dostál, J. Nylk, T. Barton-Owen, D. E. K. Ferrier, R. Chmelík, K. Dholakia, and T. Čižmár, “Multimode fibre: Light-sheet microscopy at the tip of a needle,” Sci. Rep. 5(1), 18050 (2015).
[Crossref] [PubMed]

M. Plöschner, T. Tyc, and T. Čižmár, “Seeing through chaos in multimode fibres,” Nat. Photonics 9(8), 529–535 (2015).
[Crossref]

Conkey, D. B.

D. B. Conkey, E. Kakkava, T. Lanvin, D. Loterie, N. Stasio, E. Morales-Delgado, C. Moser, and D. Psaltis, “High power, ultrashort pulse control through a multi-core fiber for ablation,” Opt. Express 25(10), 11491–11502 (2017).
[Crossref] [PubMed]

D. B. Conkey, N. Stasio, E. E. Morales-Delgado, M. Romito, C. Moser, and D. Psaltis, “Lensless two-photon imaging through a multicore fiber with coherence-gated digital phase conjugation,” J. Biomed. Opt. 21(4), 45002 (2016).
[Crossref] [PubMed]

Cossart, R.

Couderc, V.

Culbertson, W.

L. He, K. Sheehy, and W. Culbertson, “Femtosecond laser-assisted cataract surgery,” Curr. Opin. Ophthalmol. 22, 43 (2010).
[Crossref] [PubMed]

Czarske, J. W.

Debord, B.

B. Debord, M. Alharbi, L. Vincetti, A. Husakou, C. Fourcade-Dutin, C. Hoenninger, E. Mottay, F. Gérôme, and F. Benabid, “Multi-meter fiber-delivery and pulse self-compression of milli-Joule femtosecond laser and fiber-aided laser-micromachining,” Opt. Express 22(9), 10735–10746 (2014).
[Crossref] [PubMed]

Y. Wang, M. Alharbi, T. D. Bradley, C. Fourcade-Dutin, B. Debord, B. Beaudou, F. Gerôme, and F. Benabid, “Hollow-core photonic crystal fibre for high power laser beam delivery,” High Power Laser Science and Engineering 1(01), 17–28 (2013).
[Crossref]

Denk, W.

F. Helmchen and W. Denk, “Deep tissue two-photon microscopy,” Nat. Methods 2(12), 932–940 (2005).
[Crossref] [PubMed]

Descloux, A.

Dholakia, K.

M. Plöschner, V. Kollárová, Z. Dostál, J. Nylk, T. Barton-Owen, D. E. K. Ferrier, R. Chmelík, K. Dholakia, and T. Čižmár, “Multimode fibre: Light-sheet microscopy at the tip of a needle,” Sci. Rep. 5(1), 18050 (2015).
[Crossref] [PubMed]

Di Leonardo, R.

Dostál, Z.

M. Plöschner, V. Kollárová, Z. Dostál, J. Nylk, T. Barton-Owen, D. E. K. Ferrier, R. Chmelík, K. Dholakia, and T. Čižmár, “Multimode fibre: Light-sheet microscopy at the tip of a needle,” Sci. Rep. 5(1), 18050 (2015).
[Crossref] [PubMed]

Dunsby, C.

Duponchel, L.

Evans, C. L.

Fallnich, C.

J. Serbin, T. Bauer, C. Fallnich, A. Kasenbacher, and W. H. Arnold, “Femtosecond lasers as novel tool in dental surgery,” Appl. Surf. Sci. 197–198, 737–740 (2002).
[Crossref]

Farahi, S.

Ferhanoglu, O.

Ferrier, D. E. K.

M. Plöschner, V. Kollárová, Z. Dostál, J. Nylk, T. Barton-Owen, D. E. K. Ferrier, R. Chmelík, K. Dholakia, and T. Čižmár, “Multimode fibre: Light-sheet microscopy at the tip of a needle,” Sci. Rep. 5(1), 18050 (2015).
[Crossref] [PubMed]

Fourcade-Dutin, C.

