Abstract

A red-green-blue camera-based imaging method is proposed for estimating spatial maps of concentrations of oxyhemoglobin (CHbO), deoxyhemoglobin (CHbR), total hemoglobin (CHbT), tissue oxygen saturation (StO2), and scattering power (b) in liver tissue. Hemodynamic responses to hepatic ischemia-reperfusion of in vivo rat liver tissues induced by portal triad occlusion were evaluated. Upon portal triad occlusion, this method yielded images of decreased CHbO, CHbT, StO2, and b, and increased CHbR followed by a progressive increase in CHbO and StO2 during reperfusion. Time courses of the changes in CHbO, CHbR, CHbT, and StO2 over different regions of interest (ROIs) revealed that ischemia results in an abrupt significant (P<0.05) reduction in CHbO, CHbT, and StO2 with a simultaneous increase in CHbR compared to the baseline level, indicative of the hemodynamic responses during hepatic ischemia-reperfusion. Upon reperfusion, there was a gradual increase in CHbO and StO2, and decrease in CHbR. The change in average scattering power b implies the presence of morphological alterations in the cellular and subcellular structures induced by ischemia or anoxia. This study shows the potential of monitoring spatiotemporal changes in hemodynamic parameters and morphological changes in studies of hepatic pathophysiology.

© 2017 Optical Society of America

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2016 (1)

I. Nishidate, T. Ishizuka, A. Mustari, K. Yoshida, S. Kawauchi, S. Sato, and M. Sato, “Evaluation of cerebral hemodynamics and tissue morphology of in vivo rat brain using spectral diffuse reflectance imaging,” Appl. Spectrosc. 2016, 03702816657569 (2016).
[PubMed]

2015 (4)

S. Akter, T. Tanabe, S. Maejima, S. Kawauchi, S. Sato, A. Hinoki, S. Aosasa, J. Yamamoto, and I. Nishidate, “In vivo estimation of optical properties of rat liver using single-reflectance fiber probe during ischemia and reperfusion,” Opt. Rev. 22(6), 1–6 (2015).

K. Yoshida, I. Nishidate, T. Ishizuka, S. Kawauchi, S. Sato, and M. Sato, “Multispectral imaging of absorption and scattering properties of in vivo exposed rat brain using a digital red-green-blue camera,” J. Biomed. Opt. 20(5), 051026 (2015).
[Crossref] [PubMed]

S. Akter, S. Maejima, S. Kawauchi, S. Sato, A. Hinoki, S. Aosasa, J. Yamamoto, and I. Nishidate, “Evaluation of light scattering and absorption properties of in vivo rat liver using a single-reflectance fiber probe during preischemia, ischemia-reperfusion, and postmortem,” J. Biomed. Opt. 20(7), 076010 (2015).
[Crossref] [PubMed]

H. Wang, X. Liang, Y. H. Mohammed, J. A. Thomas, K. R. Bridle, C. A. Thorling, J. E. Grice, Z. P. Xu, X. Liu, D. H. Crawford, and M. S. Roberts, “Real-time histology in liver disease using multiphoton microscopy with fluorescence lifetime imaging,” Biomed. Opt. Express 6(3), 780–792 (2015).
[Crossref] [PubMed]

2014 (4)

C. H. Li, H. D. Wang, J. J. Hu, X. L. Ge, K. Pan, A. Q. Zhang, and J. H. Dong, “The monitoring of microvascular liver blood flow changes during ischemia and reperfusion using laser speckle contrast imaging,” Microvasc. Res. 94, 28–35 (2014).
[Crossref] [PubMed]

L. Yao, C. Li, X. Ge, H. Wang, K. Xu, A. Zhang, and J. Dong, “Establishment of a rat model of portal vein ligation combined with in situ splitting,” PLoS One 9(8), e105511 (2014).
[Crossref] [PubMed]

J. Yan, Y. Kang, S. Xu, L. L. S. Ong, S. Zhuo, R. M. Bunte, N. Chen, H. H. Asada, P. T. C. So, I. R. Wanless, and H. Yu, “In vivo label-free quantification of liver microcirculation using dual-modality microscopy,” J. Biomed. Opt. 19(11), 116006 (2014).
[Crossref] [PubMed]

H. H. Lu, Y. M. Wu, W. T. Chang, T. Luo, Y. C. Yang, H. D. Cho, and I. Liau, “Molecular imaging of ischemia and reperfusion in vivo with mitochondrial autofluorescence,” Anal. Chem. 86(10), 5024–5031 (2014).
[Crossref] [PubMed]

2013 (1)

C. Sturesson, D. M. Milstein, I. C. Post, A. M. Maas, and T. M. van Gulik, “Laser speckle contrast imaging for assessment of liver microcirculation,” Microvasc. Res. 87, 34–40 (2013).
[Crossref] [PubMed]

2011 (1)

I. Nishidate, N. Tanaka, T. Kawase, T. Maeda, T. Yuasa, Y. Aizu, T. Yuasa, and K. Niizeki, “Noninvasive imaging of human skin hemodynamics using a digital red-green-blue camera,” J. Biomed. Opt. 16(8), 086012 (2011).
[Crossref] [PubMed]

2010 (1)

R. Cursio, P. Colosetti, M. C. Saint-Paul, S. Pagnotta, P. Gounon, A. Iannelli, P. Auberger, and J. Gugenheim, “Induction of different types of cell death after normothermic liver ischemia-reperfusion,” Transplant. Proc. 42(10), 3977–3980 (2010).
[Crossref] [PubMed]

2009 (1)

D. Abookasis, C. C. Lay, M. S. Mathews, M. E. Linskey, R. D. Frostig, and B. J. Tromberg, “Imaging cortical absorption, scattering, and hemodynamic response during ischemic stroke using spatially modulated near-infrared illumination,” J. Biomed. Opt. 14(2), 024033 (2009).
[Crossref] [PubMed]

2008 (1)

G. Oldani, M. Maestri, A. Gaspari, E. Lillo, G. Angelastri, L. M. Lenti, J. Rademacher, M. Alessiani, and P. Dionigi, “A novel technique for rat liver transplantation using Quick Linker system: a preliminary result,” J. Surg. Res. 149(2), 303–309 (2008).
[Crossref] [PubMed]

2005 (2)

J. W. Kupiec-Weglinski and R. W. Busuttil, “Ischemia and reperfusion injury in liver transplantation,” Transplant. Proc. 37(4), 1653–1656 (2005).
[Crossref] [PubMed]

X. Wang, B. W. Pogue, S. Jiang, X. Song, K. D. Paulsen, C. Kogel, S. P. Poplack, and W. A. Wells, “Approximation of Mie scattering parameters in near-infrared tomography of normal breast tissue in vivo,” J. Biomed. Opt. 10(5), 051704 (2005).
[Crossref] [PubMed]

2004 (1)

J. C. Ramella-Roman, K. Lee, S. A. Prahl, and S. L. Jacques, “Design, testing, and clinical studies of a handheld polarized light camera,” J. Biomed. Opt. 9(6), 1305–1310 (2004).
[Crossref] [PubMed]

2003 (2)

H. Jaeschke and J. J. Lemasters, “Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury,” Gastroenterology 125(4), 1246–1257 (2003).
[Crossref] [PubMed]

M. Kretzschmar, A. Krüger, W. Schirrmeister, A. Krüger, and W. Schirrmeister, “Hepatic ischemia-reperfusion syndrome after partial liver resection (LR): hepatic venous oxygen saturation, enzyme pattern, reduced and oxidized glutathione, procalcitonin and interleukin-6,” Exp. Toxicol. Pathol. 54(5-6), 423–431 (2003).
[Crossref] [PubMed]

2001 (2)

A. E. El-Desoky, D. T. Delpy, B. R. Davidson, and A. M. Seifalian, “Assessment of hepatic ischaemia reperfusion injury by measuring intracellular tissue oxygenation using near infrared spectroscopy,” Liver 21(1), 37–44 (2001).
[Crossref] [PubMed]

M. N. Tawadrous, X. Y. Zhang, and A. M. Wheatley, “Microvascular origin of laser-Doppler flux signal from the surface of normal and injured liver of the rat,” Microvasc. Res. 62(3), 355–365 (2001).
[Crossref] [PubMed]

1998 (3)

R. M. Zwacka, Y. Zhang, W. Zhou, J. Halldorson, and J. F. Engelhardt, “Ischemia/reperfusion injury in the liver of BALB/c mice activates AP-1 and nuclear factor kappaB independently of IkappaB degradation,” Hepatology 28(4), 1022–1030 (1998).
[Crossref] [PubMed]

T. Kondo, T. Todoroki, T. Hirano, F. W. Schildberg, and K. Messmer, “Impact of ischemia-reperfusion injury on dimensional changes of hepatic microvessels,” Res. Exp. Med. (Berl.) 198(2), 63–72 (1998).
[Crossref] [PubMed]

J. R. Mourant, J. P. Freyer, A. H. Hielscher, A. A. Eick, D. Shen, and T. M. Johnson, “Mechanisms of light scattering from biological cells relevant to noninvasive optical-tissue diagnostics,” Appl. Opt. 37(16), 3586–3593 (1998).
[Crossref] [PubMed]

1997 (2)

J. R. Mourant, T. Fuselier, J. Boyer, T. M. Johnson, and I. J. Bigio, “Predictions and measurements of scattering and absorption over broad wavelength ranges in tissue phantoms,” Appl. Opt. 36(4), 949–957 (1997).
[Crossref] [PubMed]

M. D. Menger, M. Rücker, and B. Vollmar, “Capillary dysfunction in striated muscle ischemia/reperfusion: on the mechanisms of capillary “no-reflow”,” Shock 8(1), 2–7 (1997).
[Crossref] [PubMed]

1996 (1)

F. J. Burczynski, B. A. Luxon, and R. A. Weisiger, “Intrahepatic blood flow distribution in the perfused rat liver: effect of hepatic artery perfusion,” Am. J. Physiol. 271(4 Pt 1), G561–G567 (1996).
[PubMed]

1995 (2)

L. Wang, S. L. Jacques, and L. Zheng, “MCML--Monte Carlo modeling of light transport in multi-layered tissues,” Comput. Methods Programs Biomed. 47(2), 131–146 (1995).
[Crossref] [PubMed]

J. J. Lemasters, H. Bunzendahl, and R. G. Thurman, “Reperfusion injury to donor livers stored for transplantation,” Liver Transpl. Surg. 1(2), 124–138 (1995).
[Crossref] [PubMed]

1994 (2)

B. Vollmar, J. Glasz, R. Leiderer, S. Post, and M. D. Menger, “Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia-reperfusion,” Am. J. Pathol. 145(6), 1421–1431 (1994).
[PubMed]

K. Chun, J. Zhang, J. Biewer, D. Ferguson, and M. G. Clemens, “Microcirculatory failure determines lethal hepatocyte injury in ischemic/reperfused rat livers,” Shock 1(1), 3–9 (1994).
[Crossref] [PubMed]

1993 (1)

T. Kitai, A. Tanaka, A. Tokuka, K. Tanaka, Y. Yamaoka, K. Ozawa, and K. Hirao, “Quantitative detection of hemoglobin saturation in the liver with near-infrared spectroscopy,” Hepatology 18(4), 926–936 (1993).
[Crossref] [PubMed]

