Abstract

In this paper, we propose the application of time-domain near-infrared spectroscopy to the assessment of oscillations in cerebral hemodynamics. These oscillations were observed in the statistical moments of the distributions of time of flight of photons (DTOFs) measured on the head. We analyzed the zeroth and second centralized moments of DTOFs (total number of photons and variance) to obtain their spectra to provide parameters for the frequency components of microcirculation, which differ between the extracerebral and intracerebral layers of the head. Analysis of these moments revealed statistically significant differences between a control group of healthy subjects and a group of patients with severe neurovascular disorders, which is a promising result for the assessment of cerebral microcirculation and cerebral autoregulation mechanisms.

© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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References

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  1. T. Durduran and A. G. Yodh, “Diffuse correlation spectroscopy for non-invasive, micro-vascular cerebral blood flow measurement,” Neuroimage 85(Pt 1), 51–63 (2014).
    [Crossref] [PubMed]
  2. A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85(Pt 1), 28–50 (2014).
    [Crossref] [PubMed]
  3. W. Weigl, D. Milej, D. Janusek, S. Wojtkiewicz, P. Sawosz, M. Kacprzak, A. Gerega, R. Maniewski, and A. Liebert, “Application of optical methods in the monitoring of traumatic brain injury: A review,” J. Cereb. Blood Flow Metab. 36(11), 1825–1843 (2016).
    [Crossref] [PubMed]
  4. R. Maniewski, A. Liebert, M. Kacprzak, and A. Zbiec, “Selected applications of near infrared optical methods in medical diagnosis,” Opto-Electron. Rev. 12, 255–262 (2004).
  5. D. A. Boas, T. Gaudette, G. Strangman, X. Cheng, J. J. Marota, and J. B. Mandeville, “The accuracy of near infrared spectroscopy and imaging during focal changes in cerebral hemodynamics,” Neuroimage 13(1), 76–90 (2001).
    [Crossref] [PubMed]
  6. L. Spinelli, L. Zucchelli, D. Contini, M. Caffini, J. Mehler, A. Fló, A. L. Ferry, L. Filippin, F. Macagno, L. Cattarossi, and A. Torricelli, “In vivo measure of neonate brain optical properties and hemodynamic parameters by time-domain near-infrared spectroscopy,” Neurophotonics 4(4), 041414 (2017).
    [Crossref] [PubMed]
  7. S. L. Ferradal, K. Yuki, R. Vyas, C. G. Ha, F. Yi, C. Stopp, D. Wypij, H. H. Cheng, J. W. Newburger, A. K. Kaza, M. A. Franceschini, B. D. Kussman, and P. E. Grant, “Non-invasive Assessment of Cerebral Blood Flow and Oxygen Metabolism in Neonates during Hypothermic Cardiopulmonary Bypass: Feasibility and Clinical Implications,” Sci Rep-Uk 7, 44117 (2017).
    [Crossref]
  8. G. Greisen, T. Leung, and M. Wolf, “Has the time come to use near-infrared spectroscopy as a routine clinical tool in preterm infants undergoing intensive care?” Philos Trans A Math Phys Eng Sci 369(1955), 4440–4451 (2011).
    [Crossref] [PubMed]
  9. C. Zweifel, G. Castellani, M. Czosnyka, A. Helmy, A. Manktelow, E. Carrera, K. M. Brady, P. J. Hutchinson, D. K. Menon, J. D. Pickard, and P. Smielewski, “Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients,” J. Neurotrauma 27(11), 1951–1958 (2010).
    [Crossref] [PubMed]
  10. D. Highton, A. Ghosh, I. Tachtsidis, J. Panovska-Griffiths, C. E. Elwell, and M. Smith, “Monitoring Cerebral Autoregulation After Brain Injury: Multimodal Assessment of Cerebral Slow-Wave Oscillations Using Near-Infrared Spectroscopy,” Anesth. Analg. 121(1), 198–205 (2015).
    [Crossref] [PubMed]
  11. M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
    [Crossref] [PubMed]
  12. P. Zirak, R. Delgado-Mederos, L. Dinia, D. Carrera, J. Martí-Fàbregas, and T. Durduran, “Transcranial diffuse optical monitoring of microvascular cerebral hemodynamics after thrombolysis in ischemic stroke,” J. Biomed. Opt. 19(1), 018002 (2014).
    [Crossref] [PubMed]
  13. C. C. Lo, P. Y. Lin, Z. Y. Hoe, and J. J. J. Chen, “Near Infrared Spectroscopy Study of Cortical Excitability During Electrical Stimulation-Assisted Cycling for Neurorehabilitation of Stroke Patients,” IEEE Trans. Neural Syst. Rehabil. Eng. 26(6), 1292–1300 (2018).
    [Crossref] [PubMed]
  14. C. Terborg, S. Bramer, S. Harscher, M. Simon, and O. W. Witte, “Bedside assessment of cerebral perfusion reductions in patients with acute ischaemic stroke by near-infrared spectroscopy and indocyanine green,” J. Neurol. Neurosurg. Psychiatry 75(1), 38–42 (2004).
    [PubMed]
  15. W. Weigl, D. Milej, A. Gerega, B. Toczyłowska, P. Sawosz, M. Kacprzak, D. Janusek, S. Wojtkiewicz, R. Maniewski, and A. Liebert, “Confirmation of brain death using optical methods based on tracking of an optical contrast agent: assessment of diagnostic feasibility,” Sci. Rep. 8(1), 7332 (2018).
    [Crossref] [PubMed]
  16. O. Steinkellner, C. Gruber, H. Wabnitz, A. Jelzow, J. Steinbrink, J. B. Fiebach, R. Macdonald, and H. Obrig, “Optical bedside monitoring of cerebral perfusion: technological and methodological advances applied in a study on acute ischemic stroke,” J. Biomed. Opt. 15(6), 061708 (2010).
    [Crossref] [PubMed]
  17. H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
    [Crossref] [PubMed]
  18. H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
    [Crossref] [PubMed]
  19. G. Giacalone, M. Zanoletti, D. Contini, R. Re, L. Spinelli, L. Roveri, and A. Torricelli, “Cerebral time domain-NIRS: reproducibility analysis, optical properties, hemoglobin species and tissue oxygen saturation in a cohort of adult subjects,” Biomed. Opt. Express 8(11), 4987–5000 (2017).
    [Crossref] [PubMed]
  20. P. Sawosz, M. Kacprzak, W. Weigl, A. Borowska-Solonynko, P. Krajewski, N. Zolek, B. Ciszek, R. Maniewski, and A. Liebert, “Experimental estimation of the photons visiting probability profiles in time-resolved diffuse reflectance measurement,” Phys. Med. Biol. 57(23), 7973–7981 (2012).
    [Crossref] [PubMed]
  21. J. Steinbrink, H. Wabnitz, H. Obrig, A. Villringer, and H. Rinneberg, “Determining changes in NIR absorption using a layered model of the human head,” Phys. Med. Biol. 46(3), 879–896 (2001).
    [Crossref] [PubMed]
  22. A. Liebert, H. Wabnitz, J. Steinbrink, H. Obrig, M. Möller, R. Macdonald, A. Villringer, and H. Rinneberg, “Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons,” Appl. Opt. 43(15), 3037–3047 (2004).
    [Crossref] [PubMed]
  23. A. Gerega, D. Milej, W. Weigl, M. Kacprzak, and A. Liebert, “Multiwavelength time-resolved near-infrared spectroscopy of the adult head: assessment of intracerebral and extracerebral absorption changes,” Biomed. Opt. Express 9(7), 2974–2993 (2018).
    [Crossref] [PubMed]
  24. C. Zweifel, G. Castellani, M. Czosnyka, E. Carrera, K. M. Brady, P. J. Kirkpatrick, J. D. Pickard, and P. Smielewski, “Continuous assessment of cerebral autoregulation with near-infrared spectroscopy in adults after subarachnoid hemorrhage,” Stroke 41(9), 1963–1968 (2010).
    [Crossref] [PubMed]
  25. C. Dias, M. J. Silva, E. Pereira, E. Monteiro, I. Maia, S. Barbosa, S. Silva, T. Honrado, A. Cerejo, M. J. H. Aries, P. Smielewski, J. A. Paiva, and M. Czosnyka, “Optimal Cerebral Perfusion Pressure Management at Bedside: A Single-Center Pilot Study,” Neurocrit. Care 23(1), 92–102 (2015).
    [Crossref] [PubMed]
  26. J. Diedler, C. Zweifel, K. P. Budohoski, M. Kasprowicz, E. Sorrentino, C. Haubrich, K. M. Brady, M. Czosnyka, J. D. Pickard, and P. Smielewski, “The Limitations of Near-Infrared Spectroscopy to Assess Cerebrovascular Reactivity: the Role of Slow Frequency Oscillations,” Anesth. Analg. 113(4), 849–857 (2011).
    [Crossref] [PubMed]
  27. N. A. Lassen, “Cerebral Blood Flow and Oxygen Consumption in Man,” Physiol. Rev. 39(2), 183–238 (1959).
    [Crossref] [PubMed]
  28. C. K. Willie, Y. C. Tzeng, J. A. Fisher, and P. N. Ainslie, “Integrative regulation of human brain blood flow,” J. Physiol. 592(5), 841–859 (2014).
    [Crossref] [PubMed]
  29. R. Aaslid, M. Blaha, G. Sviri, C. M. Douville, and D. W. Newell, “Asymmetric dynamic cerebral autoregulatory response to cyclic stimuli,” Stroke 38(5), 1465–1469 (2007).
    [Crossref] [PubMed]
  30. B. Schmidt, J. Klingelhöfer, I. Perkes, and M. Czosnyka, “Cerebral Autoregulatory Response Depends on the Direction of Change in Perfusion Pressure,” J. Neurotrauma 26(5), 651–656 (2009).
    [Crossref] [PubMed]
  31. C. O. Tan, “Defining the characteristic relationship between arterial pressure and cerebral flow,” J. Appl. Physiol. 113(8), 1194–1200 (2012).
    [Crossref] [PubMed]
  32. J. Donnelly, K. P. Budohoski, P. Smielewski, and M. Czosnyka, “Regulation of the cerebral circulation: bedside assessment and clinical implications,” Crit. Care 20(1), 129 (2016).
    [Crossref] [PubMed]
  33. C. A. Giller, “The Frequency-Dependent Behavior of Cerebral Autoregulation,” Neurosurgery 27(3), 362–368 (1990).
    [Crossref] [PubMed]
  34. R. R. Diehl, D. Linden, D. Lücke, and P. Berlit, “Phase Relationship Between Cerebral Blood Flow Velocity and Blood Pressure. a Clinical Test of Autoregulation,” Stroke 26(10), 1801–1804 (1995).
    [Crossref] [PubMed]
  35. C. Haubrich, W. Kruska, R. R. Diehl, W. Möller-Hartmann, and C. Klötzsch, “Dynamic autoregulation testing in patients with middle cerebral artery stenosis,” Stroke 34(8), 1881–1885 (2003).
    [Crossref] [PubMed]
  36. M. Czosnyka, K. Brady, M. Reinhard, P. Smielewski, and L. A. Steiner, “Monitoring of cerebrovascular autoregulation: facts, myths, and missing links,” Neurocrit. Care 10(3), 373–386 (2009).
    [Crossref] [PubMed]
  37. M. Kacprzak, A. Liebert, W. Staszkiewicz, A. Gabrusiewicz, P. Sawosz, G. Madycki, and R. Maniewski, “Application of a time-resolved optical brain imager for monitoring cerebral oxygenation during carotid surgery,” J. Biomed. Opt. 17(1), 016002 (2012).
    [Crossref] [PubMed]
  38. O. Steinkellner, H. Wabnitz, A. Jelzow, R. Macdonald, C. Gruber, J. Steinbrink, and H. Obrig, “Cerebral Perfusion in Acute Stroke Monitored by Time-domain Near-infrared Reflectometry,” Biocybern. Biomed. Eng. 32(1), 3–16 (2012).
    [Crossref]

2018 (3)

C. C. Lo, P. Y. Lin, Z. Y. Hoe, and J. J. J. Chen, “Near Infrared Spectroscopy Study of Cortical Excitability During Electrical Stimulation-Assisted Cycling for Neurorehabilitation of Stroke Patients,” IEEE Trans. Neural Syst. Rehabil. Eng. 26(6), 1292–1300 (2018).
[Crossref] [PubMed]

W. Weigl, D. Milej, A. Gerega, B. Toczyłowska, P. Sawosz, M. Kacprzak, D. Janusek, S. Wojtkiewicz, R. Maniewski, and A. Liebert, “Confirmation of brain death using optical methods based on tracking of an optical contrast agent: assessment of diagnostic feasibility,” Sci. Rep. 8(1), 7332 (2018).
[Crossref] [PubMed]

A. Gerega, D. Milej, W. Weigl, M. Kacprzak, and A. Liebert, “Multiwavelength time-resolved near-infrared spectroscopy of the adult head: assessment of intracerebral and extracerebral absorption changes,” Biomed. Opt. Express 9(7), 2974–2993 (2018).
[Crossref] [PubMed]

