Abstract

Multi-spectral near-infrared diffuse optical tomography (DOT) is capable of providing functional tissue assessment that can complement structural mammographic images for more comprehensive breast cancer diagnosis. To take full advantage of the readily available sub-millimeter resolution structural information in a multi-modal imaging setting, an efficient x-ray/optical joint image reconstruction model has been proposed previously to utilize anatomical information from a mammogram as a structural prior. In this work, we develop a complex digital breast phantom (available at http://openjd.sf.net/digibreast) based on direct measurements of fibroglandular tissue volume fractions using dual-energy mammographic imaging of a human breast. We also extend our prior-guided reconstruction algorithm to facilitate the recovery of breast tumors, and perform a series of simulation-based studies to systematically evaluate the impact of lesion sizes and contrasts, tissue background, mesh resolution, inaccurate priors, and regularization parameters, on the recovery of breast tumors using multi-modal DOT/x-ray measurements. Our studies reveal that the optical property estimation error can be reduced by half by utilizing structural priors; the minimum detectable tumor size can also be reduced by half when prior knowledge regarding the tumor location is provided. Moreover, our algorithm is shown to be robust to false priors on tumor location.

© 2015 Optical Society of America

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2014 (1)

M. A. Balafar, “Gaussian mixture model based segmentation methods for brain MRI images,” Artif. Intell. Rev. 41(3), 429–439 (2014).
[Crossref]

2013 (1)

E. Fredenberg, D. R. Dance, P. Willsher, E. Moa, M. von Tiedemann, K. C. Young, and M. G. Wallis, “Measurement of breast-tissue x-ray attenuation by spectral mammography: first results on cyst fluid,” Phys. Med. Biol. 58(24), 8609–8620 (2013).
[Crossref] [PubMed]

2012 (4)

H. Ding and S. Molloi, “Quantification of breast density with spectral mammography based on a scanned multi-slit photon-counting detector: a feasibility study,” Phys. Med. Biol. 57(15), 4719–4738 (2012).
[Crossref] [PubMed]

V. Venugopal and X. Intes, “Recent advances in optical mammography,” Curr. Med. Im. 8(3), 244–259 (2012).
[Crossref]

N. Ducros, C. D’Andrea, A. Bassi, G. Valentini, and S. Arridge, “A virtual source pattern method for fluorescence tomography with structured light,” Phys. Med. Biol. 57(12), 3811–3832 (2012).
[Crossref] [PubMed]

P. C. Pearlman, A. Adams, S. G. Elias, W. P. Th. M. Mali, M. A. Viergever, and J. P. Pluim, “Mono- and multimodal registration of optical breast images,” J. Biomed. Opt. 17(8), 080901 (2012).
[Crossref] [PubMed]

2011 (2)

B. Pogue, S. Davis, F. Leblond, M. Mastanduno, H. Dehghani, and K. Paulsen, “Implicit and explicit prior information in near-infrared spectral imaging: accuracy, quantification and diagnostic value,” Philos. Trans. A Math, Phys. Eng. Sci. 369(1955), 4531–4557 (2011).
[Crossref]

Q. Fang, J. Selb, S. A. Carp, G. Boverman, E. L. Miller, D. H. Brooks, R. H. Moore, D. B. Kopans, and D. A. Boas, “Combined optical and X-ray tomosynthesis breast imaging,” Radiology 258(1), 89–97 (2011).
[Crossref] [PubMed]

2010 (5)

Q. Zhu, P. U. Hegde, A. Ricci, M. Kane, E. B. Cronin, Y. Ardeshirpour, C. Xu, A. Aguirre, S. H. Kurtzman, P. J. Deckers, and S. H. Tannenbaum, “Early-stage invasive breast cancers: potential role of optical tomography with US localization in assisting diagnosis,” Radiology 256(2), 367–378 (2010).
[Crossref] [PubMed]

B. R. White and J. P. Culver, “Quantitative evaluation of high-density diffuse optical tomography: in vivo resolution and mapping performance,” J. Biomed. Opt. 15(2), 026006 (2010).
[PubMed]

D. Hyde, E. L. Miller, D. H. Brooks, and V. Ntziachristos, “Data specific spatially varying regularization for multimodal fluorescence molecular tomography,” IEEE Trans. Med. Imaging 29(2), 365–374 (2010).
[Crossref] [PubMed]

E. Fredenberg, M. Lundqvist, B. Cederström, M. Åslund, and M. Danielsson, “Energy resolution of a photon-counting silicon strip detector,” Nucl. Instrum. Methods 613(1), 156–162 (2010).
[Crossref]

Q. Fang, R. H. Moore, D. B. Kopans, and D. A. Boas, “Compositional-prior-guided image Reconstruction Algorithm for Multi-modality Imaging,” Biomed. Opt. Express 1(1), 223–235 (2010).
[Crossref] [PubMed]

2009 (1)

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

2008 (1)

2007 (4)

L. C. Enfield, A. P. Gibson, N. L. Everdell, D. T. Delpy, M. Schweiger, S. R. Arridge, C. Richardson, M. Keshtgar, M. Douek, and J. C. Hebden, “Three-dimensional time-resolved optical mammography of the uncompressed breast,” Appl. Opt. 46(17), 3628–3638 (2007).
[Crossref] [PubMed]

P. K. Yalavarthy, B. W. Pogue, H. Dehghani, C. M. Carpenter, S. Jiang, and K. D. Paulsen, “Structural information within regularization matrices improves near infrared diffuse optical tomography,” Opt. Express 15(13), 8043–8058 (2007).
[Crossref] [PubMed]

S. P. Poplack, T. D. Tosteson, W. A. Wells, B. W. Pogue, P. M. Meaney, A. Hartov, C. A. Kogel, S. K. Soho, J. J. Gibson, and K. D. Paulsen, “Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms,” Radiology 243(2), 350–359 (2007).
[Crossref] [PubMed]

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 104(10), 4014–4019 (2007).
[Crossref] [PubMed]

2006 (1)

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103(23), 8828–8833 (2006).
[Crossref] [PubMed]

2005 (5)

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography resonance imaging to study in vivo and magnetic breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, and B. J. Tromberg, “Modulated imaging: quantitative analysis and tomography of turbid media in the spatial-frequency domain,” Opt. Lett. 30(11), 1354–1356 (2005).
[Crossref] [PubMed]

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI,” Med. Phys. 32(4), 1128–1139 (2005).
[Crossref] [PubMed]

P. Taroni, A. Torricelli, L. Spinelli, A. Pifferi, F. Arpaia, G. Danesini, and R. Cubeddu, “Time-resolved optical mammography between 637 and 985 nm: clinical study on the detection and identification of breast lesions,” Phys. Med. Biol. 50(11), 2469–2488 (2005).
[Crossref] [PubMed]

A. P. Gibson, J. C. Hebden, and S. R. Arridge, “Recent advances in diffuse optical imaging,” Phys. Med. Biol. 50(4), R1–R43 (2005).
[Crossref] [PubMed]