1992 (2)

M. D. Menger, S. Pelikan, D. Steiner, and K. Messmer, “Microvascular ischemia-reperfusion injury in striated muscle: significance of “reflow paradox”,” Am. J. Physiol. 263(6 Pt 2), H1901–H1906 (1992).
[PubMed]

M. Goto, S. Kawano, H. Yoshihara, Y. Takei, T. Hijioka, H. Fukui, T. Matsunaga, M. Oshita, T. Kashiwagi, H. Fusamoto, T. Kamada, and N. Sato, “Hepatic tissue oxygenation as a predictive indicator of ischemia-reperfusion liver injury,” Hepatology 15(3), 432–437 (1992).
[Crossref] [PubMed]

1989 (1)

J. C. Caldwell-Kenkel, R. T. Currin, Y. Tanaka, R. G. Thurman, and J. J. Lemasters, “Reperfusion injury to endothelial cells following cold ischemic storage of rat livers,” Hepatology 10(3), 292–299 (1989).
[Crossref] [PubMed]

1985 (2)

W. Kamiike, M. Nakahara, K. Nakao, M. Koseki, T. Nishida, Y. Kawashima, F. Watanabe, and K. Tagawa, “Correlation between cellular ATP level and bile excretion in the rat liver,” Transplantation 39(1), 50–55 (1985).
[Crossref] [PubMed]

M. G. Clemens, P. F. McDonagh, I. H. Chaudry, and A. E. Baue, “Hepatic microcirculatory failure after ischemia and reperfusion: improvement with ATP-MgCl2 treatment,” Am. J. Physiol. 248(6 Pt 2), H804–H811 (1985).
[PubMed]

1984 (1)

M. Ohkawa, I. H. Chaudry, M. G. Clemens, and A. E. Baue, “ATP-MgCl2 produces sustained improvement in hepatic mitochondrial function and blood flow after hepatic ischemia,” J. Surg. Res. 37(3), 226–234 (1984).
[Crossref] [PubMed]

1983 (1)

N. Sato, N. Hayashi, S. Kawano, T. Kamada, and H. Abe, “Hepatic hemodynamics in patients with chronic hepatitis or cirrhosis as assessed by organ-reflectance spectrophotometry,” Gastroenterology 84(3), 611–616 (1983).
[PubMed]

1980 (1)

S. Marubayashi, M. Takenaka, K. Dohi, H. Ezaki, and T. Kawasaki, “Adenine nucleotide metabolism during hepatic ischemia and subsequent blood reflow periods and its relation to organ viability,” Transplantation 30(4), 294–296 (1980).
[Crossref] [PubMed]

1976 (1)

B. I. Sykes, E. Penny, and I. F. Purchase, “Hepatocyte vacuolation and increased liver weight occurring in anoxic rats,” Toxicol. Appl. Pharmacol. 36(1), 31–39 (1976).
[Crossref] [PubMed]

1975 (1)

A. Koo, I. Y. Liang, and K. K. Cheng, “The terminal hepatic microcirculation in the rat,” Q. J. Exp. Physiol. Cogn. Med. Sci. 60(4), 261–266 (1975).
[Crossref] [PubMed]

1973 (1)

A. Leaf, “Cell swelling. A factor in ischemic tissue injury,” Circulation 48(3), 455–458 (1973).
[Crossref] [PubMed]

1946 (1)

O. A. Trowell, “The experimental production of watery vacuolation of the liver,” J. Physiol. 105(3), 268–297 (1946).
[Crossref] [PubMed]

1908 (1)

J. H. Pringle, “Notes on the arrest of hepatic hemorrhage due to trauma,” Ann. Surg. 48(4), 541–549 (1908).
[Crossref] [PubMed]

Abe, H.

N. Sato, N. Hayashi, S. Kawano, T. Kamada, and H. Abe, “Hepatic hemodynamics in patients with chronic hepatitis or cirrhosis as assessed by organ-reflectance spectrophotometry,” Gastroenterology 84(3), 611–616 (1983).
[PubMed]

Abookasis, D.

D. Abookasis, C. C. Lay, M. S. Mathews, M. E. Linskey, R. D. Frostig, and B. J. Tromberg, “Imaging cortical absorption, scattering, and hemodynamic response during ischemic stroke using spatially modulated near-infrared illumination,” J. Biomed. Opt. 14(2), 024033 (2009).
[Crossref] [PubMed]

Aizu, Y.

I. Nishidate, N. Tanaka, T. Kawase, T. Maeda, T. Yuasa, Y. Aizu, T. Yuasa, and K. Niizeki, “Noninvasive imaging of human skin hemodynamics using a digital red-green-blue camera,” J. Biomed. Opt. 16(8), 086012 (2011).
[Crossref] [PubMed]

Akter, S.

S. Akter, T. Tanabe, S. Maejima, S. Kawauchi, S. Sato, A. Hinoki, S. Aosasa, J. Yamamoto, and I. Nishidate, “In vivo estimation of optical properties of rat liver using single-reflectance fiber probe during ischemia and reperfusion,” Opt. Rev. 22(6), 1–6 (2015).

S. Akter, S. Maejima, S. Kawauchi, S. Sato, A. Hinoki, S. Aosasa, J. Yamamoto, and I. Nishidate, “Evaluation of light scattering and absorption properties of in vivo rat liver using a single-reflectance fiber probe during preischemia, ischemia-reperfusion, and postmortem,” J. Biomed. Opt. 20(7), 076010 (2015).
[Crossref] [PubMed]

Alessiani, M.

G. Oldani, M. Maestri, A. Gaspari, E. Lillo, G. Angelastri, L. M. Lenti, J. Rademacher, M. Alessiani, and P. Dionigi, “A novel technique for rat liver transplantation using Quick Linker system: a preliminary result,” J. Surg. Res. 149(2), 303–309 (2008).
[Crossref] [PubMed]

Angelastri, G.

G. Oldani, M. Maestri, A. Gaspari, E. Lillo, G. Angelastri, L. M. Lenti, J. Rademacher, M. Alessiani, and P. Dionigi, “A novel technique for rat liver transplantation using Quick Linker system: a preliminary result,” J. Surg. Res. 149(2), 303–309 (2008).
[Crossref] [PubMed]

Aosasa, S.

S. Akter, T. Tanabe, S. Maejima, S. Kawauchi, S. Sato, A. Hinoki, S. Aosasa, J. Yamamoto, and I. Nishidate, “In vivo estimation of optical properties of rat liver using single-reflectance fiber probe during ischemia and reperfusion,” Opt. Rev. 22(6), 1–6 (2015).

S. Akter, S. Maejima, S. Kawauchi, S. Sato, A. Hinoki, S. Aosasa, J. Yamamoto, and I. Nishidate, “Evaluation of light scattering and absorption properties of in vivo rat liver using a single-reflectance fiber probe during preischemia, ischemia-reperfusion, and postmortem,” J. Biomed. Opt. 20(7), 076010 (2015).
[Crossref] [PubMed]

Asada, H. H.

J. Yan, Y. Kang, S. Xu, L. L. S. Ong, S. Zhuo, R. M. Bunte, N. Chen, H. H. Asada, P. T. C. So, I. R. Wanless, and H. Yu, “In vivo label-free quantification of liver microcirculation using dual-modality microscopy,” J. Biomed. Opt. 19(11), 116006 (2014).
[Crossref] [PubMed]

Auberger, P.

R. Cursio, P. Colosetti, M. C. Saint-Paul, S. Pagnotta, P. Gounon, A. Iannelli, P. Auberger, and J. Gugenheim, “Induction of different types of cell death after normothermic liver ischemia-reperfusion,” Transplant. Proc. 42(10), 3977–3980 (2010).
[Crossref] [PubMed]

Baue, A. E.

M. G. Clemens, P. F. McDonagh, I. H. Chaudry, and A. E. Baue, “Hepatic microcirculatory failure after ischemia and reperfusion: improvement with ATP-MgCl2 treatment,” Am. J. Physiol. 248(6 Pt 2), H804–H811 (1985).
[PubMed]

M. Ohkawa, I. H. Chaudry, M. G. Clemens, and A. E. Baue, “ATP-MgCl2 produces sustained improvement in hepatic mitochondrial function and blood flow after hepatic ischemia,” J. Surg. Res. 37(3), 226–234 (1984).
[Crossref] [PubMed]

Biewer, J.

K. Chun, J. Zhang, J. Biewer, D. Ferguson, and M. G. Clemens, “Microcirculatory failure determines lethal hepatocyte injury in ischemic/reperfused rat livers,” Shock 1(1), 3–9 (1994).
[Crossref] [PubMed]

Bigio, I. J.

Boyer, J.

Bridle, K. R.

Bunte, R. M.

J. Yan, Y. Kang, S. Xu, L. L. S. Ong, S. Zhuo, R. M. Bunte, N. Chen, H. H. Asada, P. T. C. So, I. R. Wanless, and H. Yu, “In vivo label-free quantification of liver microcirculation using dual-modality microscopy,” J. Biomed. Opt. 19(11), 116006 (2014).
[Crossref] [PubMed]

Bunzendahl, H.

J. J. Lemasters, H. Bunzendahl, and R. G. Thurman, “Reperfusion injury to donor livers stored for transplantation,” Liver Transpl. Surg. 1(2), 124–138 (1995).
[Crossref] [PubMed]

Burczynski, F. J.

F. J. Burczynski, B. A. Luxon, and R. A. Weisiger, “Intrahepatic blood flow distribution in the perfused rat liver: effect of hepatic artery perfusion,” Am. J. Physiol. 271(4 Pt 1), G561–G567 (1996).
[PubMed]

Busuttil, R. W.

J. W. Kupiec-Weglinski and R. W. Busuttil, “Ischemia and reperfusion injury in liver transplantation,” Transplant. Proc. 37(4), 1653–1656 (2005).
[Crossref] [PubMed]

Caldwell-Kenkel, J. C.

J. C. Caldwell-Kenkel, R. T. Currin, Y. Tanaka, R. G. Thurman, and J. J. Lemasters, “Reperfusion injury to endothelial cells following cold ischemic storage of rat livers,” Hepatology 10(3), 292–299 (1989).
[Crossref] [PubMed]

Chang, W. T.

H. H. Lu, Y. M. Wu, W. T. Chang, T. Luo, Y. C. Yang, H. D. Cho, and I. Liau, “Molecular imaging of ischemia and reperfusion in vivo with mitochondrial autofluorescence,” Anal. Chem. 86(10), 5024–5031 (2014).
[Crossref] [PubMed]

Chaudry, I. H.

M. G. Clemens, P. F. McDonagh, I. H. Chaudry, and A. E. Baue, “Hepatic microcirculatory failure after ischemia and reperfusion: improvement with ATP-MgCl2 treatment,” Am. J. Physiol. 248(6 Pt 2), H804–H811 (1985).
[PubMed]

M. Ohkawa, I. H. Chaudry, M. G. Clemens, and A. E. Baue, “ATP-MgCl2 produces sustained improvement in hepatic mitochondrial function and blood flow after hepatic ischemia,” J. Surg. Res. 37(3), 226–234 (1984).
[Crossref] [PubMed]

Chen, N.

