Abstract

We propose a new near-infrared spectroscopy (NIRS) method for quantitative measurements of cerebral blood flow (CBF). Because this method uses concepts of coherent hemodynamics spectroscopy (CHS), we identify this new method with the acronym NIRS-CHS. We tested this method on the prefrontal cortex of six healthy human subjects during mean arterial pressure (MAP) transients induced by the rapid deflation of pneumatic thigh cuffs. A comparison of CBF dynamics measured with NIRS-CHS and with diffuse correlation spectroscopy (DCS) showed a good agreement for characteristic times of the CBF transient. We also report absolute measurements of baseline CBF with NIRS-CHS (69 ± 6 ml/100g/min over the six subjects). NIRS-CHS can provide more accurate measurements of CBF with respect to previously reported NIRS surrogates of CBF.

© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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2019 (1)

K. Tgavalekos, T. Pham, N. Krishnamurthy, A. Sassaroli, and S. Fantini, “Frequency-resolved analysis of coherent oscillations of local cerebral blood volume and systemic arterial pressure,” PLoS One 14(2), e0211710 (2019).
[Crossref] [PubMed]

2018 (2)

K. Khaksari, G. Blaney, A. Sassaroli, N. Krishnamurthy, T. Pham, and S. Fantini, “Depth dependence of coherent hemodynamics in the human head,” J. Biomed. Opt. 23(12), 1–9 (2018).
[Crossref] [PubMed]

A. B. Parthasarathy, K. P. Gannon, W. B. Baker, C. G. Favilla, R. Balu, S. E. Kasner, A. G. Yodh, J. A. Detre, and M. T. Mullen, “Dynamic autoregulation of cerebral blood flow measured non-invasively with fast diffuse correlation spectroscopy,” J. Cereb. Blood Flow Metab. 38(2), 230–240 (2018).
[Crossref] [PubMed]

2016 (3)

S. Fantini, A. Sassaroli, J. M. Kainerstorfer, K. T. Tgavalekos, and X. Zang, “Non-invasive assessment of cerebral microcirculation with diffuse optics and coherent hemodynamics spectroscopy,” Proc. SPIE 9690B, 1–9 (2016).

S. Fantini, A. Sassaroli, K. T. Tgavalekos, and J. Kornbluth, “Cerebral blood flow and autoregulation: current measurement techniques and prospects for noninvasive optical methods,” Neurophotonics 3(3), 031411 (2016).
[Crossref] [PubMed]

A. L. de Oliveira Manoel, A. Goffi, T. R. Marotta, T. A. Schweizer, S. Abrahamson, and R. L. Macdonald, “The critical care management of poor-grade subarachnoid haemorrhage,” Crit. Care 20(1), 21 (2016).
[Crossref] [PubMed]

2015 (4)

J. M. Kainerstorfer, A. Sassaroli, K. T. Tgavalekos, and S. Fantini, “Dynamic cerebral autoregulation measured with coherent hemodynamics spectroscopy (CHS),” Prog. Biomed. Opt. Imaging - Proc. SPIE 9319, 1–6 (2015).

J. M. Kainerstorfer, A. Sassaroli, K. T. Tgavalekos, and S. Fantini, “Cerebral autoregulation in the microvasculature measured with near-infrared spectroscopy,” J. Cereb. Blood Flow Metab. 35(6), 959–966 (2015).
[Crossref] [PubMed]

R. B. Panerai, N. P. Saeed, and T. G. Robinson, “Cerebrovascular effects of the thigh cuff maneuver,” Am. J. Physiol. Heart Circ. Physiol. 308(7), H688–H696 (2015).
[Crossref] [PubMed]

W. B. Baker, A. B. Parthasarathy, T. S. Ko, D. R. Busch, K. Abramson, S.-Y. Tzeng, R. C. Mesquita, T. Durduran, J. H. Greenberg, D. K. Kung, and A. G. Yodh, “Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts,” Neurophotonics 2(3), 035004 (2015).
[Crossref] [PubMed]

2014 (7)

E. M. Buckley, A. B. Parthasarathy, P. E. Grant, A. G. Yodh, and M. A. Franceschini, “Diffuse correlation spectroscopy for measurement of cerebral blood flow: future prospects,” Neurophotonics 1(1), 011009 (2014).
[Crossref] [PubMed]

J. Selb, D. A. Boas, S.-T. Chan, K. C. Evans, E. M. Buckley, and S. A. Carp, “Sensitivity of near-infrared spectroscopy and diffuse correlation spectroscopy to brain hemodynamics: simulations and experimental findings during hypercapnia,” Neurophotonics 1(1), 015005 (2014).
[Crossref] [PubMed]

M. A. Kirkman, G. Citerio, and M. Smith, “The intensive care management of acute ischemic stroke: An overview,” Intensive Care Med. 40(5), 640–653 (2014).
[Crossref] [PubMed]

S. Fantini, “A new hemodynamic model shows that temporal perturbations of cerebral blood flow and metabolic rate of oxygen cannot be measured individually using functional near-infrared spectroscopy,” Physiol. Meas. 35(1), N1–N9 (2014).
[Crossref] [PubMed]

S. Fantini, “Dynamic model for the tissue concentration and oxygen saturation of hemoglobin in relation to blood volume, flow velocity, and oxygen consumption: Implications for functional neuroimaging and coherent hemodynamics spectroscopy (CHS),” Neuroimage 85(Pt 1), 202–221 (2014).
[Crossref] [PubMed]

J. M. Kainerstorfer, A. Sassaroli, B. Hallacoglu, M. L. Pierro, and S. Fantini, “Practical Steps for Applying a New Dynamic Model to Near-Infrared Spectroscopy Measurements of Hemodynamic Oscillations and Transient Changes: Implications for Cerebrovascular and Functional Brain Studies,” Acad. Radiol. 21(2), 185–196 (2014).
[Crossref] [PubMed]

N. Roche-Labarbe, A. Fenoglio, H. Radhakrishnan, M. Kocienski-Filip, S. A. Carp, J. Dubb, D. A. Boas, P. E. Grant, and M. A. Franceschini, “Somatosensory evoked changes in cerebral oxygen consumption measured non-invasively in premature neonates,” Neuroimage 85(Pt 1), 279–286 (2014).
[Crossref] [PubMed]

2013 (2)

2012 (4)

O. M. Henriksen, H. B. W. Larsson, A. E. Hansen, J. M. Grüner, I. Law, and E. Rostrup, “Estimation of intersubject variability of cerebral blood flow measurements using MRI and positron emission tomography,” J. Magn. Reson. Imaging 35(6), 1290–1299 (2012).
[Crossref] [PubMed]

S. N. Jespersen and L. Østergaard, “The Roles of Cerebral Blood Flow, Capillary Transit Time Heterogeneity, and Oxygen Tension in Brain Oxygenation and Metabolism,” J. Cereb. Blood Flow Metab. 32(2), 264–277 (2012).
[Crossref] [PubMed]

B. Hallacoglu, A. Sassaroli, M. Wysocki, E. Guerrero-Berroa, M. Schnaider Beeri, V. Haroutunian, M. Shaul, I. H. Rosenberg, A. M. Troen, and S. Fantini, “Absolute measurement of cerebral optical coefficients, hemoglobin concentration and oxygen saturation in old and young adults with near-infrared spectroscopy,” J. Biomed. Opt. 17(8), 081406 (2012).
[Crossref] [PubMed]

E. M. Buckley, D. Hance, T. Pawlowski, J. Lynch, F. B. Wilson, R. C. Mesquita, T. Durduran, L. K. Diaz, M. E. Putt, D. J. Licht, M. A. Fogel, and A. G. Yodh, “Validation of diffuse correlation spectroscopic measurement of cerebral blood flow using phase-encoded velocity mapping magnetic resonance imaging,” J. Biomed. Opt. 17(3), 037007 (2012).
[Crossref] [PubMed]

2011 (1)

2010 (3)

S. A. Carp, G. P. Dai, D. A. Boas, M. A. Franceschini, and Y. R. Kim, “Validation of diffuse correlation spectroscopy measurements of rodent cerebral blood flow with simultaneous arterial spin labeling MRI; towards MRI-optical continuous cerebral metabolic monitoring,” Biomed. Opt. Express 1(2), 553–565 (2010).
[Crossref] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Y. Z. Al-Tamimi, N. M. Orsi, A. C. Quinn, S. Homer-Vanniasinkam, and S. A. Ross, “A review of delayed ischemic neurologic deficit following aneurysmal subarachnoid hemorrhage: Historical overview, current treatment, and Pathophysiology,” World Neurosurg. 73(6), 654–667 (2010).
[Crossref] [PubMed]

2009 (1)

C. W. A. Pennekamp, M. L. Bots, L. J. Kappelle, F. L. Moll, and G. J. de Borst, “The Value of Near-Infrared Spectroscopy Measured Cerebral Oximetry During Carotid Endarterectomy in Perioperative Stroke Prevention. A Review,” Eur. J. Vasc. Endovasc. Surg. 38(5), 539–545 (2009).
[Crossref] [PubMed]

2008 (1)

A. R. Pries and T. W. Secomb, “Blood Flow in Microvascular Networks,” Microcirculation 67, 3–36 (2008).

2007 (1)

J. S. Soul, P. E. Hammer, M. Tsuji, J. P. Saul, H. Bassan, C. Limperopoulos, D. N. Disalvo, M. Moore, P. Akins, S. Ringer, J. J. Volpe, F. Trachtenberg, and A. J. du Plessis, “Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infants,” Pediatr. Res. 61(4), 467–473 (2007).
[Crossref] [PubMed]

2006 (1)

F. Cassot, F. Lauwers, C. Fouard, S. Prohaska, and V. Lauwers-Cances, “A novel three-dimensional computer-assisted method for a quantitative study of microvascular networks of the human cerebral cortex,” Microcirculation 13(1), 1–18 (2006).
[Crossref] [PubMed]

2005 (3)

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J.-F. Soustiel, T. Nariai, G. Zaharchuk, J.-M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke 36(9), e83–e99 (2005).
[Crossref] [PubMed]