B. Debord, M. Alharbi, L. Vincetti, A. Husakou, C. Fourcade-Dutin, C. Hoenninger, E. Mottay, F. Gérôme, and F. Benabid, “Multi-meter fiber-delivery and pulse self-compression of milli-Joule femtosecond laser and fiber-aided laser-micromachining,” Opt. Express 22(9), 10735–10746 (2014).
[Crossref] [PubMed]

Y. Wang, M. Alharbi, T. D. Bradley, C. Fourcade-Dutin, B. Debord, B. Beaudou, F. Gerôme, and F. Benabid, “Hollow-core photonic crystal fibre for high power laser beam delivery,” High Power Laser Science and Engineering 1(01), 17–28 (2013).
[Crossref]

French, P. M. W.

Frosz, M. H.

Gabay, I.

Gallais, L.

Ganikhanov, F.

Gerôme, F.

Y. Wang, M. Alharbi, T. D. Bradley, C. Fourcade-Dutin, B. Debord, B. Beaudou, F. Gerôme, and F. Benabid, “Hollow-core photonic crystal fibre for high power laser beam delivery,” High Power Laser Science and Engineering 1(01), 17–28 (2013).
[Crossref]

Gérôme, F.

Gigan, S.

D. J. McCabe, A. Tajalli, D. R. Austin, P. Bondareff, I. A. Walmsley, S. Gigan, and B. Chatel, “Spatio-temporal focusing of an ultrafast pulse through a multiply scattering medium,” Nat. Commun. 2(1), 447 (2011).
[Crossref] [PubMed]

Gilboa, D.

S. Rosen, D. Gilboa, O. Katz, and Y. Silberberg, “Focusing and Scanning through Flexible Multimode Fibers without Access to the Distal End,” 8 (n.d.).

Goy, A.

He, L.

L. He, K. Sheehy, and W. Culbertson, “Femtosecond laser-assisted cataract surgery,” Curr. Opin. Ophthalmol. 22, 43 (2010).
[Crossref] [PubMed]

Helmchen, F.

F. Helmchen and W. Denk, “Deep tissue two-photon microscopy,” Nat. Methods 2(12), 932–940 (2005).
[Crossref] [PubMed]

Hoenninger, C.

Hosokawa, Y.

K. Nakamura, Y. Sora, H. Y. Yoshikawa, Y. Hosokawa, R. Murai, H. Adachi, Y. Mori, T. Sasaki, and H. Masuhara, “Femtosecond laser-induced crystallization of protein in gel medium,” Appl. Surf. Sci. 253(15), 6425–6429 (2007).
[Crossref]

Huo, T.

Husakou, A.

Jiang, X.

Jing, J.

Kakkava, E.

Kano, H.

Kasenbacher, A.

J. Serbin, T. Bauer, C. Fallnich, A. Kasenbacher, and W. H. Arnold, “Femtosecond lasers as novel tool in dental surgery,” Appl. Surf. Sci. 197–198, 737–740 (2002).
[Crossref]

Katz, O.

S. Rosen, D. Gilboa, O. Katz, and Y. Silberberg, “Focusing and Scanning through Flexible Multimode Fibers without Access to the Distal End,” 8 (n.d.).

Kim, Y.

Knight, J. C.

Kollárová, V.

M. Plöschner, V. Kollárová, Z. Dostál, J. Nylk, T. Barton-Owen, D. E. K. Ferrier, R. Chmelík, K. Dholakia, and T. Čižmár, “Multimode fibre: Light-sheet microscopy at the tip of a needle,” Sci. Rep. 5(1), 18050 (2015).
[Crossref] [PubMed]

Koukourakis, N.

Kuschmierz, R.

Lanvin, T.

Légaré, F.

Leproux, P.

Lévêque, P.

Li, M.-J.

Li, X.

Li, Y.

Loew, L. M.

P. J. Campagnola and L. M. Loew, “Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms,” Nat. Biotechnol. 21(11), 1356–1360 (2003).
[Crossref] [PubMed]

Loterie, D.

Louot, C.

Masuhara, H.