J. Yan, Y. Kang, S. Xu, L. L. S. Ong, S. Zhuo, R. M. Bunte, N. Chen, H. H. Asada, P. T. C. So, I. R. Wanless, and H. Yu, “In vivo label-free quantification of liver microcirculation using dual-modality microscopy,” J. Biomed. Opt. 19(11), 116006 (2014).
[Crossref] [PubMed]

Cheng, K. K.

A. Koo, I. Y. Liang, and K. K. Cheng, “The terminal hepatic microcirculation in the rat,” Q. J. Exp. Physiol. Cogn. Med. Sci. 60(4), 261–266 (1975).
[Crossref] [PubMed]

Cho, H. D.

H. H. Lu, Y. M. Wu, W. T. Chang, T. Luo, Y. C. Yang, H. D. Cho, and I. Liau, “Molecular imaging of ischemia and reperfusion in vivo with mitochondrial autofluorescence,” Anal. Chem. 86(10), 5024–5031 (2014).
[Crossref] [PubMed]

Chun, K.

K. Chun, J. Zhang, J. Biewer, D. Ferguson, and M. G. Clemens, “Microcirculatory failure determines lethal hepatocyte injury in ischemic/reperfused rat livers,” Shock 1(1), 3–9 (1994).
[Crossref] [PubMed]

Clemens, M. G.

K. Chun, J. Zhang, J. Biewer, D. Ferguson, and M. G. Clemens, “Microcirculatory failure determines lethal hepatocyte injury in ischemic/reperfused rat livers,” Shock 1(1), 3–9 (1994).
[Crossref] [PubMed]

M. G. Clemens, P. F. McDonagh, I. H. Chaudry, and A. E. Baue, “Hepatic microcirculatory failure after ischemia and reperfusion: improvement with ATP-MgCl2 treatment,” Am. J. Physiol. 248(6 Pt 2), H804–H811 (1985).
[PubMed]

M. Ohkawa, I. H. Chaudry, M. G. Clemens, and A. E. Baue, “ATP-MgCl2 produces sustained improvement in hepatic mitochondrial function and blood flow after hepatic ischemia,” J. Surg. Res. 37(3), 226–234 (1984).
[Crossref] [PubMed]

Colosetti, P.

R. Cursio, P. Colosetti, M. C. Saint-Paul, S. Pagnotta, P. Gounon, A. Iannelli, P. Auberger, and J. Gugenheim, “Induction of different types of cell death after normothermic liver ischemia-reperfusion,” Transplant. Proc. 42(10), 3977–3980 (2010).
[Crossref] [PubMed]

Crawford, D. H.

Currin, R. T.

J. C. Caldwell-Kenkel, R. T. Currin, Y. Tanaka, R. G. Thurman, and J. J. Lemasters, “Reperfusion injury to endothelial cells following cold ischemic storage of rat livers,” Hepatology 10(3), 292–299 (1989).
[Crossref] [PubMed]

Cursio, R.

R. Cursio, P. Colosetti, M. C. Saint-Paul, S. Pagnotta, P. Gounon, A. Iannelli, P. Auberger, and J. Gugenheim, “Induction of different types of cell death after normothermic liver ischemia-reperfusion,” Transplant. Proc. 42(10), 3977–3980 (2010).
[Crossref] [PubMed]

Davidson, B. R.

A. E. El-Desoky, D. T. Delpy, B. R. Davidson, and A. M. Seifalian, “Assessment of hepatic ischaemia reperfusion injury by measuring intracellular tissue oxygenation using near infrared spectroscopy,” Liver 21(1), 37–44 (2001).
[Crossref] [PubMed]

Delpy, D. T.

A. E. El-Desoky, D. T. Delpy, B. R. Davidson, and A. M. Seifalian, “Assessment of hepatic ischaemia reperfusion injury by measuring intracellular tissue oxygenation using near infrared spectroscopy,” Liver 21(1), 37–44 (2001).
[Crossref] [PubMed]

Dionigi, P.

G. Oldani, M. Maestri, A. Gaspari, E. Lillo, G. Angelastri, L. M. Lenti, J. Rademacher, M. Alessiani, and P. Dionigi, “A novel technique for rat liver transplantation using Quick Linker system: a preliminary result,” J. Surg. Res. 149(2), 303–309 (2008).
[Crossref] [PubMed]

Dohi, K.

S. Marubayashi, M. Takenaka, K. Dohi, H. Ezaki, and T. Kawasaki, “Adenine nucleotide metabolism during hepatic ischemia and subsequent blood reflow periods and its relation to organ viability,” Transplantation 30(4), 294–296 (1980).
[Crossref] [PubMed]

Dong, J.

L. Yao, C. Li, X. Ge, H. Wang, K. Xu, A. Zhang, and J. Dong, “Establishment of a rat model of portal vein ligation combined with in situ splitting,” PLoS One 9(8), e105511 (2014).
[Crossref] [PubMed]

Dong, J. H.

C. H. Li, H. D. Wang, J. J. Hu, X. L. Ge, K. Pan, A. Q. Zhang, and J. H. Dong, “The monitoring of microvascular liver blood flow changes during ischemia and reperfusion using laser speckle contrast imaging,” Microvasc. Res. 94, 28–35 (2014).
[Crossref] [PubMed]

Eick, A. A.

El-Desoky, A. E.

A. E. El-Desoky, D. T. Delpy, B. R. Davidson, and A. M. Seifalian, “Assessment of hepatic ischaemia reperfusion injury by measuring intracellular tissue oxygenation using near infrared spectroscopy,” Liver 21(1), 37–44 (2001).
[Crossref] [PubMed]

Engelhardt, J. F.

R. M. Zwacka, Y. Zhang, W. Zhou, J. Halldorson, and J. F. Engelhardt, “Ischemia/reperfusion injury in the liver of BALB/c mice activates AP-1 and nuclear factor kappaB independently of IkappaB degradation,” Hepatology 28(4), 1022–1030 (1998).
[Crossref] [PubMed]

Ezaki, H.

S. Marubayashi, M. Takenaka, K. Dohi, H. Ezaki, and T. Kawasaki, “Adenine nucleotide metabolism during hepatic ischemia and subsequent blood reflow periods and its relation to organ viability,” Transplantation 30(4), 294–296 (1980).
[Crossref] [PubMed]

Ferguson, D.

K. Chun, J. Zhang, J. Biewer, D. Ferguson, and M. G. Clemens, “Microcirculatory failure determines lethal hepatocyte injury in ischemic/reperfused rat livers,” Shock 1(1), 3–9 (1994).
[Crossref] [PubMed]

Freyer, J. P.

Frostig, R. D.

D. Abookasis, C. C. Lay, M. S. Mathews, M. E. Linskey, R. D. Frostig, and B. J. Tromberg, “Imaging cortical absorption, scattering, and hemodynamic response during ischemic stroke using spatially modulated near-infrared illumination,” J. Biomed. Opt. 14(2), 024033 (2009).
[Crossref] [PubMed]

Fukui, H.

M. Goto, S. Kawano, H. Yoshihara, Y. Takei, T. Hijioka, H. Fukui, T. Matsunaga, M. Oshita, T. Kashiwagi, H. Fusamoto, T. Kamada, and N. Sato, “Hepatic tissue oxygenation as a predictive indicator of ischemia-reperfusion liver injury,” Hepatology 15(3), 432–437 (1992).
[Crossref] [PubMed]

Fusamoto, H.

M. Goto, S. Kawano, H. Yoshihara, Y. Takei, T. Hijioka, H. Fukui, T. Matsunaga, M. Oshita, T. Kashiwagi, H. Fusamoto, T. Kamada, and N. Sato, “Hepatic tissue oxygenation as a predictive indicator of ischemia-reperfusion liver injury,” Hepatology 15(3), 432–437 (1992).
[Crossref] [PubMed]

Fuselier, T.

Gaspari, A.

G. Oldani, M. Maestri, A. Gaspari, E. Lillo, G. Angelastri, L. M. Lenti, J. Rademacher, M. Alessiani, and P. Dionigi, “A novel technique for rat liver transplantation using Quick Linker system: a preliminary result,” J. Surg. Res. 149(2), 303–309 (2008).
[Crossref] [PubMed]

Ge, X.

L. Yao, C. Li, X. Ge, H. Wang, K. Xu, A. Zhang, and J. Dong, “Establishment of a rat model of portal vein ligation combined with in situ splitting,” PLoS One 9(8), e105511 (2014).
[Crossref] [PubMed]

Ge, X. L.

C. H. Li, H. D. Wang, J. J. Hu, X. L. Ge, K. Pan, A. Q. Zhang, and J. H. Dong, “The monitoring of microvascular liver blood flow changes during ischemia and reperfusion using laser speckle contrast imaging,” Microvasc. Res. 94, 28–35 (2014).
[Crossref] [PubMed]

Glasz, J.

B. Vollmar, J. Glasz, R. Leiderer, S. Post, and M. D. Menger, “Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia-reperfusion,” Am. J. Pathol. 145(6), 1421–1431 (1994).
[PubMed]

Goto, M.

M. Goto, S. Kawano, H. Yoshihara, Y. Takei, T. Hijioka, H. Fukui, T. Matsunaga, M. Oshita, T. Kashiwagi, H. Fusamoto, T. Kamada, and N. Sato, “Hepatic tissue oxygenation as a predictive indicator of ischemia-reperfusion liver injury,” Hepatology 15(3), 432–437 (1992).
[Crossref] [PubMed]

Gounon, P.

R. Cursio, P. Colosetti, M. C. Saint-Paul, S. Pagnotta, P. Gounon, A. Iannelli, P. Auberger, and J. Gugenheim, “Induction of different types of cell death after normothermic liver ischemia-reperfusion,” Transplant. Proc. 42(10), 3977–3980 (2010).
[Crossref] [PubMed]

Grice, J. E.

Gugenheim, J.

R. Cursio, P. Colosetti, M. C. Saint-Paul, S. Pagnotta, P. Gounon, A. Iannelli, P. Auberger, and J. Gugenheim, “Induction of different types of cell death after normothermic liver ischemia-reperfusion,” Transplant. Proc. 42(10), 3977–3980 (2010).
[Crossref] [PubMed]

Halldorson, J.

R. M. Zwacka, Y. Zhang, W. Zhou, J. Halldorson, and J. F. Engelhardt, “Ischemia/reperfusion injury in the liver of BALB/c mice activates AP-1 and nuclear factor kappaB independently of IkappaB degradation,” Hepatology 28(4), 1022–1030 (1998).
[Crossref] [PubMed]

Hayashi, N.

N. Sato, N. Hayashi, S. Kawano, T. Kamada, and H. Abe, “Hepatic hemodynamics in patients with chronic hepatitis or cirrhosis as assessed by organ-reflectance spectrophotometry,” Gastroenterology 84(3), 611–616 (1983).
[PubMed]

Hielscher, A. H.

Hijioka, T.

M. Goto, S. Kawano, H. Yoshihara, Y. Takei, T. Hijioka, H. Fukui, T. Matsunaga, M. Oshita, T. Kashiwagi, H. Fusamoto, T. Kamada, and N. Sato, “Hepatic tissue oxygenation as a predictive indicator of ischemia-reperfusion liver injury,” Hepatology 15(3), 432–437 (1992).
[Crossref] [PubMed]

Hinoki, A.