H. Bassan, K. Gauvreau, J. W. Newburger, M. Tsuji, C. Limperopoulos, J. S. Soul, G. Walter, P. C. Laussen, R. A. Jonas, and A. J. du Plessis, “Identification of pressure passive cerebral perfusion and its mediators after infant cardiac surgery,” Pediatr. Res. 57(1), 35–41 (2005).
[Crossref] [PubMed]

C. B. Grandin, A. Bol, A. M. Smith, C. Michel, and G. Cosnard, “Absolute CBF and CBV measurements by MRI bolus tracking before and after acetazolamide challenge: repeatabilily and comparison with PET in humans,” Neuroimage 26(2), 525–535 (2005).
[Crossref] [PubMed]

2004 (1)

A. Sassaroli and S. Fantini, “Comment on the modified Beer-Lambert law for scattering media,” Phys. Med. Biol. 49(14), N255–N257 (2004).
[Crossref] [PubMed]

2003 (1)

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23(8), 911–924 (2003).
[Crossref] [PubMed]

2001 (2)

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46(8), 2053–2065 (2001).
[Crossref] [PubMed]

H. Ito, I. Kanno, H. Iida, J. Hatazawa, E. Shimosegawa, H. Tamura, and T. Okudera, “Arterial fraction of cerebral blood volume in humans measured by positron emission tomography,” Ann. Nucl. Med. 15(2), 111–116 (2001).
[Crossref] [PubMed]

2000 (1)

M. Tsuji, J. P. Saul, A. du Plessis, E. Eichenwald, J. Sobh, R. Crocker, and J. J. Volpe, “Cerebral Intravascular Oxygenation Correlates With Mean Arterial Pressure in Critically Ill Premature Infants,” Pediatrics 106(4), 625–632 (2000).
[Crossref] [PubMed]

1999 (3)

S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic, “Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy,” Phys. Med. Biol. 44(6), 1543–1563 (1999).
[Crossref] [PubMed]

A. V. Alexandrov, A. M. Demchuk, T. H. Wein, and J. C. Grotta, “Yield of transcranial Doppler in acute cerebral ischemia,” Stroke 30(8), 1604–1609 (1999).
[Crossref] [PubMed]

E. J. P. A. Vonken, M. J. P. van Osch, C. J. G. Bakker, and M. A. Viergever, “Measurement of cerebral perfusion with dual-echo multi-slice quantitative dynamic susceptibility contrast MRI,” J. Magn. Reson. Imaging 10(2), 109–117 (1999).
[Crossref] [PubMed]

1998 (2)

R. B. Panerai, R. P. White, H. S. Markus, and D. H. Evans, “Grading of cerebral dynamic autoregulation from spontaneous fluctuations in arterial blood pressure,” Stroke 29(11), 2341–2346 (1998).
[Crossref] [PubMed]

M. Tsuji, A. duPlessis, G. Taylor, R. Crocker, and J. J. Volpe, “Near infrared spectroscopy detects cerebral ischemia during hypotension in piglets,” Pediatr. Res. 44(4), 591–595 (1998).
[Crossref] [PubMed]

1997 (1)

M. A. Franceschini, S. Fantini, A. E. Cerussi, B. B. Barbieri, B. Chance, and E. Gratton, “Quantitative spectroscopic determination of hemoglobin concentration and saturation in a turbid medium: analysis of the effect of water absorption,” J. Biomed. Opt. 2(2), 147–153 (1997).
[Crossref] [PubMed]

1994 (2)

1992 (1)

W. Kuschinsky and O. B. Paulson, “Capillary circulation in the brain,” Cerebrovasc. Brain Metab. Rev. 4(3), 261–286 (1992).
[PubMed]

1989 (3)

R. Aaslid, K. F. Lindegaard, W. Sorteberg, and H. Nornes, “Cerebral autoregulation dynamics in humans,” Stroke 20(1), 45–52 (1989).
[Crossref] [PubMed]

R. Aaslid, K. F. Lindegaard, W. Sorteberg, and H. Nornes, “Cerebral autoregulation dynamics in humans,” Stroke 20(1), 45–52 (1989).
[Crossref] [PubMed]

U. Göbel, B. Klein, H. Schröck, and W. Kuschinsky, “Lack of capillary recruitment in the brains of awake rats during hypercapnia,” J. Cereb. Blood Flow Metab. 9(4), 491–499 (1989).
[Crossref] [PubMed]

1986 (2)

P. T. Fox and M. E. Raichle, “Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects,” Proc. Natl. Acad. Sci. U.S.A. 83(4), 1140–1144 (1986).
[Crossref] [PubMed]

P. T. Fox, M. E. Raichle, M. A. Mintun, and C. Dence, “Nonoxidative glucose consumption during focal physiologic neural activity,” Proc. Natl. Acad. Sci. U.S.A. 83(4), 1140–1144 (1986).
[Crossref] [PubMed]

Aaslid, R.

R. Aaslid, K. F. Lindegaard, W. Sorteberg, and H. Nornes, “Cerebral autoregulation dynamics in humans,” Stroke 20(1), 45–52 (1989).
[Crossref] [PubMed]

R. Aaslid, K. F. Lindegaard, W. Sorteberg, and H. Nornes, “Cerebral autoregulation dynamics in humans,” Stroke 20(1), 45–52 (1989).
[Crossref] [PubMed]

Abrahamson, S.

A. L. de Oliveira Manoel, A. Goffi, T. R. Marotta, T. A. Schweizer, S. Abrahamson, and R. L. Macdonald, “The critical care management of poor-grade subarachnoid haemorrhage,” Crit. Care 20(1), 21 (2016).
[Crossref] [PubMed]

Abramson, K.

W. B. Baker, A. B. Parthasarathy, T. S. Ko, D. R. Busch, K. Abramson, S.-Y. Tzeng, R. C. Mesquita, T. Durduran, J. H. Greenberg, D. K. Kung, and A. G. Yodh, “Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts,” Neurophotonics 2(3), 035004 (2015).
[Crossref] [PubMed]

Akins, P.

J. S. Soul, P. E. Hammer, M. Tsuji, J. P. Saul, H. Bassan, C. Limperopoulos, D. N. Disalvo, M. Moore, P. Akins, S. Ringer, J. J. Volpe, F. Trachtenberg, and A. J. du Plessis, “Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infants,” Pediatr. Res. 61(4), 467–473 (2007).
[Crossref] [PubMed]

Alexandrov, A. V.

A. V. Alexandrov, A. M. Demchuk, T. H. Wein, and J. C. Grotta, “Yield of transcranial Doppler in acute cerebral ischemia,” Stroke 30(8), 1604–1609 (1999).
[Crossref] [PubMed]

Al-Tamimi, Y. Z.

Y. Z. Al-Tamimi, N. M. Orsi, A. C. Quinn, S. Homer-Vanniasinkam, and S. A. Ross, “A review of delayed ischemic neurologic deficit following aneurysmal subarachnoid hemorrhage: Historical overview, current treatment, and Pathophysiology,” World Neurosurg. 73(6), 654–667 (2010).
[Crossref] [PubMed]

Baker, W. B.

A. B. Parthasarathy, K. P. Gannon, W. B. Baker, C. G. Favilla, R. Balu, S. E. Kasner, A. G. Yodh, J. A. Detre, and M. T. Mullen, “Dynamic autoregulation of cerebral blood flow measured non-invasively with fast diffuse correlation spectroscopy,” J. Cereb. Blood Flow Metab. 38(2), 230–240 (2018).
[Crossref] [PubMed]

W. B. Baker, A. B. Parthasarathy, T. S. Ko, D. R. Busch, K. Abramson, S.-Y. Tzeng, R. C. Mesquita, T. Durduran, J. H. Greenberg, D. K. Kung, and A. G. Yodh, “Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts,” Neurophotonics 2(3), 035004 (2015).
[Crossref] [PubMed]

Bakker, C. J. G.

E. J. P. A. Vonken, M. J. P. van Osch, C. J. G. Bakker, and M. A. Viergever, “Measurement of cerebral perfusion with dual-echo multi-slice quantitative dynamic susceptibility contrast MRI,” J. Magn. Reson. Imaging 10(2), 109–117 (1999).
[Crossref] [PubMed]

Balu, R.

A. B. Parthasarathy, K. P. Gannon, W. B. Baker, C. G. Favilla, R. Balu, S. E. Kasner, A. G. Yodh, J. A. Detre, and M. T. Mullen, “Dynamic autoregulation of cerebral blood flow measured non-invasively with fast diffuse correlation spectroscopy,” J. Cereb. Blood Flow Metab. 38(2), 230–240 (2018).
[Crossref] [PubMed]

Barbier, E.

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J.-F. Soustiel, T. Nariai, G. Zaharchuk, J.-M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke 36(9), e83–e99 (2005).
[Crossref] [PubMed]

Barbieri, B.

Barbieri, B. B.

M. A. Franceschini, S. Fantini, A. E. Cerussi, B. B. Barbieri, B. Chance, and E. Gratton, “Quantitative spectroscopic determination of hemoglobin concentration and saturation in a turbid medium: analysis of the effect of water absorption,” J. Biomed. Opt. 2(2), 147–153 (1997).
[Crossref] [PubMed]

Bassan, H.

J. S. Soul, P. E. Hammer, M. Tsuji, J. P. Saul, H. Bassan, C. Limperopoulos, D. N. Disalvo, M. Moore, P. Akins, S. Ringer, J. J. Volpe, F. Trachtenberg, and A. J. du Plessis, “Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infants,” Pediatr. Res. 61(4), 467–473 (2007).
[Crossref] [PubMed]

H. Bassan, K. Gauvreau, J. W. Newburger, M. Tsuji, C. Limperopoulos, J. S. Soul, G. Walter, P. C. Laussen, R. A. Jonas, and A. J. du Plessis, “Identification of pressure passive cerebral perfusion and its mediators after infant cardiac surgery,” Pediatr. Res. 57(1), 35–41 (2005).
[Crossref] [PubMed]

Blaney, G.

K. Khaksari, G. Blaney, A. Sassaroli, N. Krishnamurthy, T. Pham, and S. Fantini, “Depth dependence of coherent hemodynamics in the human head,” J. Biomed. Opt. 23(12), 1–9 (2018).
[Crossref] [PubMed]

Boas, D. A.