2017 (2)

L. Spinelli, L. Zucchelli, D. Contini, M. Caffini, J. Mehler, A. Fló, A. L. Ferry, L. Filippin, F. Macagno, L. Cattarossi, and A. Torricelli, “In vivo measure of neonate brain optical properties and hemodynamic parameters by time-domain near-infrared spectroscopy,” Neurophotonics 4(4), 041414 (2017).
[Crossref] [PubMed]

G. Giacalone, M. Zanoletti, D. Contini, R. Re, L. Spinelli, L. Roveri, and A. Torricelli, “Cerebral time domain-NIRS: reproducibility analysis, optical properties, hemoglobin species and tissue oxygen saturation in a cohort of adult subjects,” Biomed. Opt. Express 8(11), 4987–5000 (2017).
[Crossref] [PubMed]

2016 (2)

J. Donnelly, K. P. Budohoski, P. Smielewski, and M. Czosnyka, “Regulation of the cerebral circulation: bedside assessment and clinical implications,” Crit. Care 20(1), 129 (2016).
[Crossref] [PubMed]

W. Weigl, D. Milej, D. Janusek, S. Wojtkiewicz, P. Sawosz, M. Kacprzak, A. Gerega, R. Maniewski, and A. Liebert, “Application of optical methods in the monitoring of traumatic brain injury: A review,” J. Cereb. Blood Flow Metab. 36(11), 1825–1843 (2016).
[Crossref] [PubMed]

2015 (2)

D. Highton, A. Ghosh, I. Tachtsidis, J. Panovska-Griffiths, C. E. Elwell, and M. Smith, “Monitoring Cerebral Autoregulation After Brain Injury: Multimodal Assessment of Cerebral Slow-Wave Oscillations Using Near-Infrared Spectroscopy,” Anesth. Analg. 121(1), 198–205 (2015).
[Crossref] [PubMed]

C. Dias, M. J. Silva, E. Pereira, E. Monteiro, I. Maia, S. Barbosa, S. Silva, T. Honrado, A. Cerejo, M. J. H. Aries, P. Smielewski, J. A. Paiva, and M. Czosnyka, “Optimal Cerebral Perfusion Pressure Management at Bedside: A Single-Center Pilot Study,” Neurocrit. Care 23(1), 92–102 (2015).
[Crossref] [PubMed]

2014 (6)

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

T. Durduran and A. G. Yodh, “Diffuse correlation spectroscopy for non-invasive, micro-vascular cerebral blood flow measurement,” Neuroimage 85(Pt 1), 51–63 (2014).
[Crossref] [PubMed]

A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85(Pt 1), 28–50 (2014).
[Crossref] [PubMed]

C. K. Willie, Y. C. Tzeng, J. A. Fisher, and P. N. Ainslie, “Integrative regulation of human brain blood flow,” J. Physiol. 592(5), 841–859 (2014).
[Crossref] [PubMed]

P. Zirak, R. Delgado-Mederos, L. Dinia, D. Carrera, J. Martí-Fàbregas, and T. Durduran, “Transcranial diffuse optical monitoring of microvascular cerebral hemodynamics after thrombolysis in ischemic stroke,” J. Biomed. Opt. 19(1), 018002 (2014).
[Crossref] [PubMed]

2012 (4)

C. O. Tan, “Defining the characteristic relationship between arterial pressure and cerebral flow,” J. Appl. Physiol. 113(8), 1194–1200 (2012).
[Crossref] [PubMed]

M. Kacprzak, A. Liebert, W. Staszkiewicz, A. Gabrusiewicz, P. Sawosz, G. Madycki, and R. Maniewski, “Application of a time-resolved optical brain imager for monitoring cerebral oxygenation during carotid surgery,” J. Biomed. Opt. 17(1), 016002 (2012).
[Crossref] [PubMed]

O. Steinkellner, H. Wabnitz, A. Jelzow, R. Macdonald, C. Gruber, J. Steinbrink, and H. Obrig, “Cerebral Perfusion in Acute Stroke Monitored by Time-domain Near-infrared Reflectometry,” Biocybern. Biomed. Eng. 32(1), 3–16 (2012).
[Crossref]

P. Sawosz, M. Kacprzak, W. Weigl, A. Borowska-Solonynko, P. Krajewski, N. Zolek, B. Ciszek, R. Maniewski, and A. Liebert, “Experimental estimation of the photons visiting probability profiles in time-resolved diffuse reflectance measurement,” Phys. Med. Biol. 57(23), 7973–7981 (2012).
[Crossref] [PubMed]

2011 (2)

G. Greisen, T. Leung, and M. Wolf, “Has the time come to use near-infrared spectroscopy as a routine clinical tool in preterm infants undergoing intensive care?” Philos Trans A Math Phys Eng Sci 369(1955), 4440–4451 (2011).
[Crossref] [PubMed]

J. Diedler, C. Zweifel, K. P. Budohoski, M. Kasprowicz, E. Sorrentino, C. Haubrich, K. M. Brady, M. Czosnyka, J. D. Pickard, and P. Smielewski, “The Limitations of Near-Infrared Spectroscopy to Assess Cerebrovascular Reactivity: the Role of Slow Frequency Oscillations,” Anesth. Analg. 113(4), 849–857 (2011).
[Crossref] [PubMed]

2010 (4)

C. Zweifel, G. Castellani, M. Czosnyka, E. Carrera, K. M. Brady, P. J. Kirkpatrick, J. D. Pickard, and P. Smielewski, “Continuous assessment of cerebral autoregulation with near-infrared spectroscopy in adults after subarachnoid hemorrhage,” Stroke 41(9), 1963–1968 (2010).
[Crossref] [PubMed]

O. Steinkellner, C. Gruber, H. Wabnitz, A. Jelzow, J. Steinbrink, J. B. Fiebach, R. Macdonald, and H. Obrig, “Optical bedside monitoring of cerebral perfusion: technological and methodological advances applied in a study on acute ischemic stroke,” J. Biomed. Opt. 15(6), 061708 (2010).
[Crossref] [PubMed]

C. Zweifel, G. Castellani, M. Czosnyka, A. Helmy, A. Manktelow, E. Carrera, K. M. Brady, P. J. Hutchinson, D. K. Menon, J. D. Pickard, and P. Smielewski, “Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients,” J. Neurotrauma 27(11), 1951–1958 (2010).
[Crossref] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

2009 (2)

M. Czosnyka, K. Brady, M. Reinhard, P. Smielewski, and L. A. Steiner, “Monitoring of cerebrovascular autoregulation: facts, myths, and missing links,” Neurocrit. Care 10(3), 373–386 (2009).
[Crossref] [PubMed]

B. Schmidt, J. Klingelhöfer, I. Perkes, and M. Czosnyka, “Cerebral Autoregulatory Response Depends on the Direction of Change in Perfusion Pressure,” J. Neurotrauma 26(5), 651–656 (2009).
[Crossref] [PubMed]

2007 (1)

R. Aaslid, M. Blaha, G. Sviri, C. M. Douville, and D. W. Newell, “Asymmetric dynamic cerebral autoregulatory response to cyclic stimuli,” Stroke 38(5), 1465–1469 (2007).
[Crossref] [PubMed]

2004 (3)

A. Liebert, H. Wabnitz, J. Steinbrink, H. Obrig, M. Möller, R. Macdonald, A. Villringer, and H. Rinneberg, “Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons,” Appl. Opt. 43(15), 3037–3047 (2004).
[Crossref] [PubMed]

R. Maniewski, A. Liebert, M. Kacprzak, and A. Zbiec, “Selected applications of near infrared optical methods in medical diagnosis,” Opto-Electron. Rev. 12, 255–262 (2004).

C. Terborg, S. Bramer, S. Harscher, M. Simon, and O. W. Witte, “Bedside assessment of cerebral perfusion reductions in patients with acute ischaemic stroke by near-infrared spectroscopy and indocyanine green,” J. Neurol. Neurosurg. Psychiatry 75(1), 38–42 (2004).
[PubMed]

2003 (1)

C. Haubrich, W. Kruska, R. R. Diehl, W. Möller-Hartmann, and C. Klötzsch, “Dynamic autoregulation testing in patients with middle cerebral artery stenosis,” Stroke 34(8), 1881–1885 (2003).
[Crossref] [PubMed]

2001 (2)

J. Steinbrink, H. Wabnitz, H. Obrig, A. Villringer, and H. Rinneberg, “Determining changes in NIR absorption using a layered model of the human head,” Phys. Med. Biol. 46(3), 879–896 (2001).
[Crossref] [PubMed]

D. A. Boas, T. Gaudette, G. Strangman, X. Cheng, J. J. Marota, and J. B. Mandeville, “The accuracy of near infrared spectroscopy and imaging during focal changes in cerebral hemodynamics,” Neuroimage 13(1), 76–90 (2001).
[Crossref] [PubMed]

1995 (1)

R. R. Diehl, D. Linden, D. Lücke, and P. Berlit, “Phase Relationship Between Cerebral Blood Flow Velocity and Blood Pressure. a Clinical Test of Autoregulation,” Stroke 26(10), 1801–1804 (1995).
[Crossref] [PubMed]

1990 (1)

C. A. Giller, “The Frequency-Dependent Behavior of Cerebral Autoregulation,” Neurosurgery 27(3), 362–368 (1990).
[Crossref] [PubMed]

1959 (1)

N. A. Lassen, “Cerebral Blood Flow and Oxygen Consumption in Man,” Physiol. Rev. 39(2), 183–238 (1959).
[Crossref] [PubMed]

Aaslid, R.

R. Aaslid, M. Blaha, G. Sviri, C. M. Douville, and D. W. Newell, “Asymmetric dynamic cerebral autoregulatory response to cyclic stimuli,” Stroke 38(5), 1465–1469 (2007).
[Crossref] [PubMed]

Ainslie, P. N.

C. K. Willie, Y. C. Tzeng, J. A. Fisher, and P. N. Ainslie, “Integrative regulation of human brain blood flow,” J. Physiol. 592(5), 841–859 (2014).
[Crossref] [PubMed]

Aries, M. J. H.

C. Dias, M. J. Silva, E. Pereira, E. Monteiro, I. Maia, S. Barbosa, S. Silva, T. Honrado, A. Cerejo, M. J. H. Aries, P. Smielewski, J. A. Paiva, and M. Czosnyka, “Optimal Cerebral Perfusion Pressure Management at Bedside: A Single-Center Pilot Study,” Neurocrit. Care 23(1), 92–102 (2015).
[Crossref] [PubMed]

Barbosa, S.

C. Dias, M. J. Silva, E. Pereira, E. Monteiro, I. Maia, S. Barbosa, S. Silva, T. Honrado, A. Cerejo, M. J. H. Aries, P. Smielewski, J. A. Paiva, and M. Czosnyka, “Optimal Cerebral Perfusion Pressure Management at Bedside: A Single-Center Pilot Study,” Neurocrit. Care 23(1), 92–102 (2015).
[Crossref] [PubMed]

Bargigia, I.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

Berlit, P.

R. R. Diehl, D. Linden, D. Lücke, and P. Berlit, “Phase Relationship Between Cerebral Blood Flow Velocity and Blood Pressure. a Clinical Test of Autoregulation,” Stroke 26(10), 1801–1804 (1995).
[Crossref] [PubMed]

Blaha, M.

R. Aaslid, M. Blaha, G. Sviri, C. M. Douville, and D. W. Newell, “Asymmetric dynamic cerebral autoregulatory response to cyclic stimuli,” Stroke 38(5), 1465–1469 (2007).
[Crossref] [PubMed]

Boas, D. A.

D. A. Boas, T. Gaudette, G. Strangman, X. Cheng, J. J. Marota, and J. B. Mandeville, “The accuracy of near infrared spectroscopy and imaging during focal changes in cerebral hemodynamics,” Neuroimage 13(1), 76–90 (2001).
[Crossref] [PubMed]

Borowska-Solonynko, A.

P. Sawosz, M. Kacprzak, W. Weigl, A. Borowska-Solonynko, P. Krajewski, N. Zolek, B. Ciszek, R. Maniewski, and A. Liebert, “Experimental estimation of the photons visiting probability profiles in time-resolved diffuse reflectance measurement,” Phys. Med. Biol. 57(23), 7973–7981 (2012).
[Crossref] [PubMed]

Brady, K.

M. Czosnyka, K. Brady, M. Reinhard, P. Smielewski, and L. A. Steiner, “Monitoring of cerebrovascular autoregulation: facts, myths, and missing links,” Neurocrit. Care 10(3), 373–386 (2009).
[Crossref] [PubMed]

Brady, K. M.