K. Nakamura, Y. Sora, H. Y. Yoshikawa, Y. Hosokawa, R. Murai, H. Adachi, Y. Mori, T. Sasaki, and H. Masuhara, “Femtosecond laser-induced crystallization of protein in gel medium,” Appl. Surf. Sci. 253(15), 6425–6429 (2007).
[Crossref]

McCabe, D. J.

D. J. McCabe, A. Tajalli, D. R. Austin, P. Bondareff, I. A. Walmsley, S. Gigan, and B. Chatel, “Spatio-temporal focusing of an ultrafast pulse through a multiply scattering medium,” Nat. Commun. 2(1), 447 (2011).
[Crossref] [PubMed]

Milner, T. E.

J. Qiu, J. Neev, T. Wang, and T. E. Milner, “Deep subsurface cavities in skin utilizing mechanical optical clearing and femtosecond laser ablation,” Lasers Surg. Med. 45(6), 383–390 (2013).
[Crossref] [PubMed]

Mitchell, C.

Monneret, S.

Morales-Delgado, E.

Morales-Delgado, E. E.

Mori, Y.

K. Nakamura, Y. Sora, H. Y. Yoshikawa, Y. Hosokawa, R. Murai, H. Adachi, Y. Mori, T. Sasaki, and H. Masuhara, “Femtosecond laser-induced crystallization of protein in gel medium,” Appl. Surf. Sci. 253(15), 6425–6429 (2007).
[Crossref]

Moser, C.

D. B. Conkey, E. Kakkava, T. Lanvin, D. Loterie, N. Stasio, E. Morales-Delgado, C. Moser, and D. Psaltis, “High power, ultrashort pulse control through a multi-core fiber for ablation,” Opt. Express 25(10), 11491–11502 (2017).
[Crossref] [PubMed]

D. B. Conkey, N. Stasio, E. E. Morales-Delgado, M. Romito, C. Moser, and D. Psaltis, “Lensless two-photon imaging through a multicore fiber with coherence-gated digital phase conjugation,” J. Biomed. Opt. 21(4), 45002 (2016).
[Crossref] [PubMed]

E. E. Morales-Delgado, D. Psaltis, and C. Moser, “Two-photon imaging through a multimode fiber,” Opt. Express 23(25), 32158–32170 (2015).
[Crossref] [PubMed]

D. Loterie, S. Farahi, I. Papadopoulos, A. Goy, D. Psaltis, and C. Moser, “Digital confocal microscopy through a multimode fiber,” Opt. Express 23(18), 23845–23858 (2015).
[Crossref] [PubMed]

E. E. Morales-Delgado, S. Farahi, I. N. Papadopoulos, D. Psaltis, and C. Moser, “Delivery of focused short pulses through a multimode fiber,” Opt. Express 23(7), 9109–9120 (2015).
[Crossref] [PubMed]

I. N. Papadopoulos, S. Farahi, C. Moser, and D. Psaltis, “High-resolution, lensless endoscope based on digital scanning through a multimode optical fiber,” Biomed. Opt. Express 4(2), 260–270 (2013).
[Crossref] [PubMed]

I. N. Papadopoulos, S. Farahi, C. Moser, and D. Psaltis, “Focusing and scanning light through a multimode optical fiber using digital phase conjugation,” Opt. Express 20(10), 10583–10590 (2012).
[Crossref] [PubMed]

Mosk, A. P.

Mottay, E.

Moussa, N. O.

Murai, R.

K. Nakamura, Y. Sora, H. Y. Yoshikawa, Y. Hosokawa, R. Murai, H. Adachi, Y. Mori, T. Sasaki, and H. Masuhara, “Femtosecond laser-induced crystallization of protein in gel medium,” Appl. Surf. Sci. 253(15), 6425–6429 (2007).
[Crossref]

Murari, K.

Murukeshan, V. M.

A. Shinde, S. M. Perinchery, and V. M. Murukeshan, “A targeted illumination optical fiber probe for high resolution fluorescence imaging and optical switching,” Sci. Rep. 7(1), 45654 (2017).
[Crossref] [PubMed]

Nakamura, K.