J. Selb, D. A. Boas, S.-T. Chan, K. C. Evans, E. M. Buckley, and S. A. Carp, “Sensitivity of near-infrared spectroscopy and diffuse correlation spectroscopy to brain hemodynamics: simulations and experimental findings during hypercapnia,” Neurophotonics 1(1), 015005 (2014).
[Crossref] [PubMed]

N. Roche-Labarbe, A. Fenoglio, H. Radhakrishnan, M. Kocienski-Filip, S. A. Carp, J. Dubb, D. A. Boas, P. E. Grant, and M. A. Franceschini, “Somatosensory evoked changes in cerebral oxygen consumption measured non-invasively in premature neonates,” Neuroimage 85(Pt 1), 279–286 (2014).
[Crossref] [PubMed]

S. A. Carp, G. P. Dai, D. A. Boas, M. A. Franceschini, and Y. R. Kim, “Validation of diffuse correlation spectroscopy measurements of rodent cerebral blood flow with simultaneous arterial spin labeling MRI; towards MRI-optical continuous cerebral metabolic monitoring,” Biomed. Opt. Express 1(2), 553–565 (2010).
[Crossref] [PubMed]

Bol, A.

C. B. Grandin, A. Bol, A. M. Smith, C. Michel, and G. Cosnard, “Absolute CBF and CBV measurements by MRI bolus tracking before and after acetazolamide challenge: repeatabilily and comparison with PET in humans,” Neuroimage 26(2), 525–535 (2005).
[Crossref] [PubMed]

Borbély, K.

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J.-F. Soustiel, T. Nariai, G. Zaharchuk, J.-M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke 36(9), e83–e99 (2005).
[Crossref] [PubMed]

Bots, M. L.

C. W. A. Pennekamp, M. L. Bots, L. J. Kappelle, F. L. Moll, and G. J. de Borst, “The Value of Near-Infrared Spectroscopy Measured Cerebral Oximetry During Carotid Endarterectomy in Perioperative Stroke Prevention. A Review,” Eur. J. Vasc. Endovasc. Surg. 38(5), 539–545 (2009).
[Crossref] [PubMed]

Buckley, E. M.

J. Selb, D. A. Boas, S.-T. Chan, K. C. Evans, E. M. Buckley, and S. A. Carp, “Sensitivity of near-infrared spectroscopy and diffuse correlation spectroscopy to brain hemodynamics: simulations and experimental findings during hypercapnia,” Neurophotonics 1(1), 015005 (2014).
[Crossref] [PubMed]

E. M. Buckley, A. B. Parthasarathy, P. E. Grant, A. G. Yodh, and M. A. Franceschini, “Diffuse correlation spectroscopy for measurement of cerebral blood flow: future prospects,” Neurophotonics 1(1), 011009 (2014).
[Crossref] [PubMed]

E. M. Buckley, D. Hance, T. Pawlowski, J. Lynch, F. B. Wilson, R. C. Mesquita, T. Durduran, L. K. Diaz, M. E. Putt, D. J. Licht, M. A. Fogel, and A. G. Yodh, “Validation of diffuse correlation spectroscopic measurement of cerebral blood flow using phase-encoded velocity mapping magnetic resonance imaging,” J. Biomed. Opt. 17(3), 037007 (2012).
[Crossref] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Busch, D. R.

W. B. Baker, A. B. Parthasarathy, T. S. Ko, D. R. Busch, K. Abramson, S.-Y. Tzeng, R. C. Mesquita, T. Durduran, J. H. Greenberg, D. K. Kung, and A. G. Yodh, “Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts,” Neurophotonics 2(3), 035004 (2015).
[Crossref] [PubMed]

R. C. Mesquita, S. S. Schenkel, D. L. Minkoff, X. Lu, C. G. Favilla, P. M. Vora, D. R. Busch, M. Chandra, J. H. Greenberg, J. A. Detre, and A. G. Yodh, “Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions,” Biomed. Opt. Express 4(7), 978–994 (2013).
[Crossref] [PubMed]

Caillé, J.-M.

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J.-F. Soustiel, T. Nariai, G. Zaharchuk, J.-M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke 36(9), e83–e99 (2005).
[Crossref] [PubMed]

Carp, S. A.

N. Roche-Labarbe, A. Fenoglio, H. Radhakrishnan, M. Kocienski-Filip, S. A. Carp, J. Dubb, D. A. Boas, P. E. Grant, and M. A. Franceschini, “Somatosensory evoked changes in cerebral oxygen consumption measured non-invasively in premature neonates,” Neuroimage 85(Pt 1), 279–286 (2014).
[Crossref] [PubMed]

J. Selb, D. A. Boas, S.-T. Chan, K. C. Evans, E. M. Buckley, and S. A. Carp, “Sensitivity of near-infrared spectroscopy and diffuse correlation spectroscopy to brain hemodynamics: simulations and experimental findings during hypercapnia,” Neurophotonics 1(1), 015005 (2014).
[Crossref] [PubMed]

S. A. Carp, G. P. Dai, D. A. Boas, M. A. Franceschini, and Y. R. Kim, “Validation of diffuse correlation spectroscopy measurements of rodent cerebral blood flow with simultaneous arterial spin labeling MRI; towards MRI-optical continuous cerebral metabolic monitoring,” Biomed. Opt. Express 1(2), 553–565 (2010).
[Crossref] [PubMed]

Cassot, F.

F. Cassot, F. Lauwers, C. Fouard, S. Prohaska, and V. Lauwers-Cances, “A novel three-dimensional computer-assisted method for a quantitative study of microvascular networks of the human cerebral cortex,” Microcirculation 13(1), 1–18 (2006).
[Crossref] [PubMed]

Cerussi, A. E.

M. A. Franceschini, S. Fantini, A. E. Cerussi, B. B. Barbieri, B. Chance, and E. Gratton, “Quantitative spectroscopic determination of hemoglobin concentration and saturation in a turbid medium: analysis of the effect of water absorption,” J. Biomed. Opt. 2(2), 147–153 (1997).
[Crossref] [PubMed]

Chan, S.-T.

J. Selb, D. A. Boas, S.-T. Chan, K. C. Evans, E. M. Buckley, and S. A. Carp, “Sensitivity of near-infrared spectroscopy and diffuse correlation spectroscopy to brain hemodynamics: simulations and experimental findings during hypercapnia,” Neurophotonics 1(1), 015005 (2014).
[Crossref] [PubMed]

Chance, B.

M. A. Franceschini, S. Fantini, A. E. Cerussi, B. B. Barbieri, B. Chance, and E. Gratton, “Quantitative spectroscopic determination of hemoglobin concentration and saturation in a turbid medium: analysis of the effect of water absorption,” J. Biomed. Opt. 2(2), 147–153 (1997).
[Crossref] [PubMed]

Chandra, M.

Cheung, C.

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23(8), 911–924 (2003).
[Crossref] [PubMed]

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46(8), 2053–2065 (2001).
[Crossref] [PubMed]

Choe, R.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Citerio, G.

M. A. Kirkman, G. Citerio, and M. Smith, “The intensive care management of acute ischemic stroke: An overview,” Intensive Care Med. 40(5), 640–653 (2014).
[Crossref] [PubMed]

Cosnard, G.

C. B. Grandin, A. Bol, A. M. Smith, C. Michel, and G. Cosnard, “Absolute CBF and CBV measurements by MRI bolus tracking before and after acetazolamide challenge: repeatabilily and comparison with PET in humans,” Neuroimage 26(2), 525–535 (2005).
[Crossref] [PubMed]

Crocker, R.

M. Tsuji, J. P. Saul, A. du Plessis, E. Eichenwald, J. Sobh, R. Crocker, and J. J. Volpe, “Cerebral Intravascular Oxygenation Correlates With Mean Arterial Pressure in Critically Ill Premature Infants,” Pediatrics 106(4), 625–632 (2000).
[Crossref] [PubMed]

M. Tsuji, A. duPlessis, G. Taylor, R. Crocker, and J. J. Volpe, “Near infrared spectroscopy detects cerebral ischemia during hypotension in piglets,” Pediatr. Res. 44(4), 591–595 (1998).
[Crossref] [PubMed]

Culver, J. P.

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23(8), 911–924 (2003).
[Crossref] [PubMed]

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46(8), 2053–2065 (2001).
[Crossref] [PubMed]

Dai, G. P.

de Borst, G. J.

C. W. A. Pennekamp, M. L. Bots, L. J. Kappelle, F. L. Moll, and G. J. de Borst, “The Value of Near-Infrared Spectroscopy Measured Cerebral Oximetry During Carotid Endarterectomy in Perioperative Stroke Prevention. A Review,” Eur. J. Vasc. Endovasc. Surg. 38(5), 539–545 (2009).
[Crossref] [PubMed]

de Oliveira Manoel, A. L.

A. L. de Oliveira Manoel, A. Goffi, T. R. Marotta, T. A. Schweizer, S. Abrahamson, and R. L. Macdonald, “The critical care management of poor-grade subarachnoid haemorrhage,” Crit. Care 20(1), 21 (2016).
[Crossref] [PubMed]

Demchuk, A. M.

A. V. Alexandrov, A. M. Demchuk, T. H. Wein, and J. C. Grotta, “Yield of transcranial Doppler in acute cerebral ischemia,” Stroke 30(8), 1604–1609 (1999).
[Crossref] [PubMed]

Dence, C.

P. T. Fox, M. E. Raichle, M. A. Mintun, and C. Dence, “Nonoxidative glucose consumption during focal physiologic neural activity,” Proc. Natl. Acad. Sci. U.S.A. 83(4), 1140–1144 (1986).
[Crossref] [PubMed]

Detre, J. A.

A. B. Parthasarathy, K. P. Gannon, W. B. Baker, C. G. Favilla, R. Balu, S. E. Kasner, A. G. Yodh, J. A. Detre, and M. T. Mullen, “Dynamic autoregulation of cerebral blood flow measured non-invasively with fast diffuse correlation spectroscopy,” J. Cereb. Blood Flow Metab. 38(2), 230–240 (2018).
[Crossref] [PubMed]

R. C. Mesquita, S. S. Schenkel, D. L. Minkoff, X. Lu, C. G. Favilla, P. M. Vora, D. R. Busch, M. Chandra, J. H. Greenberg, J. A. Detre, and A. G. Yodh, “Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions,” Biomed. Opt. Express 4(7), 978–994 (2013).
[Crossref] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Diaz, L. K.