J. Diedler, C. Zweifel, K. P. Budohoski, M. Kasprowicz, E. Sorrentino, C. Haubrich, K. M. Brady, M. Czosnyka, J. D. Pickard, and P. Smielewski, “The Limitations of Near-Infrared Spectroscopy to Assess Cerebrovascular Reactivity: the Role of Slow Frequency Oscillations,” Anesth. Analg. 113(4), 849–857 (2011).
[Crossref] [PubMed]

C. Zweifel, G. Castellani, M. Czosnyka, E. Carrera, K. M. Brady, P. J. Kirkpatrick, J. D. Pickard, and P. Smielewski, “Continuous assessment of cerebral autoregulation with near-infrared spectroscopy in adults after subarachnoid hemorrhage,” Stroke 41(9), 1963–1968 (2010).
[Crossref] [PubMed]

C. Zweifel, G. Castellani, M. Czosnyka, A. Helmy, A. Manktelow, E. Carrera, K. M. Brady, P. J. Hutchinson, D. K. Menon, J. D. Pickard, and P. Smielewski, “Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients,” J. Neurotrauma 27(11), 1951–1958 (2010).
[Crossref] [PubMed]

Bramer, S.

C. Terborg, S. Bramer, S. Harscher, M. Simon, and O. W. Witte, “Bedside assessment of cerebral perfusion reductions in patients with acute ischaemic stroke by near-infrared spectroscopy and indocyanine green,” J. Neurol. Neurosurg. Psychiatry 75(1), 38–42 (2004).
[PubMed]

Buckley, E. M.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Budohoski, K. P.

J. Donnelly, K. P. Budohoski, P. Smielewski, and M. Czosnyka, “Regulation of the cerebral circulation: bedside assessment and clinical implications,” Crit. Care 20(1), 129 (2016).
[Crossref] [PubMed]

J. Diedler, C. Zweifel, K. P. Budohoski, M. Kasprowicz, E. Sorrentino, C. Haubrich, K. M. Brady, M. Czosnyka, J. D. Pickard, and P. Smielewski, “The Limitations of Near-Infrared Spectroscopy to Assess Cerebrovascular Reactivity: the Role of Slow Frequency Oscillations,” Anesth. Analg. 113(4), 849–857 (2011).
[Crossref] [PubMed]

Caffini, M.

L. Spinelli, L. Zucchelli, D. Contini, M. Caffini, J. Mehler, A. Fló, A. L. Ferry, L. Filippin, F. Macagno, L. Cattarossi, and A. Torricelli, “In vivo measure of neonate brain optical properties and hemodynamic parameters by time-domain near-infrared spectroscopy,” Neurophotonics 4(4), 041414 (2017).
[Crossref] [PubMed]

A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85(Pt 1), 28–50 (2014).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

Carrera, D.

P. Zirak, R. Delgado-Mederos, L. Dinia, D. Carrera, J. Martí-Fàbregas, and T. Durduran, “Transcranial diffuse optical monitoring of microvascular cerebral hemodynamics after thrombolysis in ischemic stroke,” J. Biomed. Opt. 19(1), 018002 (2014).
[Crossref] [PubMed]

Carrera, E.

C. Zweifel, G. Castellani, M. Czosnyka, A. Helmy, A. Manktelow, E. Carrera, K. M. Brady, P. J. Hutchinson, D. K. Menon, J. D. Pickard, and P. Smielewski, “Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients,” J. Neurotrauma 27(11), 1951–1958 (2010).
[Crossref] [PubMed]

C. Zweifel, G. Castellani, M. Czosnyka, E. Carrera, K. M. Brady, P. J. Kirkpatrick, J. D. Pickard, and P. Smielewski, “Continuous assessment of cerebral autoregulation with near-infrared spectroscopy in adults after subarachnoid hemorrhage,” Stroke 41(9), 1963–1968 (2010).
[Crossref] [PubMed]

Castellani, G.

C. Zweifel, G. Castellani, M. Czosnyka, E. Carrera, K. M. Brady, P. J. Kirkpatrick, J. D. Pickard, and P. Smielewski, “Continuous assessment of cerebral autoregulation with near-infrared spectroscopy in adults after subarachnoid hemorrhage,” Stroke 41(9), 1963–1968 (2010).
[Crossref] [PubMed]

C. Zweifel, G. Castellani, M. Czosnyka, A. Helmy, A. Manktelow, E. Carrera, K. M. Brady, P. J. Hutchinson, D. K. Menon, J. D. Pickard, and P. Smielewski, “Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients,” J. Neurotrauma 27(11), 1951–1958 (2010).
[Crossref] [PubMed]

Cattarossi, L.

L. Spinelli, L. Zucchelli, D. Contini, M. Caffini, J. Mehler, A. Fló, A. L. Ferry, L. Filippin, F. Macagno, L. Cattarossi, and A. Torricelli, “In vivo measure of neonate brain optical properties and hemodynamic parameters by time-domain near-infrared spectroscopy,” Neurophotonics 4(4), 041414 (2017).
[Crossref] [PubMed]

Cerejo, A.

C. Dias, M. J. Silva, E. Pereira, E. Monteiro, I. Maia, S. Barbosa, S. Silva, T. Honrado, A. Cerejo, M. J. H. Aries, P. Smielewski, J. A. Paiva, and M. Czosnyka, “Optimal Cerebral Perfusion Pressure Management at Bedside: A Single-Center Pilot Study,” Neurocrit. Care 23(1), 92–102 (2015).
[Crossref] [PubMed]

Chen, J. J. J.

C. C. Lo, P. Y. Lin, Z. Y. Hoe, and J. J. J. Chen, “Near Infrared Spectroscopy Study of Cortical Excitability During Electrical Stimulation-Assisted Cycling for Neurorehabilitation of Stroke Patients,” IEEE Trans. Neural Syst. Rehabil. Eng. 26(6), 1292–1300 (2018).
[Crossref] [PubMed]

Cheng, X.

D. A. Boas, T. Gaudette, G. Strangman, X. Cheng, J. J. Marota, and J. B. Mandeville, “The accuracy of near infrared spectroscopy and imaging during focal changes in cerebral hemodynamics,” Neuroimage 13(1), 76–90 (2001).
[Crossref] [PubMed]

Choe, R.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Ciszek, B.

P. Sawosz, M. Kacprzak, W. Weigl, A. Borowska-Solonynko, P. Krajewski, N. Zolek, B. Ciszek, R. Maniewski, and A. Liebert, “Experimental estimation of the photons visiting probability profiles in time-resolved diffuse reflectance measurement,” Phys. Med. Biol. 57(23), 7973–7981 (2012).
[Crossref] [PubMed]

Contini, D.

G. Giacalone, M. Zanoletti, D. Contini, R. Re, L. Spinelli, L. Roveri, and A. Torricelli, “Cerebral time domain-NIRS: reproducibility analysis, optical properties, hemoglobin species and tissue oxygen saturation in a cohort of adult subjects,” Biomed. Opt. Express 8(11), 4987–5000 (2017).
[Crossref] [PubMed]

L. Spinelli, L. Zucchelli, D. Contini, M. Caffini, J. Mehler, A. Fló, A. L. Ferry, L. Filippin, F. Macagno, L. Cattarossi, and A. Torricelli, “In vivo measure of neonate brain optical properties and hemodynamic parameters by time-domain near-infrared spectroscopy,” Neurophotonics 4(4), 041414 (2017).
[Crossref] [PubMed]

A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85(Pt 1), 28–50 (2014).
[Crossref] [PubMed]

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

Cooper, R.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

Cubeddu, R.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

Czosnyka, M.

J. Donnelly, K. P. Budohoski, P. Smielewski, and M. Czosnyka, “Regulation of the cerebral circulation: bedside assessment and clinical implications,” Crit. Care 20(1), 129 (2016).
[Crossref] [PubMed]

C. Dias, M. J. Silva, E. Pereira, E. Monteiro, I. Maia, S. Barbosa, S. Silva, T. Honrado, A. Cerejo, M. J. H. Aries, P. Smielewski, J. A. Paiva, and M. Czosnyka, “Optimal Cerebral Perfusion Pressure Management at Bedside: A Single-Center Pilot Study,” Neurocrit. Care 23(1), 92–102 (2015).
[Crossref] [PubMed]

J. Diedler, C. Zweifel, K. P. Budohoski, M. Kasprowicz, E. Sorrentino, C. Haubrich, K. M. Brady, M. Czosnyka, J. D. Pickard, and P. Smielewski, “The Limitations of Near-Infrared Spectroscopy to Assess Cerebrovascular Reactivity: the Role of Slow Frequency Oscillations,” Anesth. Analg. 113(4), 849–857 (2011).
[Crossref] [PubMed]

C. Zweifel, G. Castellani, M. Czosnyka, E. Carrera, K. M. Brady, P. J. Kirkpatrick, J. D. Pickard, and P. Smielewski, “Continuous assessment of cerebral autoregulation with near-infrared spectroscopy in adults after subarachnoid hemorrhage,” Stroke 41(9), 1963–1968 (2010).
[Crossref] [PubMed]

C. Zweifel, G. Castellani, M. Czosnyka, A. Helmy, A. Manktelow, E. Carrera, K. M. Brady, P. J. Hutchinson, D. K. Menon, J. D. Pickard, and P. Smielewski, “Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients,” J. Neurotrauma 27(11), 1951–1958 (2010).
[Crossref] [PubMed]

B. Schmidt, J. Klingelhöfer, I. Perkes, and M. Czosnyka, “Cerebral Autoregulatory Response Depends on the Direction of Change in Perfusion Pressure,” J. Neurotrauma 26(5), 651–656 (2009).
[Crossref] [PubMed]

M. Czosnyka, K. Brady, M. Reinhard, P. Smielewski, and L. A. Steiner, “Monitoring of cerebrovascular autoregulation: facts, myths, and missing links,” Neurocrit. Care 10(3), 373–386 (2009).
[Crossref] [PubMed]

Delgado-Mederos, R.

P. Zirak, R. Delgado-Mederos, L. Dinia, D. Carrera, J. Martí-Fàbregas, and T. Durduran, “Transcranial diffuse optical monitoring of microvascular cerebral hemodynamics after thrombolysis in ischemic stroke,” J. Biomed. Opt. 19(1), 018002 (2014).
[Crossref] [PubMed]

Detre, J. A.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Di Ninni, P.

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

Dias, C.

C. Dias, M. J. Silva, E. Pereira, E. Monteiro, I. Maia, S. Barbosa, S. Silva, T. Honrado, A. Cerejo, M. J. H. Aries, P. Smielewski, J. A. Paiva, and M. Czosnyka, “Optimal Cerebral Perfusion Pressure Management at Bedside: A Single-Center Pilot Study,” Neurocrit. Care 23(1), 92–102 (2015).
[Crossref] [PubMed]

Diedler, J.

J. Diedler, C. Zweifel, K. P. Budohoski, M. Kasprowicz, E. Sorrentino, C. Haubrich, K. M. Brady, M. Czosnyka, J. D. Pickard, and P. Smielewski, “The Limitations of Near-Infrared Spectroscopy to Assess Cerebrovascular Reactivity: the Role of Slow Frequency Oscillations,” Anesth. Analg. 113(4), 849–857 (2011).
[Crossref] [PubMed]

Diehl, R. R.

C. Haubrich, W. Kruska, R. R. Diehl, W. Möller-Hartmann, and C. Klötzsch, “Dynamic autoregulation testing in patients with middle cerebral artery stenosis,” Stroke 34(8), 1881–1885 (2003).
[Crossref] [PubMed]

R. R. Diehl, D. Linden, D. Lücke, and P. Berlit, “Phase Relationship Between Cerebral Blood Flow Velocity and Blood Pressure. a Clinical Test of Autoregulation,” Stroke 26(10), 1801–1804 (1995).
[Crossref] [PubMed]

Dinia, L.

P. Zirak, R. Delgado-Mederos, L. Dinia, D. Carrera, J. Martí-Fàbregas, and T. Durduran, “Transcranial diffuse optical monitoring of microvascular cerebral hemodynamics after thrombolysis in ischemic stroke,” J. Biomed. Opt. 19(1), 018002 (2014).
[Crossref] [PubMed]

Donnelly, J.

J. Donnelly, K. P. Budohoski, P. Smielewski, and M. Czosnyka, “Regulation of the cerebral circulation: bedside assessment and clinical implications,” Crit. Care 20(1), 129 (2016).
[Crossref] [PubMed]

Douville, C. M.

R. Aaslid, M. Blaha, G. Sviri, C. M. Douville, and D. W. Newell, “Asymmetric dynamic cerebral autoregulatory response to cyclic stimuli,” Stroke 38(5), 1465–1469 (2007).
[Crossref] [PubMed]

Durduran, T.

P. Zirak, R. Delgado-Mederos, L. Dinia, D. Carrera, J. Martí-Fàbregas, and T. Durduran, “Transcranial diffuse optical monitoring of microvascular cerebral hemodynamics after thrombolysis in ischemic stroke,” J. Biomed. Opt. 19(1), 018002 (2014).
[Crossref] [PubMed]

T. Durduran and A. G. Yodh, “Diffuse correlation spectroscopy for non-invasive, micro-vascular cerebral blood flow measurement,” Neuroimage 85(Pt 1), 51–63 (2014).
[Crossref] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Edlow, B. L.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Elwell, C. E.