K. Nakamura, Y. Sora, H. Y. Yoshikawa, Y. Hosokawa, R. Murai, H. Adachi, Y. Mori, T. Sasaki, and H. Masuhara, “Femtosecond laser-induced crystallization of protein in gel medium,” Appl. Surf. Sci. 253(15), 6425–6429 (2007).
[Crossref]

Neev, J.

J. Qiu, J. Neev, T. Wang, and T. E. Milner, “Deep subsurface cavities in skin utilizing mechanical optical clearing and femtosecond laser ablation,” Lasers Surg. Med. 45(6), 383–390 (2013).
[Crossref] [PubMed]

Neil, M. A. A.

Nylk, J.

M. Plöschner, V. Kollárová, Z. Dostál, J. Nylk, T. Barton-Owen, D. E. K. Ferrier, R. Chmelík, K. Dholakia, and T. Čižmár, “Multimode fibre: Light-sheet microscopy at the tip of a needle,” Sci. Rep. 5(1), 18050 (2015).
[Crossref] [PubMed]

Papadopoulos, I.

Papadopoulos, I. N.

Paterson, C.

Pawlowski, M.

Perinchery, S. M.

A. Shinde, S. M. Perinchery, and V. M. Murukeshan, “A targeted illumination optical fiber probe for high resolution fluorescence imaging and optical switching,” Sci. Rep. 7(1), 45654 (2017).
[Crossref] [PubMed]

Perry, S. W.

S. W. Perry, R. M. Burke, and E. B. Brown, “Two-photon and second harmonic microscopy in clinical and translational cancer research,” Ann. Biomed. Eng. 40(2), 277–291 (2012).
[Crossref] [PubMed]

Petschulat, J.

Piestun, R.

O. Tzang, A. M. Caravaca-Aguirre, K. Wagner, and R. Piestun, “Adaptive wavefront shaping for controlling nonlinear multimode interactions in optical fibres,” Nat. Photonics 12(6), 368–374 (2018).
[Crossref]

Pinkse, P. W. H.

Plöschner, M.

M. Plöschner, V. Kollárová, Z. Dostál, J. Nylk, T. Barton-Owen, D. E. K. Ferrier, R. Chmelík, K. Dholakia, and T. Čižmár, “Multimode fibre: Light-sheet microscopy at the tip of a needle,” Sci. Rep. 5(1), 18050 (2015).
[Crossref] [PubMed]

M. Plöschner, T. Tyc, and T. Čižmár, “Seeing through chaos in multimode fibres,” Nat. Photonics 9(8), 529–535 (2015).
[Crossref]

Psaltis, D.

D. B. Conkey, E. Kakkava, T. Lanvin, D. Loterie, N. Stasio, E. Morales-Delgado, C. Moser, and D. Psaltis, “High power, ultrashort pulse control through a multi-core fiber for ablation,” Opt. Express 25(10), 11491–11502 (2017).
[Crossref] [PubMed]

D. B. Conkey, N. Stasio, E. E. Morales-Delgado, M. Romito, C. Moser, and D. Psaltis, “Lensless two-photon imaging through a multicore fiber with coherence-gated digital phase conjugation,” J. Biomed. Opt. 21(4), 45002 (2016).
[Crossref] [PubMed]

D. Loterie, S. Farahi, I. Papadopoulos, A. Goy, D. Psaltis, and C. Moser, “Digital confocal microscopy through a multimode fiber,” Opt. Express 23(18), 23845–23858 (2015).
[Crossref] [PubMed]

E. E. Morales-Delgado, D. Psaltis, and C. Moser, “Two-photon imaging through a multimode fiber,” Opt. Express 23(25), 32158–32170 (2015).
[Crossref] [PubMed]

E. E. Morales-Delgado, S. Farahi, I. N. Papadopoulos, D. Psaltis, and C. Moser, “Delivery of focused short pulses through a multimode fiber,” Opt. Express 23(7), 9109–9120 (2015).
[Crossref] [PubMed]

I. N. Papadopoulos, S. Farahi, C. Moser, and D. Psaltis, “High-resolution, lensless endoscope based on digital scanning through a multimode optical fiber,” Biomed. Opt. Express 4(2), 260–270 (2013).
[Crossref] [PubMed]

I. N. Papadopoulos, S. Farahi, C. Moser, and D. Psaltis, “Focusing and scanning light through a multimode optical fiber using digital phase conjugation,” Opt. Express 20(10), 10583–10590 (2012).
[Crossref] [PubMed]

Qiu, J.