E. M. Buckley, D. Hance, T. Pawlowski, J. Lynch, F. B. Wilson, R. C. Mesquita, T. Durduran, L. K. Diaz, M. E. Putt, D. J. Licht, M. A. Fogel, and A. G. Yodh, “Validation of diffuse correlation spectroscopic measurement of cerebral blood flow using phase-encoded velocity mapping magnetic resonance imaging,” J. Biomed. Opt. 17(3), 037007 (2012).
[Crossref] [PubMed]

Dillon, W. P.

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J.-F. Soustiel, T. Nariai, G. Zaharchuk, J.-M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke 36(9), e83–e99 (2005).
[Crossref] [PubMed]

Diop, M.

Dirnagl, U.

A. Villringer, A. Them, U. Lindauer, K. Einhäupl, and U. Dirnagl, “Capillary perfusion of the rat brain cortex. An in vivo confocal microscopy study,” Circ. Res. 75(1), 55–62 (1994).
[Crossref] [PubMed]

Disalvo, D. N.

J. S. Soul, P. E. Hammer, M. Tsuji, J. P. Saul, H. Bassan, C. Limperopoulos, D. N. Disalvo, M. Moore, P. Akins, S. Ringer, J. J. Volpe, F. Trachtenberg, and A. J. du Plessis, “Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infants,” Pediatr. Res. 61(4), 467–473 (2007).
[Crossref] [PubMed]

Dousset, V.

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J.-F. Soustiel, T. Nariai, G. Zaharchuk, J.-M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke 36(9), e83–e99 (2005).
[Crossref] [PubMed]

du Plessis, A.

M. Tsuji, J. P. Saul, A. du Plessis, E. Eichenwald, J. Sobh, R. Crocker, and J. J. Volpe, “Cerebral Intravascular Oxygenation Correlates With Mean Arterial Pressure in Critically Ill Premature Infants,” Pediatrics 106(4), 625–632 (2000).
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du Plessis, A. J.

J. S. Soul, P. E. Hammer, M. Tsuji, J. P. Saul, H. Bassan, C. Limperopoulos, D. N. Disalvo, M. Moore, P. Akins, S. Ringer, J. J. Volpe, F. Trachtenberg, and A. J. du Plessis, “Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infants,” Pediatr. Res. 61(4), 467–473 (2007).
[Crossref] [PubMed]

H. Bassan, K. Gauvreau, J. W. Newburger, M. Tsuji, C. Limperopoulos, J. S. Soul, G. Walter, P. C. Laussen, R. A. Jonas, and A. J. du Plessis, “Identification of pressure passive cerebral perfusion and its mediators after infant cardiac surgery,” Pediatr. Res. 57(1), 35–41 (2005).
[Crossref] [PubMed]

Dubb, J.

N. Roche-Labarbe, A. Fenoglio, H. Radhakrishnan, M. Kocienski-Filip, S. A. Carp, J. Dubb, D. A. Boas, P. E. Grant, and M. A. Franceschini, “Somatosensory evoked changes in cerebral oxygen consumption measured non-invasively in premature neonates,” Neuroimage 85(Pt 1), 279–286 (2014).
[Crossref] [PubMed]

duPlessis, A.

M. Tsuji, A. duPlessis, G. Taylor, R. Crocker, and J. J. Volpe, “Near infrared spectroscopy detects cerebral ischemia during hypotension in piglets,” Pediatr. Res. 44(4), 591–595 (1998).
[Crossref] [PubMed]

Durduran, T.

W. B. Baker, A. B. Parthasarathy, T. S. Ko, D. R. Busch, K. Abramson, S.-Y. Tzeng, R. C. Mesquita, T. Durduran, J. H. Greenberg, D. K. Kung, and A. G. Yodh, “Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts,” Neurophotonics 2(3), 035004 (2015).
[Crossref] [PubMed]

E. M. Buckley, D. Hance, T. Pawlowski, J. Lynch, F. B. Wilson, R. C. Mesquita, T. Durduran, L. K. Diaz, M. E. Putt, D. J. Licht, M. A. Fogel, and A. G. Yodh, “Validation of diffuse correlation spectroscopic measurement of cerebral blood flow using phase-encoded velocity mapping magnetic resonance imaging,” J. Biomed. Opt. 17(3), 037007 (2012).
[Crossref] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23(8), 911–924 (2003).
[Crossref] [PubMed]

Eastwood, J. D.

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J.-F. Soustiel, T. Nariai, G. Zaharchuk, J.-M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke 36(9), e83–e99 (2005).
[Crossref] [PubMed]

Edlow, B. L.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Eichenwald, E.

M. Tsuji, J. P. Saul, A. du Plessis, E. Eichenwald, J. Sobh, R. Crocker, and J. J. Volpe, “Cerebral Intravascular Oxygenation Correlates With Mean Arterial Pressure in Critically Ill Premature Infants,” Pediatrics 106(4), 625–632 (2000).
[Crossref] [PubMed]

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A. Villringer, A. Them, U. Lindauer, K. Einhäupl, and U. Dirnagl, “Capillary perfusion of the rat brain cortex. An in vivo confocal microscopy study,” Circ. Res. 75(1), 55–62 (1994).
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Evans, D. H.

R. B. Panerai, R. P. White, H. S. Markus, and D. H. Evans, “Grading of cerebral dynamic autoregulation from spontaneous fluctuations in arterial blood pressure,” Stroke 29(11), 2341–2346 (1998).
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Evans, K. C.

J. Selb, D. A. Boas, S.-T. Chan, K. C. Evans, E. M. Buckley, and S. A. Carp, “Sensitivity of near-infrared spectroscopy and diffuse correlation spectroscopy to brain hemodynamics: simulations and experimental findings during hypercapnia,” Neurophotonics 1(1), 015005 (2014).
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Fantini, S.

K. Tgavalekos, T. Pham, N. Krishnamurthy, A. Sassaroli, and S. Fantini, “Frequency-resolved analysis of coherent oscillations of local cerebral blood volume and systemic arterial pressure,” PLoS One 14(2), e0211710 (2019).
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K. Khaksari, G. Blaney, A. Sassaroli, N. Krishnamurthy, T. Pham, and S. Fantini, “Depth dependence of coherent hemodynamics in the human head,” J. Biomed. Opt. 23(12), 1–9 (2018).
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S. Fantini, A. Sassaroli, J. M. Kainerstorfer, K. T. Tgavalekos, and X. Zang, “Non-invasive assessment of cerebral microcirculation with diffuse optics and coherent hemodynamics spectroscopy,” Proc. SPIE 9690B, 1–9 (2016).

S. Fantini, A. Sassaroli, K. T. Tgavalekos, and J. Kornbluth, “Cerebral blood flow and autoregulation: current measurement techniques and prospects for noninvasive optical methods,” Neurophotonics 3(3), 031411 (2016).
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J. M. Kainerstorfer, A. Sassaroli, K. T. Tgavalekos, and S. Fantini, “Dynamic cerebral autoregulation measured with coherent hemodynamics spectroscopy (CHS),” Prog. Biomed. Opt. Imaging - Proc. SPIE 9319, 1–6 (2015).

J. M. Kainerstorfer, A. Sassaroli, K. T. Tgavalekos, and S. Fantini, “Cerebral autoregulation in the microvasculature measured with near-infrared spectroscopy,” J. Cereb. Blood Flow Metab. 35(6), 959–966 (2015).
[Crossref] [PubMed]

J. M. Kainerstorfer, A. Sassaroli, B. Hallacoglu, M. L. Pierro, and S. Fantini, “Practical Steps for Applying a New Dynamic Model to Near-Infrared Spectroscopy Measurements of Hemodynamic Oscillations and Transient Changes: Implications for Cerebrovascular and Functional Brain Studies,” Acad. Radiol. 21(2), 185–196 (2014).
[Crossref] [PubMed]

S. Fantini, “A new hemodynamic model shows that temporal perturbations of cerebral blood flow and metabolic rate of oxygen cannot be measured individually using functional near-infrared spectroscopy,” Physiol. Meas. 35(1), N1–N9 (2014).
[Crossref] [PubMed]

S. Fantini, “Dynamic model for the tissue concentration and oxygen saturation of hemoglobin in relation to blood volume, flow velocity, and oxygen consumption: Implications for functional neuroimaging and coherent hemodynamics spectroscopy (CHS),” Neuroimage 85(Pt 1), 202–221 (2014).
[Crossref] [PubMed]

B. Hallacoglu, A. Sassaroli, and S. Fantini, “Optical Characterization of Two-Layered Turbid Media for Non-Invasive, Absolute Oximetry in Cerebral and Extracerebral Tissue,” PLoS One 8(5), e64095 (2013).
[Crossref] [PubMed]

B. Hallacoglu, A. Sassaroli, M. Wysocki, E. Guerrero-Berroa, M. Schnaider Beeri, V. Haroutunian, M. Shaul, I. H. Rosenberg, A. M. Troen, and S. Fantini, “Absolute measurement of cerebral optical coefficients, hemoglobin concentration and oxygen saturation in old and young adults with near-infrared spectroscopy,” J. Biomed. Opt. 17(8), 081406 (2012).
[Crossref] [PubMed]

A. Sassaroli and S. Fantini, “Comment on the modified Beer-Lambert law for scattering media,” Phys. Med. Biol. 49(14), N255–N257 (2004).
[Crossref] [PubMed]

S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic, “Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy,” Phys. Med. Biol. 44(6), 1543–1563 (1999).
[Crossref] [PubMed]

M. A. Franceschini, S. Fantini, A. E. Cerussi, B. B. Barbieri, B. Chance, and E. Gratton, “Quantitative spectroscopic determination of hemoglobin concentration and saturation in a turbid medium: analysis of the effect of water absorption,” J. Biomed. Opt. 2(2), 147–153 (1997).
[Crossref] [PubMed]

S. Fantini, M. A. Franceschini, J. B. Fishkin, B. Barbieri, and E. Gratton, “Quantitative determination of the absorption spectra of chromophores in strongly scattering media: a light-emitting-diode based technique,” Appl. Opt. 33(22), 5204–5213 (1994).
[Crossref] [PubMed]

Favilla, C. G.