D. Highton, A. Ghosh, I. Tachtsidis, J. Panovska-Griffiths, C. E. Elwell, and M. Smith, “Monitoring Cerebral Autoregulation After Brain Injury: Multimodal Assessment of Cerebral Slow-Wave Oscillations Using Near-Infrared Spectroscopy,” Anesth. Analg. 121(1), 198–205 (2015).
[Crossref] [PubMed]

Farina, A.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

Ferry, A. L.

L. Spinelli, L. Zucchelli, D. Contini, M. Caffini, J. Mehler, A. Fló, A. L. Ferry, L. Filippin, F. Macagno, L. Cattarossi, and A. Torricelli, “In vivo measure of neonate brain optical properties and hemodynamic parameters by time-domain near-infrared spectroscopy,” Neurophotonics 4(4), 041414 (2017).
[Crossref] [PubMed]

Fiebach, J. B.

O. Steinkellner, C. Gruber, H. Wabnitz, A. Jelzow, J. Steinbrink, J. B. Fiebach, R. Macdonald, and H. Obrig, “Optical bedside monitoring of cerebral perfusion: technological and methodological advances applied in a study on acute ischemic stroke,” J. Biomed. Opt. 15(6), 061708 (2010).
[Crossref] [PubMed]

Filippin, L.

L. Spinelli, L. Zucchelli, D. Contini, M. Caffini, J. Mehler, A. Fló, A. L. Ferry, L. Filippin, F. Macagno, L. Cattarossi, and A. Torricelli, “In vivo measure of neonate brain optical properties and hemodynamic parameters by time-domain near-infrared spectroscopy,” Neurophotonics 4(4), 041414 (2017).
[Crossref] [PubMed]

Fisher, J. A.

C. K. Willie, Y. C. Tzeng, J. A. Fisher, and P. N. Ainslie, “Integrative regulation of human brain blood flow,” J. Physiol. 592(5), 841–859 (2014).
[Crossref] [PubMed]

Fló, A.

L. Spinelli, L. Zucchelli, D. Contini, M. Caffini, J. Mehler, A. Fló, A. L. Ferry, L. Filippin, F. Macagno, L. Cattarossi, and A. Torricelli, “In vivo measure of neonate brain optical properties and hemodynamic parameters by time-domain near-infrared spectroscopy,” Neurophotonics 4(4), 041414 (2017).
[Crossref] [PubMed]

Frangos, S.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Gabrusiewicz, A.

M. Kacprzak, A. Liebert, W. Staszkiewicz, A. Gabrusiewicz, P. Sawosz, G. Madycki, and R. Maniewski, “Application of a time-resolved optical brain imager for monitoring cerebral oxygenation during carotid surgery,” J. Biomed. Opt. 17(1), 016002 (2012).
[Crossref] [PubMed]

Gaudette, T.

D. A. Boas, T. Gaudette, G. Strangman, X. Cheng, J. J. Marota, and J. B. Mandeville, “The accuracy of near infrared spectroscopy and imaging during focal changes in cerebral hemodynamics,” Neuroimage 13(1), 76–90 (2001).
[Crossref] [PubMed]

Gerega, A.

W. Weigl, D. Milej, A. Gerega, B. Toczyłowska, P. Sawosz, M. Kacprzak, D. Janusek, S. Wojtkiewicz, R. Maniewski, and A. Liebert, “Confirmation of brain death using optical methods based on tracking of an optical contrast agent: assessment of diagnostic feasibility,” Sci. Rep. 8(1), 7332 (2018).
[Crossref] [PubMed]

A. Gerega, D. Milej, W. Weigl, M. Kacprzak, and A. Liebert, “Multiwavelength time-resolved near-infrared spectroscopy of the adult head: assessment of intracerebral and extracerebral absorption changes,” Biomed. Opt. Express 9(7), 2974–2993 (2018).
[Crossref] [PubMed]

W. Weigl, D. Milej, D. Janusek, S. Wojtkiewicz, P. Sawosz, M. Kacprzak, A. Gerega, R. Maniewski, and A. Liebert, “Application of optical methods in the monitoring of traumatic brain injury: A review,” J. Cereb. Blood Flow Metab. 36(11), 1825–1843 (2016).
[Crossref] [PubMed]

Ghosh, A.

D. Highton, A. Ghosh, I. Tachtsidis, J. Panovska-Griffiths, C. E. Elwell, and M. Smith, “Monitoring Cerebral Autoregulation After Brain Injury: Multimodal Assessment of Cerebral Slow-Wave Oscillations Using Near-Infrared Spectroscopy,” Anesth. Analg. 121(1), 198–205 (2015).
[Crossref] [PubMed]

Giacalone, G.

Giller, C. A.

C. A. Giller, “The Frequency-Dependent Behavior of Cerebral Autoregulation,” Neurosurgery 27(3), 362–368 (1990).
[Crossref] [PubMed]

Grady, M. S.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Greenberg, J. H.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Greisen, G.

G. Greisen, T. Leung, and M. Wolf, “Has the time come to use near-infrared spectroscopy as a routine clinical tool in preterm infants undergoing intensive care?” Philos Trans A Math Phys Eng Sci 369(1955), 4440–4451 (2011).
[Crossref] [PubMed]

Gruber, C.

O. Steinkellner, H. Wabnitz, A. Jelzow, R. Macdonald, C. Gruber, J. Steinbrink, and H. Obrig, “Cerebral Perfusion in Acute Stroke Monitored by Time-domain Near-infrared Reflectometry,” Biocybern. Biomed. Eng. 32(1), 3–16 (2012).
[Crossref]

O. Steinkellner, C. Gruber, H. Wabnitz, A. Jelzow, J. Steinbrink, J. B. Fiebach, R. Macdonald, and H. Obrig, “Optical bedside monitoring of cerebral perfusion: technological and methodological advances applied in a study on acute ischemic stroke,” J. Biomed. Opt. 15(6), 061708 (2010).
[Crossref] [PubMed]

Harscher, S.

C. Terborg, S. Bramer, S. Harscher, M. Simon, and O. W. Witte, “Bedside assessment of cerebral perfusion reductions in patients with acute ischaemic stroke by near-infrared spectroscopy and indocyanine green,” J. Neurol. Neurosurg. Psychiatry 75(1), 38–42 (2004).
[PubMed]

Haubrich, C.

J. Diedler, C. Zweifel, K. P. Budohoski, M. Kasprowicz, E. Sorrentino, C. Haubrich, K. M. Brady, M. Czosnyka, J. D. Pickard, and P. Smielewski, “The Limitations of Near-Infrared Spectroscopy to Assess Cerebrovascular Reactivity: the Role of Slow Frequency Oscillations,” Anesth. Analg. 113(4), 849–857 (2011).
[Crossref] [PubMed]

C. Haubrich, W. Kruska, R. R. Diehl, W. Möller-Hartmann, and C. Klötzsch, “Dynamic autoregulation testing in patients with middle cerebral artery stenosis,” Stroke 34(8), 1881–1885 (2003).
[Crossref] [PubMed]

Hebden, J.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

Helmy, A.

C. Zweifel, G. Castellani, M. Czosnyka, A. Helmy, A. Manktelow, E. Carrera, K. M. Brady, P. J. Hutchinson, D. K. Menon, J. D. Pickard, and P. Smielewski, “Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients,” J. Neurotrauma 27(11), 1951–1958 (2010).
[Crossref] [PubMed]

Highton, D.

D. Highton, A. Ghosh, I. Tachtsidis, J. Panovska-Griffiths, C. E. Elwell, and M. Smith, “Monitoring Cerebral Autoregulation After Brain Injury: Multimodal Assessment of Cerebral Slow-Wave Oscillations Using Near-Infrared Spectroscopy,” Anesth. Analg. 121(1), 198–205 (2015).
[Crossref] [PubMed]

Hoe, Z. Y.

C. C. Lo, P. Y. Lin, Z. Y. Hoe, and J. J. J. Chen, “Near Infrared Spectroscopy Study of Cortical Excitability During Electrical Stimulation-Assisted Cycling for Neurorehabilitation of Stroke Patients,” IEEE Trans. Neural Syst. Rehabil. Eng. 26(6), 1292–1300 (2018).
[Crossref] [PubMed]

Honrado, T.

C. Dias, M. J. Silva, E. Pereira, E. Monteiro, I. Maia, S. Barbosa, S. Silva, T. Honrado, A. Cerejo, M. J. H. Aries, P. Smielewski, J. A. Paiva, and M. Czosnyka, “Optimal Cerebral Perfusion Pressure Management at Bedside: A Single-Center Pilot Study,” Neurocrit. Care 23(1), 92–102 (2015).
[Crossref] [PubMed]

Hutchinson, P. J.

C. Zweifel, G. Castellani, M. Czosnyka, A. Helmy, A. Manktelow, E. Carrera, K. M. Brady, P. J. Hutchinson, D. K. Menon, J. D. Pickard, and P. Smielewski, “Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients,” J. Neurotrauma 27(11), 1951–1958 (2010).
[Crossref] [PubMed]

Janusek, D.

W. Weigl, D. Milej, A. Gerega, B. Toczyłowska, P. Sawosz, M. Kacprzak, D. Janusek, S. Wojtkiewicz, R. Maniewski, and A. Liebert, “Confirmation of brain death using optical methods based on tracking of an optical contrast agent: assessment of diagnostic feasibility,” Sci. Rep. 8(1), 7332 (2018).
[Crossref] [PubMed]

W. Weigl, D. Milej, D. Janusek, S. Wojtkiewicz, P. Sawosz, M. Kacprzak, A. Gerega, R. Maniewski, and A. Liebert, “Application of optical methods in the monitoring of traumatic brain injury: A review,” J. Cereb. Blood Flow Metab. 36(11), 1825–1843 (2016).
[Crossref] [PubMed]

Jelzow, A.

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

O. Steinkellner, H. Wabnitz, A. Jelzow, R. Macdonald, C. Gruber, J. Steinbrink, and H. Obrig, “Cerebral Perfusion in Acute Stroke Monitored by Time-domain Near-infrared Reflectometry,” Biocybern. Biomed. Eng. 32(1), 3–16 (2012).
[Crossref]

O. Steinkellner, C. Gruber, H. Wabnitz, A. Jelzow, J. Steinbrink, J. B. Fiebach, R. Macdonald, and H. Obrig, “Optical bedside monitoring of cerebral perfusion: technological and methodological advances applied in a study on acute ischemic stroke,” J. Biomed. Opt. 15(6), 061708 (2010).
[Crossref] [PubMed]

Kacprzak, M.

W. Weigl, D. Milej, A. Gerega, B. Toczyłowska, P. Sawosz, M. Kacprzak, D. Janusek, S. Wojtkiewicz, R. Maniewski, and A. Liebert, “Confirmation of brain death using optical methods based on tracking of an optical contrast agent: assessment of diagnostic feasibility,” Sci. Rep. 8(1), 7332 (2018).
[Crossref] [PubMed]

A. Gerega, D. Milej, W. Weigl, M. Kacprzak, and A. Liebert, “Multiwavelength time-resolved near-infrared spectroscopy of the adult head: assessment of intracerebral and extracerebral absorption changes,” Biomed. Opt. Express 9(7), 2974–2993 (2018).
[Crossref] [PubMed]

W. Weigl, D. Milej, D. Janusek, S. Wojtkiewicz, P. Sawosz, M. Kacprzak, A. Gerega, R. Maniewski, and A. Liebert, “Application of optical methods in the monitoring of traumatic brain injury: A review,” J. Cereb. Blood Flow Metab. 36(11), 1825–1843 (2016).
[Crossref] [PubMed]

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

M. Kacprzak, A. Liebert, W. Staszkiewicz, A. Gabrusiewicz, P. Sawosz, G. Madycki, and R. Maniewski, “Application of a time-resolved optical brain imager for monitoring cerebral oxygenation during carotid surgery,” J. Biomed. Opt. 17(1), 016002 (2012).
[Crossref] [PubMed]

P. Sawosz, M. Kacprzak, W. Weigl, A. Borowska-Solonynko, P. Krajewski, N. Zolek, B. Ciszek, R. Maniewski, and A. Liebert, “Experimental estimation of the photons visiting probability profiles in time-resolved diffuse reflectance measurement,” Phys. Med. Biol. 57(23), 7973–7981 (2012).
[Crossref] [PubMed]

R. Maniewski, A. Liebert, M. Kacprzak, and A. Zbiec, “Selected applications of near infrared optical methods in medical diagnosis,” Opto-Electron. Rev. 12, 255–262 (2004).

Kasprowicz, M.

J. Diedler, C. Zweifel, K. P. Budohoski, M. Kasprowicz, E. Sorrentino, C. Haubrich, K. M. Brady, M. Czosnyka, J. D. Pickard, and P. Smielewski, “The Limitations of Near-Infrared Spectroscopy to Assess Cerebrovascular Reactivity: the Role of Slow Frequency Oscillations,” Anesth. Analg. 113(4), 849–857 (2011).
[Crossref] [PubMed]

Kim, M. N.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Kirkpatrick, P. J.

