Abstract

Reliable, continuous and noninvasive blood flow and hemoglobin monitoring in trauma patients remains a critical, but generally unachieved goal. Two optical sensing methods - diffuse correlation spectroscopy (DCS) and diffuse reflectance spectroscopy (DRS) – are used to monitor and detect internal hemorrhage. Specifically, we investigate if cutaneous perfusion measurements acquired using DCS and DRS in peripheral (thighs and ear-lobe) tissues could detect severe hemorrhagic shock in a porcine model. Four animals underwent high-grade hepato-portal injury in a closed abdomen, to induce uncontrolled hemorrhage and were subsequently allowed to bleed for 10 minutes before fluid resuscitation. DRS and DCS measurements of cutaneous blood flow were acquired using fiber optical probes placed on the thigh and earlobe of the animals and were obtained repeatedly starting from 1 to 5 minutes pre-injury, up to several minutes post shock. Clear changes were observed in measured optical spectra across all animals at both sites. DCS-derived cutaneous blood flow decreased sharply during hemorrhage, while DRS-derived vascular saturation and hemoglobin paralleled cardiac output. All derived optical parameters had the steepest changes during the rapid initial hemorrhage unambiguously. This suggests that a combined DCS and DRS based device might provide an easy-to-use, non-invasive, internal-hemorrhage detection system that can be used across a wide array of clinical settings.

© 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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References

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2017 (1)

Y. Shang, T. Li, and G. Yu, “Clinical applications of near-infrared diffuse correlation spectroscopy and tomography for tissue blood flow monitoring and imaging,” Physiol. Meas. 38(4), R1–R26 (2017).
[Crossref] [PubMed]

2016 (4)

M. C. Salcedo, K. Tart, and K. Hall, “A systematic review of human and veterinary applications of noninvasive tissue oxygen monitoring,” J. Vet Emerg Crit Care 26(3), 323–332 (2016).
[Crossref] [PubMed]

A. Lima, “Current status of tissue monitoring in the management of shock,” Curr. Opin. Crit. Care 22(3), 274–278 (2016).
[Crossref] [PubMed]

M. S. Green, S. Sehgal, and R. Tariq, “Near-Infrared Spectroscopy: The New Must Have Tool in the Intensive Care Unit?” Semin. Cardiothorac. Vasc. Anesth. 20(3), 213–224 (2016).
[Crossref] [PubMed]

J. D. Sprick, B. R. Soller, and C. A. Rickards, “The efficacy of novel anatomical sites for the assessment of muscle oxygenation during central hypovolemia,” Exp. Biol. Med. (Maywood) 241(17), 2007–2013 (2016).
[Crossref] [PubMed]

2015 (2)

M. Tivnan, R. Gurjar, D. E. Wolf, and K. Vishwanath, “High Frequency Sampling of TTL Pulses on a Raspberry Pi for Diffuse Correlation Spectroscopy Applications,” Sensors (Basel) 15(8), 19709–19722 (2015).
[Crossref] [PubMed]

T. Kurita, K. Morita, and S. Sato, “The Influence of Hypovolemia and Fluid Resuscitation During Hemorrhagic Shock on Apneic Oxygen Desaturation After Preoxygenation in a Swine Model,” Anesth. Analg. 121(6), 1555–1561 (2015).
[Crossref] [PubMed]

2014 (7)

D. Gagnon, R. Matthew Brothers, M. S. Ganio, J. L. Hastings, and C. G. Crandall, “Forehead versus forearm skin vascular responses at presyncope in humans,” Am. J. Physiol. Regul. Integr. Comp. Physiol. 307(7), R908–R913 (2014).
[Crossref] [PubMed]

T. Durduran and A. G. Yodh, “Diffuse correlation spectroscopy for non-invasive, micro-vascular cerebral blood flow measurement,” Neuroimage 85(Pt 1), 51–63 (2014).
[Crossref] [PubMed]

C. Hinojosa-Laborde, R. E. Shade, G. W. Muniz, C. Bauer, K. A. Goei, H. F. Pidcoke, K. K. Chung, A. P. Cap, and V. A. Convertino, “Validation of lower body negative pressure as an experimental model of hemorrhage,” J Appl Physiol (1985) 116, 406– 415 (2014).