2004 (1)

X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49(12), N155–N163 (2004).
[Crossref] [PubMed]

2003 (2)

A. Li, E. L. Miller, M. E. Kilmer, T. J. Brukilacchio, T. Chaves, J. Stott, Q. Zhang, T. Wu, M. Chorlton, R. H. Moore, D. B. Kopans, and D. A. Boas, “Tomographic optical breast imaging guided by three-dimensional mammography,” Appl. Opt. 42(25), 5181–5190 (2003).
[Crossref] [PubMed]

B. Brooksby, H. Dehghani, B. Pogue, and K. Paulsen, “Near-infrared tomography breast image reconstruction with a priori structural information from MRI: algorithm development for reconstructing heterogeneities,” IEEE J. Sel. Top. Quantum Electron. 9(2), 199–209 (2003).
[Crossref]

2002 (1)

V. Ntziachristos, A. G. Yodh, M. D. Schnall, and B. Chance, “MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions,” Neoplasia 4(4), 347–354 (2002).
[Crossref] [PubMed]

2001 (1)

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18(6), 57–75 (2001).
[Crossref]

1999 (2)

S. R. Arridge, “Optical tomography in medical imaging,” Inverse Probl. 15(2), R41–R93 (1999).
[Crossref]

A. H. Gandjbakhche, R. Nossal, and R. F. Bonner, “Resolution limits for optical transillumination of abnormalities deeply embedded in tissues,” Med. Phys. 21(2), 185–191 (1999).
[Crossref] [PubMed]

1997 (1)

S. R. Arridge and J. C. Hebden, “Optical imaging in medicine: II. Modelling and reconstruction,” Phys. Med. Biol. 42(5), 841–853 (1997).
[Crossref] [PubMed]

1987 (1)

P. C. Johns and M. J. Yaffe, “X-ray characterisation of normal and neoplastic breast tissues,” Phys. Med. Biol. 32(6), 675–695 (1987).
[Crossref] [PubMed]

Adams, A.

P. C. Pearlman, A. Adams, S. G. Elias, W. P. Th. M. Mali, M. A. Viergever, and J. P. Pluim, “Mono- and multimodal registration of optical breast images,” J. Biomed. Opt. 17(8), 080901 (2012).
[Crossref] [PubMed]

Aguirre, A.

Q. Zhu, P. U. Hegde, A. Ricci, M. Kane, E. B. Cronin, Y. Ardeshirpour, C. Xu, A. Aguirre, S. H. Kurtzman, P. J. Deckers, and S. H. Tannenbaum, “Early-stage invasive breast cancers: potential role of optical tomography with US localization in assisting diagnosis,” Radiology 256(2), 367–378 (2010).
[Crossref] [PubMed]

Ardeshirpour, Y.

Q. Zhu, P. U. Hegde, A. Ricci, M. Kane, E. B. Cronin, Y. Ardeshirpour, C. Xu, A. Aguirre, S. H. Kurtzman, P. J. Deckers, and S. H. Tannenbaum, “Early-stage invasive breast cancers: potential role of optical tomography with US localization in assisting diagnosis,” Radiology 256(2), 367–378 (2010).
[Crossref] [PubMed]

Arpaia, F.

P. Taroni, A. Torricelli, L. Spinelli, A. Pifferi, F. Arpaia, G. Danesini, and R. Cubeddu, “Time-resolved optical mammography between 637 and 985 nm: clinical study on the detection and identification of breast lesions,” Phys. Med. Biol. 50(11), 2469–2488 (2005).
[Crossref] [PubMed]

Arridge, S.

N. Ducros, C. D’Andrea, A. Bassi, G. Valentini, and S. Arridge, “A virtual source pattern method for fluorescence tomography with structured light,” Phys. Med. Biol. 57(12), 3811–3832 (2012).
[Crossref] [PubMed]

Arridge, S. R.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

L. C. Enfield, A. P. Gibson, N. L. Everdell, D. T. Delpy, M. Schweiger, S. R. Arridge, C. Richardson, M. Keshtgar, M. Douek, and J. C. Hebden, “Three-dimensional time-resolved optical mammography of the uncompressed breast,” Appl. Opt. 46(17), 3628–3638 (2007).
[Crossref] [PubMed]

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI,” Med. Phys. 32(4), 1128–1139 (2005).
[Crossref] [PubMed]

A. P. Gibson, J. C. Hebden, and S. R. Arridge, “Recent advances in diffuse optical imaging,” Phys. Med. Biol. 50(4), R1–R43 (2005).
[Crossref] [PubMed]

S. R. Arridge, “Optical tomography in medical imaging,” Inverse Probl. 15(2), R41–R93 (1999).
[Crossref]

S. R. Arridge and J. C. Hebden, “Optical imaging in medicine: II. Modelling and reconstruction,” Phys. Med. Biol. 42(5), 841–853 (1997).
[Crossref] [PubMed]

Åslund, M.

E. Fredenberg, M. Lundqvist, B. Cederström, M. Åslund, and M. Danielsson, “Energy resolution of a photon-counting silicon strip detector,” Nucl. Instrum. Methods 613(1), 156–162 (2010).
[Crossref]

Balafar, M. A.

M. A. Balafar, “Gaussian mixture model based segmentation methods for brain MRI images,” Artif. Intell. Rev. 41(3), 429–439 (2014).
[Crossref]

Bassi, A.

N. Ducros, C. D’Andrea, A. Bassi, G. Valentini, and S. Arridge, “A virtual source pattern method for fluorescence tomography with structured light,” Phys. Med. Biol. 57(12), 3811–3832 (2012).
[Crossref] [PubMed]

Bevilacqua, F.

Boas, D. A.

Q. Fang, J. Selb, S. A. Carp, G. Boverman, E. L. Miller, D. H. Brooks, R. H. Moore, D. B. Kopans, and D. A. Boas, “Combined optical and X-ray tomosynthesis breast imaging,” Radiology 258(1), 89–97 (2011).
[Crossref] [PubMed]

Q. Fang, R. H. Moore, D. B. Kopans, and D. A. Boas, “Compositional-prior-guided image Reconstruction Algorithm for Multi-modality Imaging,” Biomed. Opt. Express 1(1), 223–235 (2010).
[Crossref] [PubMed]

A. Li, E. L. Miller, M. E. Kilmer, T. J. Brukilacchio, T. Chaves, J. Stott, Q. Zhang, T. Wu, M. Chorlton, R. H. Moore, D. B. Kopans, and D. A. Boas, “Tomographic optical breast imaging guided by three-dimensional mammography,” Appl. Opt. 42(25), 5181–5190 (2003).
[Crossref] [PubMed]

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18(6), 57–75 (2001).
[Crossref]

Bonner, R. F.

A. H. Gandjbakhche, R. Nossal, and R. F. Bonner, “Resolution limits for optical transillumination of abnormalities deeply embedded in tissues,” Med. Phys. 21(2), 185–191 (1999).
[Crossref] [PubMed]

Boverman, G.