A. B. Parthasarathy, K. P. Gannon, W. B. Baker, C. G. Favilla, R. Balu, S. E. Kasner, A. G. Yodh, J. A. Detre, and M. T. Mullen, “Dynamic autoregulation of cerebral blood flow measured non-invasively with fast diffuse correlation spectroscopy,” J. Cereb. Blood Flow Metab. 38(2), 230–240 (2018).
[Crossref] [PubMed]

R. C. Mesquita, S. S. Schenkel, D. L. Minkoff, X. Lu, C. G. Favilla, P. M. Vora, D. R. Busch, M. Chandra, J. H. Greenberg, J. A. Detre, and A. G. Yodh, “Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions,” Biomed. Opt. Express 4(7), 978–994 (2013).
[Crossref] [PubMed]

Fenoglio, A.

N. Roche-Labarbe, A. Fenoglio, H. Radhakrishnan, M. Kocienski-Filip, S. A. Carp, J. Dubb, D. A. Boas, P. E. Grant, and M. A. Franceschini, “Somatosensory evoked changes in cerebral oxygen consumption measured non-invasively in premature neonates,” Neuroimage 85(Pt 1), 279–286 (2014).
[Crossref] [PubMed]

Fishkin, J. B.

Fogel, M. A.

E. M. Buckley, D. Hance, T. Pawlowski, J. Lynch, F. B. Wilson, R. C. Mesquita, T. Durduran, L. K. Diaz, M. E. Putt, D. J. Licht, M. A. Fogel, and A. G. Yodh, “Validation of diffuse correlation spectroscopic measurement of cerebral blood flow using phase-encoded velocity mapping magnetic resonance imaging,” J. Biomed. Opt. 17(3), 037007 (2012).
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Fouard, C.

F. Cassot, F. Lauwers, C. Fouard, S. Prohaska, and V. Lauwers-Cances, “A novel three-dimensional computer-assisted method for a quantitative study of microvascular networks of the human cerebral cortex,” Microcirculation 13(1), 1–18 (2006).
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Fox, P. T.

P. T. Fox and M. E. Raichle, “Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects,” Proc. Natl. Acad. Sci. U.S.A. 83(4), 1140–1144 (1986).
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P. T. Fox, M. E. Raichle, M. A. Mintun, and C. Dence, “Nonoxidative glucose consumption during focal physiologic neural activity,” Proc. Natl. Acad. Sci. U.S.A. 83(4), 1140–1144 (1986).
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Franceschini, M. A.

E. M. Buckley, A. B. Parthasarathy, P. E. Grant, A. G. Yodh, and M. A. Franceschini, “Diffuse correlation spectroscopy for measurement of cerebral blood flow: future prospects,” Neurophotonics 1(1), 011009 (2014).
[Crossref] [PubMed]

N. Roche-Labarbe, A. Fenoglio, H. Radhakrishnan, M. Kocienski-Filip, S. A. Carp, J. Dubb, D. A. Boas, P. E. Grant, and M. A. Franceschini, “Somatosensory evoked changes in cerebral oxygen consumption measured non-invasively in premature neonates,” Neuroimage 85(Pt 1), 279–286 (2014).
[Crossref] [PubMed]

S. A. Carp, G. P. Dai, D. A. Boas, M. A. Franceschini, and Y. R. Kim, “Validation of diffuse correlation spectroscopy measurements of rodent cerebral blood flow with simultaneous arterial spin labeling MRI; towards MRI-optical continuous cerebral metabolic monitoring,” Biomed. Opt. Express 1(2), 553–565 (2010).
[Crossref] [PubMed]

S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic, “Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy,” Phys. Med. Biol. 44(6), 1543–1563 (1999).
[Crossref] [PubMed]

M. A. Franceschini, S. Fantini, A. E. Cerussi, B. B. Barbieri, B. Chance, and E. Gratton, “Quantitative spectroscopic determination of hemoglobin concentration and saturation in a turbid medium: analysis of the effect of water absorption,” J. Biomed. Opt. 2(2), 147–153 (1997).
[Crossref] [PubMed]

S. Fantini, M. A. Franceschini, J. B. Fishkin, B. Barbieri, and E. Gratton, “Quantitative determination of the absorption spectra of chromophores in strongly scattering media: a light-emitting-diode based technique,” Appl. Opt. 33(22), 5204–5213 (1994).
[Crossref] [PubMed]

Frangos, S.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Furuya, D.

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23(8), 911–924 (2003).
[Crossref] [PubMed]

Gannon, K. P.

A. B. Parthasarathy, K. P. Gannon, W. B. Baker, C. G. Favilla, R. Balu, S. E. Kasner, A. G. Yodh, J. A. Detre, and M. T. Mullen, “Dynamic autoregulation of cerebral blood flow measured non-invasively with fast diffuse correlation spectroscopy,” J. Cereb. Blood Flow Metab. 38(2), 230–240 (2018).
[Crossref] [PubMed]

Gauvreau, K.

H. Bassan, K. Gauvreau, J. W. Newburger, M. Tsuji, C. Limperopoulos, J. S. Soul, G. Walter, P. C. Laussen, R. A. Jonas, and A. J. du Plessis, “Identification of pressure passive cerebral perfusion and its mediators after infant cardiac surgery,” Pediatr. Res. 57(1), 35–41 (2005).
[Crossref] [PubMed]

Glenn, T. C.

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J.-F. Soustiel, T. Nariai, G. Zaharchuk, J.-M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke 36(9), e83–e99 (2005).
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Göbel, U.

U. Göbel, B. Klein, H. Schröck, and W. Kuschinsky, “Lack of capillary recruitment in the brains of awake rats during hypercapnia,” J. Cereb. Blood Flow Metab. 9(4), 491–499 (1989).
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A. L. de Oliveira Manoel, A. Goffi, T. R. Marotta, T. A. Schweizer, S. Abrahamson, and R. L. Macdonald, “The critical care management of poor-grade subarachnoid haemorrhage,” Crit. Care 20(1), 21 (2016).
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Grady, M. S.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
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Grandin, C. B.

C. B. Grandin, A. Bol, A. M. Smith, C. Michel, and G. Cosnard, “Absolute CBF and CBV measurements by MRI bolus tracking before and after acetazolamide challenge: repeatabilily and comparison with PET in humans,” Neuroimage 26(2), 525–535 (2005).
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M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J.-F. Soustiel, T. Nariai, G. Zaharchuk, J.-M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke 36(9), e83–e99 (2005).
[Crossref] [PubMed]

Grant, P. E.

E. M. Buckley, A. B. Parthasarathy, P. E. Grant, A. G. Yodh, and M. A. Franceschini, “Diffuse correlation spectroscopy for measurement of cerebral blood flow: future prospects,” Neurophotonics 1(1), 011009 (2014).
[Crossref] [PubMed]

N. Roche-Labarbe, A. Fenoglio, H. Radhakrishnan, M. Kocienski-Filip, S. A. Carp, J. Dubb, D. A. Boas, P. E. Grant, and M. A. Franceschini, “Somatosensory evoked changes in cerebral oxygen consumption measured non-invasively in premature neonates,” Neuroimage 85(Pt 1), 279–286 (2014).
[Crossref] [PubMed]

Gratton, E.

S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic, “Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy,” Phys. Med. Biol. 44(6), 1543–1563 (1999).
[Crossref] [PubMed]

M. A. Franceschini, S. Fantini, A. E. Cerussi, B. B. Barbieri, B. Chance, and E. Gratton, “Quantitative spectroscopic determination of hemoglobin concentration and saturation in a turbid medium: analysis of the effect of water absorption,” J. Biomed. Opt. 2(2), 147–153 (1997).
[Crossref] [PubMed]

S. Fantini, M. A. Franceschini, J. B. Fishkin, B. Barbieri, and E. Gratton, “Quantitative determination of the absorption spectra of chromophores in strongly scattering media: a light-emitting-diode based technique,” Appl. Opt. 33(22), 5204–5213 (1994).
[Crossref] [PubMed]

Greenberg, J. H.

W. B. Baker, A. B. Parthasarathy, T. S. Ko, D. R. Busch, K. Abramson, S.-Y. Tzeng, R. C. Mesquita, T. Durduran, J. H. Greenberg, D. K. Kung, and A. G. Yodh, “Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts,” Neurophotonics 2(3), 035004 (2015).
[Crossref] [PubMed]

R. C. Mesquita, S. S. Schenkel, D. L. Minkoff, X. Lu, C. G. Favilla, P. M. Vora, D. R. Busch, M. Chandra, J. H. Greenberg, J. A. Detre, and A. G. Yodh, “Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions,” Biomed. Opt. Express 4(7), 978–994 (2013).
[Crossref] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23(8), 911–924 (2003).
[Crossref] [PubMed]

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46(8), 2053–2065 (2001).
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Grotta, J. C.

A. V. Alexandrov, A. M. Demchuk, T. H. Wein, and J. C. Grotta, “Yield of transcranial Doppler in acute cerebral ischemia,” Stroke 30(8), 1604–1609 (1999).
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Grüner, J. M.

O. M. Henriksen, H. B. W. Larsson, A. E. Hansen, J. M. Grüner, I. Law, and E. Rostrup, “Estimation of intersubject variability of cerebral blood flow measurements using MRI and positron emission tomography,” J. Magn. Reson. Imaging 35(6), 1290–1299 (2012).
[Crossref] [PubMed]

Guerrero-Berroa, E.

B. Hallacoglu, A. Sassaroli, M. Wysocki, E. Guerrero-Berroa, M. Schnaider Beeri, V. Haroutunian, M. Shaul, I. H. Rosenberg, A. M. Troen, and S. Fantini, “Absolute measurement of cerebral optical coefficients, hemoglobin concentration and oxygen saturation in old and young adults with near-infrared spectroscopy,” J. Biomed. Opt. 17(8), 081406 (2012).
[Crossref] [PubMed]

Hallacoglu, B.