S. Akter, S. Maejima, S. Kawauchi, S. Sato, A. Hinoki, S. Aosasa, J. Yamamoto, and I. Nishidate, “Evaluation of light scattering and absorption properties of in vivo rat liver using a single-reflectance fiber probe during preischemia, ischemia-reperfusion, and postmortem,” J. Biomed. Opt. 20(7), 076010 (2015).
[Crossref] [PubMed]

S. Akter, T. Tanabe, S. Maejima, S. Kawauchi, S. Sato, A. Hinoki, S. Aosasa, J. Yamamoto, and I. Nishidate, “In vivo estimation of optical properties of rat liver using single-reflectance fiber probe during ischemia and reperfusion,” Opt. Rev. 22(6), 1–6 (2015).

Hirano, T.

T. Kondo, T. Todoroki, T. Hirano, F. W. Schildberg, and K. Messmer, “Impact of ischemia-reperfusion injury on dimensional changes of hepatic microvessels,” Res. Exp. Med. (Berl.) 198(2), 63–72 (1998).
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Hirao, K.

T. Kitai, A. Tanaka, A. Tokuka, K. Tanaka, Y. Yamaoka, K. Ozawa, and K. Hirao, “Quantitative detection of hemoglobin saturation in the liver with near-infrared spectroscopy,” Hepatology 18(4), 926–936 (1993).
[Crossref] [PubMed]

Hu, J. J.

C. H. Li, H. D. Wang, J. J. Hu, X. L. Ge, K. Pan, A. Q. Zhang, and J. H. Dong, “The monitoring of microvascular liver blood flow changes during ischemia and reperfusion using laser speckle contrast imaging,” Microvasc. Res. 94, 28–35 (2014).
[Crossref] [PubMed]

Iannelli, A.

R. Cursio, P. Colosetti, M. C. Saint-Paul, S. Pagnotta, P. Gounon, A. Iannelli, P. Auberger, and J. Gugenheim, “Induction of different types of cell death after normothermic liver ischemia-reperfusion,” Transplant. Proc. 42(10), 3977–3980 (2010).
[Crossref] [PubMed]

Ishizuka, T.

I. Nishidate, T. Ishizuka, A. Mustari, K. Yoshida, S. Kawauchi, S. Sato, and M. Sato, “Evaluation of cerebral hemodynamics and tissue morphology of in vivo rat brain using spectral diffuse reflectance imaging,” Appl. Spectrosc. 2016, 03702816657569 (2016).
[PubMed]

K. Yoshida, I. Nishidate, T. Ishizuka, S. Kawauchi, S. Sato, and M. Sato, “Multispectral imaging of absorption and scattering properties of in vivo exposed rat brain using a digital red-green-blue camera,” J. Biomed. Opt. 20(5), 051026 (2015).
[Crossref] [PubMed]

Jacques, S. L.

J. C. Ramella-Roman, K. Lee, S. A. Prahl, and S. L. Jacques, “Design, testing, and clinical studies of a handheld polarized light camera,” J. Biomed. Opt. 9(6), 1305–1310 (2004).
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L. Wang, S. L. Jacques, and L. Zheng, “MCML--Monte Carlo modeling of light transport in multi-layered tissues,” Comput. Methods Programs Biomed. 47(2), 131–146 (1995).
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Jaeschke, H.

H. Jaeschke and J. J. Lemasters, “Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury,” Gastroenterology 125(4), 1246–1257 (2003).
[Crossref] [PubMed]

Jiang, S.

X. Wang, B. W. Pogue, S. Jiang, X. Song, K. D. Paulsen, C. Kogel, S. P. Poplack, and W. A. Wells, “Approximation of Mie scattering parameters in near-infrared tomography of normal breast tissue in vivo,” J. Biomed. Opt. 10(5), 051704 (2005).
[Crossref] [PubMed]

Johnson, T. M.

Kamada, T.

M. Goto, S. Kawano, H. Yoshihara, Y. Takei, T. Hijioka, H. Fukui, T. Matsunaga, M. Oshita, T. Kashiwagi, H. Fusamoto, T. Kamada, and N. Sato, “Hepatic tissue oxygenation as a predictive indicator of ischemia-reperfusion liver injury,” Hepatology 15(3), 432–437 (1992).
[Crossref] [PubMed]

N. Sato, N. Hayashi, S. Kawano, T. Kamada, and H. Abe, “Hepatic hemodynamics in patients with chronic hepatitis or cirrhosis as assessed by organ-reflectance spectrophotometry,” Gastroenterology 84(3), 611–616 (1983).
[PubMed]

Kamiike, W.

W. Kamiike, M. Nakahara, K. Nakao, M. Koseki, T. Nishida, Y. Kawashima, F. Watanabe, and K. Tagawa, “Correlation between cellular ATP level and bile excretion in the rat liver,” Transplantation 39(1), 50–55 (1985).
[Crossref] [PubMed]

Kang, Y.

J. Yan, Y. Kang, S. Xu, L. L. S. Ong, S. Zhuo, R. M. Bunte, N. Chen, H. H. Asada, P. T. C. So, I. R. Wanless, and H. Yu, “In vivo label-free quantification of liver microcirculation using dual-modality microscopy,” J. Biomed. Opt. 19(11), 116006 (2014).
[Crossref] [PubMed]

Kashiwagi, T.

M. Goto, S. Kawano, H. Yoshihara, Y. Takei, T. Hijioka, H. Fukui, T. Matsunaga, M. Oshita, T. Kashiwagi, H. Fusamoto, T. Kamada, and N. Sato, “Hepatic tissue oxygenation as a predictive indicator of ischemia-reperfusion liver injury,” Hepatology 15(3), 432–437 (1992).
[Crossref] [PubMed]

Kawano, S.

M. Goto, S. Kawano, H. Yoshihara, Y. Takei, T. Hijioka, H. Fukui, T. Matsunaga, M. Oshita, T. Kashiwagi, H. Fusamoto, T. Kamada, and N. Sato, “Hepatic tissue oxygenation as a predictive indicator of ischemia-reperfusion liver injury,” Hepatology 15(3), 432–437 (1992).
[Crossref] [PubMed]

N. Sato, N. Hayashi, S. Kawano, T. Kamada, and H. Abe, “Hepatic hemodynamics in patients with chronic hepatitis or cirrhosis as assessed by organ-reflectance spectrophotometry,” Gastroenterology 84(3), 611–616 (1983).
[PubMed]

Kawasaki, T.

S. Marubayashi, M. Takenaka, K. Dohi, H. Ezaki, and T. Kawasaki, “Adenine nucleotide metabolism during hepatic ischemia and subsequent blood reflow periods and its relation to organ viability,” Transplantation 30(4), 294–296 (1980).
[Crossref] [PubMed]

Kawase, T.

I. Nishidate, N. Tanaka, T. Kawase, T. Maeda, T. Yuasa, Y. Aizu, T. Yuasa, and K. Niizeki, “Noninvasive imaging of human skin hemodynamics using a digital red-green-blue camera,” J. Biomed. Opt. 16(8), 086012 (2011).
[Crossref] [PubMed]

Kawashima, Y.

W. Kamiike, M. Nakahara, K. Nakao, M. Koseki, T. Nishida, Y. Kawashima, F. Watanabe, and K. Tagawa, “Correlation between cellular ATP level and bile excretion in the rat liver,” Transplantation 39(1), 50–55 (1985).
[Crossref] [PubMed]

Kawauchi, S.

I. Nishidate, T. Ishizuka, A. Mustari, K. Yoshida, S. Kawauchi, S. Sato, and M. Sato, “Evaluation of cerebral hemodynamics and tissue morphology of in vivo rat brain using spectral diffuse reflectance imaging,” Appl. Spectrosc. 2016, 03702816657569 (2016).
[PubMed]

K. Yoshida, I. Nishidate, T. Ishizuka, S. Kawauchi, S. Sato, and M. Sato, “Multispectral imaging of absorption and scattering properties of in vivo exposed rat brain using a digital red-green-blue camera,” J. Biomed. Opt. 20(5), 051026 (2015).
[Crossref] [PubMed]

S. Akter, T. Tanabe, S. Maejima, S. Kawauchi, S. Sato, A. Hinoki, S. Aosasa, J. Yamamoto, and I. Nishidate, “In vivo estimation of optical properties of rat liver using single-reflectance fiber probe during ischemia and reperfusion,” Opt. Rev. 22(6), 1–6 (2015).

S. Akter, S. Maejima, S. Kawauchi, S. Sato, A. Hinoki, S. Aosasa, J. Yamamoto, and I. Nishidate, “Evaluation of light scattering and absorption properties of in vivo rat liver using a single-reflectance fiber probe during preischemia, ischemia-reperfusion, and postmortem,” J. Biomed. Opt. 20(7), 076010 (2015).
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Kitai, T.

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A. Koo, I. Y. Liang, and K. K. Cheng, “The terminal hepatic microcirculation in the rat,” Q. J. Exp. Physiol. Cogn. Med. Sci. 60(4), 261–266 (1975).
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M. D. Menger, S. Pelikan, D. Steiner, and K. Messmer, “Microvascular ischemia-reperfusion injury in striated muscle: significance of “reflow paradox”,” Am. J. Physiol. 263(6 Pt 2), H1901–H1906 (1992).
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C. Sturesson, D. M. Milstein, I. C. Post, A. M. Maas, and T. M. van Gulik, “Laser speckle contrast imaging for assessment of liver microcirculation,” Microvasc. Res. 87, 34–40 (2013).
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Mourant, J. R.

Mustari, A.

I. Nishidate, T. Ishizuka, A. Mustari, K. Yoshida, S. Kawauchi, S. Sato, and M. Sato, “Evaluation of cerebral hemodynamics and tissue morphology of in vivo rat brain using spectral diffuse reflectance imaging,” Appl. Spectrosc. 2016, 03702816657569 (2016).
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W. Kamiike, M. Nakahara, K. Nakao, M. Koseki, T. Nishida, Y. Kawashima, F. Watanabe, and K. Tagawa, “Correlation between cellular ATP level and bile excretion in the rat liver,” Transplantation 39(1), 50–55 (1985).
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I. Nishidate, N. Tanaka, T. Kawase, T. Maeda, T. Yuasa, Y. Aizu, T. Yuasa, and K. Niizeki, “Noninvasive imaging of human skin hemodynamics using a digital red-green-blue camera,” J. Biomed. Opt. 16(8), 086012 (2011).
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I. Nishidate, T. Ishizuka, A. Mustari, K. Yoshida, S. Kawauchi, S. Sato, and M. Sato, “Evaluation of cerebral hemodynamics and tissue morphology of in vivo rat brain using spectral diffuse reflectance imaging,” Appl. Spectrosc. 2016, 03702816657569 (2016).
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S. Akter, T. Tanabe, S. Maejima, S. Kawauchi, S. Sato, A. Hinoki, S. Aosasa, J. Yamamoto, and I. Nishidate, “In vivo estimation of optical properties of rat liver using single-reflectance fiber probe during ischemia and reperfusion,” Opt. Rev. 22(6), 1–6 (2015).