J. Qiu, J. Neev, T. Wang, and T. E. Milner, “Deep subsurface cavities in skin utilizing mechanical optical clearing and femtosecond laser ablation,” Lasers Surg. Med. 45(6), 383–390 (2013).
[Crossref] [PubMed]

Reichenbach, K. L.

Rigneault, H.

Romito, M.

D. B. Conkey, N. Stasio, E. E. Morales-Delgado, M. Romito, C. Moser, and D. Psaltis, “Lensless two-photon imaging through a multicore fiber with coherence-gated digital phase conjugation,” J. Biomed. Opt. 21(4), 45002 (2016).
[Crossref] [PubMed]

Rosen, S.

S. Rosen, D. Gilboa, O. Katz, and Y. Silberberg, “Focusing and Scanning through Flexible Multimode Fibers without Access to the Distal End,” 8 (n.d.).

Russell, P.

P. Russell, “Photonic crystal fibers,” Science 299(5605), 358–362 (2003).
[Crossref] [PubMed]

Russell, P. S. J.

Sasaki, T.

K. Nakamura, Y. Sora, H. Y. Yoshikawa, Y. Hosokawa, R. Murai, H. Adachi, Y. Mori, T. Sasaki, and H. Masuhara, “Femtosecond laser-induced crystallization of protein in gel medium,” Appl. Surf. Sci. 253(15), 6425–6429 (2007).
[Crossref]

Scharf, E.

Serbin, J.

J. Serbin, T. Bauer, C. Fallnich, A. Kasenbacher, and W. H. Arnold, “Femtosecond lasers as novel tool in dental surgery,” Appl. Surf. Sci. 197–198, 737–740 (2002).
[Crossref]

Shadfan, A.

Sheehy, K.

L. He, K. Sheehy, and W. Culbertson, “Femtosecond laser-assisted cataract surgery,” Curr. Opin. Ophthalmol. 22, 43 (2010).
[Crossref] [PubMed]

Shinde, A.

A. Shinde, S. M. Perinchery, and V. M. Murukeshan, “A targeted illumination optical fiber probe for high resolution fluorescence imaging and optical switching,” Sci. Rep. 7(1), 45654 (2017).
[Crossref] [PubMed]

Silberberg, Y.

S. Rosen, D. Gilboa, O. Katz, and Y. Silberberg, “Focusing and Scanning through Flexible Multimode Fibers without Access to the Distal End,” 8 (n.d.).

Sivankutty, S.

Sora, Y.

K. Nakamura, Y. Sora, H. Y. Yoshikawa, Y. Hosokawa, R. Murai, H. Adachi, Y. Mori, T. Sasaki, and H. Masuhara, “Femtosecond laser-induced crystallization of protein in gel medium,” Appl. Surf. Sci. 253(15), 6425–6429 (2007).
[Crossref]

Stasio, N.

D. B. Conkey, E. Kakkava, T. Lanvin, D. Loterie, N. Stasio, E. Morales-Delgado, C. Moser, and D. Psaltis, “High power, ultrashort pulse control through a multi-core fiber for ablation,” Opt. Express 25(10), 11491–11502 (2017).
[Crossref] [PubMed]

D. B. Conkey, N. Stasio, E. E. Morales-Delgado, M. Romito, C. Moser, and D. Psaltis, “Lensless two-photon imaging through a multicore fiber with coherence-gated digital phase conjugation,” J. Biomed. Opt. 21(4), 45002 (2016).
[Crossref] [PubMed]

Stone, J. M.

Subramanian, K.

Tajalli, A.