Q. Fang, J. Selb, S. A. Carp, G. Boverman, E. L. Miller, D. H. Brooks, R. H. Moore, D. B. Kopans, and D. A. Boas, “Combined optical and X-ray tomosynthesis breast imaging,” Radiology 258(1), 89–97 (2011).
[Crossref] [PubMed]

Brooks, D. H.

Q. Fang, J. Selb, S. A. Carp, G. Boverman, E. L. Miller, D. H. Brooks, R. H. Moore, D. B. Kopans, and D. A. Boas, “Combined optical and X-ray tomosynthesis breast imaging,” Radiology 258(1), 89–97 (2011).
[Crossref] [PubMed]

D. Hyde, E. L. Miller, D. H. Brooks, and V. Ntziachristos, “Data specific spatially varying regularization for multimodal fluorescence molecular tomography,” IEEE Trans. Med. Imaging 29(2), 365–374 (2010).
[Crossref] [PubMed]

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18(6), 57–75 (2001).
[Crossref]

Brooksby, B.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103(23), 8828–8833 (2006).
[Crossref] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography resonance imaging to study in vivo and magnetic breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[Crossref] [PubMed]

B. Brooksby, H. Dehghani, B. Pogue, and K. Paulsen, “Near-infrared tomography breast image reconstruction with a priori structural information from MRI: algorithm development for reconstructing heterogeneities,” IEEE J. Sel. Top. Quantum Electron. 9(2), 199–209 (2003).
[Crossref]

Brukilacchio, T. J.

Busch, D. R.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Butler, J.

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 104(10), 4014–4019 (2007).
[Crossref] [PubMed]

Carp, S. A.

Q. Fang, J. Selb, S. A. Carp, G. Boverman, E. L. Miller, D. H. Brooks, R. H. Moore, D. B. Kopans, and D. A. Boas, “Combined optical and X-ray tomosynthesis breast imaging,” Radiology 258(1), 89–97 (2011).
[Crossref] [PubMed]

Carpenter, C. M.

Cederström, B.

E. Fredenberg, M. Lundqvist, B. Cederström, M. Åslund, and M. Danielsson, “Energy resolution of a photon-counting silicon strip detector,” Nucl. Instrum. Methods 613(1), 156–162 (2010).
[Crossref]

Cerussi, A.

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 104(10), 4014–4019 (2007).
[Crossref] [PubMed]

Chance, B.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI,” Med. Phys. 32(4), 1128–1139 (2005).
[Crossref] [PubMed]

X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49(12), N155–N163 (2004).
[Crossref] [PubMed]

V. Ntziachristos, A. G. Yodh, M. D. Schnall, and B. Chance, “MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions,” Neoplasia 4(4), 347–354 (2002).
[Crossref] [PubMed]

Chaves, T.

Choe, R.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI,” Med. Phys. 32(4), 1128–1139 (2005).
[Crossref] [PubMed]

Chorlton, M.

Corlu, A.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI,” Med. Phys. 32(4), 1128–1139 (2005).
[Crossref] [PubMed]

Cronin, E. B.

Q. Zhu, P. U. Hegde, A. Ricci, M. Kane, E. B. Cronin, Y. Ardeshirpour, C. Xu, A. Aguirre, S. H. Kurtzman, P. J. Deckers, and S. H. Tannenbaum, “Early-stage invasive breast cancers: potential role of optical tomography with US localization in assisting diagnosis,” Radiology 256(2), 367–378 (2010).
[Crossref] [PubMed]

Cubeddu, R.

P. Taroni, A. Torricelli, L. Spinelli, A. Pifferi, F. Arpaia, G. Danesini, and R. Cubeddu, “Time-resolved optical mammography between 637 and 985 nm: clinical study on the detection and identification of breast lesions,” Phys. Med. Biol. 50(11), 2469–2488 (2005).
[Crossref] [PubMed]

Cuccia, D. J.

Culver, J. P.

B. R. White and J. P. Culver, “Quantitative evaluation of high-density diffuse optical tomography: in vivo resolution and mapping performance,” J. Biomed. Opt. 15(2), 026006 (2010).
[PubMed]

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Czerniecki, B. J.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI,” Med. Phys. 32(4), 1128–1139 (2005).
[Crossref] [PubMed]

D’Andrea, C.

N. Ducros, C. D’Andrea, A. Bassi, G. Valentini, and S. Arridge, “A virtual source pattern method for fluorescence tomography with structured light,” Phys. Med. Biol. 57(12), 3811–3832 (2012).
[Crossref] [PubMed]

Dance, D. R.

E. Fredenberg, D. R. Dance, P. Willsher, E. Moa, M. von Tiedemann, K. C. Young, and M. G. Wallis, “Measurement of breast-tissue x-ray attenuation by spectral mammography: first results on cyst fluid,” Phys. Med. Biol. 58(24), 8609–8620 (2013).
[Crossref] [PubMed]

Danesini, G.

P. Taroni, A. Torricelli, L. Spinelli, A. Pifferi, F. Arpaia, G. Danesini, and R. Cubeddu, “Time-resolved optical mammography between 637 and 985 nm: clinical study on the detection and identification of breast lesions,” Phys. Med. Biol. 50(11), 2469–2488 (2005).
[Crossref] [PubMed]

Danielsson, M.

E. Fredenberg, M. Lundqvist, B. Cederström, M. Åslund, and M. Danielsson, “Energy resolution of a photon-counting silicon strip detector,” Nucl. Instrum. Methods 613(1), 156–162 (2010).
[Crossref]

Davis, S.

B. Pogue, S. Davis, F. Leblond, M. Mastanduno, H. Dehghani, and K. Paulsen, “Implicit and explicit prior information in near-infrared spectral imaging: accuracy, quantification and diagnostic value,” Philos. Trans. A Math, Phys. Eng. Sci. 369(1955), 4531–4557 (2011).
[Crossref]

Deckers, P. J.

Q. Zhu, P. U. Hegde, A. Ricci, M. Kane, E. B. Cronin, Y. Ardeshirpour, C. Xu, A. Aguirre, S. H. Kurtzman, P. J. Deckers, and S. H. Tannenbaum, “Early-stage invasive breast cancers: potential role of optical tomography with US localization in assisting diagnosis,” Radiology 256(2), 367–378 (2010).
[Crossref] [PubMed]

Dehghani, H.