S. Akter, S. Maejima, S. Kawauchi, S. Sato, A. Hinoki, S. Aosasa, J. Yamamoto, and I. Nishidate, “Evaluation of light scattering and absorption properties of in vivo rat liver using a single-reflectance fiber probe during preischemia, ischemia-reperfusion, and postmortem,” J. Biomed. Opt. 20(7), 076010 (2015).
[Crossref] [PubMed]

I. Nishidate, N. Tanaka, T. Kawase, T. Maeda, T. Yuasa, Y. Aizu, T. Yuasa, and K. Niizeki, “Noninvasive imaging of human skin hemodynamics using a digital red-green-blue camera,” J. Biomed. Opt. 16(8), 086012 (2011).
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M. Ohkawa, I. H. Chaudry, M. G. Clemens, and A. E. Baue, “ATP-MgCl2 produces sustained improvement in hepatic mitochondrial function and blood flow after hepatic ischemia,” J. Surg. Res. 37(3), 226–234 (1984).
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T. Kitai, A. Tanaka, A. Tokuka, K. Tanaka, Y. Yamaoka, K. Ozawa, and K. Hirao, “Quantitative detection of hemoglobin saturation in the liver with near-infrared spectroscopy,” Hepatology 18(4), 926–936 (1993).
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C. H. Li, H. D. Wang, J. J. Hu, X. L. Ge, K. Pan, A. Q. Zhang, and J. H. Dong, “The monitoring of microvascular liver blood flow changes during ischemia and reperfusion using laser speckle contrast imaging,” Microvasc. Res. 94, 28–35 (2014).
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X. Wang, B. W. Pogue, S. Jiang, X. Song, K. D. Paulsen, C. Kogel, S. P. Poplack, and W. A. Wells, “Approximation of Mie scattering parameters in near-infrared tomography of normal breast tissue in vivo,” J. Biomed. Opt. 10(5), 051704 (2005).
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Pelikan, S.

M. D. Menger, S. Pelikan, D. Steiner, and K. Messmer, “Microvascular ischemia-reperfusion injury in striated muscle: significance of “reflow paradox”,” Am. J. Physiol. 263(6 Pt 2), H1901–H1906 (1992).
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X. Wang, B. W. Pogue, S. Jiang, X. Song, K. D. Paulsen, C. Kogel, S. P. Poplack, and W. A. Wells, “Approximation of Mie scattering parameters in near-infrared tomography of normal breast tissue in vivo,” J. Biomed. Opt. 10(5), 051704 (2005).
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X. Wang, B. W. Pogue, S. Jiang, X. Song, K. D. Paulsen, C. Kogel, S. P. Poplack, and W. A. Wells, “Approximation of Mie scattering parameters in near-infrared tomography of normal breast tissue in vivo,” J. Biomed. Opt. 10(5), 051704 (2005).
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Post, I. C.

C. Sturesson, D. M. Milstein, I. C. Post, A. M. Maas, and T. M. van Gulik, “Laser speckle contrast imaging for assessment of liver microcirculation,” Microvasc. Res. 87, 34–40 (2013).
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Post, S.

B. Vollmar, J. Glasz, R. Leiderer, S. Post, and M. D. Menger, “Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia-reperfusion,” Am. J. Pathol. 145(6), 1421–1431 (1994).
[PubMed]

Prahl, S. A.

J. C. Ramella-Roman, K. Lee, S. A. Prahl, and S. L. Jacques, “Design, testing, and clinical studies of a handheld polarized light camera,” J. Biomed. Opt. 9(6), 1305–1310 (2004).
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B. I. Sykes, E. Penny, and I. F. Purchase, “Hepatocyte vacuolation and increased liver weight occurring in anoxic rats,” Toxicol. Appl. Pharmacol. 36(1), 31–39 (1976).
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Rademacher, J.

G. Oldani, M. Maestri, A. Gaspari, E. Lillo, G. Angelastri, L. M. Lenti, J. Rademacher, M. Alessiani, and P. Dionigi, “A novel technique for rat liver transplantation using Quick Linker system: a preliminary result,” J. Surg. Res. 149(2), 303–309 (2008).
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Ramella-Roman, J. C.

J. C. Ramella-Roman, K. Lee, S. A. Prahl, and S. L. Jacques, “Design, testing, and clinical studies of a handheld polarized light camera,” J. Biomed. Opt. 9(6), 1305–1310 (2004).
[Crossref] [PubMed]

Roberts, M. S.

Rücker, M.

M. D. Menger, M. Rücker, and B. Vollmar, “Capillary dysfunction in striated muscle ischemia/reperfusion: on the mechanisms of capillary “no-reflow”,” Shock 8(1), 2–7 (1997).
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Saint-Paul, M. C.

R. Cursio, P. Colosetti, M. C. Saint-Paul, S. Pagnotta, P. Gounon, A. Iannelli, P. Auberger, and J. Gugenheim, “Induction of different types of cell death after normothermic liver ischemia-reperfusion,” Transplant. Proc. 42(10), 3977–3980 (2010).
[Crossref] [PubMed]

Sato, M.

I. Nishidate, T. Ishizuka, A. Mustari, K. Yoshida, S. Kawauchi, S. Sato, and M. Sato, “Evaluation of cerebral hemodynamics and tissue morphology of in vivo rat brain using spectral diffuse reflectance imaging,” Appl. Spectrosc. 2016, 03702816657569 (2016).
[PubMed]

K. Yoshida, I. Nishidate, T. Ishizuka, S. Kawauchi, S. Sato, and M. Sato, “Multispectral imaging of absorption and scattering properties of in vivo exposed rat brain using a digital red-green-blue camera,” J. Biomed. Opt. 20(5), 051026 (2015).
[Crossref] [PubMed]

Sato, N.

M. Goto, S. Kawano, H. Yoshihara, Y. Takei, T. Hijioka, H. Fukui, T. Matsunaga, M. Oshita, T. Kashiwagi, H. Fusamoto, T. Kamada, and N. Sato, “Hepatic tissue oxygenation as a predictive indicator of ischemia-reperfusion liver injury,” Hepatology 15(3), 432–437 (1992).
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Sato, S.

I. Nishidate, T. Ishizuka, A. Mustari, K. Yoshida, S. Kawauchi, S. Sato, and M. Sato, “Evaluation of cerebral hemodynamics and tissue morphology of in vivo rat brain using spectral diffuse reflectance imaging,” Appl. Spectrosc. 2016, 03702816657569 (2016).
[PubMed]

K. Yoshida, I. Nishidate, T. Ishizuka, S. Kawauchi, S. Sato, and M. Sato, “Multispectral imaging of absorption and scattering properties of in vivo exposed rat brain using a digital red-green-blue camera,” J. Biomed. Opt. 20(5), 051026 (2015).
[Crossref] [PubMed]

S. Akter, T. Tanabe, S. Maejima, S. Kawauchi, S. Sato, A. Hinoki, S. Aosasa, J. Yamamoto, and I. Nishidate, “In vivo estimation of optical properties of rat liver using single-reflectance fiber probe during ischemia and reperfusion,” Opt. Rev. 22(6), 1–6 (2015).

S. Akter, S. Maejima, S. Kawauchi, S. Sato, A. Hinoki, S. Aosasa, J. Yamamoto, and I. Nishidate, “Evaluation of light scattering and absorption properties of in vivo rat liver using a single-reflectance fiber probe during preischemia, ischemia-reperfusion, and postmortem,” J. Biomed. Opt. 20(7), 076010 (2015).
[Crossref] [PubMed]

Schildberg, F. W.

T. Kondo, T. Todoroki, T. Hirano, F. W. Schildberg, and K. Messmer, “Impact of ischemia-reperfusion injury on dimensional changes of hepatic microvessels,” Res. Exp. Med. (Berl.) 198(2), 63–72 (1998).
[Crossref] [PubMed]

Schirrmeister, W.

M. Kretzschmar, A. Krüger, W. Schirrmeister, A. Krüger, and W. Schirrmeister, “Hepatic ischemia-reperfusion syndrome after partial liver resection (LR): hepatic venous oxygen saturation, enzyme pattern, reduced and oxidized glutathione, procalcitonin and interleukin-6,” Exp. Toxicol. Pathol. 54(5-6), 423–431 (2003).
[Crossref] [PubMed]

M. Kretzschmar, A. Krüger, W. Schirrmeister, A. Krüger, and W. Schirrmeister, “Hepatic ischemia-reperfusion syndrome after partial liver resection (LR): hepatic venous oxygen saturation, enzyme pattern, reduced and oxidized glutathione, procalcitonin and interleukin-6,” Exp. Toxicol. Pathol. 54(5-6), 423–431 (2003).
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Shen, D.

So, P. T. C.

J. Yan, Y. Kang, S. Xu, L. L. S. Ong, S. Zhuo, R. M. Bunte, N. Chen, H. H. Asada, P. T. C. So, I. R. Wanless, and H. Yu, “In vivo label-free quantification of liver microcirculation using dual-modality microscopy,” J. Biomed. Opt. 19(11), 116006 (2014).
[Crossref] [PubMed]

Song, X.

X. Wang, B. W. Pogue, S. Jiang, X. Song, K. D. Paulsen, C. Kogel, S. P. Poplack, and W. A. Wells, “Approximation of Mie scattering parameters in near-infrared tomography of normal breast tissue in vivo,” J. Biomed. Opt. 10(5), 051704 (2005).
[Crossref] [PubMed]

Steiner, D.

M. D. Menger, S. Pelikan, D. Steiner, and K. Messmer, “Microvascular ischemia-reperfusion injury in striated muscle: significance of “reflow paradox”,” Am. J. Physiol. 263(6 Pt 2), H1901–H1906 (1992).
[PubMed]

Sturesson, C.

C. Sturesson, D. M. Milstein, I. C. Post, A. M. Maas, and T. M. van Gulik, “Laser speckle contrast imaging for assessment of liver microcirculation,” Microvasc. Res. 87, 34–40 (2013).
[Crossref] [PubMed]

Sykes, B. I.

B. I. Sykes, E. Penny, and I. F. Purchase, “Hepatocyte vacuolation and increased liver weight occurring in anoxic rats,” Toxicol. Appl. Pharmacol. 36(1), 31–39 (1976).
[Crossref] [PubMed]

Tagawa, K.

W. Kamiike, M. Nakahara, K. Nakao, M. Koseki, T. Nishida, Y. Kawashima, F. Watanabe, and K. Tagawa, “Correlation between cellular ATP level and bile excretion in the rat liver,” Transplantation 39(1), 50–55 (1985).
[Crossref] [PubMed]

Takei, Y.

M. Goto, S. Kawano, H. Yoshihara, Y. Takei, T. Hijioka, H. Fukui, T. Matsunaga, M. Oshita, T. Kashiwagi, H. Fusamoto, T. Kamada, and N. Sato, “Hepatic tissue oxygenation as a predictive indicator of ischemia-reperfusion liver injury,” Hepatology 15(3), 432–437 (1992).
[Crossref] [PubMed]

Takenaka, M.

S. Marubayashi, M. Takenaka, K. Dohi, H. Ezaki, and T. Kawasaki, “Adenine nucleotide metabolism during hepatic ischemia and subsequent blood reflow periods and its relation to organ viability,” Transplantation 30(4), 294–296 (1980).
[Crossref] [PubMed]

Tanabe, T.