J. M. Kainerstorfer, A. Sassaroli, B. Hallacoglu, M. L. Pierro, and S. Fantini, “Practical Steps for Applying a New Dynamic Model to Near-Infrared Spectroscopy Measurements of Hemodynamic Oscillations and Transient Changes: Implications for Cerebrovascular and Functional Brain Studies,” Acad. Radiol. 21(2), 185–196 (2014).
[Crossref] [PubMed]

B. Hallacoglu, A. Sassaroli, and S. Fantini, “Optical Characterization of Two-Layered Turbid Media for Non-Invasive, Absolute Oximetry in Cerebral and Extracerebral Tissue,” PLoS One 8(5), e64095 (2013).
[Crossref] [PubMed]

B. Hallacoglu, A. Sassaroli, M. Wysocki, E. Guerrero-Berroa, M. Schnaider Beeri, V. Haroutunian, M. Shaul, I. H. Rosenberg, A. M. Troen, and S. Fantini, “Absolute measurement of cerebral optical coefficients, hemoglobin concentration and oxygen saturation in old and young adults with near-infrared spectroscopy,” J. Biomed. Opt. 17(8), 081406 (2012).
[Crossref] [PubMed]

Hammer, P. E.

J. S. Soul, P. E. Hammer, M. Tsuji, J. P. Saul, H. Bassan, C. Limperopoulos, D. N. Disalvo, M. Moore, P. Akins, S. Ringer, J. J. Volpe, F. Trachtenberg, and A. J. du Plessis, “Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infants,” Pediatr. Res. 61(4), 467–473 (2007).
[Crossref] [PubMed]

Hance, D.

E. M. Buckley, D. Hance, T. Pawlowski, J. Lynch, F. B. Wilson, R. C. Mesquita, T. Durduran, L. K. Diaz, M. E. Putt, D. J. Licht, M. A. Fogel, and A. G. Yodh, “Validation of diffuse correlation spectroscopic measurement of cerebral blood flow using phase-encoded velocity mapping magnetic resonance imaging,” J. Biomed. Opt. 17(3), 037007 (2012).
[Crossref] [PubMed]

Hansen, A. E.

O. M. Henriksen, H. B. W. Larsson, A. E. Hansen, J. M. Grüner, I. Law, and E. Rostrup, “Estimation of intersubject variability of cerebral blood flow measurements using MRI and positron emission tomography,” J. Magn. Reson. Imaging 35(6), 1290–1299 (2012).
[Crossref] [PubMed]

Haroutunian, V.

B. Hallacoglu, A. Sassaroli, M. Wysocki, E. Guerrero-Berroa, M. Schnaider Beeri, V. Haroutunian, M. Shaul, I. H. Rosenberg, A. M. Troen, and S. Fantini, “Absolute measurement of cerebral optical coefficients, hemoglobin concentration and oxygen saturation in old and young adults with near-infrared spectroscopy,” J. Biomed. Opt. 17(8), 081406 (2012).
[Crossref] [PubMed]

Hatazawa, J.

H. Ito, I. Kanno, H. Iida, J. Hatazawa, E. Shimosegawa, H. Tamura, and T. Okudera, “Arterial fraction of cerebral blood volume in humans measured by positron emission tomography,” Ann. Nucl. Med. 15(2), 111–116 (2001).
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Henriksen, O. M.

O. M. Henriksen, H. B. W. Larsson, A. E. Hansen, J. M. Grüner, I. Law, and E. Rostrup, “Estimation of intersubject variability of cerebral blood flow measurements using MRI and positron emission tomography,” J. Magn. Reson. Imaging 35(6), 1290–1299 (2012).
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Homer-Vanniasinkam, S.

Y. Z. Al-Tamimi, N. M. Orsi, A. C. Quinn, S. Homer-Vanniasinkam, and S. A. Ross, “A review of delayed ischemic neurologic deficit following aneurysmal subarachnoid hemorrhage: Historical overview, current treatment, and Pathophysiology,” World Neurosurg. 73(6), 654–667 (2010).
[Crossref] [PubMed]

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S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic, “Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy,” Phys. Med. Biol. 44(6), 1543–1563 (1999).
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H. Ito, I. Kanno, H. Iida, J. Hatazawa, E. Shimosegawa, H. Tamura, and T. Okudera, “Arterial fraction of cerebral blood volume in humans measured by positron emission tomography,” Ann. Nucl. Med. 15(2), 111–116 (2001).
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H. Ito, I. Kanno, H. Iida, J. Hatazawa, E. Shimosegawa, H. Tamura, and T. Okudera, “Arterial fraction of cerebral blood volume in humans measured by positron emission tomography,” Ann. Nucl. Med. 15(2), 111–116 (2001).
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Jespersen, S. N.

S. N. Jespersen and L. Østergaard, “The Roles of Cerebral Blood Flow, Capillary Transit Time Heterogeneity, and Oxygen Tension in Brain Oxygenation and Metabolism,” J. Cereb. Blood Flow Metab. 32(2), 264–277 (2012).
[Crossref] [PubMed]

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H. Bassan, K. Gauvreau, J. W. Newburger, M. Tsuji, C. Limperopoulos, J. S. Soul, G. Walter, P. C. Laussen, R. A. Jonas, and A. J. du Plessis, “Identification of pressure passive cerebral perfusion and its mediators after infant cardiac surgery,” Pediatr. Res. 57(1), 35–41 (2005).
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S. Fantini, A. Sassaroli, J. M. Kainerstorfer, K. T. Tgavalekos, and X. Zang, “Non-invasive assessment of cerebral microcirculation with diffuse optics and coherent hemodynamics spectroscopy,” Proc. SPIE 9690B, 1–9 (2016).

J. M. Kainerstorfer, A. Sassaroli, K. T. Tgavalekos, and S. Fantini, “Dynamic cerebral autoregulation measured with coherent hemodynamics spectroscopy (CHS),” Prog. Biomed. Opt. Imaging - Proc. SPIE 9319, 1–6 (2015).

J. M. Kainerstorfer, A. Sassaroli, K. T. Tgavalekos, and S. Fantini, “Cerebral autoregulation in the microvasculature measured with near-infrared spectroscopy,” J. Cereb. Blood Flow Metab. 35(6), 959–966 (2015).
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J. M. Kainerstorfer, A. Sassaroli, B. Hallacoglu, M. L. Pierro, and S. Fantini, “Practical Steps for Applying a New Dynamic Model to Near-Infrared Spectroscopy Measurements of Hemodynamic Oscillations and Transient Changes: Implications for Cerebrovascular and Functional Brain Studies,” Acad. Radiol. 21(2), 185–196 (2014).
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H. Ito, I. Kanno, H. Iida, J. Hatazawa, E. Shimosegawa, H. Tamura, and T. Okudera, “Arterial fraction of cerebral blood volume in humans measured by positron emission tomography,” Ann. Nucl. Med. 15(2), 111–116 (2001).
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C. W. A. Pennekamp, M. L. Bots, L. J. Kappelle, F. L. Moll, and G. J. de Borst, “The Value of Near-Infrared Spectroscopy Measured Cerebral Oximetry During Carotid Endarterectomy in Perioperative Stroke Prevention. A Review,” Eur. J. Vasc. Endovasc. Surg. 38(5), 539–545 (2009).
[Crossref] [PubMed]

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A. B. Parthasarathy, K. P. Gannon, W. B. Baker, C. G. Favilla, R. Balu, S. E. Kasner, A. G. Yodh, J. A. Detre, and M. T. Mullen, “Dynamic autoregulation of cerebral blood flow measured non-invasively with fast diffuse correlation spectroscopy,” J. Cereb. Blood Flow Metab. 38(2), 230–240 (2018).
[Crossref] [PubMed]

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K. Khaksari, G. Blaney, A. Sassaroli, N. Krishnamurthy, T. Pham, and S. Fantini, “Depth dependence of coherent hemodynamics in the human head,” J. Biomed. Opt. 23(12), 1–9 (2018).
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M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
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Kim, Y. R.

Kirkman, M. A.

M. A. Kirkman, G. Citerio, and M. Smith, “The intensive care management of acute ischemic stroke: An overview,” Intensive Care Med. 40(5), 640–653 (2014).
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U. Göbel, B. Klein, H. Schröck, and W. Kuschinsky, “Lack of capillary recruitment in the brains of awake rats during hypercapnia,” J. Cereb. Blood Flow Metab. 9(4), 491–499 (1989).
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W. B. Baker, A. B. Parthasarathy, T. S. Ko, D. R. Busch, K. Abramson, S.-Y. Tzeng, R. C. Mesquita, T. Durduran, J. H. Greenberg, D. K. Kung, and A. G. Yodh, “Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts,” Neurophotonics 2(3), 035004 (2015).
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N. Roche-Labarbe, A. Fenoglio, H. Radhakrishnan, M. Kocienski-Filip, S. A. Carp, J. Dubb, D. A. Boas, P. E. Grant, and M. A. Franceschini, “Somatosensory evoked changes in cerebral oxygen consumption measured non-invasively in premature neonates,” Neuroimage 85(Pt 1), 279–286 (2014).
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M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
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Kornbluth, J.

S. Fantini, A. Sassaroli, K. T. Tgavalekos, and J. Kornbluth, “Cerebral blood flow and autoregulation: current measurement techniques and prospects for noninvasive optical methods,” Neurophotonics 3(3), 031411 (2016).
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Krishnamurthy, N.

K. Tgavalekos, T. Pham, N. Krishnamurthy, A. Sassaroli, and S. Fantini, “Frequency-resolved analysis of coherent oscillations of local cerebral blood volume and systemic arterial pressure,” PLoS One 14(2), e0211710 (2019).
[Crossref] [PubMed]

K. Khaksari, G. Blaney, A. Sassaroli, N. Krishnamurthy, T. Pham, and S. Fantini, “Depth dependence of coherent hemodynamics in the human head,” J. Biomed. Opt. 23(12), 1–9 (2018).
[Crossref] [PubMed]

Kung, D. K.

W. B. Baker, A. B. Parthasarathy, T. S. Ko, D. R. Busch, K. Abramson, S.-Y. Tzeng, R. C. Mesquita, T. Durduran, J. H. Greenberg, D. K. Kung, and A. G. Yodh, “Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts,” Neurophotonics 2(3), 035004 (2015).
[Crossref] [PubMed]

Kuschinsky, W.