B. Pogue, S. Davis, F. Leblond, M. Mastanduno, H. Dehghani, and K. Paulsen, “Implicit and explicit prior information in near-infrared spectral imaging: accuracy, quantification and diagnostic value,” Philos. Trans. A Math, Phys. Eng. Sci. 369(1955), 4531–4557 (2011).
[Crossref]

P. K. Yalavarthy, B. W. Pogue, H. Dehghani, C. M. Carpenter, S. Jiang, and K. D. Paulsen, “Structural information within regularization matrices improves near infrared diffuse optical tomography,” Opt. Express 15(13), 8043–8058 (2007).
[Crossref] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103(23), 8828–8833 (2006).
[Crossref] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography resonance imaging to study in vivo and magnetic breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[Crossref] [PubMed]

B. Brooksby, H. Dehghani, B. Pogue, and K. Paulsen, “Near-infrared tomography breast image reconstruction with a priori structural information from MRI: algorithm development for reconstructing heterogeneities,” IEEE J. Sel. Top. Quantum Electron. 9(2), 199–209 (2003).
[Crossref]

Delpy, D. T.

Demichele, A.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI,” Med. Phys. 32(4), 1128–1139 (2005).
[Crossref] [PubMed]

DiMarzio, C. A.

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18(6), 57–75 (2001).
[Crossref]

Ding, H.

H. Ding and S. Molloi, “Quantification of breast density with spectral mammography based on a scanned multi-slit photon-counting detector: a feasibility study,” Phys. Med. Biol. 57(15), 4719–4738 (2012).
[Crossref] [PubMed]

Douek, M.

Ducros, N.

N. Ducros, C. D’Andrea, A. Bassi, G. Valentini, and S. Arridge, “A virtual source pattern method for fluorescence tomography with structured light,” Phys. Med. Biol. 57(12), 3811–3832 (2012).
[Crossref] [PubMed]

Durduran, T.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI,” Med. Phys. 32(4), 1128–1139 (2005).
[Crossref] [PubMed]

Durkin, A.

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 104(10), 4014–4019 (2007).
[Crossref] [PubMed]

Durkin, A. J.

Elias, S. G.

P. C. Pearlman, A. Adams, S. G. Elias, W. P. Th. M. Mali, M. A. Viergever, and J. P. Pluim, “Mono- and multimodal registration of optical breast images,” J. Biomed. Opt. 17(8), 080901 (2012).
[Crossref] [PubMed]

Enfield, L. C.

Everdell, N. L.

Fang, Q.

Q. Fang, J. Selb, S. A. Carp, G. Boverman, E. L. Miller, D. H. Brooks, R. H. Moore, D. B. Kopans, and D. A. Boas, “Combined optical and X-ray tomosynthesis breast imaging,” Radiology 258(1), 89–97 (2011).
[Crossref] [PubMed]

Q. Fang, R. H. Moore, D. B. Kopans, and D. A. Boas, “Compositional-prior-guided image Reconstruction Algorithm for Multi-modality Imaging,” Biomed. Opt. Express 1(1), 223–235 (2010).
[Crossref] [PubMed]

Fraker, D. L.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI,” Med. Phys. 32(4), 1128–1139 (2005).
[Crossref] [PubMed]

Fredenberg, E.

E. Fredenberg, D. R. Dance, P. Willsher, E. Moa, M. von Tiedemann, K. C. Young, and M. G. Wallis, “Measurement of breast-tissue x-ray attenuation by spectral mammography: first results on cyst fluid,” Phys. Med. Biol. 58(24), 8609–8620 (2013).
[Crossref] [PubMed]

E. Fredenberg, M. Lundqvist, B. Cederström, M. Åslund, and M. Danielsson, “Energy resolution of a photon-counting silicon strip detector,” Nucl. Instrum. Methods 613(1), 156–162 (2010).
[Crossref]

Gandjbakhche, A. H.

A. H. Gandjbakhche, R. Nossal, and R. F. Bonner, “Resolution limits for optical transillumination of abnormalities deeply embedded in tissues,” Med. Phys. 21(2), 185–191 (1999).
[Crossref] [PubMed]

Gaudette, R. J.

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18(6), 57–75 (2001).
[Crossref]

Gibson, A. P.

Gibson, J. J.

S. P. Poplack, T. D. Tosteson, W. A. Wells, B. W. Pogue, P. M. Meaney, A. Hartov, C. A. Kogel, S. K. Soho, J. J. Gibson, and K. D. Paulsen, “Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms,” Radiology 243(2), 350–359 (2007).
[Crossref] [PubMed]

Grosicka-Koptyra, M.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI,” Med. Phys. 32(4), 1128–1139 (2005).
[Crossref] [PubMed]

Guven, M.

X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49(12), N155–N163 (2004).
[Crossref] [PubMed]

Hartov, A.

S. P. Poplack, T. D. Tosteson, W. A. Wells, B. W. Pogue, P. M. Meaney, A. Hartov, C. A. Kogel, S. K. Soho, J. J. Gibson, and K. D. Paulsen, “Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms,” Radiology 243(2), 350–359 (2007).
[Crossref] [PubMed]

Hebden, J. C.

L. C. Enfield, A. P. Gibson, N. L. Everdell, D. T. Delpy, M. Schweiger, S. R. Arridge, C. Richardson, M. Keshtgar, M. Douek, and J. C. Hebden, “Three-dimensional time-resolved optical mammography of the uncompressed breast,” Appl. Opt. 46(17), 3628–3638 (2007).
[Crossref] [PubMed]

A. P. Gibson, J. C. Hebden, and S. R. Arridge, “Recent advances in diffuse optical imaging,” Phys. Med. Biol. 50(4), R1–R43 (2005).
[Crossref] [PubMed]

S. R. Arridge and J. C. Hebden, “Optical imaging in medicine: II. Modelling and reconstruction,” Phys. Med. Biol. 42(5), 841–853 (1997).
[Crossref] [PubMed]

Hegde, P. U.

Q. Zhu, P. U. Hegde, A. Ricci, M. Kane, E. B. Cronin, Y. Ardeshirpour, C. Xu, A. Aguirre, S. H. Kurtzman, P. J. Deckers, and S. H. Tannenbaum, “Early-stage invasive breast cancers: potential role of optical tomography with US localization in assisting diagnosis,” Radiology 256(2), 367–378 (2010).
[Crossref] [PubMed]

Hsiang, D.

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 104(10), 4014–4019 (2007).
[Crossref] [PubMed]

Hyde, D.

D. Hyde, E. L. Miller, D. H. Brooks, and V. Ntziachristos, “Data specific spatially varying regularization for multimodal fluorescence molecular tomography,” IEEE Trans. Med. Imaging 29(2), 365–374 (2010).
[Crossref] [PubMed]

Intes, X.

V. Venugopal and X. Intes, “Recent advances in optical mammography,” Curr. Med. Im. 8(3), 244–259 (2012).
[Crossref]

X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49(12), N155–N163 (2004).
[Crossref] [PubMed]

Jiang, S.

P. K. Yalavarthy, B. W. Pogue, H. Dehghani, C. M. Carpenter, S. Jiang, and K. D. Paulsen, “Structural information within regularization matrices improves near infrared diffuse optical tomography,” Opt. Express 15(13), 8043–8058 (2007).
[Crossref] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103(23), 8828–8833 (2006).
[Crossref] [PubMed]

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Kilmer, M.

D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18(6), 57–75 (2001).
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Kilmer, M. E.