S. Akter, T. Tanabe, S. Maejima, S. Kawauchi, S. Sato, A. Hinoki, S. Aosasa, J. Yamamoto, and I. Nishidate, “In vivo estimation of optical properties of rat liver using single-reflectance fiber probe during ischemia and reperfusion,” Opt. Rev. 22(6), 1–6 (2015).

Tanaka, A.

T. Kitai, A. Tanaka, A. Tokuka, K. Tanaka, Y. Yamaoka, K. Ozawa, and K. Hirao, “Quantitative detection of hemoglobin saturation in the liver with near-infrared spectroscopy,” Hepatology 18(4), 926–936 (1993).
[Crossref] [PubMed]

Tanaka, K.

T. Kitai, A. Tanaka, A. Tokuka, K. Tanaka, Y. Yamaoka, K. Ozawa, and K. Hirao, “Quantitative detection of hemoglobin saturation in the liver with near-infrared spectroscopy,” Hepatology 18(4), 926–936 (1993).
[Crossref] [PubMed]

Tanaka, N.

I. Nishidate, N. Tanaka, T. Kawase, T. Maeda, T. Yuasa, Y. Aizu, T. Yuasa, and K. Niizeki, “Noninvasive imaging of human skin hemodynamics using a digital red-green-blue camera,” J. Biomed. Opt. 16(8), 086012 (2011).
[Crossref] [PubMed]

Tanaka, Y.

J. C. Caldwell-Kenkel, R. T. Currin, Y. Tanaka, R. G. Thurman, and J. J. Lemasters, “Reperfusion injury to endothelial cells following cold ischemic storage of rat livers,” Hepatology 10(3), 292–299 (1989).
[Crossref] [PubMed]

Tawadrous, M. N.

M. N. Tawadrous, X. Y. Zhang, and A. M. Wheatley, “Microvascular origin of laser-Doppler flux signal from the surface of normal and injured liver of the rat,” Microvasc. Res. 62(3), 355–365 (2001).
[Crossref] [PubMed]

Thomas, J. A.

Thorling, C. A.

Thurman, R. G.

J. J. Lemasters, H. Bunzendahl, and R. G. Thurman, “Reperfusion injury to donor livers stored for transplantation,” Liver Transpl. Surg. 1(2), 124–138 (1995).
[Crossref] [PubMed]

J. C. Caldwell-Kenkel, R. T. Currin, Y. Tanaka, R. G. Thurman, and J. J. Lemasters, “Reperfusion injury to endothelial cells following cold ischemic storage of rat livers,” Hepatology 10(3), 292–299 (1989).
[Crossref] [PubMed]

Todoroki, T.

T. Kondo, T. Todoroki, T. Hirano, F. W. Schildberg, and K. Messmer, “Impact of ischemia-reperfusion injury on dimensional changes of hepatic microvessels,” Res. Exp. Med. (Berl.) 198(2), 63–72 (1998).
[Crossref] [PubMed]

Tokuka, A.

T. Kitai, A. Tanaka, A. Tokuka, K. Tanaka, Y. Yamaoka, K. Ozawa, and K. Hirao, “Quantitative detection of hemoglobin saturation in the liver with near-infrared spectroscopy,” Hepatology 18(4), 926–936 (1993).
[Crossref] [PubMed]

Tromberg, B. J.

D. Abookasis, C. C. Lay, M. S. Mathews, M. E. Linskey, R. D. Frostig, and B. J. Tromberg, “Imaging cortical absorption, scattering, and hemodynamic response during ischemic stroke using spatially modulated near-infrared illumination,” J. Biomed. Opt. 14(2), 024033 (2009).
[Crossref] [PubMed]

Trowell, O. A.

O. A. Trowell, “The experimental production of watery vacuolation of the liver,” J. Physiol. 105(3), 268–297 (1946).
[Crossref] [PubMed]

van Gulik, T. M.

C. Sturesson, D. M. Milstein, I. C. Post, A. M. Maas, and T. M. van Gulik, “Laser speckle contrast imaging for assessment of liver microcirculation,” Microvasc. Res. 87, 34–40 (2013).
[Crossref] [PubMed]

Vollmar, B.

M. D. Menger, M. Rücker, and B. Vollmar, “Capillary dysfunction in striated muscle ischemia/reperfusion: on the mechanisms of capillary “no-reflow”,” Shock 8(1), 2–7 (1997).
[Crossref] [PubMed]

B. Vollmar, J. Glasz, R. Leiderer, S. Post, and M. D. Menger, “Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia-reperfusion,” Am. J. Pathol. 145(6), 1421–1431 (1994).
[PubMed]

Wang, H.

Wang, H. D.

C. H. Li, H. D. Wang, J. J. Hu, X. L. Ge, K. Pan, A. Q. Zhang, and J. H. Dong, “The monitoring of microvascular liver blood flow changes during ischemia and reperfusion using laser speckle contrast imaging,” Microvasc. Res. 94, 28–35 (2014).
[Crossref] [PubMed]

Wang, L.

L. Wang, S. L. Jacques, and L. Zheng, “MCML--Monte Carlo modeling of light transport in multi-layered tissues,” Comput. Methods Programs Biomed. 47(2), 131–146 (1995).
[Crossref] [PubMed]

Wang, X.

X. Wang, B. W. Pogue, S. Jiang, X. Song, K. D. Paulsen, C. Kogel, S. P. Poplack, and W. A. Wells, “Approximation of Mie scattering parameters in near-infrared tomography of normal breast tissue in vivo,” J. Biomed. Opt. 10(5), 051704 (2005).
[Crossref] [PubMed]

Wanless, I. R.

J. Yan, Y. Kang, S. Xu, L. L. S. Ong, S. Zhuo, R. M. Bunte, N. Chen, H. H. Asada, P. T. C. So, I. R. Wanless, and H. Yu, “In vivo label-free quantification of liver microcirculation using dual-modality microscopy,” J. Biomed. Opt. 19(11), 116006 (2014).
[Crossref] [PubMed]

Watanabe, F.

W. Kamiike, M. Nakahara, K. Nakao, M. Koseki, T. Nishida, Y. Kawashima, F. Watanabe, and K. Tagawa, “Correlation between cellular ATP level and bile excretion in the rat liver,” Transplantation 39(1), 50–55 (1985).
[Crossref] [PubMed]

Weisiger, R. A.

F. J. Burczynski, B. A. Luxon, and R. A. Weisiger, “Intrahepatic blood flow distribution in the perfused rat liver: effect of hepatic artery perfusion,” Am. J. Physiol. 271(4 Pt 1), G561–G567 (1996).
[PubMed]

Wells, W. A.

X. Wang, B. W. Pogue, S. Jiang, X. Song, K. D. Paulsen, C. Kogel, S. P. Poplack, and W. A. Wells, “Approximation of Mie scattering parameters in near-infrared tomography of normal breast tissue in vivo,” J. Biomed. Opt. 10(5), 051704 (2005).
[Crossref] [PubMed]

Wheatley, A. M.

M. N. Tawadrous, X. Y. Zhang, and A. M. Wheatley, “Microvascular origin of laser-Doppler flux signal from the surface of normal and injured liver of the rat,” Microvasc. Res. 62(3), 355–365 (2001).
[Crossref] [PubMed]

Wu, Y. M.

H. H. Lu, Y. M. Wu, W. T. Chang, T. Luo, Y. C. Yang, H. D. Cho, and I. Liau, “Molecular imaging of ischemia and reperfusion in vivo with mitochondrial autofluorescence,” Anal. Chem. 86(10), 5024–5031 (2014).
[Crossref] [PubMed]

Xu, K.

L. Yao, C. Li, X. Ge, H. Wang, K. Xu, A. Zhang, and J. Dong, “Establishment of a rat model of portal vein ligation combined with in situ splitting,” PLoS One 9(8), e105511 (2014).
[Crossref] [PubMed]

Xu, S.

J. Yan, Y. Kang, S. Xu, L. L. S. Ong, S. Zhuo, R. M. Bunte, N. Chen, H. H. Asada, P. T. C. So, I. R. Wanless, and H. Yu, “In vivo label-free quantification of liver microcirculation using dual-modality microscopy,” J. Biomed. Opt. 19(11), 116006 (2014).
[Crossref] [PubMed]

Xu, Z. P.

Yamamoto, J.

S. Akter, S. Maejima, S. Kawauchi, S. Sato, A. Hinoki, S. Aosasa, J. Yamamoto, and I. Nishidate, “Evaluation of light scattering and absorption properties of in vivo rat liver using a single-reflectance fiber probe during preischemia, ischemia-reperfusion, and postmortem,” J. Biomed. Opt. 20(7), 076010 (2015).
[Crossref] [PubMed]

S. Akter, T. Tanabe, S. Maejima, S. Kawauchi, S. Sato, A. Hinoki, S. Aosasa, J. Yamamoto, and I. Nishidate, “In vivo estimation of optical properties of rat liver using single-reflectance fiber probe during ischemia and reperfusion,” Opt. Rev. 22(6), 1–6 (2015).

Yamaoka, Y.

T. Kitai, A. Tanaka, A. Tokuka, K. Tanaka, Y. Yamaoka, K. Ozawa, and K. Hirao, “Quantitative detection of hemoglobin saturation in the liver with near-infrared spectroscopy,” Hepatology 18(4), 926–936 (1993).
[Crossref] [PubMed]

Yan, J.

J. Yan, Y. Kang, S. Xu, L. L. S. Ong, S. Zhuo, R. M. Bunte, N. Chen, H. H. Asada, P. T. C. So, I. R. Wanless, and H. Yu, “In vivo label-free quantification of liver microcirculation using dual-modality microscopy,” J. Biomed. Opt. 19(11), 116006 (2014).
[Crossref] [PubMed]

Yang, Y. C.

H. H. Lu, Y. M. Wu, W. T. Chang, T. Luo, Y. C. Yang, H. D. Cho, and I. Liau, “Molecular imaging of ischemia and reperfusion in vivo with mitochondrial autofluorescence,” Anal. Chem. 86(10), 5024–5031 (2014).
[Crossref] [PubMed]

Yao, L.

L. Yao, C. Li, X. Ge, H. Wang, K. Xu, A. Zhang, and J. Dong, “Establishment of a rat model of portal vein ligation combined with in situ splitting,” PLoS One 9(8), e105511 (2014).
[Crossref] [PubMed]

Yoshida, K.

I. Nishidate, T. Ishizuka, A. Mustari, K. Yoshida, S. Kawauchi, S. Sato, and M. Sato, “Evaluation of cerebral hemodynamics and tissue morphology of in vivo rat brain using spectral diffuse reflectance imaging,” Appl. Spectrosc. 2016, 03702816657569 (2016).
[PubMed]

K. Yoshida, I. Nishidate, T. Ishizuka, S. Kawauchi, S. Sato, and M. Sato, “Multispectral imaging of absorption and scattering properties of in vivo exposed rat brain using a digital red-green-blue camera,” J. Biomed. Opt. 20(5), 051026 (2015).
[Crossref] [PubMed]

Yoshihara, H.