W. Kuschinsky and O. B. Paulson, “Capillary circulation in the brain,” Cerebrovasc. Brain Metab. Rev. 4(3), 261–286 (1992).
[PubMed]

U. Göbel, B. Klein, H. Schröck, and W. Kuschinsky, “Lack of capillary recruitment in the brains of awake rats during hypercapnia,” J. Cereb. Blood Flow Metab. 9(4), 491–499 (1989).
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Larsson, H. B. W.

O. M. Henriksen, H. B. W. Larsson, A. E. Hansen, J. M. Grüner, I. Law, and E. Rostrup, “Estimation of intersubject variability of cerebral blood flow measurements using MRI and positron emission tomography,” J. Magn. Reson. Imaging 35(6), 1290–1299 (2012).
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H. Bassan, K. Gauvreau, J. W. Newburger, M. Tsuji, C. Limperopoulos, J. S. Soul, G. Walter, P. C. Laussen, R. A. Jonas, and A. J. du Plessis, “Identification of pressure passive cerebral perfusion and its mediators after infant cardiac surgery,” Pediatr. Res. 57(1), 35–41 (2005).
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F. Cassot, F. Lauwers, C. Fouard, S. Prohaska, and V. Lauwers-Cances, “A novel three-dimensional computer-assisted method for a quantitative study of microvascular networks of the human cerebral cortex,” Microcirculation 13(1), 1–18 (2006).
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Lauwers-Cances, V.

F. Cassot, F. Lauwers, C. Fouard, S. Prohaska, and V. Lauwers-Cances, “A novel three-dimensional computer-assisted method for a quantitative study of microvascular networks of the human cerebral cortex,” Microcirculation 13(1), 1–18 (2006).
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Levine, J. M.

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E. M. Buckley, D. Hance, T. Pawlowski, J. Lynch, F. B. Wilson, R. C. Mesquita, T. Durduran, L. K. Diaz, M. E. Putt, D. J. Licht, M. A. Fogel, and A. G. Yodh, “Validation of diffuse correlation spectroscopic measurement of cerebral blood flow using phase-encoded velocity mapping magnetic resonance imaging,” J. Biomed. Opt. 17(3), 037007 (2012).
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R. Aaslid, K. F. Lindegaard, W. Sorteberg, and H. Nornes, “Cerebral autoregulation dynamics in humans,” Stroke 20(1), 45–52 (1989).
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R. Aaslid, K. F. Lindegaard, W. Sorteberg, and H. Nornes, “Cerebral autoregulation dynamics in humans,” Stroke 20(1), 45–52 (1989).
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Lynch, J.

E. M. Buckley, D. Hance, T. Pawlowski, J. Lynch, F. B. Wilson, R. C. Mesquita, T. Durduran, L. K. Diaz, M. E. Putt, D. J. Licht, M. A. Fogel, and A. G. Yodh, “Validation of diffuse correlation spectroscopic measurement of cerebral blood flow using phase-encoded velocity mapping magnetic resonance imaging,” J. Biomed. Opt. 17(3), 037007 (2012).
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A. L. de Oliveira Manoel, A. Goffi, T. R. Marotta, T. A. Schweizer, S. Abrahamson, and R. L. Macdonald, “The critical care management of poor-grade subarachnoid haemorrhage,” Crit. Care 20(1), 21 (2016).
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M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
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Markus, H. S.

R. B. Panerai, R. P. White, H. S. Markus, and D. H. Evans, “Grading of cerebral dynamic autoregulation from spontaneous fluctuations in arterial blood pressure,” Stroke 29(11), 2341–2346 (1998).
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Marotta, T. R.

A. L. de Oliveira Manoel, A. Goffi, T. R. Marotta, T. A. Schweizer, S. Abrahamson, and R. L. Macdonald, “The critical care management of poor-grade subarachnoid haemorrhage,” Crit. Care 20(1), 21 (2016).
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Maulik, D.

S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic, “Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy,” Phys. Med. Biol. 44(6), 1543–1563 (1999).
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Mesquita, R. C.

W. B. Baker, A. B. Parthasarathy, T. S. Ko, D. R. Busch, K. Abramson, S.-Y. Tzeng, R. C. Mesquita, T. Durduran, J. H. Greenberg, D. K. Kung, and A. G. Yodh, “Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts,” Neurophotonics 2(3), 035004 (2015).
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R. C. Mesquita, S. S. Schenkel, D. L. Minkoff, X. Lu, C. G. Favilla, P. M. Vora, D. R. Busch, M. Chandra, J. H. Greenberg, J. A. Detre, and A. G. Yodh, “Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions,” Biomed. Opt. Express 4(7), 978–994 (2013).
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E. M. Buckley, D. Hance, T. Pawlowski, J. Lynch, F. B. Wilson, R. C. Mesquita, T. Durduran, L. K. Diaz, M. E. Putt, D. J. Licht, M. A. Fogel, and A. G. Yodh, “Validation of diffuse correlation spectroscopic measurement of cerebral blood flow using phase-encoded velocity mapping magnetic resonance imaging,” J. Biomed. Opt. 17(3), 037007 (2012).
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Mintun, M. A.

P. T. Fox, M. E. Raichle, M. A. Mintun, and C. Dence, “Nonoxidative glucose consumption during focal physiologic neural activity,” Proc. Natl. Acad. Sci. U.S.A. 83(4), 1140–1144 (1986).
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C. W. A. Pennekamp, M. L. Bots, L. J. Kappelle, F. L. Moll, and G. J. de Borst, “The Value of Near-Infrared Spectroscopy Measured Cerebral Oximetry During Carotid Endarterectomy in Perioperative Stroke Prevention. A Review,” Eur. J. Vasc. Endovasc. Surg. 38(5), 539–545 (2009).
[Crossref] [PubMed]

Moore, M.

J. S. Soul, P. E. Hammer, M. Tsuji, J. P. Saul, H. Bassan, C. Limperopoulos, D. N. Disalvo, M. Moore, P. Akins, S. Ringer, J. J. Volpe, F. Trachtenberg, and A. J. du Plessis, “Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infants,” Pediatr. Res. 61(4), 467–473 (2007).
[Crossref] [PubMed]

Moss, H. E.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Mullen, M. T.

A. B. Parthasarathy, K. P. Gannon, W. B. Baker, C. G. Favilla, R. Balu, S. E. Kasner, A. G. Yodh, J. A. Detre, and M. T. Mullen, “Dynamic autoregulation of cerebral blood flow measured non-invasively with fast diffuse correlation spectroscopy,” J. Cereb. Blood Flow Metab. 38(2), 230–240 (2018).
[Crossref] [PubMed]

Nariai, T.

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J.-F. Soustiel, T. Nariai, G. Zaharchuk, J.-M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke 36(9), e83–e99 (2005).
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Newburger, J. W.

H. Bassan, K. Gauvreau, J. W. Newburger, M. Tsuji, C. Limperopoulos, J. S. Soul, G. Walter, P. C. Laussen, R. A. Jonas, and A. J. du Plessis, “Identification of pressure passive cerebral perfusion and its mediators after infant cardiac surgery,” Pediatr. Res. 57(1), 35–41 (2005).
[Crossref] [PubMed]

Nornes, H.

R. Aaslid, K. F. Lindegaard, W. Sorteberg, and H. Nornes, “Cerebral autoregulation dynamics in humans,” Stroke 20(1), 45–52 (1989).
[Crossref] [PubMed]

R. Aaslid, K. F. Lindegaard, W. Sorteberg, and H. Nornes, “Cerebral autoregulation dynamics in humans,” Stroke 20(1), 45–52 (1989).
[Crossref] [PubMed]

Okudera, T.

H. Ito, I. Kanno, H. Iida, J. Hatazawa, E. Shimosegawa, H. Tamura, and T. Okudera, “Arterial fraction of cerebral blood volume in humans measured by positron emission tomography,” Ann. Nucl. Med. 15(2), 111–116 (2001).
[Crossref] [PubMed]

Orsi, N. M.

Y. Z. Al-Tamimi, N. M. Orsi, A. C. Quinn, S. Homer-Vanniasinkam, and S. A. Ross, “A review of delayed ischemic neurologic deficit following aneurysmal subarachnoid hemorrhage: Historical overview, current treatment, and Pathophysiology,” World Neurosurg. 73(6), 654–667 (2010).
[Crossref] [PubMed]

Østergaard, L.

S. N. Jespersen and L. Østergaard, “The Roles of Cerebral Blood Flow, Capillary Transit Time Heterogeneity, and Oxygen Tension in Brain Oxygenation and Metabolism,” J. Cereb. Blood Flow Metab. 32(2), 264–277 (2012).
[Crossref] [PubMed]

Panerai, R. B.

R. B. Panerai, N. P. Saeed, and T. G. Robinson, “Cerebrovascular effects of the thigh cuff maneuver,” Am. J. Physiol. Heart Circ. Physiol. 308(7), H688–H696 (2015).
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R. B. Panerai, R. P. White, H. S. Markus, and D. H. Evans, “Grading of cerebral dynamic autoregulation from spontaneous fluctuations in arterial blood pressure,” Stroke 29(11), 2341–2346 (1998).
[Crossref] [PubMed]

Parthasarathy, A. B.

A. B. Parthasarathy, K. P. Gannon, W. B. Baker, C. G. Favilla, R. Balu, S. E. Kasner, A. G. Yodh, J. A. Detre, and M. T. Mullen, “Dynamic autoregulation of cerebral blood flow measured non-invasively with fast diffuse correlation spectroscopy,” J. Cereb. Blood Flow Metab. 38(2), 230–240 (2018).
[Crossref] [PubMed]

W. B. Baker, A. B. Parthasarathy, T. S. Ko, D. R. Busch, K. Abramson, S.-Y. Tzeng, R. C. Mesquita, T. Durduran, J. H. Greenberg, D. K. Kung, and A. G. Yodh, “Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts,” Neurophotonics 2(3), 035004 (2015).
[Crossref] [PubMed]

E. M. Buckley, A. B. Parthasarathy, P. E. Grant, A. G. Yodh, and M. A. Franceschini, “Diffuse correlation spectroscopy for measurement of cerebral blood flow: future prospects,” Neurophotonics 1(1), 011009 (2014).
[Crossref] [PubMed]

Paulson, O. B.