B. Soller, C. Smith, F. Zou, G. E. Ellerby, M. D. Prince, and J. L. Sondeen, “Investigation of noninvasive muscle pH and oxygen saturation during uncontrolled hemorrhage and resuscitation in swine,” Shock 42(1), 44–51 (2014).
[Crossref] [PubMed]

V. Jain, E. M. Buckley, D. J. Licht, J. M. Lynch, P. J. Schwab, M. Y. Naim, N. A. Lavin, S. C. Nicolson, L. M. Montenegro, A. G. Yodh, and F. W. Wehrli, “Cerebral oxygen metabolism in neonates with congenital heart disease quantified by MRI and optics,” J. Cereb. Blood Flow Metab. 34(3), 380–388 (2014).
[Crossref] [PubMed]

G. Tachon, A. Harrois, S. Tanaka, H. Kato, O. Huet, J. Pottecher, E. Vicaut, and J. Duranteau, “Microcirculatory alterations in traumatic hemorrhagic shock,” Crit. Care Med. 42(6), 1433–1441 (2014).
[Crossref] [PubMed]

M. P. Peev, A. Rago, J. O. Hwabejire, M. J. Duggan, J. Beagle, J. Marini, G. Zugates, R. Busold, T. Freyman, G. S. Velmahos, M. A. Demoya, D. D. Yeh, P. J. Fagenholz, U. Sharma, and D. R. King, “Self-expanding foam for prehospital treatment of severe intra-abdominal hemorrhage: dose finding study,” J. Trauma Acute Care Surg. 76(3), 619–624 (2014).
[Crossref]

2013 (3)

A. Y. Mejaddam, O. A. Birkhan, A. C. Sideris, G. M. Van der Wilden, A. M. Imam, J. O. Hwabejire, Y. Chang, G. C. Velmahos, P. J. Fagenholz, D. D. Yeh, M. A. de Moya, and D. R. King, “Real-time heart rate entropy predicts the need for lifesaving interventions in trauma activation patients,” J. Trauma Acute Care Surg. 75(4), 607–612 (2013).
[Crossref] [PubMed]

M. Duggan, A. Rago, U. Sharma, G. Zugates, T. Freyman, R. Busold, J. Caulkins, Q. Pham, Y. Chang, A. Mejaddam, J. Beagle, G. Velmahos, M. deMoya, L. Zukerberg, T. F. Ng, and L. T. C. D. R. King, “Self-expanding polyurethane polymer improves survival in a model of noncompressible massive abdominal hemorrhage,” J. Trauma Acute Care Surg. 74(6), 1462–1467 (2013).
[Crossref]

M. J. Duggan, A. Y. Mejaddam, J. Beagle, M. A. Demoya, G. C. Velmahosa, H. B. Alam, A. Rago, G. Zugates, R. Busold, T. Freyman, U. Sharma, and D. R. King, “Development of a lethal, closed-abdomen grade V hepato-portal injury model in non-coagulopathic swine,” J. Surg. Res. 182(1), 101–107 (2013).
[Crossref] [PubMed]

2012 (2)

B. J. Eastridge, R. L. Mabry, P. Seguin, J. Cantrell, T. Tops, P. Uribe, O. Mallett, T. Zubko, L. Oetjen-Gerdes, T. E. Rasmussen, F. K. Butler, R. S. Kotwal, J. B. Holcomb, C. Wade, H. Champion, M. Lawnick, L. Moores, and L. H. Blackbourne, “Death on the battlefield (2001-2011): implications for the future of combat casualty care,” J. Trauma Acute Care Surg. 73(6Suppl 5), S431–S437 (2012).
[Crossref] [PubMed]

M. Lipcsey, N. C. Woinarski, and R. Bellomo, “Near infrared spectroscopy (NIRS) of the thenar eminence in anesthesia and intensive care,” Ann. Intensive Care 2(1), 11 (2012).
[Crossref] [PubMed]