C. Zweifel, G. Castellani, M. Czosnyka, E. Carrera, K. M. Brady, P. J. Kirkpatrick, J. D. Pickard, and P. Smielewski, “Continuous assessment of cerebral autoregulation with near-infrared spectroscopy in adults after subarachnoid hemorrhage,” Stroke 41(9), 1963–1968 (2010).
[Crossref] [PubMed]

Klingelhöfer, J.

B. Schmidt, J. Klingelhöfer, I. Perkes, and M. Czosnyka, “Cerebral Autoregulatory Response Depends on the Direction of Change in Perfusion Pressure,” J. Neurotrauma 26(5), 651–656 (2009).
[Crossref] [PubMed]

Klötzsch, C.

C. Haubrich, W. Kruska, R. R. Diehl, W. Möller-Hartmann, and C. Klötzsch, “Dynamic autoregulation testing in patients with middle cerebral artery stenosis,” Stroke 34(8), 1881–1885 (2003).
[Crossref] [PubMed]

Kofke, W. A.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Krajewski, P.

P. Sawosz, M. Kacprzak, W. Weigl, A. Borowska-Solonynko, P. Krajewski, N. Zolek, B. Ciszek, R. Maniewski, and A. Liebert, “Experimental estimation of the photons visiting probability profiles in time-resolved diffuse reflectance measurement,” Phys. Med. Biol. 57(23), 7973–7981 (2012).
[Crossref] [PubMed]

Kruska, W.

C. Haubrich, W. Kruska, R. R. Diehl, W. Möller-Hartmann, and C. Klötzsch, “Dynamic autoregulation testing in patients with middle cerebral artery stenosis,” Stroke 34(8), 1881–1885 (2003).
[Crossref] [PubMed]

Lassen, N. A.

N. A. Lassen, “Cerebral Blood Flow and Oxygen Consumption in Man,” Physiol. Rev. 39(2), 183–238 (1959).
[Crossref] [PubMed]

Leung, T.

G. Greisen, T. Leung, and M. Wolf, “Has the time come to use near-infrared spectroscopy as a routine clinical tool in preterm infants undergoing intensive care?” Philos Trans A Math Phys Eng Sci 369(1955), 4440–4451 (2011).
[Crossref] [PubMed]

Levine, J. M.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Liebert, A.

W. Weigl, D. Milej, A. Gerega, B. Toczyłowska, P. Sawosz, M. Kacprzak, D. Janusek, S. Wojtkiewicz, R. Maniewski, and A. Liebert, “Confirmation of brain death using optical methods based on tracking of an optical contrast agent: assessment of diagnostic feasibility,” Sci. Rep. 8(1), 7332 (2018).
[Crossref] [PubMed]

A. Gerega, D. Milej, W. Weigl, M. Kacprzak, and A. Liebert, “Multiwavelength time-resolved near-infrared spectroscopy of the adult head: assessment of intracerebral and extracerebral absorption changes,” Biomed. Opt. Express 9(7), 2974–2993 (2018).
[Crossref] [PubMed]

W. Weigl, D. Milej, D. Janusek, S. Wojtkiewicz, P. Sawosz, M. Kacprzak, A. Gerega, R. Maniewski, and A. Liebert, “Application of optical methods in the monitoring of traumatic brain injury: A review,” J. Cereb. Blood Flow Metab. 36(11), 1825–1843 (2016).
[Crossref] [PubMed]

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

P. Sawosz, M. Kacprzak, W. Weigl, A. Borowska-Solonynko, P. Krajewski, N. Zolek, B. Ciszek, R. Maniewski, and A. Liebert, “Experimental estimation of the photons visiting probability profiles in time-resolved diffuse reflectance measurement,” Phys. Med. Biol. 57(23), 7973–7981 (2012).
[Crossref] [PubMed]

M. Kacprzak, A. Liebert, W. Staszkiewicz, A. Gabrusiewicz, P. Sawosz, G. Madycki, and R. Maniewski, “Application of a time-resolved optical brain imager for monitoring cerebral oxygenation during carotid surgery,” J. Biomed. Opt. 17(1), 016002 (2012).
[Crossref] [PubMed]

A. Liebert, H. Wabnitz, J. Steinbrink, H. Obrig, M. Möller, R. Macdonald, A. Villringer, and H. Rinneberg, “Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons,” Appl. Opt. 43(15), 3037–3047 (2004).
[Crossref] [PubMed]

R. Maniewski, A. Liebert, M. Kacprzak, and A. Zbiec, “Selected applications of near infrared optical methods in medical diagnosis,” Opto-Electron. Rev. 12, 255–262 (2004).

Lin, P. Y.

C. C. Lo, P. Y. Lin, Z. Y. Hoe, and J. J. J. Chen, “Near Infrared Spectroscopy Study of Cortical Excitability During Electrical Stimulation-Assisted Cycling for Neurorehabilitation of Stroke Patients,” IEEE Trans. Neural Syst. Rehabil. Eng. 26(6), 1292–1300 (2018).
[Crossref] [PubMed]

Linden, D.

R. R. Diehl, D. Linden, D. Lücke, and P. Berlit, “Phase Relationship Between Cerebral Blood Flow Velocity and Blood Pressure. a Clinical Test of Autoregulation,” Stroke 26(10), 1801–1804 (1995).
[Crossref] [PubMed]

Lo, C. C.

C. C. Lo, P. Y. Lin, Z. Y. Hoe, and J. J. J. Chen, “Near Infrared Spectroscopy Study of Cortical Excitability During Electrical Stimulation-Assisted Cycling for Neurorehabilitation of Stroke Patients,” IEEE Trans. Neural Syst. Rehabil. Eng. 26(6), 1292–1300 (2018).
[Crossref] [PubMed]

Lücke, D.

R. R. Diehl, D. Linden, D. Lücke, and P. Berlit, “Phase Relationship Between Cerebral Blood Flow Velocity and Blood Pressure. a Clinical Test of Autoregulation,” Stroke 26(10), 1801–1804 (1995).
[Crossref] [PubMed]

Macagno, F.

L. Spinelli, L. Zucchelli, D. Contini, M. Caffini, J. Mehler, A. Fló, A. L. Ferry, L. Filippin, F. Macagno, L. Cattarossi, and A. Torricelli, “In vivo measure of neonate brain optical properties and hemodynamic parameters by time-domain near-infrared spectroscopy,” Neurophotonics 4(4), 041414 (2017).
[Crossref] [PubMed]

Macdonald, R.

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

O. Steinkellner, H. Wabnitz, A. Jelzow, R. Macdonald, C. Gruber, J. Steinbrink, and H. Obrig, “Cerebral Perfusion in Acute Stroke Monitored by Time-domain Near-infrared Reflectometry,” Biocybern. Biomed. Eng. 32(1), 3–16 (2012).
[Crossref]

O. Steinkellner, C. Gruber, H. Wabnitz, A. Jelzow, J. Steinbrink, J. B. Fiebach, R. Macdonald, and H. Obrig, “Optical bedside monitoring of cerebral perfusion: technological and methodological advances applied in a study on acute ischemic stroke,” J. Biomed. Opt. 15(6), 061708 (2010).
[Crossref] [PubMed]

A. Liebert, H. Wabnitz, J. Steinbrink, H. Obrig, M. Möller, R. Macdonald, A. Villringer, and H. Rinneberg, “Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons,” Appl. Opt. 43(15), 3037–3047 (2004).
[Crossref] [PubMed]

Madycki, G.

M. Kacprzak, A. Liebert, W. Staszkiewicz, A. Gabrusiewicz, P. Sawosz, G. Madycki, and R. Maniewski, “Application of a time-resolved optical brain imager for monitoring cerebral oxygenation during carotid surgery,” J. Biomed. Opt. 17(1), 016002 (2012).
[Crossref] [PubMed]

Magazov, S.

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

Maia, I.

C. Dias, M. J. Silva, E. Pereira, E. Monteiro, I. Maia, S. Barbosa, S. Silva, T. Honrado, A. Cerejo, M. J. H. Aries, P. Smielewski, J. A. Paiva, and M. Czosnyka, “Optimal Cerebral Perfusion Pressure Management at Bedside: A Single-Center Pilot Study,” Neurocrit. Care 23(1), 92–102 (2015).
[Crossref] [PubMed]

Maloney-Wilensky, E.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Mandeville, J. B.

D. A. Boas, T. Gaudette, G. Strangman, X. Cheng, J. J. Marota, and J. B. Mandeville, “The accuracy of near infrared spectroscopy and imaging during focal changes in cerebral hemodynamics,” Neuroimage 13(1), 76–90 (2001).
[Crossref] [PubMed]

Maniewski, R.

W. Weigl, D. Milej, A. Gerega, B. Toczyłowska, P. Sawosz, M. Kacprzak, D. Janusek, S. Wojtkiewicz, R. Maniewski, and A. Liebert, “Confirmation of brain death using optical methods based on tracking of an optical contrast agent: assessment of diagnostic feasibility,” Sci. Rep. 8(1), 7332 (2018).
[Crossref] [PubMed]

W. Weigl, D. Milej, D. Janusek, S. Wojtkiewicz, P. Sawosz, M. Kacprzak, A. Gerega, R. Maniewski, and A. Liebert, “Application of optical methods in the monitoring of traumatic brain injury: A review,” J. Cereb. Blood Flow Metab. 36(11), 1825–1843 (2016).
[Crossref] [PubMed]

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

M. Kacprzak, A. Liebert, W. Staszkiewicz, A. Gabrusiewicz, P. Sawosz, G. Madycki, and R. Maniewski, “Application of a time-resolved optical brain imager for monitoring cerebral oxygenation during carotid surgery,” J. Biomed. Opt. 17(1), 016002 (2012).
[Crossref] [PubMed]

P. Sawosz, M. Kacprzak, W. Weigl, A. Borowska-Solonynko, P. Krajewski, N. Zolek, B. Ciszek, R. Maniewski, and A. Liebert, “Experimental estimation of the photons visiting probability profiles in time-resolved diffuse reflectance measurement,” Phys. Med. Biol. 57(23), 7973–7981 (2012).
[Crossref] [PubMed]

R. Maniewski, A. Liebert, M. Kacprzak, and A. Zbiec, “Selected applications of near infrared optical methods in medical diagnosis,” Opto-Electron. Rev. 12, 255–262 (2004).

Manktelow, A.

C. Zweifel, G. Castellani, M. Czosnyka, A. Helmy, A. Manktelow, E. Carrera, K. M. Brady, P. J. Hutchinson, D. K. Menon, J. D. Pickard, and P. Smielewski, “Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients,” J. Neurotrauma 27(11), 1951–1958 (2010).
[Crossref] [PubMed]

Marota, J. J.

D. A. Boas, T. Gaudette, G. Strangman, X. Cheng, J. J. Marota, and J. B. Mandeville, “The accuracy of near infrared spectroscopy and imaging during focal changes in cerebral hemodynamics,” Neuroimage 13(1), 76–90 (2001).
[Crossref] [PubMed]

Martelli, F.

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

Martí-Fàbregas, J.

P. Zirak, R. Delgado-Mederos, L. Dinia, D. Carrera, J. Martí-Fàbregas, and T. Durduran, “Transcranial diffuse optical monitoring of microvascular cerebral hemodynamics after thrombolysis in ischemic stroke,” J. Biomed. Opt. 19(1), 018002 (2014).
[Crossref] [PubMed]

Mazurenka, M.

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

Mehler, J.

L. Spinelli, L. Zucchelli, D. Contini, M. Caffini, J. Mehler, A. Fló, A. L. Ferry, L. Filippin, F. Macagno, L. Cattarossi, and A. Torricelli, “In vivo measure of neonate brain optical properties and hemodynamic parameters by time-domain near-infrared spectroscopy,” Neurophotonics 4(4), 041414 (2017).
[Crossref] [PubMed]

Menon, D. K.

C. Zweifel, G. Castellani, M. Czosnyka, A. Helmy, A. Manktelow, E. Carrera, K. M. Brady, P. J. Hutchinson, D. K. Menon, J. D. Pickard, and P. Smielewski, “Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients,” J. Neurotrauma 27(11), 1951–1958 (2010).
[Crossref] [PubMed]

Milej, D.

W. Weigl, D. Milej, A. Gerega, B. Toczyłowska, P. Sawosz, M. Kacprzak, D. Janusek, S. Wojtkiewicz, R. Maniewski, and A. Liebert, “Confirmation of brain death using optical methods based on tracking of an optical contrast agent: assessment of diagnostic feasibility,” Sci. Rep. 8(1), 7332 (2018).
[Crossref] [PubMed]

A. Gerega, D. Milej, W. Weigl, M. Kacprzak, and A. Liebert, “Multiwavelength time-resolved near-infrared spectroscopy of the adult head: assessment of intracerebral and extracerebral absorption changes,” Biomed. Opt. Express 9(7), 2974–2993 (2018).
[Crossref] [PubMed]

W. Weigl, D. Milej, D. Janusek, S. Wojtkiewicz, P. Sawosz, M. Kacprzak, A. Gerega, R. Maniewski, and A. Liebert, “Application of optical methods in the monitoring of traumatic brain injury: A review,” J. Cereb. Blood Flow Metab. 36(11), 1825–1843 (2016).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

Möller, M.