W. Kuschinsky and O. B. Paulson, “Capillary circulation in the brain,” Cerebrovasc. Brain Metab. Rev. 4(3), 261–286 (1992).
[PubMed]

Pawlowski, T.

E. M. Buckley, D. Hance, T. Pawlowski, J. Lynch, F. B. Wilson, R. C. Mesquita, T. Durduran, L. K. Diaz, M. E. Putt, D. J. Licht, M. A. Fogel, and A. G. Yodh, “Validation of diffuse correlation spectroscopic measurement of cerebral blood flow using phase-encoded velocity mapping magnetic resonance imaging,” J. Biomed. Opt. 17(3), 037007 (2012).
[Crossref] [PubMed]

Pedraza, S.

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J.-F. Soustiel, T. Nariai, G. Zaharchuk, J.-M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke 36(9), e83–e99 (2005).
[Crossref] [PubMed]

Pennekamp, C. W. A.

C. W. A. Pennekamp, M. L. Bots, L. J. Kappelle, F. L. Moll, and G. J. de Borst, “The Value of Near-Infrared Spectroscopy Measured Cerebral Oximetry During Carotid Endarterectomy in Perioperative Stroke Prevention. A Review,” Eur. J. Vasc. Endovasc. Surg. 38(5), 539–545 (2009).
[Crossref] [PubMed]

Pham, T.

K. Tgavalekos, T. Pham, N. Krishnamurthy, A. Sassaroli, and S. Fantini, “Frequency-resolved analysis of coherent oscillations of local cerebral blood volume and systemic arterial pressure,” PLoS One 14(2), e0211710 (2019).
[Crossref] [PubMed]

K. Khaksari, G. Blaney, A. Sassaroli, N. Krishnamurthy, T. Pham, and S. Fantini, “Depth dependence of coherent hemodynamics in the human head,” J. Biomed. Opt. 23(12), 1–9 (2018).
[Crossref] [PubMed]

Pierro, M. L.

J. M. Kainerstorfer, A. Sassaroli, B. Hallacoglu, M. L. Pierro, and S. Fantini, “Practical Steps for Applying a New Dynamic Model to Near-Infrared Spectroscopy Measurements of Hemodynamic Oscillations and Transient Changes: Implications for Cerebrovascular and Functional Brain Studies,” Acad. Radiol. 21(2), 185–196 (2014).
[Crossref] [PubMed]

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A. R. Pries and T. W. Secomb, “Blood Flow in Microvascular Networks,” Microcirculation 67, 3–36 (2008).

Prohaska, S.

F. Cassot, F. Lauwers, C. Fouard, S. Prohaska, and V. Lauwers-Cances, “A novel three-dimensional computer-assisted method for a quantitative study of microvascular networks of the human cerebral cortex,” Microcirculation 13(1), 1–18 (2006).
[Crossref] [PubMed]

Putt, M. E.

E. M. Buckley, D. Hance, T. Pawlowski, J. Lynch, F. B. Wilson, R. C. Mesquita, T. Durduran, L. K. Diaz, M. E. Putt, D. J. Licht, M. A. Fogel, and A. G. Yodh, “Validation of diffuse correlation spectroscopic measurement of cerebral blood flow using phase-encoded velocity mapping magnetic resonance imaging,” J. Biomed. Opt. 17(3), 037007 (2012).
[Crossref] [PubMed]

Quinn, A. C.

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J. M. Kainerstorfer, A. Sassaroli, K. T. Tgavalekos, and S. Fantini, “Dynamic cerebral autoregulation measured with coherent hemodynamics spectroscopy (CHS),” Prog. Biomed. Opt. Imaging - Proc. SPIE 9319, 1–6 (2015).

J. M. Kainerstorfer, A. Sassaroli, K. T. Tgavalekos, and S. Fantini, “Cerebral autoregulation in the microvasculature measured with near-infrared spectroscopy,” J. Cereb. Blood Flow Metab. 35(6), 959–966 (2015).
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S. Fantini, A. Sassaroli, J. M. Kainerstorfer, K. T. Tgavalekos, and X. Zang, “Non-invasive assessment of cerebral microcirculation with diffuse optics and coherent hemodynamics spectroscopy,” Proc. SPIE 9690B, 1–9 (2016).

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M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
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M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
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S. Fantini, “Dynamic model for the tissue concentration and oxygen saturation of hemoglobin in relation to blood volume, flow velocity, and oxygen consumption: Implications for functional neuroimaging and coherent hemodynamics spectroscopy (CHS),” Neuroimage 85(Pt 1), 202–221 (2014).
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Prog. Biomed. Opt. Imaging - Proc. SPIE (1)

J. M. Kainerstorfer, A. Sassaroli, K. T. Tgavalekos, and S. Fantini, “Dynamic cerebral autoregulation measured with coherent hemodynamics spectroscopy (CHS),” Prog. Biomed. Opt. Imaging - Proc. SPIE 9319, 1–6 (2015).

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Figures (6)

Fig. 1
Fig. 1 (a) Experimental setup. (b) Optical probe for NIRS and DCS data collection from the right side of the subject’s forehead.
Fig. 2
Fig. 2 Measured intensity autocorrelation curves during baseline and during the cuff-release-induced transient (5 s following the cuff deflation) as a function of delay time τ. The fits to the hemogeneous semi-infinite DCS model are presented in black dashed lines. The fits are constrained to the early delays corresponding to g 2 (τ) ≥ 1.05. BFI value is 3.4 × 10−9 cm2/s during baseline and 1.9 × 10−9 cm2/s at 5 s following the cuff release.
Fig. 3
Fig. 3 (a) Simulated time traces of Δ[HbO2] and Δ[Hb] as can be measured with NIRS. (b) The NIRS measurements of panel (a) are converted by CHS into cbv(t) and cbf(t), under the assumption cmro2(t) = 0, by using the parameter values t(c) = 0.7 s, t(ν) = 5 s, F (c) CBV 0 (c) CBV 0 =0.4, CBV 0 (a) CBV 0 =0.3, and by assuming Δ CBV (a) (t)=Δ CBV (v) (t).
Fig. 4
Fig. 4 Sensitivity of cbfNIRS-CHS(t) to (a) capillary transit time (t(c)), (b) venous transit time (t(v)), and (c) the arterial baseline cerebral blood volume ratio CBV 0 (a) CBV 0 . For each panel, three conditions are illustrated left to right for the relative arterial-to-venous blood volume dynamics: arterial only ( Δ CBV (v) (t)=0), equally venous and arterial ( Δ CBV (a) (t)=Δ CBV (v) (t)), and venous only ( Δ CBV (a) (t)=0). The cbf(t) traces indicated by solid lines in the middle plots for (a)-(c) are the same with the cbf(t) trace in Fig. 3(b).
Fig. 5
Fig. 5 Typical time traces after thigh-cuff release (t = 0; data from subject 3). Symbols show measured hemoglobin concentrations, solid lines depict the model fit obtained from the MATLAB function “GlobalSeach”.
Fig. 6
Fig. 6 Grand averages of ΔMAP, Δ[HbT], Δ[HbD], rCBF NIRSCHS , and rCBF DCS , (all relative to baseline) across six subjects. Symbols represent the mean, and error bars represent standard errors. The dashed vertical line indicates the time of cuff deflation (t = 0).

Tables (2)

Tables Icon

Table 1 Sensitivity of the CBF dynamics to CHS parameters (capillary and venous transit times, baseline arterial to venous blood volume, relative arterial-to-venous blood volume changes).

Tables Icon

Table 2 Baseline CBF0 measured on the six subjects with NIRS-CHS

Equations (11)

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rCBF DCS (t)= BFI(t) BFI 0 ,
[ HbO 2 ](t)=ctHb [ S (a) CBV 0 (a) (1+ cbv (a) (t))+ S (c) F (c) CBV 0 (c) + S (v) CBV 0 (v) (1+ cbv (v) (t))] +ctHb [ S (c) S (v) ( S (c) S (v) ) F (c) CBV 0 (c) h RC-LP (c) (t)+( S (a) S (v) ) CBV 0 (v) h G-LP (v) (t)]*[cbf(t) cmro 2 (t)] ,
[Hb](t)=ctHb [( 1 S (a) ) CBV 0 (a) (1+ cbv (a) (t))+( 1 S (c) ) F (c) CBV 0 (c) +( 1 S (v) ) CBV 0 (v) (1+ cbv (v) (t))] ctHb [ S (c) S (v) ( S (c) S (v) ) F (c) CBV 0 (c) h RC-LP (c) (t)+( S (a) S (v) ) CBV 0 (v) h G-LP (v) (t)]*[cbf(t)- cmro 2 (t)] ,
[HbT](t)=ctHb CBV 0 [1+cbv(t)] ,
CBV 0 = CBV 0 (a) + F (c) CBV 0 (c) + CBV 0 (v) ,
1= CBV 0 (a) CBV 0 + F (c) CBV 0 (c) CBV 0 + CBV 0 (v) CBV 0 .
cbv(t)= Δ[HbT](t) [HbT] 0 = CBV 0 (a) CBV 0 cbv (a) (t)+ CBV 0 (v) CBV 0 cbv (v) (t) ,
cbv (a) (t)=0.2 ( CBV 0 (a) CBV 0 ) 1 cbv(t) ,
cbv (v) (t)=0.8 ( CBV 0 (v) CBV 0 ) 1 cbv(t) .
CBF 0 = 1 ρ b F (c) CBV 0 (c) t (c) = 1 ρ b [HbT] 0 ctHb F (c) CBV 0 (c) CBV 0 t (c) ,
cbf ˜ NIRS-CHS (ω)= Δ[ HbO ˜ 2 ](ω)Δ[ Hb ˜ ](ω) [HbT] 0 (2 S (a) 1) Δ CBV ˜ (a) (ω) CBV 0 (2 S (v) 1) Δ CBV ˜ (v) (ω) CBV 0 2[ S (c) S (v) ( S (c) S (v) ) F (c) CBV 0 (c) CBV 0 H RCLP (c) (ω)+( S (a) S (v) ) CBV 0 (v) CBV 0 H GLP (v) (ω) ] ,

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