M. Goto, S. Kawano, H. Yoshihara, Y. Takei, T. Hijioka, H. Fukui, T. Matsunaga, M. Oshita, T. Kashiwagi, H. Fusamoto, T. Kamada, and N. Sato, “Hepatic tissue oxygenation as a predictive indicator of ischemia-reperfusion liver injury,” Hepatology 15(3), 432–437 (1992).
[Crossref] [PubMed]

Yu, H.

J. Yan, Y. Kang, S. Xu, L. L. S. Ong, S. Zhuo, R. M. Bunte, N. Chen, H. H. Asada, P. T. C. So, I. R. Wanless, and H. Yu, “In vivo label-free quantification of liver microcirculation using dual-modality microscopy,” J. Biomed. Opt. 19(11), 116006 (2014).
[Crossref] [PubMed]

Yuasa, T.

I. Nishidate, N. Tanaka, T. Kawase, T. Maeda, T. Yuasa, Y. Aizu, T. Yuasa, and K. Niizeki, “Noninvasive imaging of human skin hemodynamics using a digital red-green-blue camera,” J. Biomed. Opt. 16(8), 086012 (2011).
[Crossref] [PubMed]

I. Nishidate, N. Tanaka, T. Kawase, T. Maeda, T. Yuasa, Y. Aizu, T. Yuasa, and K. Niizeki, “Noninvasive imaging of human skin hemodynamics using a digital red-green-blue camera,” J. Biomed. Opt. 16(8), 086012 (2011).
[Crossref] [PubMed]

Zhang, A.

L. Yao, C. Li, X. Ge, H. Wang, K. Xu, A. Zhang, and J. Dong, “Establishment of a rat model of portal vein ligation combined with in situ splitting,” PLoS One 9(8), e105511 (2014).
[Crossref] [PubMed]

Zhang, A. Q.

C. H. Li, H. D. Wang, J. J. Hu, X. L. Ge, K. Pan, A. Q. Zhang, and J. H. Dong, “The monitoring of microvascular liver blood flow changes during ischemia and reperfusion using laser speckle contrast imaging,” Microvasc. Res. 94, 28–35 (2014).
[Crossref] [PubMed]

Zhang, J.

K. Chun, J. Zhang, J. Biewer, D. Ferguson, and M. G. Clemens, “Microcirculatory failure determines lethal hepatocyte injury in ischemic/reperfused rat livers,” Shock 1(1), 3–9 (1994).
[Crossref] [PubMed]

Zhang, X. Y.

M. N. Tawadrous, X. Y. Zhang, and A. M. Wheatley, “Microvascular origin of laser-Doppler flux signal from the surface of normal and injured liver of the rat,” Microvasc. Res. 62(3), 355–365 (2001).
[Crossref] [PubMed]

Zhang, Y.

R. M. Zwacka, Y. Zhang, W. Zhou, J. Halldorson, and J. F. Engelhardt, “Ischemia/reperfusion injury in the liver of BALB/c mice activates AP-1 and nuclear factor kappaB independently of IkappaB degradation,” Hepatology 28(4), 1022–1030 (1998).
[Crossref] [PubMed]

Zheng, L.

L. Wang, S. L. Jacques, and L. Zheng, “MCML--Monte Carlo modeling of light transport in multi-layered tissues,” Comput. Methods Programs Biomed. 47(2), 131–146 (1995).
[Crossref] [PubMed]

Zhou, W.

R. M. Zwacka, Y. Zhang, W. Zhou, J. Halldorson, and J. F. Engelhardt, “Ischemia/reperfusion injury in the liver of BALB/c mice activates AP-1 and nuclear factor kappaB independently of IkappaB degradation,” Hepatology 28(4), 1022–1030 (1998).
[Crossref] [PubMed]

Zhuo, S.

J. Yan, Y. Kang, S. Xu, L. L. S. Ong, S. Zhuo, R. M. Bunte, N. Chen, H. H. Asada, P. T. C. So, I. R. Wanless, and H. Yu, “In vivo label-free quantification of liver microcirculation using dual-modality microscopy,” J. Biomed. Opt. 19(11), 116006 (2014).
[Crossref] [PubMed]

Zwacka, R. M.

R. M. Zwacka, Y. Zhang, W. Zhou, J. Halldorson, and J. F. Engelhardt, “Ischemia/reperfusion injury in the liver of BALB/c mice activates AP-1 and nuclear factor kappaB independently of IkappaB degradation,” Hepatology 28(4), 1022–1030 (1998).
[Crossref] [PubMed]

Am. J. Pathol. (1)

B. Vollmar, J. Glasz, R. Leiderer, S. Post, and M. D. Menger, “Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia-reperfusion,” Am. J. Pathol. 145(6), 1421–1431 (1994).
[PubMed]

Am. J. Physiol. (3)

F. J. Burczynski, B. A. Luxon, and R. A. Weisiger, “Intrahepatic blood flow distribution in the perfused rat liver: effect of hepatic artery perfusion,” Am. J. Physiol. 271(4 Pt 1), G561–G567 (1996).
[PubMed]

M. G. Clemens, P. F. McDonagh, I. H. Chaudry, and A. E. Baue, “Hepatic microcirculatory failure after ischemia and reperfusion: improvement with ATP-MgCl2 treatment,” Am. J. Physiol. 248(6 Pt 2), H804–H811 (1985).
[PubMed]

M. D. Menger, S. Pelikan, D. Steiner, and K. Messmer, “Microvascular ischemia-reperfusion injury in striated muscle: significance of “reflow paradox”,” Am. J. Physiol. 263(6 Pt 2), H1901–H1906 (1992).
[PubMed]

Anal. Chem. (1)

H. H. Lu, Y. M. Wu, W. T. Chang, T. Luo, Y. C. Yang, H. D. Cho, and I. Liau, “Molecular imaging of ischemia and reperfusion in vivo with mitochondrial autofluorescence,” Anal. Chem. 86(10), 5024–5031 (2014).
[Crossref] [PubMed]

Ann. Surg. (1)

J. H. Pringle, “Notes on the arrest of hepatic hemorrhage due to trauma,” Ann. Surg. 48(4), 541–549 (1908).
[Crossref] [PubMed]

Appl. Opt. (2)

Appl. Spectrosc. (1)

I. Nishidate, T. Ishizuka, A. Mustari, K. Yoshida, S. Kawauchi, S. Sato, and M. Sato, “Evaluation of cerebral hemodynamics and tissue morphology of in vivo rat brain using spectral diffuse reflectance imaging,” Appl. Spectrosc. 2016, 03702816657569 (2016).
[PubMed]

Biomed. Opt. Express (1)

Circulation (1)

A. Leaf, “Cell swelling. A factor in ischemic tissue injury,” Circulation 48(3), 455–458 (1973).
[Crossref] [PubMed]

Comput. Methods Programs Biomed. (1)

L. Wang, S. L. Jacques, and L. Zheng, “MCML--Monte Carlo modeling of light transport in multi-layered tissues,” Comput. Methods Programs Biomed. 47(2), 131–146 (1995).
[Crossref] [PubMed]

Exp. Toxicol. Pathol. (1)

M. Kretzschmar, A. Krüger, W. Schirrmeister, A. Krüger, and W. Schirrmeister, “Hepatic ischemia-reperfusion syndrome after partial liver resection (LR): hepatic venous oxygen saturation, enzyme pattern, reduced and oxidized glutathione, procalcitonin and interleukin-6,” Exp. Toxicol. Pathol. 54(5-6), 423–431 (2003).
[Crossref] [PubMed]

Gastroenterology (2)

N. Sato, N. Hayashi, S. Kawano, T. Kamada, and H. Abe, “Hepatic hemodynamics in patients with chronic hepatitis or cirrhosis as assessed by organ-reflectance spectrophotometry,” Gastroenterology 84(3), 611–616 (1983).
[PubMed]

H. Jaeschke and J. J. Lemasters, “Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury,” Gastroenterology 125(4), 1246–1257 (2003).
[Crossref] [PubMed]

Hepatology (4)

J. C. Caldwell-Kenkel, R. T. Currin, Y. Tanaka, R. G. Thurman, and J. J. Lemasters, “Reperfusion injury to endothelial cells following cold ischemic storage of rat livers,” Hepatology 10(3), 292–299 (1989).
[Crossref] [PubMed]

R. M. Zwacka, Y. Zhang, W. Zhou, J. Halldorson, and J. F. Engelhardt, “Ischemia/reperfusion injury in the liver of BALB/c mice activates AP-1 and nuclear factor kappaB independently of IkappaB degradation,” Hepatology 28(4), 1022–1030 (1998).
[Crossref] [PubMed]

M. Goto, S. Kawano, H. Yoshihara, Y. Takei, T. Hijioka, H. Fukui, T. Matsunaga, M. Oshita, T. Kashiwagi, H. Fusamoto, T. Kamada, and N. Sato, “Hepatic tissue oxygenation as a predictive indicator of ischemia-reperfusion liver injury,” Hepatology 15(3), 432–437 (1992).
[Crossref] [PubMed]

T. Kitai, A. Tanaka, A. Tokuka, K. Tanaka, Y. Yamaoka, K. Ozawa, and K. Hirao, “Quantitative detection of hemoglobin saturation in the liver with near-infrared spectroscopy,” Hepatology 18(4), 926–936 (1993).
[Crossref] [PubMed]

J. Biomed. Opt. (7)

J. Yan, Y. Kang, S. Xu, L. L. S. Ong, S. Zhuo, R. M. Bunte, N. Chen, H. H. Asada, P. T. C. So, I. R. Wanless, and H. Yu, “In vivo label-free quantification of liver microcirculation using dual-modality microscopy,” J. Biomed. Opt. 19(11), 116006 (2014).
[Crossref] [PubMed]

I. Nishidate, N. Tanaka, T. Kawase, T. Maeda, T. Yuasa, Y. Aizu, T. Yuasa, and K. Niizeki, “Noninvasive imaging of human skin hemodynamics using a digital red-green-blue camera,” J. Biomed. Opt. 16(8), 086012 (2011).
[Crossref] [PubMed]

K. Yoshida, I. Nishidate, T. Ishizuka, S. Kawauchi, S. Sato, and M. Sato, “Multispectral imaging of absorption and scattering properties of in vivo exposed rat brain using a digital red-green-blue camera,” J. Biomed. Opt. 20(5), 051026 (2015).
[Crossref] [PubMed]

S. Akter, S. Maejima, S. Kawauchi, S. Sato, A. Hinoki, S. Aosasa, J. Yamamoto, and I. Nishidate, “Evaluation of light scattering and absorption properties of in vivo rat liver using a single-reflectance fiber probe during preischemia, ischemia-reperfusion, and postmortem,” J. Biomed. Opt. 20(7), 076010 (2015).
[Crossref] [PubMed]

D. Abookasis, C. C. Lay, M. S. Mathews, M. E. Linskey, R. D. Frostig, and B. J. Tromberg, “Imaging cortical absorption, scattering, and hemodynamic response during ischemic stroke using spatially modulated near-infrared illumination,” J. Biomed. Opt. 14(2), 024033 (2009).
[Crossref] [PubMed]

X. Wang, B. W. Pogue, S. Jiang, X. Song, K. D. Paulsen, C. Kogel, S. P. Poplack, and W. A. Wells, “Approximation of Mie scattering parameters in near-infrared tomography of normal breast tissue in vivo,” J. Biomed. Opt. 10(5), 051704 (2005).
[Crossref] [PubMed]