Möller-Hartmann, W.

C. Haubrich, W. Kruska, R. R. Diehl, W. Möller-Hartmann, and C. Klötzsch, “Dynamic autoregulation testing in patients with middle cerebral artery stenosis,” Stroke 34(8), 1881–1885 (2003).
[Crossref] [PubMed]

Monteiro, E.

C. Dias, M. J. Silva, E. Pereira, E. Monteiro, I. Maia, S. Barbosa, S. Silva, T. Honrado, A. Cerejo, M. J. H. Aries, P. Smielewski, J. A. Paiva, and M. Czosnyka, “Optimal Cerebral Perfusion Pressure Management at Bedside: A Single-Center Pilot Study,” Neurocrit. Care 23(1), 92–102 (2015).
[Crossref] [PubMed]

Moss, H. E.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Newell, D. W.

R. Aaslid, M. Blaha, G. Sviri, C. M. Douville, and D. W. Newell, “Asymmetric dynamic cerebral autoregulatory response to cyclic stimuli,” Stroke 38(5), 1465–1469 (2007).
[Crossref] [PubMed]

Obrig, H.

O. Steinkellner, H. Wabnitz, A. Jelzow, R. Macdonald, C. Gruber, J. Steinbrink, and H. Obrig, “Cerebral Perfusion in Acute Stroke Monitored by Time-domain Near-infrared Reflectometry,” Biocybern. Biomed. Eng. 32(1), 3–16 (2012).
[Crossref]

O. Steinkellner, C. Gruber, H. Wabnitz, A. Jelzow, J. Steinbrink, J. B. Fiebach, R. Macdonald, and H. Obrig, “Optical bedside monitoring of cerebral perfusion: technological and methodological advances applied in a study on acute ischemic stroke,” J. Biomed. Opt. 15(6), 061708 (2010).
[Crossref] [PubMed]

A. Liebert, H. Wabnitz, J. Steinbrink, H. Obrig, M. Möller, R. Macdonald, A. Villringer, and H. Rinneberg, “Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons,” Appl. Opt. 43(15), 3037–3047 (2004).
[Crossref] [PubMed]

J. Steinbrink, H. Wabnitz, H. Obrig, A. Villringer, and H. Rinneberg, “Determining changes in NIR absorption using a layered model of the human head,” Phys. Med. Biol. 46(3), 879–896 (2001).
[Crossref] [PubMed]

Paiva, J. A.

C. Dias, M. J. Silva, E. Pereira, E. Monteiro, I. Maia, S. Barbosa, S. Silva, T. Honrado, A. Cerejo, M. J. H. Aries, P. Smielewski, J. A. Paiva, and M. Czosnyka, “Optimal Cerebral Perfusion Pressure Management at Bedside: A Single-Center Pilot Study,” Neurocrit. Care 23(1), 92–102 (2015).
[Crossref] [PubMed]

Panovska-Griffiths, J.

D. Highton, A. Ghosh, I. Tachtsidis, J. Panovska-Griffiths, C. E. Elwell, and M. Smith, “Monitoring Cerebral Autoregulation After Brain Injury: Multimodal Assessment of Cerebral Slow-Wave Oscillations Using Near-Infrared Spectroscopy,” Anesth. Analg. 121(1), 198–205 (2015).
[Crossref] [PubMed]

Pereira, E.

C. Dias, M. J. Silva, E. Pereira, E. Monteiro, I. Maia, S. Barbosa, S. Silva, T. Honrado, A. Cerejo, M. J. H. Aries, P. Smielewski, J. A. Paiva, and M. Czosnyka, “Optimal Cerebral Perfusion Pressure Management at Bedside: A Single-Center Pilot Study,” Neurocrit. Care 23(1), 92–102 (2015).
[Crossref] [PubMed]

Perkes, I.

B. Schmidt, J. Klingelhöfer, I. Perkes, and M. Czosnyka, “Cerebral Autoregulatory Response Depends on the Direction of Change in Perfusion Pressure,” J. Neurotrauma 26(5), 651–656 (2009).
[Crossref] [PubMed]

Pickard, J. D.

J. Diedler, C. Zweifel, K. P. Budohoski, M. Kasprowicz, E. Sorrentino, C. Haubrich, K. M. Brady, M. Czosnyka, J. D. Pickard, and P. Smielewski, “The Limitations of Near-Infrared Spectroscopy to Assess Cerebrovascular Reactivity: the Role of Slow Frequency Oscillations,” Anesth. Analg. 113(4), 849–857 (2011).
[Crossref] [PubMed]

C. Zweifel, G. Castellani, M. Czosnyka, E. Carrera, K. M. Brady, P. J. Kirkpatrick, J. D. Pickard, and P. Smielewski, “Continuous assessment of cerebral autoregulation with near-infrared spectroscopy in adults after subarachnoid hemorrhage,” Stroke 41(9), 1963–1968 (2010).
[Crossref] [PubMed]

C. Zweifel, G. Castellani, M. Czosnyka, A. Helmy, A. Manktelow, E. Carrera, K. M. Brady, P. J. Hutchinson, D. K. Menon, J. D. Pickard, and P. Smielewski, “Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients,” J. Neurotrauma 27(11), 1951–1958 (2010).
[Crossref] [PubMed]

Pifferi, A.

A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85(Pt 1), 28–50 (2014).
[Crossref] [PubMed]

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

Re, R.

G. Giacalone, M. Zanoletti, D. Contini, R. Re, L. Spinelli, L. Roveri, and A. Torricelli, “Cerebral time domain-NIRS: reproducibility analysis, optical properties, hemoglobin species and tissue oxygen saturation in a cohort of adult subjects,” Biomed. Opt. Express 8(11), 4987–5000 (2017).
[Crossref] [PubMed]

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85(Pt 1), 28–50 (2014).
[Crossref] [PubMed]

Reinhard, M.

M. Czosnyka, K. Brady, M. Reinhard, P. Smielewski, and L. A. Steiner, “Monitoring of cerebrovascular autoregulation: facts, myths, and missing links,” Neurocrit. Care 10(3), 373–386 (2009).
[Crossref] [PubMed]

Rinneberg, H.

Roveri, L.

Sawosz, P.

W. Weigl, D. Milej, A. Gerega, B. Toczyłowska, P. Sawosz, M. Kacprzak, D. Janusek, S. Wojtkiewicz, R. Maniewski, and A. Liebert, “Confirmation of brain death using optical methods based on tracking of an optical contrast agent: assessment of diagnostic feasibility,” Sci. Rep. 8(1), 7332 (2018).
[Crossref] [PubMed]

W. Weigl, D. Milej, D. Janusek, S. Wojtkiewicz, P. Sawosz, M. Kacprzak, A. Gerega, R. Maniewski, and A. Liebert, “Application of optical methods in the monitoring of traumatic brain injury: A review,” J. Cereb. Blood Flow Metab. 36(11), 1825–1843 (2016).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

M. Kacprzak, A. Liebert, W. Staszkiewicz, A. Gabrusiewicz, P. Sawosz, G. Madycki, and R. Maniewski, “Application of a time-resolved optical brain imager for monitoring cerebral oxygenation during carotid surgery,” J. Biomed. Opt. 17(1), 016002 (2012).
[Crossref] [PubMed]

P. Sawosz, M. Kacprzak, W. Weigl, A. Borowska-Solonynko, P. Krajewski, N. Zolek, B. Ciszek, R. Maniewski, and A. Liebert, “Experimental estimation of the photons visiting probability profiles in time-resolved diffuse reflectance measurement,” Phys. Med. Biol. 57(23), 7973–7981 (2012).
[Crossref] [PubMed]

Schmidt, B.

B. Schmidt, J. Klingelhöfer, I. Perkes, and M. Czosnyka, “Cerebral Autoregulatory Response Depends on the Direction of Change in Perfusion Pressure,” J. Neurotrauma 26(5), 651–656 (2009).
[Crossref] [PubMed]

Silva, M. J.

C. Dias, M. J. Silva, E. Pereira, E. Monteiro, I. Maia, S. Barbosa, S. Silva, T. Honrado, A. Cerejo, M. J. H. Aries, P. Smielewski, J. A. Paiva, and M. Czosnyka, “Optimal Cerebral Perfusion Pressure Management at Bedside: A Single-Center Pilot Study,” Neurocrit. Care 23(1), 92–102 (2015).
[Crossref] [PubMed]

Silva, S.

C. Dias, M. J. Silva, E. Pereira, E. Monteiro, I. Maia, S. Barbosa, S. Silva, T. Honrado, A. Cerejo, M. J. H. Aries, P. Smielewski, J. A. Paiva, and M. Czosnyka, “Optimal Cerebral Perfusion Pressure Management at Bedside: A Single-Center Pilot Study,” Neurocrit. Care 23(1), 92–102 (2015).
[Crossref] [PubMed]

Simon, M.

C. Terborg, S. Bramer, S. Harscher, M. Simon, and O. W. Witte, “Bedside assessment of cerebral perfusion reductions in patients with acute ischaemic stroke by near-infrared spectroscopy and indocyanine green,” J. Neurol. Neurosurg. Psychiatry 75(1), 38–42 (2004).
[PubMed]

Smielewski, P.

J. Donnelly, K. P. Budohoski, P. Smielewski, and M. Czosnyka, “Regulation of the cerebral circulation: bedside assessment and clinical implications,” Crit. Care 20(1), 129 (2016).
[Crossref] [PubMed]

C. Dias, M. J. Silva, E. Pereira, E. Monteiro, I. Maia, S. Barbosa, S. Silva, T. Honrado, A. Cerejo, M. J. H. Aries, P. Smielewski, J. A. Paiva, and M. Czosnyka, “Optimal Cerebral Perfusion Pressure Management at Bedside: A Single-Center Pilot Study,” Neurocrit. Care 23(1), 92–102 (2015).
[Crossref] [PubMed]

J. Diedler, C. Zweifel, K. P. Budohoski, M. Kasprowicz, E. Sorrentino, C. Haubrich, K. M. Brady, M. Czosnyka, J. D. Pickard, and P. Smielewski, “The Limitations of Near-Infrared Spectroscopy to Assess Cerebrovascular Reactivity: the Role of Slow Frequency Oscillations,” Anesth. Analg. 113(4), 849–857 (2011).
[Crossref] [PubMed]

C. Zweifel, G. Castellani, M. Czosnyka, E. Carrera, K. M. Brady, P. J. Kirkpatrick, J. D. Pickard, and P. Smielewski, “Continuous assessment of cerebral autoregulation with near-infrared spectroscopy in adults after subarachnoid hemorrhage,” Stroke 41(9), 1963–1968 (2010).
[Crossref] [PubMed]

C. Zweifel, G. Castellani, M. Czosnyka, A. Helmy, A. Manktelow, E. Carrera, K. M. Brady, P. J. Hutchinson, D. K. Menon, J. D. Pickard, and P. Smielewski, “Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients,” J. Neurotrauma 27(11), 1951–1958 (2010).
[Crossref] [PubMed]

M. Czosnyka, K. Brady, M. Reinhard, P. Smielewski, and L. A. Steiner, “Monitoring of cerebrovascular autoregulation: facts, myths, and missing links,” Neurocrit. Care 10(3), 373–386 (2009).
[Crossref] [PubMed]

Smith, M.

D. Highton, A. Ghosh, I. Tachtsidis, J. Panovska-Griffiths, C. E. Elwell, and M. Smith, “Monitoring Cerebral Autoregulation After Brain Injury: Multimodal Assessment of Cerebral Slow-Wave Oscillations Using Near-Infrared Spectroscopy,” Anesth. Analg. 121(1), 198–205 (2015).
[Crossref] [PubMed]

Sorrentino, E.

J. Diedler, C. Zweifel, K. P. Budohoski, M. Kasprowicz, E. Sorrentino, C. Haubrich, K. M. Brady, M. Czosnyka, J. D. Pickard, and P. Smielewski, “The Limitations of Near-Infrared Spectroscopy to Assess Cerebrovascular Reactivity: the Role of Slow Frequency Oscillations,” Anesth. Analg. 113(4), 849–857 (2011).
[Crossref] [PubMed]

Spinelli, L.

G. Giacalone, M. Zanoletti, D. Contini, R. Re, L. Spinelli, L. Roveri, and A. Torricelli, “Cerebral time domain-NIRS: reproducibility analysis, optical properties, hemoglobin species and tissue oxygen saturation in a cohort of adult subjects,” Biomed. Opt. Express 8(11), 4987–5000 (2017).
[Crossref] [PubMed]

L. Spinelli, L. Zucchelli, D. Contini, M. Caffini, J. Mehler, A. Fló, A. L. Ferry, L. Filippin, F. Macagno, L. Cattarossi, and A. Torricelli, “In vivo measure of neonate brain optical properties and hemodynamic parameters by time-domain near-infrared spectroscopy,” Neurophotonics 4(4), 041414 (2017).
[Crossref] [PubMed]

A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85(Pt 1), 28–50 (2014).
[Crossref] [PubMed]

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

Staszkiewicz, W.