Kogel, C.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103(23), 8828–8833 (2006).
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B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography resonance imaging to study in vivo and magnetic breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
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Kogel, C. A.

S. P. Poplack, T. D. Tosteson, W. A. Wells, B. W. Pogue, P. M. Meaney, A. Hartov, C. A. Kogel, S. K. Soho, J. J. Gibson, and K. D. Paulsen, “Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms,” Radiology 243(2), 350–359 (2007).
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R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
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S. D. Konecky, G. Y. Panasyuk, K. Lee, V. Markel, A. G. Yodh, and J. C. Schotland, “Imaging complex structures with diffuse light,” Opt. Express 16(7), 5048–5060 (2008).
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R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI,” Med. Phys. 32(4), 1128–1139 (2005).
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Kopans, D. B.

Kurtzman, S. H.

Q. Zhu, P. U. Hegde, A. Ricci, M. Kane, E. B. Cronin, Y. Ardeshirpour, C. Xu, A. Aguirre, S. H. Kurtzman, P. J. Deckers, and S. H. Tannenbaum, “Early-stage invasive breast cancers: potential role of optical tomography with US localization in assisting diagnosis,” Radiology 256(2), 367–378 (2010).
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Leblond, F.

B. Pogue, S. Davis, F. Leblond, M. Mastanduno, H. Dehghani, and K. Paulsen, “Implicit and explicit prior information in near-infrared spectral imaging: accuracy, quantification and diagnostic value,” Philos. Trans. A Math, Phys. Eng. Sci. 369(1955), 4531–4557 (2011).
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R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
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S. D. Konecky, G. Y. Panasyuk, K. Lee, V. Markel, A. G. Yodh, and J. C. Schotland, “Imaging complex structures with diffuse light,” Opt. Express 16(7), 5048–5060 (2008).
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R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI,” Med. Phys. 32(4), 1128–1139 (2005).
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Lundqvist, M.

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Mastanduno, M.

B. Pogue, S. Davis, F. Leblond, M. Mastanduno, H. Dehghani, and K. Paulsen, “Implicit and explicit prior information in near-infrared spectral imaging: accuracy, quantification and diagnostic value,” Philos. Trans. A Math, Phys. Eng. Sci. 369(1955), 4531–4557 (2011).
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S. P. Poplack, T. D. Tosteson, W. A. Wells, B. W. Pogue, P. M. Meaney, A. Hartov, C. A. Kogel, S. K. Soho, J. J. Gibson, and K. D. Paulsen, “Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms,” Radiology 243(2), 350–359 (2007).
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Mehta, R.

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 104(10), 4014–4019 (2007).
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Miller, E. L.

Q. Fang, J. Selb, S. A. Carp, G. Boverman, E. L. Miller, D. H. Brooks, R. H. Moore, D. B. Kopans, and D. A. Boas, “Combined optical and X-ray tomosynthesis breast imaging,” Radiology 258(1), 89–97 (2011).
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D. Hyde, E. L. Miller, D. H. Brooks, and V. Ntziachristos, “Data specific spatially varying regularization for multimodal fluorescence molecular tomography,” IEEE Trans. Med. Imaging 29(2), 365–374 (2010).
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A. Li, E. L. Miller, M. E. Kilmer, T. J. Brukilacchio, T. Chaves, J. Stott, Q. Zhang, T. Wu, M. Chorlton, R. H. Moore, D. B. Kopans, and D. A. Boas, “Tomographic optical breast imaging guided by three-dimensional mammography,” Appl. Opt. 42(25), 5181–5190 (2003).
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D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18(6), 57–75 (2001).
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E. Fredenberg, D. R. Dance, P. Willsher, E. Moa, M. von Tiedemann, K. C. Young, and M. G. Wallis, “Measurement of breast-tissue x-ray attenuation by spectral mammography: first results on cyst fluid,” Phys. Med. Biol. 58(24), 8609–8620 (2013).
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D. Hyde, E. L. Miller, D. H. Brooks, and V. Ntziachristos, “Data specific spatially varying regularization for multimodal fluorescence molecular tomography,” IEEE Trans. Med. Imaging 29(2), 365–374 (2010).
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V. Ntziachristos, A. G. Yodh, M. D. Schnall, and B. Chance, “MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions,” Neoplasia 4(4), 347–354 (2002).
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Panasyuk, G. Y.

Pathak, S.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
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Paulsen, K.

B. Pogue, S. Davis, F. Leblond, M. Mastanduno, H. Dehghani, and K. Paulsen, “Implicit and explicit prior information in near-infrared spectral imaging: accuracy, quantification and diagnostic value,” Philos. Trans. A Math, Phys. Eng. Sci. 369(1955), 4531–4557 (2011).
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B. Brooksby, H. Dehghani, B. Pogue, and K. Paulsen, “Near-infrared tomography breast image reconstruction with a priori structural information from MRI: algorithm development for reconstructing heterogeneities,” IEEE J. Sel. Top. Quantum Electron. 9(2), 199–209 (2003).
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S. P. Poplack, T. D. Tosteson, W. A. Wells, B. W. Pogue, P. M. Meaney, A. Hartov, C. A. Kogel, S. K. Soho, J. J. Gibson, and K. D. Paulsen, “Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms,” Radiology 243(2), 350–359 (2007).
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P. K. Yalavarthy, B. W. Pogue, H. Dehghani, C. M. Carpenter, S. Jiang, and K. D. Paulsen, “Structural information within regularization matrices improves near infrared diffuse optical tomography,” Opt. Express 15(13), 8043–8058 (2007).
[Crossref] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103(23), 8828–8833 (2006).
[Crossref] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography resonance imaging to study in vivo and magnetic breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
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Pearlman, P. C.

P. C. Pearlman, A. Adams, S. G. Elias, W. P. Th. M. Mali, M. A. Viergever, and J. P. Pluim, “Mono- and multimodal registration of optical breast images,” J. Biomed. Opt. 17(8), 080901 (2012).
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Pifferi, A.

P. Taroni, A. Torricelli, L. Spinelli, A. Pifferi, F. Arpaia, G. Danesini, and R. Cubeddu, “Time-resolved optical mammography between 637 and 985 nm: clinical study on the detection and identification of breast lesions,” Phys. Med. Biol. 50(11), 2469–2488 (2005).
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Pluim, J. P.

P. C. Pearlman, A. Adams, S. G. Elias, W. P. Th. M. Mali, M. A. Viergever, and J. P. Pluim, “Mono- and multimodal registration of optical breast images,” J. Biomed. Opt. 17(8), 080901 (2012).
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Pogue, B.

B. Pogue, S. Davis, F. Leblond, M. Mastanduno, H. Dehghani, and K. Paulsen, “Implicit and explicit prior information in near-infrared spectral imaging: accuracy, quantification and diagnostic value,” Philos. Trans. A Math, Phys. Eng. Sci. 369(1955), 4531–4557 (2011).
[Crossref]

B. Brooksby, H. Dehghani, B. Pogue, and K. Paulsen, “Near-infrared tomography breast image reconstruction with a priori structural information from MRI: algorithm development for reconstructing heterogeneities,” IEEE J. Sel. Top. Quantum Electron. 9(2), 199–209 (2003).
[Crossref]

Pogue, B. W.