D. J. McCabe, A. Tajalli, D. R. Austin, P. Bondareff, I. A. Walmsley, S. Gigan, and B. Chatel, “Spatio-temporal focusing of an ultrafast pulse through a multiply scattering medium,” Nat. Commun. 2(1), 447 (2011).
[Crossref] [PubMed]

Tkaczyk, T.

Tyc, T.

M. Plöschner, T. Tyc, and T. Čižmár, “Seeing through chaos in multimode fibres,” Nat. Photonics 9(8), 529–535 (2015).
[Crossref]

Tzang, O.

O. Tzang, A. M. Caravaca-Aguirre, K. Wagner, and R. Piestun, “Adaptive wavefront shaping for controlling nonlinear multimode interactions in optical fibres,” Nat. Photonics 12(6), 368–374 (2018).
[Crossref]

Vellekoop, I. M.

Venugopalan, V.

A. Vogel and V. Venugopalan, “Mechanisms of pulsed laser ablation of biological tissues,” Chem. Rev. 103(2), 577–644 (2003).
[Crossref] [PubMed]

Vincetti, L.

Vogel, A.

A. Vogel and V. Venugopalan, “Mechanisms of pulsed laser ablation of biological tissues,” Chem. Rev. 103(2), 577–644 (2003).
[Crossref] [PubMed]

Wagner, K.

O. Tzang, A. M. Caravaca-Aguirre, K. Wagner, and R. Piestun, “Adaptive wavefront shaping for controlling nonlinear multimode interactions in optical fibres,” Nat. Photonics 12(6), 368–374 (2018).
[Crossref]

Walmsley, I. A.

D. J. McCabe, A. Tajalli, D. R. Austin, P. Bondareff, I. A. Walmsley, S. Gigan, and B. Chatel, “Spatio-temporal focusing of an ultrafast pulse through a multiply scattering medium,” Nat. Commun. 2(1), 447 (2011).
[Crossref] [PubMed]

Wang, T.

J. Qiu, J. Neev, T. Wang, and T. E. Milner, “Deep subsurface cavities in skin utilizing mechanical optical clearing and femtosecond laser ablation,” Lasers Surg. Med. 45(6), 383–390 (2013).
[Crossref] [PubMed]

Wang, Y.

K. Subramanian, I. Gabay, O. Ferhanoğlu, A. Shadfan, M. Pawlowski, Y. Wang, T. Tkaczyk, and A. Ben-Yakar, “Kagome fiber based ultrafast laser microsurgery probe delivering micro-Joule pulse energies,” Biomed. Opt. Express 7(11), 4639–4653 (2016).
[Crossref] [PubMed]

Y. Wang, M. Alharbi, T. D. Bradley, C. Fourcade-Dutin, B. Debord, B. Beaudou, F. Gerôme, and F. Benabid, “Hollow-core photonic crystal fibre for high power laser beam delivery,” High Power Laser Science and Engineering 1(01), 17–28 (2013).
[Crossref]

Warren, S. C.

Xi, J.

Xie, X. S.

Xu, C.

Yang, Q.

Yoshikawa, H. Y.

K. Nakamura, Y. Sora, H. Y. Yoshikawa, Y. Hosokawa, R. Murai, H. Adachi, Y. Mori, T. Sasaki, and H. Masuhara, “Femtosecond laser-induced crystallization of protein in gel medium,” Appl. Surf. Sci. 253(15), 6425–6429 (2007).
[Crossref]

Yu, J.

Zhang, B.

Zhang, Y.

Ann. Biomed. Eng. (1)

S. W. Perry, R. M. Burke, and E. B. Brown, “Two-photon and second harmonic microscopy in clinical and translational cancer research,” Ann. Biomed. Eng. 40(2), 277–291 (2012).
[Crossref] [PubMed]

Appl. Surf. Sci. (2)

J. Serbin, T. Bauer, C. Fallnich, A. Kasenbacher, and W. H. Arnold, “Femtosecond lasers as novel tool in dental surgery,” Appl. Surf. Sci. 197–198, 737–740 (2002).
[Crossref]