M. Kacprzak, A. Liebert, W. Staszkiewicz, A. Gabrusiewicz, P. Sawosz, G. Madycki, and R. Maniewski, “Application of a time-resolved optical brain imager for monitoring cerebral oxygenation during carotid surgery,” J. Biomed. Opt. 17(1), 016002 (2012).
[Crossref] [PubMed]

Steinbrink, J.

O. Steinkellner, H. Wabnitz, A. Jelzow, R. Macdonald, C. Gruber, J. Steinbrink, and H. Obrig, “Cerebral Perfusion in Acute Stroke Monitored by Time-domain Near-infrared Reflectometry,” Biocybern. Biomed. Eng. 32(1), 3–16 (2012).
[Crossref]

O. Steinkellner, C. Gruber, H. Wabnitz, A. Jelzow, J. Steinbrink, J. B. Fiebach, R. Macdonald, and H. Obrig, “Optical bedside monitoring of cerebral perfusion: technological and methodological advances applied in a study on acute ischemic stroke,” J. Biomed. Opt. 15(6), 061708 (2010).
[Crossref] [PubMed]

A. Liebert, H. Wabnitz, J. Steinbrink, H. Obrig, M. Möller, R. Macdonald, A. Villringer, and H. Rinneberg, “Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons,” Appl. Opt. 43(15), 3037–3047 (2004).
[Crossref] [PubMed]

J. Steinbrink, H. Wabnitz, H. Obrig, A. Villringer, and H. Rinneberg, “Determining changes in NIR absorption using a layered model of the human head,” Phys. Med. Biol. 46(3), 879–896 (2001).
[Crossref] [PubMed]

Steiner, L. A.

M. Czosnyka, K. Brady, M. Reinhard, P. Smielewski, and L. A. Steiner, “Monitoring of cerebrovascular autoregulation: facts, myths, and missing links,” Neurocrit. Care 10(3), 373–386 (2009).
[Crossref] [PubMed]

Steinkellner, O.

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

O. Steinkellner, H. Wabnitz, A. Jelzow, R. Macdonald, C. Gruber, J. Steinbrink, and H. Obrig, “Cerebral Perfusion in Acute Stroke Monitored by Time-domain Near-infrared Reflectometry,” Biocybern. Biomed. Eng. 32(1), 3–16 (2012).
[Crossref]

O. Steinkellner, C. Gruber, H. Wabnitz, A. Jelzow, J. Steinbrink, J. B. Fiebach, R. Macdonald, and H. Obrig, “Optical bedside monitoring of cerebral perfusion: technological and methodological advances applied in a study on acute ischemic stroke,” J. Biomed. Opt. 15(6), 061708 (2010).
[Crossref] [PubMed]

Strangman, G.

D. A. Boas, T. Gaudette, G. Strangman, X. Cheng, J. J. Marota, and J. B. Mandeville, “The accuracy of near infrared spectroscopy and imaging during focal changes in cerebral hemodynamics,” Neuroimage 13(1), 76–90 (2001).
[Crossref] [PubMed]

Sviri, G.

R. Aaslid, M. Blaha, G. Sviri, C. M. Douville, and D. W. Newell, “Asymmetric dynamic cerebral autoregulatory response to cyclic stimuli,” Stroke 38(5), 1465–1469 (2007).
[Crossref] [PubMed]

Tachtsidis, I.

D. Highton, A. Ghosh, I. Tachtsidis, J. Panovska-Griffiths, C. E. Elwell, and M. Smith, “Monitoring Cerebral Autoregulation After Brain Injury: Multimodal Assessment of Cerebral Slow-Wave Oscillations Using Near-Infrared Spectroscopy,” Anesth. Analg. 121(1), 198–205 (2015).
[Crossref] [PubMed]

Tan, C. O.

C. O. Tan, “Defining the characteristic relationship between arterial pressure and cerebral flow,” J. Appl. Physiol. 113(8), 1194–1200 (2012).
[Crossref] [PubMed]

Taubert, D. R.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

Terborg, C.

C. Terborg, S. Bramer, S. Harscher, M. Simon, and O. W. Witte, “Bedside assessment of cerebral perfusion reductions in patients with acute ischaemic stroke by near-infrared spectroscopy and indocyanine green,” J. Neurol. Neurosurg. Psychiatry 75(1), 38–42 (2004).
[PubMed]

Toczylowska, B.

W. Weigl, D. Milej, A. Gerega, B. Toczyłowska, P. Sawosz, M. Kacprzak, D. Janusek, S. Wojtkiewicz, R. Maniewski, and A. Liebert, “Confirmation of brain death using optical methods based on tracking of an optical contrast agent: assessment of diagnostic feasibility,” Sci. Rep. 8(1), 7332 (2018).
[Crossref] [PubMed]

Torricelli, A.

L. Spinelli, L. Zucchelli, D. Contini, M. Caffini, J. Mehler, A. Fló, A. L. Ferry, L. Filippin, F. Macagno, L. Cattarossi, and A. Torricelli, “In vivo measure of neonate brain optical properties and hemodynamic parameters by time-domain near-infrared spectroscopy,” Neurophotonics 4(4), 041414 (2017).
[Crossref] [PubMed]

G. Giacalone, M. Zanoletti, D. Contini, R. Re, L. Spinelli, L. Roveri, and A. Torricelli, “Cerebral time domain-NIRS: reproducibility analysis, optical properties, hemoglobin species and tissue oxygen saturation in a cohort of adult subjects,” Biomed. Opt. Express 8(11), 4987–5000 (2017).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85(Pt 1), 28–50 (2014).
[Crossref] [PubMed]

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

Tzeng, Y. C.

C. K. Willie, Y. C. Tzeng, J. A. Fisher, and P. N. Ainslie, “Integrative regulation of human brain blood flow,” J. Physiol. 592(5), 841–859 (2014).
[Crossref] [PubMed]

Villringer, A.

Wabnitz, H.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

O. Steinkellner, H. Wabnitz, A. Jelzow, R. Macdonald, C. Gruber, J. Steinbrink, and H. Obrig, “Cerebral Perfusion in Acute Stroke Monitored by Time-domain Near-infrared Reflectometry,” Biocybern. Biomed. Eng. 32(1), 3–16 (2012).
[Crossref]

O. Steinkellner, C. Gruber, H. Wabnitz, A. Jelzow, J. Steinbrink, J. B. Fiebach, R. Macdonald, and H. Obrig, “Optical bedside monitoring of cerebral perfusion: technological and methodological advances applied in a study on acute ischemic stroke,” J. Biomed. Opt. 15(6), 061708 (2010).
[Crossref] [PubMed]

A. Liebert, H. Wabnitz, J. Steinbrink, H. Obrig, M. Möller, R. Macdonald, A. Villringer, and H. Rinneberg, “Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons,” Appl. Opt. 43(15), 3037–3047 (2004).
[Crossref] [PubMed]

J. Steinbrink, H. Wabnitz, H. Obrig, A. Villringer, and H. Rinneberg, “Determining changes in NIR absorption using a layered model of the human head,” Phys. Med. Biol. 46(3), 879–896 (2001).
[Crossref] [PubMed]

Weigl, W.

A. Gerega, D. Milej, W. Weigl, M. Kacprzak, and A. Liebert, “Multiwavelength time-resolved near-infrared spectroscopy of the adult head: assessment of intracerebral and extracerebral absorption changes,” Biomed. Opt. Express 9(7), 2974–2993 (2018).
[Crossref] [PubMed]

W. Weigl, D. Milej, A. Gerega, B. Toczyłowska, P. Sawosz, M. Kacprzak, D. Janusek, S. Wojtkiewicz, R. Maniewski, and A. Liebert, “Confirmation of brain death using optical methods based on tracking of an optical contrast agent: assessment of diagnostic feasibility,” Sci. Rep. 8(1), 7332 (2018).
[Crossref] [PubMed]

W. Weigl, D. Milej, D. Janusek, S. Wojtkiewicz, P. Sawosz, M. Kacprzak, A. Gerega, R. Maniewski, and A. Liebert, “Application of optical methods in the monitoring of traumatic brain injury: A review,” J. Cereb. Blood Flow Metab. 36(11), 1825–1843 (2016).
[Crossref] [PubMed]

P. Sawosz, M. Kacprzak, W. Weigl, A. Borowska-Solonynko, P. Krajewski, N. Zolek, B. Ciszek, R. Maniewski, and A. Liebert, “Experimental estimation of the photons visiting probability profiles in time-resolved diffuse reflectance measurement,” Phys. Med. Biol. 57(23), 7973–7981 (2012).
[Crossref] [PubMed]

Willie, C. K.

C. K. Willie, Y. C. Tzeng, J. A. Fisher, and P. N. Ainslie, “Integrative regulation of human brain blood flow,” J. Physiol. 592(5), 841–859 (2014).
[Crossref] [PubMed]

Witte, O. W.

C. Terborg, S. Bramer, S. Harscher, M. Simon, and O. W. Witte, “Bedside assessment of cerebral perfusion reductions in patients with acute ischaemic stroke by near-infrared spectroscopy and indocyanine green,” J. Neurol. Neurosurg. Psychiatry 75(1), 38–42 (2004).
[PubMed]

Wojtkiewicz, S.

W. Weigl, D. Milej, A. Gerega, B. Toczyłowska, P. Sawosz, M. Kacprzak, D. Janusek, S. Wojtkiewicz, R. Maniewski, and A. Liebert, “Confirmation of brain death using optical methods based on tracking of an optical contrast agent: assessment of diagnostic feasibility,” Sci. Rep. 8(1), 7332 (2018).
[Crossref] [PubMed]

W. Weigl, D. Milej, D. Janusek, S. Wojtkiewicz, P. Sawosz, M. Kacprzak, A. Gerega, R. Maniewski, and A. Liebert, “Application of optical methods in the monitoring of traumatic brain injury: A review,” J. Cereb. Blood Flow Metab. 36(11), 1825–1843 (2016).
[Crossref] [PubMed]

Wolf, M.

G. Greisen, T. Leung, and M. Wolf, “Has the time come to use near-infrared spectroscopy as a routine clinical tool in preterm infants undergoing intensive care?” Philos Trans A Math Phys Eng Sci 369(1955), 4440–4451 (2011).
[Crossref] [PubMed]

Wolf, R. L.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Yodh, A. G.

T. Durduran and A. G. Yodh, “Diffuse correlation spectroscopy for non-invasive, micro-vascular cerebral blood flow measurement,” Neuroimage 85(Pt 1), 51–63 (2014).
[Crossref] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Yu, G.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Zaccanti, G.

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

Zanoletti, M.

Zbiec, A.

R. Maniewski, A. Liebert, M. Kacprzak, and A. Zbiec, “Selected applications of near infrared optical methods in medical diagnosis,” Opto-Electron. Rev. 12, 255–262 (2004).

Zhou, C.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Zirak, P.

P. Zirak, R. Delgado-Mederos, L. Dinia, D. Carrera, J. Martí-Fàbregas, and T. Durduran, “Transcranial diffuse optical monitoring of microvascular cerebral hemodynamics after thrombolysis in ischemic stroke,” J. Biomed. Opt. 19(1), 018002 (2014).
[Crossref] [PubMed]

Zolek, N.

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

P. Sawosz, M. Kacprzak, W. Weigl, A. Borowska-Solonynko, P. Krajewski, N. Zolek, B. Ciszek, R. Maniewski, and A. Liebert, “Experimental estimation of the photons visiting probability profiles in time-resolved diffuse reflectance measurement,” Phys. Med. Biol. 57(23), 7973–7981 (2012).
[Crossref] [PubMed]

Zucchelli, L.

L. Spinelli, L. Zucchelli, D. Contini, M. Caffini, J. Mehler, A. Fló, A. L. Ferry, L. Filippin, F. Macagno, L. Cattarossi, and A. Torricelli, “In vivo measure of neonate brain optical properties and hemodynamic parameters by time-domain near-infrared spectroscopy,” Neurophotonics 4(4), 041414 (2017).
[Crossref] [PubMed]

A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85(Pt 1), 28–50 (2014).
[Crossref] [PubMed]

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

Zweifel, C.