S. P. Poplack, T. D. Tosteson, W. A. Wells, B. W. Pogue, P. M. Meaney, A. Hartov, C. A. Kogel, S. K. Soho, J. J. Gibson, and K. D. Paulsen, “Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms,” Radiology 243(2), 350–359 (2007).
[Crossref] [PubMed]

P. K. Yalavarthy, B. W. Pogue, H. Dehghani, C. M. Carpenter, S. Jiang, and K. D. Paulsen, “Structural information within regularization matrices improves near infrared diffuse optical tomography,” Opt. Express 15(13), 8043–8058 (2007).
[Crossref] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103(23), 8828–8833 (2006).
[Crossref] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography resonance imaging to study in vivo and magnetic breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[Crossref] [PubMed]

Poplack, S. P.

S. P. Poplack, T. D. Tosteson, W. A. Wells, B. W. Pogue, P. M. Meaney, A. Hartov, C. A. Kogel, S. K. Soho, J. J. Gibson, and K. D. Paulsen, “Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms,” Radiology 243(2), 350–359 (2007).
[Crossref] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103(23), 8828–8833 (2006).
[Crossref] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography resonance imaging to study in vivo and magnetic breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[Crossref] [PubMed]

Putt, M. E.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Ricci, A.

Q. Zhu, P. U. Hegde, A. Ricci, M. Kane, E. B. Cronin, Y. Ardeshirpour, C. Xu, A. Aguirre, S. H. Kurtzman, P. J. Deckers, and S. H. Tannenbaum, “Early-stage invasive breast cancers: potential role of optical tomography with US localization in assisting diagnosis,” Radiology 256(2), 367–378 (2010).
[Crossref] [PubMed]

Richardson, C.

Rosen, M. A.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI,” Med. Phys. 32(4), 1128–1139 (2005).
[Crossref] [PubMed]

Schnall, M. D.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

V. Ntziachristos, A. G. Yodh, M. D. Schnall, and B. Chance, “MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions,” Neoplasia 4(4), 347–354 (2002).
[Crossref] [PubMed]

Schotland, J. C.

Schweiger, M.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
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L. C. Enfield, A. P. Gibson, N. L. Everdell, D. T. Delpy, M. Schweiger, S. R. Arridge, C. Richardson, M. Keshtgar, M. Douek, and J. C. Hebden, “Three-dimensional time-resolved optical mammography of the uncompressed breast,” Appl. Opt. 46(17), 3628–3638 (2007).
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Selb, J.

Q. Fang, J. Selb, S. A. Carp, G. Boverman, E. L. Miller, D. H. Brooks, R. H. Moore, D. B. Kopans, and D. A. Boas, “Combined optical and X-ray tomosynthesis breast imaging,” Radiology 258(1), 89–97 (2011).
[Crossref] [PubMed]

Shah, N.

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 104(10), 4014–4019 (2007).
[Crossref] [PubMed]

Soho, S. K.

S. P. Poplack, T. D. Tosteson, W. A. Wells, B. W. Pogue, P. M. Meaney, A. Hartov, C. A. Kogel, S. K. Soho, J. J. Gibson, and K. D. Paulsen, “Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms,” Radiology 243(2), 350–359 (2007).
[Crossref] [PubMed]

Spinelli, L.

P. Taroni, A. Torricelli, L. Spinelli, A. Pifferi, F. Arpaia, G. Danesini, and R. Cubeddu, “Time-resolved optical mammography between 637 and 985 nm: clinical study on the detection and identification of breast lesions,” Phys. Med. Biol. 50(11), 2469–2488 (2005).
[Crossref] [PubMed]

Srinivasan, S.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103(23), 8828–8833 (2006).
[Crossref] [PubMed]

Stott, J.

Tannenbaum, S. H.

Q. Zhu, P. U. Hegde, A. Ricci, M. Kane, E. B. Cronin, Y. Ardeshirpour, C. Xu, A. Aguirre, S. H. Kurtzman, P. J. Deckers, and S. H. Tannenbaum, “Early-stage invasive breast cancers: potential role of optical tomography with US localization in assisting diagnosis,” Radiology 256(2), 367–378 (2010).
[Crossref] [PubMed]

Taroni, P.

P. Taroni, A. Torricelli, L. Spinelli, A. Pifferi, F. Arpaia, G. Danesini, and R. Cubeddu, “Time-resolved optical mammography between 637 and 985 nm: clinical study on the detection and identification of breast lesions,” Phys. Med. Biol. 50(11), 2469–2488 (2005).
[Crossref] [PubMed]

Tchou, J.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Torricelli, A.

P. Taroni, A. Torricelli, L. Spinelli, A. Pifferi, F. Arpaia, G. Danesini, and R. Cubeddu, “Time-resolved optical mammography between 637 and 985 nm: clinical study on the detection and identification of breast lesions,” Phys. Med. Biol. 50(11), 2469–2488 (2005).
[Crossref] [PubMed]

Tosteson, T. D.

S. P. Poplack, T. D. Tosteson, W. A. Wells, B. W. Pogue, P. M. Meaney, A. Hartov, C. A. Kogel, S. K. Soho, J. J. Gibson, and K. D. Paulsen, “Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms,” Radiology 243(2), 350–359 (2007).
[Crossref] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103(23), 8828–8833 (2006).
[Crossref] [PubMed]

Tromberg, B. J.

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 104(10), 4014–4019 (2007).
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D. J. Cuccia, F. Bevilacqua, A. J. Durkin, and B. J. Tromberg, “Modulated imaging: quantitative analysis and tomography of turbid media in the spatial-frequency domain,” Opt. Lett. 30(11), 1354–1356 (2005).
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Venugopal, V.

V. Venugopal and X. Intes, “Recent advances in optical mammography,” Curr. Med. Im. 8(3), 244–259 (2012).
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P. C. Pearlman, A. Adams, S. G. Elias, W. P. Th. M. Mali, M. A. Viergever, and J. P. Pluim, “Mono- and multimodal registration of optical breast images,” J. Biomed. Opt. 17(8), 080901 (2012).
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von Tiedemann, M.

E. Fredenberg, D. R. Dance, P. Willsher, E. Moa, M. von Tiedemann, K. C. Young, and M. G. Wallis, “Measurement of breast-tissue x-ray attenuation by spectral mammography: first results on cyst fluid,” Phys. Med. Biol. 58(24), 8609–8620 (2013).
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Wallis, M. G.

E. Fredenberg, D. R. Dance, P. Willsher, E. Moa, M. von Tiedemann, K. C. Young, and M. G. Wallis, “Measurement of breast-tissue x-ray attenuation by spectral mammography: first results on cyst fluid,” Phys. Med. Biol. 58(24), 8609–8620 (2013).
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Weaver, J.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103(23), 8828–8833 (2006).
[Crossref] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography resonance imaging to study in vivo and magnetic breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
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Wells, W. A.