K. Nakamura, Y. Sora, H. Y. Yoshikawa, Y. Hosokawa, R. Murai, H. Adachi, Y. Mori, T. Sasaki, and H. Masuhara, “Femtosecond laser-induced crystallization of protein in gel medium,” Appl. Surf. Sci. 253(15), 6425–6429 (2007).
[Crossref]

Biomed. Opt. Express (3)

Chem. Rev. (1)

A. Vogel and V. Venugopalan, “Mechanisms of pulsed laser ablation of biological tissues,” Chem. Rev. 103(2), 577–644 (2003).
[Crossref] [PubMed]

Curr. Opin. Ophthalmol. (1)

L. He, K. Sheehy, and W. Culbertson, “Femtosecond laser-assisted cataract surgery,” Curr. Opin. Ophthalmol. 22, 43 (2010).
[Crossref] [PubMed]

High Power Laser Science and Engineering (1)

Y. Wang, M. Alharbi, T. D. Bradley, C. Fourcade-Dutin, B. Debord, B. Beaudou, F. Gerôme, and F. Benabid, “Hollow-core photonic crystal fibre for high power laser beam delivery,” High Power Laser Science and Engineering 1(01), 17–28 (2013).
[Crossref]

J. Biomed. Opt. (1)

D. B. Conkey, N. Stasio, E. E. Morales-Delgado, M. Romito, C. Moser, and D. Psaltis, “Lensless two-photon imaging through a multicore fiber with coherence-gated digital phase conjugation,” J. Biomed. Opt. 21(4), 45002 (2016).
[Crossref] [PubMed]

J. Opt. Soc. Am. B (1)

Lasers Surg. Med. (1)

J. Qiu, J. Neev, T. Wang, and T. E. Milner, “Deep subsurface cavities in skin utilizing mechanical optical clearing and femtosecond laser ablation,” Lasers Surg. Med. 45(6), 383–390 (2013).
[Crossref] [PubMed]

Nat. Biotechnol. (1)

P. J. Campagnola and L. M. Loew, “Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms,” Nat. Biotechnol. 21(11), 1356–1360 (2003).
[Crossref] [PubMed]

Nat. Commun. (1)

D. J. McCabe, A. Tajalli, D. R. Austin, P. Bondareff, I. A. Walmsley, S. Gigan, and B. Chatel, “Spatio-temporal focusing of an ultrafast pulse through a multiply scattering medium,” Nat. Commun. 2(1), 447 (2011).
[Crossref] [PubMed]

Nat. Methods (1)

F. Helmchen and W. Denk, “Deep tissue two-photon microscopy,” Nat. Methods 2(12), 932–940 (2005).
[Crossref] [PubMed]

Nat. Photonics (2)

M. Plöschner, T. Tyc, and T. Čižmár, “Seeing through chaos in multimode fibres,” Nat. Photonics 9(8), 529–535 (2015).
[Crossref]

O. Tzang, A. M. Caravaca-Aguirre, K. Wagner, and R. Piestun, “Adaptive wavefront shaping for controlling nonlinear multimode interactions in optical fibres,” Nat. Photonics 12(6), 368–374 (2018).
[Crossref]

Opt. Express (14)

A. Descloux, L. V. Amitonova, and P. W. H. Pinkse, “Aberrations of the point spread function of a multimode fiber due to partial mode excitation,” Opt. Express 24(16), 18501–18512 (2016).
[Crossref] [PubMed]

X. Chen, K. L. Reichenbach, and C. Xu, “Experimental and theoretical analysis of core-to-core coupling on fiber bundle imaging,” Opt. Express 16(26), 21598–21607 (2008).
[Crossref] [PubMed]

B. Debord, M. Alharbi, L. Vincetti, A. Husakou, C. Fourcade-Dutin, C. Hoenninger, E. Mottay, F. Gérôme, and F. Benabid, “Multi-meter fiber-delivery and pulse self-compression of milli-Joule femtosecond laser and fiber-aided laser-micromachining,” Opt. Express 22(9), 10735–10746 (2014).
[Crossref] [PubMed]