J. C. Ramella-Roman, K. Lee, S. A. Prahl, and S. L. Jacques, “Design, testing, and clinical studies of a handheld polarized light camera,” J. Biomed. Opt. 9(6), 1305–1310 (2004).
[Crossref] [PubMed]

J. Physiol. (1)

O. A. Trowell, “The experimental production of watery vacuolation of the liver,” J. Physiol. 105(3), 268–297 (1946).
[Crossref] [PubMed]

J. Surg. Res. (2)

G. Oldani, M. Maestri, A. Gaspari, E. Lillo, G. Angelastri, L. M. Lenti, J. Rademacher, M. Alessiani, and P. Dionigi, “A novel technique for rat liver transplantation using Quick Linker system: a preliminary result,” J. Surg. Res. 149(2), 303–309 (2008).
[Crossref] [PubMed]

M. Ohkawa, I. H. Chaudry, M. G. Clemens, and A. E. Baue, “ATP-MgCl2 produces sustained improvement in hepatic mitochondrial function and blood flow after hepatic ischemia,” J. Surg. Res. 37(3), 226–234 (1984).
[Crossref] [PubMed]

Liver (1)

A. E. El-Desoky, D. T. Delpy, B. R. Davidson, and A. M. Seifalian, “Assessment of hepatic ischaemia reperfusion injury by measuring intracellular tissue oxygenation using near infrared spectroscopy,” Liver 21(1), 37–44 (2001).
[Crossref] [PubMed]

Liver Transpl. Surg. (1)

J. J. Lemasters, H. Bunzendahl, and R. G. Thurman, “Reperfusion injury to donor livers stored for transplantation,” Liver Transpl. Surg. 1(2), 124–138 (1995).
[Crossref] [PubMed]

Microvasc. Res. (3)

C. Sturesson, D. M. Milstein, I. C. Post, A. M. Maas, and T. M. van Gulik, “Laser speckle contrast imaging for assessment of liver microcirculation,” Microvasc. Res. 87, 34–40 (2013).
[Crossref] [PubMed]

C. H. Li, H. D. Wang, J. J. Hu, X. L. Ge, K. Pan, A. Q. Zhang, and J. H. Dong, “The monitoring of microvascular liver blood flow changes during ischemia and reperfusion using laser speckle contrast imaging,” Microvasc. Res. 94, 28–35 (2014).
[Crossref] [PubMed]

M. N. Tawadrous, X. Y. Zhang, and A. M. Wheatley, “Microvascular origin of laser-Doppler flux signal from the surface of normal and injured liver of the rat,” Microvasc. Res. 62(3), 355–365 (2001).
[Crossref] [PubMed]

Opt. Rev. (1)

S. Akter, T. Tanabe, S. Maejima, S. Kawauchi, S. Sato, A. Hinoki, S. Aosasa, J. Yamamoto, and I. Nishidate, “In vivo estimation of optical properties of rat liver using single-reflectance fiber probe during ischemia and reperfusion,” Opt. Rev. 22(6), 1–6 (2015).

PLoS One (1)

L. Yao, C. Li, X. Ge, H. Wang, K. Xu, A. Zhang, and J. Dong, “Establishment of a rat model of portal vein ligation combined with in situ splitting,” PLoS One 9(8), e105511 (2014).
[Crossref] [PubMed]

Q. J. Exp. Physiol. Cogn. Med. Sci. (1)

A. Koo, I. Y. Liang, and K. K. Cheng, “The terminal hepatic microcirculation in the rat,” Q. J. Exp. Physiol. Cogn. Med. Sci. 60(4), 261–266 (1975).
[Crossref] [PubMed]

Res. Exp. Med. (Berl.) (1)

T. Kondo, T. Todoroki, T. Hirano, F. W. Schildberg, and K. Messmer, “Impact of ischemia-reperfusion injury on dimensional changes of hepatic microvessels,” Res. Exp. Med. (Berl.) 198(2), 63–72 (1998).
[Crossref] [PubMed]

Shock (2)

M. D. Menger, M. Rücker, and B. Vollmar, “Capillary dysfunction in striated muscle ischemia/reperfusion: on the mechanisms of capillary “no-reflow”,” Shock 8(1), 2–7 (1997).
[Crossref] [PubMed]

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Toxicol. Appl. Pharmacol. (1)

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Figures (12)

Fig. 1
Fig. 1 Flowchart of the process for estimating the concentration of oxyhemoglobin CHbO, deoxyhemoglobin CHbR, total hemoglobin CHbT, tissue oxygen saturation, StO2, and scattering power b from the measured RGB-values.
Fig. 2
Fig. 2 Schematic illustration of setup for RGB imaging of hepatic hemodynamics. A white LED is used to illuminate the exposed rat liver, which is imaged using an RGB CCD camera. The computer acquires raw RGB images.
Fig. 3
Fig. 3 Illustration of the (a) ventral surface of normal rat liver in which the left lateral and median lobes have been retracted to expose the portal vein (blue), hepatic artery (red), and common bile duct (yellow). (b) Cross-clamping of portal triad (green) induces ischemia to the left lateral and median lobes of the liver. (c) The dorsal surface of the liver lobe is shown as the imaging area.
Fig. 4
Fig. 4 Typical images of in vivo liver tissue at different measurement time points. Left to right: the first column of Fig. 4 shows images at t = 0-min (the beginning of measurement and 0-min after start of oxygen breathing), the second column shows images at t = 8-min (3-min after start of air breathing), the third column shows images at t = 15-min (5-min after the onset of ischemia), the fourth column shows images at t = 25-min (5-min after the onset of reperfusion), the fifth column shows images at t = 40-min (20-min after the onset of reperfusion), the sixth column shows images at t = 110-min (90-min after the onset of reperfusion), the seventh column shows images at t = 142-min (2-min after the onset of nitrogen breathing), and the eighth column shows images at t = 145-min (5-min after the onset of nitrogen breathing). Top to bottom: raw RGB images are shown in the top row with the corresponding CHbO, CHbR, CHbT, StO2 and scattering power b images reconstructed from the RGB images) under white light illumination shown in the following rows. Successive images recorded 5-min post-reperfusion show the spatial changes in CHbO and StO2 that are indicated by a white arrow on the less perfused portion of the imaged area, which is accompanied with scattered hepatic lobular perfusion.
Fig. 5
Fig. 5 Typical time courses of average chromophore concentration and tissue oxygen saturation averaged over the region of interest (ROI1, entire image) for (a) oxygenated hemoglobin CHbO, (b) deoxygenated hemoglobin CHbR, (c) total hemoglobin CHbT, and (d) tissue oxygen saturation StO2. Data are expressed as mean ± SD (n = 5). The symbols i, ii, iii, iv, v, and vi in each figure indicate O2-breathing, air-breathing, ischemia under air-breathing, reperfusion under air-breathing, N2-breathing, and post-mortem, respectively.
Fig. 6
Fig. 6 Typical time courses of average chromophore concentration and tissue oxygen saturation averaged over the region of interest (ROI2, relatively homogeneous region of perfusion) for (a) oxygenated hemoglobin CHbO, (b) deoxygenated hemoglobin CHbR, (c) total hemoglobin CHbT, and (d) tissue oxygen saturation StO2. Data are expressed as mean ± SD (n = 5). The symbols i, ii, iii, iv, v, and vi in each figure indicate O2-breathing, air-breathing, ischemia under air-breathing, reperfusion under air-breathing, N2-breathing, and post-mortem, respectively.
Fig. 7
Fig. 7 Typical time courses of chromophore concentration and tissue oxygen saturation averaged over the region of interest (ROI3, relatively heterogeneous region of perfusion) for (a) oxygenated hemoglobin CHbO, (b) deoxygenated hemoglobin CHbR, (c) total hemoglobin CHbT, and (d) tissue oxygen saturation StO2. Data are expressed as mean ± SD (n = 5). The symbols i, ii, iii, iv, v, and vi in each figure indicate O2-breathing, air-breathing, ischemia under air-breathing, reperfusion under air-breathing, N2-breathing, and post-mortem, respectively.
Fig. 8
Fig. 8 The relative change in chromophore concentrations and tissue oxygen saturation (for ROI1 shown in Fig. 2) at the ends of each period. (a) Oxygenated hemoglobin CHbO, (b) deoxygenated hemoglobin CHbR, (c) total hemoglobin CHbT, and (d) tissue oxygen saturation StO2. Data are expressed as mean ± SD (n = 5). *P < 0.05/4.
Fig. 9
Fig. 9 The relative change in chromophore concentrations and tissue oxygen saturation (for ROI2 shown in Fig. 2) at the ends of each period. (a) Oxygenated hemoglobin CHbO, (b) deoxygenated hemoglobin CHbR, (c) total hemoglobin CHbT, and (d) tissue oxygen saturation StO2. Data are expressed as mean ± SD (n = 5). *P < 0.05/4.
Fig. 10
Fig. 10 The relative change in chromophore concentrations and tissue oxygen saturation (for ROI3 shown in Fig. 2) at the ends of each period. (a) Oxygenated hemoglobin CHbO, (b) deoxygenated hemoglobin CHbR, (c) total hemoglobin CHbT, and (d) tissue oxygen saturation StO2. Data are expressed as mean ± SD (n = 5). *P < 0.05/4.
Fig. 11
Fig. 11 Typical time course of scattering power b averaged over the regions of interest (ROI1, entire image; ROI2, relatively homogeneous region of perfusion; ROI3, relatively heterogeneous region of perfusion). Data are expressed as mean ± SD (n = 5). The symbols i, ii, iii, iv, v, and vi in each figure indicate O2-breathing, air-breathing, ischemia under air-breathing, reperfusion under air-breathing, N2-breathing, and post-mortem, respectively.
Fig. 12
Fig. 12 The relative change in scattering power b at the ends of each period. (a) Entire imaged area (ROI1), (b) relatively homogeneous region (ROI2), and (c) relatively heterogeneous region (ROI3). Data are expressed as mean ± SD (n = 5). *P < 0.05/4.

Equations (14)

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μ s ' (λ)=a λ b ,
[ I R I G I B ]= L 1 [ X Y Z ],
X=κ Ε(λ) x ¯ (λ)Θ(λ) ,
Y=κ Ε(λ) y ¯ (λ)Θ(λ) ,
Z=κ Ε(λ) z ¯ (λ)Θ(λ) ,
κ= 100 Ε(λ) y ¯ (λ) .
Θ= I d I i = 0 P( μ s ,l)exp[( μ a,HbO + μ a,HbR )l]dl,
μ a =C×ε.
[ X Y Z ]= N 1 [ I R I G I B ].
C HbO = α 0 + α 1 X+ α 2 Y+ α 3 Z,
C HbR = β 0 + β 1 X+ β 2 Y+ β 3 Z,
b= γ 0 + γ 1 X+ γ 2 Y+ γ 3 Z,
N 2 =[ α 0 β 0 γ 0 α 1 β 1 γ 1 α 2 β 2 γ 2 α 3 β 3 γ 3 ].
[ C HbO C HbR b ]= N 2 [ 1 X Y Z ].

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