J. Diedler, C. Zweifel, K. P. Budohoski, M. Kasprowicz, E. Sorrentino, C. Haubrich, K. M. Brady, M. Czosnyka, J. D. Pickard, and P. Smielewski, “The Limitations of Near-Infrared Spectroscopy to Assess Cerebrovascular Reactivity: the Role of Slow Frequency Oscillations,” Anesth. Analg. 113(4), 849–857 (2011).
[Crossref] [PubMed]

C. Zweifel, G. Castellani, M. Czosnyka, E. Carrera, K. M. Brady, P. J. Kirkpatrick, J. D. Pickard, and P. Smielewski, “Continuous assessment of cerebral autoregulation with near-infrared spectroscopy in adults after subarachnoid hemorrhage,” Stroke 41(9), 1963–1968 (2010).
[Crossref] [PubMed]

C. Zweifel, G. Castellani, M. Czosnyka, A. Helmy, A. Manktelow, E. Carrera, K. M. Brady, P. J. Hutchinson, D. K. Menon, J. D. Pickard, and P. Smielewski, “Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients,” J. Neurotrauma 27(11), 1951–1958 (2010).
[Crossref] [PubMed]

Anesth. Analg. (2)

D. Highton, A. Ghosh, I. Tachtsidis, J. Panovska-Griffiths, C. E. Elwell, and M. Smith, “Monitoring Cerebral Autoregulation After Brain Injury: Multimodal Assessment of Cerebral Slow-Wave Oscillations Using Near-Infrared Spectroscopy,” Anesth. Analg. 121(1), 198–205 (2015).
[Crossref] [PubMed]

J. Diedler, C. Zweifel, K. P. Budohoski, M. Kasprowicz, E. Sorrentino, C. Haubrich, K. M. Brady, M. Czosnyka, J. D. Pickard, and P. Smielewski, “The Limitations of Near-Infrared Spectroscopy to Assess Cerebrovascular Reactivity: the Role of Slow Frequency Oscillations,” Anesth. Analg. 113(4), 849–857 (2011).
[Crossref] [PubMed]

Appl. Opt. (1)

Biocybern. Biomed. Eng. (1)

O. Steinkellner, H. Wabnitz, A. Jelzow, R. Macdonald, C. Gruber, J. Steinbrink, and H. Obrig, “Cerebral Perfusion in Acute Stroke Monitored by Time-domain Near-infrared Reflectometry,” Biocybern. Biomed. Eng. 32(1), 3–16 (2012).
[Crossref]

Biomed. Opt. Express (2)

Crit. Care (1)

J. Donnelly, K. P. Budohoski, P. Smielewski, and M. Czosnyka, “Regulation of the cerebral circulation: bedside assessment and clinical implications,” Crit. Care 20(1), 129 (2016).
[Crossref] [PubMed]

IEEE Trans. Neural Syst. Rehabil. Eng. (1)

C. C. Lo, P. Y. Lin, Z. Y. Hoe, and J. J. J. Chen, “Near Infrared Spectroscopy Study of Cortical Excitability During Electrical Stimulation-Assisted Cycling for Neurorehabilitation of Stroke Patients,” IEEE Trans. Neural Syst. Rehabil. Eng. 26(6), 1292–1300 (2018).
[Crossref] [PubMed]

J. Appl. Physiol. (1)

C. O. Tan, “Defining the characteristic relationship between arterial pressure and cerebral flow,” J. Appl. Physiol. 113(8), 1194–1200 (2012).
[Crossref] [PubMed]

J. Biomed. Opt. (5)

P. Zirak, R. Delgado-Mederos, L. Dinia, D. Carrera, J. Martí-Fàbregas, and T. Durduran, “Transcranial diffuse optical monitoring of microvascular cerebral hemodynamics after thrombolysis in ischemic stroke,” J. Biomed. Opt. 19(1), 018002 (2014).
[Crossref] [PubMed]

M. Kacprzak, A. Liebert, W. Staszkiewicz, A. Gabrusiewicz, P. Sawosz, G. Madycki, and R. Maniewski, “Application of a time-resolved optical brain imager for monitoring cerebral oxygenation during carotid surgery,” J. Biomed. Opt. 17(1), 016002 (2012).
[Crossref] [PubMed]

O. Steinkellner, C. Gruber, H. Wabnitz, A. Jelzow, J. Steinbrink, J. B. Fiebach, R. Macdonald, and H. Obrig, “Optical bedside monitoring of cerebral perfusion: technological and methodological advances applied in a study on acute ischemic stroke,” J. Biomed. Opt. 15(6), 061708 (2010).
[Crossref] [PubMed]

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

J. Cereb. Blood Flow Metab. (1)

W. Weigl, D. Milej, D. Janusek, S. Wojtkiewicz, P. Sawosz, M. Kacprzak, A. Gerega, R. Maniewski, and A. Liebert, “Application of optical methods in the monitoring of traumatic brain injury: A review,” J. Cereb. Blood Flow Metab. 36(11), 1825–1843 (2016).
[Crossref] [PubMed]

J. Neurol. Neurosurg. Psychiatry (1)

C. Terborg, S. Bramer, S. Harscher, M. Simon, and O. W. Witte, “Bedside assessment of cerebral perfusion reductions in patients with acute ischaemic stroke by near-infrared spectroscopy and indocyanine green,” J. Neurol. Neurosurg. Psychiatry 75(1), 38–42 (2004).
[PubMed]

J. Neurotrauma (2)

C. Zweifel, G. Castellani, M. Czosnyka, A. Helmy, A. Manktelow, E. Carrera, K. M. Brady, P. J. Hutchinson, D. K. Menon, J. D. Pickard, and P. Smielewski, “Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients,” J. Neurotrauma 27(11), 1951–1958 (2010).
[Crossref] [PubMed]

B. Schmidt, J. Klingelhöfer, I. Perkes, and M. Czosnyka, “Cerebral Autoregulatory Response Depends on the Direction of Change in Perfusion Pressure,” J. Neurotrauma 26(5), 651–656 (2009).
[Crossref] [PubMed]

J. Physiol. (1)

C. K. Willie, Y. C. Tzeng, J. A. Fisher, and P. N. Ainslie, “Integrative regulation of human brain blood flow,” J. Physiol. 592(5), 841–859 (2014).
[Crossref] [PubMed]

Neurocrit. Care (3)

C. Dias, M. J. Silva, E. Pereira, E. Monteiro, I. Maia, S. Barbosa, S. Silva, T. Honrado, A. Cerejo, M. J. H. Aries, P. Smielewski, J. A. Paiva, and M. Czosnyka, “Optimal Cerebral Perfusion Pressure Management at Bedside: A Single-Center Pilot Study,” Neurocrit. Care 23(1), 92–102 (2015).
[Crossref] [PubMed]

M. Czosnyka, K. Brady, M. Reinhard, P. Smielewski, and L. A. Steiner, “Monitoring of cerebrovascular autoregulation: facts, myths, and missing links,” Neurocrit. Care 10(3), 373–386 (2009).
[Crossref] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Neuroimage (3)

D. A. Boas, T. Gaudette, G. Strangman, X. Cheng, J. J. Marota, and J. B. Mandeville, “The accuracy of near infrared spectroscopy and imaging during focal changes in cerebral hemodynamics,” Neuroimage 13(1), 76–90 (2001).
[Crossref] [PubMed]

T. Durduran and A. G. Yodh, “Diffuse correlation spectroscopy for non-invasive, micro-vascular cerebral blood flow measurement,” Neuroimage 85(Pt 1), 51–63 (2014).
[Crossref] [PubMed]

A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85(Pt 1), 28–50 (2014).
[Crossref] [PubMed]

Neurophotonics (1)

L. Spinelli, L. Zucchelli, D. Contini, M. Caffini, J. Mehler, A. Fló, A. L. Ferry, L. Filippin, F. Macagno, L. Cattarossi, and A. Torricelli, “In vivo measure of neonate brain optical properties and hemodynamic parameters by time-domain near-infrared spectroscopy,” Neurophotonics 4(4), 041414 (2017).
[Crossref] [PubMed]

Neurosurgery (1)

C. A. Giller, “The Frequency-Dependent Behavior of Cerebral Autoregulation,” Neurosurgery 27(3), 362–368 (1990).
[Crossref] [PubMed]

Opto-Electron. Rev. (1)

R. Maniewski, A. Liebert, M. Kacprzak, and A. Zbiec, “Selected applications of near infrared optical methods in medical diagnosis,” Opto-Electron. Rev. 12, 255–262 (2004).

Philos Trans A Math Phys Eng Sci (1)

G. Greisen, T. Leung, and M. Wolf, “Has the time come to use near-infrared spectroscopy as a routine clinical tool in preterm infants undergoing intensive care?” Philos Trans A Math Phys Eng Sci 369(1955), 4440–4451 (2011).
[Crossref] [PubMed]

Phys. Med. Biol. (2)

P. Sawosz, M. Kacprzak, W. Weigl, A. Borowska-Solonynko, P. Krajewski, N. Zolek, B. Ciszek, R. Maniewski, and A. Liebert, “Experimental estimation of the photons visiting probability profiles in time-resolved diffuse reflectance measurement,” Phys. Med. Biol. 57(23), 7973–7981 (2012).
[Crossref] [PubMed]

J. Steinbrink, H. Wabnitz, H. Obrig, A. Villringer, and H. Rinneberg, “Determining changes in NIR absorption using a layered model of the human head,” Phys. Med. Biol. 46(3), 879–896 (2001).
[Crossref] [PubMed]

Physiol. Rev. (1)

N. A. Lassen, “Cerebral Blood Flow and Oxygen Consumption in Man,” Physiol. Rev. 39(2), 183–238 (1959).
[Crossref] [PubMed]

Sci. Rep. (1)

W. Weigl, D. Milej, A. Gerega, B. Toczyłowska, P. Sawosz, M. Kacprzak, D. Janusek, S. Wojtkiewicz, R. Maniewski, and A. Liebert, “Confirmation of brain death using optical methods based on tracking of an optical contrast agent: assessment of diagnostic feasibility,” Sci. Rep. 8(1), 7332 (2018).
[Crossref] [PubMed]

Stroke (4)

C. Zweifel, G. Castellani, M. Czosnyka, E. Carrera, K. M. Brady, P. J. Kirkpatrick, J. D. Pickard, and P. Smielewski, “Continuous assessment of cerebral autoregulation with near-infrared spectroscopy in adults after subarachnoid hemorrhage,” Stroke 41(9), 1963–1968 (2010).
[Crossref] [PubMed]

R. Aaslid, M. Blaha, G. Sviri, C. M. Douville, and D. W. Newell, “Asymmetric dynamic cerebral autoregulatory response to cyclic stimuli,” Stroke 38(5), 1465–1469 (2007).
[Crossref] [PubMed]

R. R. Diehl, D. Linden, D. Lücke, and P. Berlit, “Phase Relationship Between Cerebral Blood Flow Velocity and Blood Pressure. a Clinical Test of Autoregulation,” Stroke 26(10), 1801–1804 (1995).
[Crossref] [PubMed]

C. Haubrich, W. Kruska, R. R. Diehl, W. Möller-Hartmann, and C. Klötzsch, “Dynamic autoregulation testing in patients with middle cerebral artery stenosis,” Stroke 34(8), 1881–1885 (2003).
[Crossref] [PubMed]

Other (1)

S. L. Ferradal, K. Yuki, R. Vyas, C. G. Ha, F. Yi, C. Stopp, D. Wypij, H. H. Cheng, J. W. Newburger, A. K. Kaza, M. A. Franceschini, B. D. Kussman, and P. E. Grant, “Non-invasive Assessment of Cerebral Blood Flow and Oxygen Metabolism in Neonates during Hypothermic Cardiopulmonary Bypass: Feasibility and Clinical Implications,” Sci Rep-Uk 7, 44117 (2017).
[Crossref]

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Figures (6)

Fig. 1
Fig. 1 Two-channel tdNIRS system equipped with four independent pulsed laser sources and two hybrid photomultipliers.
Fig. 2
Fig. 2 Representative long-term recording of the changes in statistical moments of the DTOFs obtained during the measurement of a healthy subject at rest at two wavelengths: 687 and 830 nm. Frequency components related to heart rate and respiration are clearly visible in the light attenuation signal (a), but are not clear in the signals for change in the mean time of flight of photons (b) and variance of DTOF (c), where noise contamination is apparently higher.
Fig. 3
Fig. 3 Illustrative example of the amplitude spectrum analysis of the ΔA (a) and ΔV (b) signals for a healthy subject. In both graphs, the arterial pulsation components are visible, whereas the respiration arterial pulsation first harmonic and Mayer oscillations are only present in the ΔA (a) amplitude spectrum.
Fig. 4
Fig. 4 Illustrative example of the amplitude spectrum analysis of the ΔA (a) and ΔV (b) signals for a TBI patient. In the ΔA signal (a), the arterial pulsation and respiration components are visible, whereas in the variance amplitude spectrum (b), all components are covered by noise, except for the LF components (f < 0.3 Hz).
Fig. 5
Fig. 5 Comparison of the amplitude spectra of the light attenuation signal (ΔA) (a and c) and variance (ΔV) (b and d) of DTOFs for LF (0.005–0.1 Hz) and HF (0.3 – 3 Hz) ranges for the group of healthy subjects and patients at wavelengths of 687 nm (a and b) and 830 nm (c and d). The boxes indicate the 25th and 75th percentiles of the distributions. The horizontal red lines inside the rectangles denote median values and the vertical bars reflect the maximum–minimum ranges.
Fig. 6
Fig. 6 AAF and VAF levels calculated for healthy subjects and patients with brain disorders at wavelengths of 687 nm (a) and 830 nm (b).

Tables (1)

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Table 1 Clinical data of patients included in the study

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