S. Sivankutty, E. R. Andresen, R. Cossart, G. Bouwmans, S. Monneret, and H. Rigneault, “Ultra-thin rigid endoscope: two-photon imaging through a graded-index multi-mode fiber,” Opt. Express 24(2), 825–841 (2016).
[Crossref] [PubMed]

K. L. Reichenbach and C. Xu, “Numerical analysis of light propagation in image fibers or coherent fiber bundles,” Opt. Express 15(5), 2151–2165 (2007).
[Crossref] [PubMed]

E. E. Morales-Delgado, S. Farahi, I. N. Papadopoulos, D. Psaltis, and C. Moser, “Delivery of focused short pulses through a multimode fiber,” Opt. Express 23(7), 9109–9120 (2015).
[Crossref] [PubMed]

E. E. Morales-Delgado, D. Psaltis, and C. Moser, “Two-photon imaging through a multimode fiber,” Opt. Express 23(25), 32158–32170 (2015).
[Crossref] [PubMed]

E. R. Andresen, G. Bouwmans, S. Monneret, and H. Rigneault, “Two-photon lensless endoscope,” Opt. Express 21(18), 20713–20721 (2013).
[Crossref] [PubMed]

S. C. Warren, Y. Kim, J. M. Stone, C. Mitchell, J. C. Knight, M. A. A. Neil, C. Paterson, P. M. W. French, and C. Dunsby, “Adaptive multiphoton endomicroscopy through a dynamically deformed multicore optical fiber using proximal detection,” Opt. Express 24(19), 21474–21484 (2016).
[Crossref] [PubMed]

F. Légaré, C. L. Evans, F. Ganikhanov, and X. S. Xie, “Towards CARS Endoscopy,” Opt. Express 14(10), 4427–4432 (2006).
[Crossref] [PubMed]

I. N. Papadopoulos, S. Farahi, C. Moser, and D. Psaltis, “Focusing and scanning light through a multimode optical fiber using digital phase conjugation,” Opt. Express 20(10), 10583–10590 (2012).
[Crossref] [PubMed]

D. Loterie, S. Farahi, I. Papadopoulos, A. Goy, D. Psaltis, and C. Moser, “Digital confocal microscopy through a multimode fiber,” Opt. Express 23(18), 23845–23858 (2015).
[Crossref] [PubMed]

D. B. Conkey, E. Kakkava, T. Lanvin, D. Loterie, N. Stasio, E. Morales-Delgado, C. Moser, and D. Psaltis, “High power, ultrashort pulse control through a multi-core fiber for ablation,” Opt. Express 25(10), 11491–11502 (2017).
[Crossref] [PubMed]

R. Di Leonardo and S. Bianchi, “Hologram transmission through multi-mode optical fibers,” Opt. Express 19(1), 247–254 (2011).
[Crossref] [PubMed]

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Figures (4)

Fig. 1
Fig. 1 Transmission matrix experimental setup for focusing and scanning the light through the optical fibers, combined with a TPF autocorrelator and a spectrometer for characterizing the temporal and spectral profile of the pulse and a TPF imaging part for the creation of the sample images. (S = sample, D = dichroic, HWP = half-wave plate, FS = fluorescent sample for TPF autocorrelator, O = microscope objective, L = lens, PBS = polarizing beam splitter, BS = beam splitter)
Fig. 2
Fig. 2 Characterization of the 200 μm (a and b) and 400 μm (c and d) core diameter fibers. (a and c) Focusing efficiency for the 200 μm and the 400 μm core GRIN fiber respectively, and (b and d) the corresponding peak intensity delivered at the distal spot as a function of input pulse energy for each of the two systems respectively.
Fig. 3
Fig. 3 TPF imaging of the Cochlear hair cell sample stained with PI in a) a wide image of the sample, b) zoomed region of interest (yellow square) and c) the same area as (b) after selectively ablating a cell marked in the white circle. The scale bar in all images is 10 μm.
Fig. 4
Fig. 4 BF images that show the time evolution of the bubble generated after FLA of a hair cell within the organ of Corti. t = 0 s is the time just after the FLA is finished. The scale bar in all the images is 10 μm.

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