S. P. Poplack, T. D. Tosteson, W. A. Wells, B. W. Pogue, P. M. Meaney, A. Hartov, C. A. Kogel, S. K. Soho, J. J. Gibson, and K. D. Paulsen, “Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms,” Radiology 243(2), 350–359 (2007).
[Crossref] [PubMed]

White, B. R.

B. R. White and J. P. Culver, “Quantitative evaluation of high-density diffuse optical tomography: in vivo resolution and mapping performance,” J. Biomed. Opt. 15(2), 026006 (2010).
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Willsher, P.

E. Fredenberg, D. R. Dance, P. Willsher, E. Moa, M. von Tiedemann, K. C. Young, and M. G. Wallis, “Measurement of breast-tissue x-ray attenuation by spectral mammography: first results on cyst fluid,” Phys. Med. Biol. 58(24), 8609–8620 (2013).
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Wu, T.

Xu, C.

Q. Zhu, P. U. Hegde, A. Ricci, M. Kane, E. B. Cronin, Y. Ardeshirpour, C. Xu, A. Aguirre, S. H. Kurtzman, P. J. Deckers, and S. H. Tannenbaum, “Early-stage invasive breast cancers: potential role of optical tomography with US localization in assisting diagnosis,” Radiology 256(2), 367–378 (2010).
[Crossref] [PubMed]

Yaffe, M. J.

P. C. Johns and M. J. Yaffe, “X-ray characterisation of normal and neoplastic breast tissues,” Phys. Med. Biol. 32(6), 675–695 (1987).
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Yalavarthy, P. K.

Yazici, B.

X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49(12), N155–N163 (2004).
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Yodh, A. G.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
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R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI,” Med. Phys. 32(4), 1128–1139 (2005).
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V. Ntziachristos, A. G. Yodh, M. D. Schnall, and B. Chance, “MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions,” Neoplasia 4(4), 347–354 (2002).
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E. Fredenberg, D. R. Dance, P. Willsher, E. Moa, M. von Tiedemann, K. C. Young, and M. G. Wallis, “Measurement of breast-tissue x-ray attenuation by spectral mammography: first results on cyst fluid,” Phys. Med. Biol. 58(24), 8609–8620 (2013).
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A. Li, E. L. Miller, M. E. Kilmer, T. J. Brukilacchio, T. Chaves, J. Stott, Q. Zhang, T. Wu, M. Chorlton, R. H. Moore, D. B. Kopans, and D. A. Boas, “Tomographic optical breast imaging guided by three-dimensional mammography,” Appl. Opt. 42(25), 5181–5190 (2003).
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Q. Zhu, P. U. Hegde, A. Ricci, M. Kane, E. B. Cronin, Y. Ardeshirpour, C. Xu, A. Aguirre, S. H. Kurtzman, P. J. Deckers, and S. H. Tannenbaum, “Early-stage invasive breast cancers: potential role of optical tomography with US localization in assisting diagnosis,” Radiology 256(2), 367–378 (2010).
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Appl. Opt. (2)

Artif. Intell. Rev. (1)

M. A. Balafar, “Gaussian mixture model based segmentation methods for brain MRI images,” Artif. Intell. Rev. 41(3), 429–439 (2014).
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Biomed. Opt. Express (1)

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V. Venugopal and X. Intes, “Recent advances in optical mammography,” Curr. Med. Im. 8(3), 244–259 (2012).
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IEEE J. Sel. Top. Quantum Electron. (1)

B. Brooksby, H. Dehghani, B. Pogue, and K. Paulsen, “Near-infrared tomography breast image reconstruction with a priori structural information from MRI: algorithm development for reconstructing heterogeneities,” IEEE J. Sel. Top. Quantum Electron. 9(2), 199–209 (2003).
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D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, “Imaging the body with diffuse optical tomography,” IEEE Signal Process. Mag. 18(6), 57–75 (2001).
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IEEE Trans. Med. Imaging (1)

D. Hyde, E. L. Miller, D. H. Brooks, and V. Ntziachristos, “Data specific spatially varying regularization for multimodal fluorescence molecular tomography,” IEEE Trans. Med. Imaging 29(2), 365–374 (2010).
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J. Biomed. Opt. (4)

B. R. White and J. P. Culver, “Quantitative evaluation of high-density diffuse optical tomography: in vivo resolution and mapping performance,” J. Biomed. Opt. 15(2), 026006 (2010).
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[Crossref] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography resonance imaging to study in vivo and magnetic breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[Crossref] [PubMed]

P. C. Pearlman, A. Adams, S. G. Elias, W. P. Th. M. Mali, M. A. Viergever, and J. P. Pluim, “Mono- and multimodal registration of optical breast images,” J. Biomed. Opt. 17(8), 080901 (2012).
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[Crossref] [PubMed]

Neoplasia (1)

V. Ntziachristos, A. G. Yodh, M. D. Schnall, and B. Chance, “MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions,” Neoplasia 4(4), 347–354 (2002).
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E. Fredenberg, M. Lundqvist, B. Cederström, M. Åslund, and M. Danielsson, “Energy resolution of a photon-counting silicon strip detector,” Nucl. Instrum. Methods 613(1), 156–162 (2010).
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X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49(12), N155–N163 (2004).
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H. Ding and S. Molloi, “Quantification of breast density with spectral mammography based on a scanned multi-slit photon-counting detector: a feasibility study,” Phys. Med. Biol. 57(15), 4719–4738 (2012).
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E. Fredenberg, D. R. Dance, P. Willsher, E. Moa, M. von Tiedemann, K. C. Young, and M. G. Wallis, “Measurement of breast-tissue x-ray attenuation by spectral mammography: first results on cyst fluid,” Phys. Med. Biol. 58(24), 8609–8620 (2013).
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P. C. Johns and M. J. Yaffe, “X-ray characterisation of normal and neoplastic breast tissues,” Phys. Med. Biol. 32(6), 675–695 (1987).
[Crossref] [PubMed]

N. Ducros, C. D’Andrea, A. Bassi, G. Valentini, and S. Arridge, “A virtual source pattern method for fluorescence tomography with structured light,” Phys. Med. Biol. 57(12), 3811–3832 (2012).
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A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 104(10), 4014–4019 (2007).
[Crossref] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography,” Proc. Natl. Acad. Sci. U.S.A. 103(23), 8828–8833 (2006).
[Crossref] [PubMed]

Radiology (3)

Q. Zhu, P. U. Hegde, A. Ricci, M. Kane, E. B. Cronin, Y. Ardeshirpour, C. Xu, A. Aguirre, S. H. Kurtzman, P. J. Deckers, and S. H. Tannenbaum, “Early-stage invasive breast cancers: potential role of optical tomography with US localization in assisting diagnosis,” Radiology 256(2), 367–378 (2010).
[Crossref] [PubMed]

Q. Fang, J. Selb, S. A. Carp, G. Boverman, E. L. Miller, D. H. Brooks, R. H. Moore, D. B. Kopans, and D. A. Boas, “Combined optical and X-ray tomosynthesis breast imaging,” Radiology 258(1), 89–97 (2011).
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S. P. Poplack, T. D. Tosteson, W. A. Wells, B. W. Pogue, P. M. Meaney, A. Hartov, C. A. Kogel, S. K. Soho, J. J. Gibson, and K. D. Paulsen, “Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms,” Radiology 243(2), 350–359 (2007).
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R. Choe and A. G. Yodh, “Chapter 18. Diffuse optical tomography of the breast,” in Emergenging Technology in Breast Imaging and Mammography, (American Scientific Publishers, 2008) pp. 317–342.

Q. Fang and D. Boas, “Tetrahedral mesh generation from volumetric binary and gray-scale images,” Proc. of IEEE Int. Symp on Biomed. Imaging (ISBI’09), 1142–45 (2009), URL: http://iso2mesh.sf.net

R. Bade, H. Haase, and B. Preim, “Comparison of fundamental mesh smoothing algorithms for medical surface models,” In Proc. of Simulation and Visualization. 289–304 (2006).

B. Zimmermann, M. Martino, A. Sajjadi, Q. Fang, D. Boas, and S. Carp, “A novel tomographic optical breast imaging system to simultaneously co-register x-ray tomosynthesis,” OSA BIOMED conference, (2014)

Q. Fang, S. A. Carp, J. Selb, R. Moore, D. B. Kopans, E. L. Miller, D. H. Brooks, and D. A. Boas, “A multi-modality image reconstruction platform for diffuse optical tomography,” OSA BIOMED conference (2008)

J. C. Russ, The Image Processing Handbook, 6th ed. (CRC Press, 2011)

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Figures (8)

Fig. 1
Fig. 1 A 3D digital breast phantom derived from a dual-energy x-ray mammography scan: (a) 2D mammogram, (b) fibroglandular volume fraction, (c) 3D uniform breast mesh (color showing total hemoglobin concentrations, inset showing the vertical profile), and (d,e) cross-sectional views of locally-refined meshes along with optical fiber locations. Two simulated tumor locations, Ω a and Ω f , are indicated with arrows.
Fig. 2
Fig. 2 The comparison in accuracy of various fuzzy segmentation algorithms. Here we show the estimated fibroglandular volume fraction (Cf ) using (a) the manual approach, (b) the dual-Gaussian approach, (c) the threshold approach with a 0.2% cutoff, and (d) the threshold approach with a 2% cutoff. The RMSEs between the estimated Cf and the ground-truth (Fig. 1(b)) are also superimposed on the figures in (a-d). The histograms of the estimated Cf using different approaches (color coded) are compared against the ground-truth (black) in (e).
Fig. 3
Fig. 3 (a) Comparison in effectiveness of various fuzzy segmentation algorithms: (a) RMSE of HbT (μM) vs. reconstruction iterations; (b) HbT ground-truth (μM); (c) HbT (μM) recovered using two-composition-prior derived from the dual-Gaussian approach; (d) HbT (μM) recovered without using priors. In (b-d), black solid lines indicate Cf = 30% based on the ground-truth. All HbT images are extracted from the middle z-slice.
Fig. 4
Fig. 4 RMSE curves for reconstructions without tissue compositional priors (solid dots), and with two- (stars) or three- (circles) compositional priors using both uniform (blue) and locally refined (red) meshes. Priors are derived using dual-Gaussian segmentation algorithm and the tumor has γ = 2 in contrast and φ = 10 mm in size and is located in the adipose background.
Fig. 5
Fig. 5 The extracted HbT line-profiles across the (a-c) adipose-surrounded tumor and (d-f) fibroglandular-surrounded tumor, including (a,d) the ground-truth, and the profiles resulted from (b,e) two- and (c,f) three-composition-prior reconstructions. The blue dotted lines mark the boundaries of the averaging interval, i.e. Ω in Eq. (8), used in the contrast calculation.
Fig. 6
Fig. 6 The recovered tumor contrasts (R) using the uniform mesh set for both (a) adipose- and (b) fibroglandular-surrounded tumors at various contrasts and sizes. Both three- and two-composition-priors are tested. Insets show the zoom-in views. Dash-dotted lines of the same color represent the true simulated contrast. Sample recovered HbT images (µM) of a small lesion (φ = 5 mm, γ = 2, adipose-surrounded) using two- and three-composition-priors are plotted in (c) and (d). Black solid lines mark the Cf = 30% contour on the ground-truth. Tumor is indicated by a dashed circle but with a radius twice the true size for easier visualization.
Fig. 7
Fig. 7 Comparisons between the uniform and refined meshes in the recovery of HbT contrasts (R) for tumors located in either (a) adipose or (b) fibroglandular vicinities. Insets show the zoom-in views. Markings are similar to those in Fig. 6. (c) The recovered HbT image (µM) of the same adipose-surrounded tumor as in Fig. 6(d), except that the refined mesh set was used.
Fig. 8
Fig. 8 Test of tumor recovery with different tissue background and inaccurate prior information: (a-e) tumor is located in the adipose tissue and (f-j) tumor is in the fibroglandular tissue. In both cases, we show the (a,f) HbT ground-truth (µM), (b,g) compositional priors of the fibroglandular tissue, (c,h) recovered HbT images (µM) using concordant tumor priors, and (d,i) those using discordant tumor priors (white dotted circle). In all cases, the tumor has φ = 10 mm and γ = 2. In comparison, the two-composition-prior guided HbT images are shown in (e,j).

Tables (2)

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Table 1 Statistics of the forward and reconstruction meshes generated from the digital breast phantom

Tables Icon

Table 2 Optical properties for various breast tissues

Equations (8)

Equations on this page are rendered with MathJax. Learn more.

μ ( r ) = C f ( r ) × μ f i b + C a ( r ) × μ a d i ,
C t ( r ) = exp ( r r 0 2 / 2 σ 2 ) ,
μ ( r ) = C f ( r ) × μ f i b + C a ( r ) × μ a d i + C t ( r ) × [ μ a d i + ( μ m 0 μ a d i ) × γ ] ,
Φ ( s , d ) = Φ 0 ( s , d ) + n 1 + n 2 ,
μ k = μ k 1 + Θ 1 J k T ( J k Θ 1 J k T + λ I ) 1 ( Φ A μ k 1 ) ,
Z Z T = ( J R 1 ) ( J R 1 ) T = J ( R T R ) 1 J T = J ( L T L ) 1 J T .
C f ( χ ) = ( C D F [ G a ( χ ) ] + C D F [ G f ( χ ) ] ) / 2.
R = [ max ( μ Ω ) m e a n ( μ b ) ] / m e a n ( μ b ) ,

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