2011 (2)

2010 (4)

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

K. R. Ward, M. H. Tiba, K. L. Ryan, I. P. Filho, C. A. Rickards, T. Witten, B. R. Soller, D. A. Ludwig, and V. A. Convertino, “Oxygen transport characterization of a human model of progressive hemorrhage,” Resuscitation 81(8), 987–993 (2010).
[Crossref] [PubMed]

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse Optics for Tissue Monitoring and Tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[Crossref] [PubMed]

R. M. Brothers, J. E. Wingo, K. A. Hubing, and C. G. Crandall, “Methodological assessment of skin and limb blood flows in the human forearm during thermal and baroreceptor provocations,” J Appl Physiol (1985) 109, 895– 900 (2010).

2009 (3)

M. J. Joyner, “Orthostatic stress, haemorrhage and a bankrupt cardiovascular system,” J. Physiol. 587(21), 5015–5016 (2009).
[Crossref] [PubMed]

D. R. King, M. P. Ogilvie, B. M. Pereira, Y. Chang, R. J. Manning, J. A. Conner, C. I. Schulman, M. G. McKenney, and K. G. Proctor, “Heart rate variability as a triage tool in patients with trauma during prehospital helicopter transport,” J. Trauma 67(3), 436–440 (2009).
[Crossref] [PubMed]

J. Q. Brown, K. Vishwanath, G. M. Palmer, and N. Ramanujam, “Advances in quantitative UV-visible spectroscopy for clinical and pre-clinical application in cancer,” Curr. Opin. Biotechnol. 20(1), 119–131 (2009).
[Crossref] [PubMed]

2008 (1)

M. K. Angele, C. P. Schneider, and I. H. Chaudry, “Bench-to-bedside review: latest results in hemorrhagic shock,” Crit. Care 12(4), 218 (2008).
[Crossref] [PubMed]

2006 (4)

G. M. Palmer and N. Ramanujam, “Monte Carlo-based inverse model for calculating tissue optical properties. Part I: Theory and validation on synthetic phantoms,” Appl. Opt. 45(5), 1062–1071 (2006).
[Crossref] [PubMed]

D. S. Kauvar, R. Lefering, and C. E. Wade, “Impact of hemorrhage on trauma outcome: an overview of epidemiology, clinical presentations, and therapeutic considerations,” J. Trauma 60(6Suppl), S3–S11 (2006).
[Crossref] [PubMed]

K. R. Ward, R. R. Ivatury, R. W. Barbee, J. Terner, R. Pittman, I. P. Filho, and B. Spiess, “Near infrared spectroscopy for evaluation of the trauma patient: a technology review,” Resuscitation 68(1), 27–44 (2006).
[Crossref] [PubMed]

P. Wellhöner, D. Rolle, P. Lönnroth, L. Strindberg, M. Elam, and C. Dodt, “Laser-Doppler flowmetry reveals rapid perfusion changes in adipose tissue of lean and obese females,” Am. J. Physiol. Endocrinol. Metab. 291(5), E1025–E1030 (2006).
[Crossref] [PubMed]

2005 (1)

J. H. Taylor, K. E. Mulier, D. E. Myers, and G. J. Beilman, “Use of near-infrared spectroscopy in early determination of irreversible hemorrhagic shock,” J. Trauma 58(6), 1119–1125 (2005).
[Crossref] [PubMed]

1998 (1)

1997 (1)

1994 (1)

V. V. Tuchin, S. R. Utz, and I. V. Yaroslavsky, “Tissue Optics, Light-Distribution, and Spectroscopy,” Opt. Eng. 33(10), 3178–3188 (1994).
[Crossref]

1991 (1)

R. Schlichtig, D. J. Kramer, and M. R. Pinsky, “Flow redistribution during progressive hemorrhage is a determinant of critical O2 delivery,” J. Appl. Physiol. 70(1), 169–178 (1991).
[Crossref] [PubMed]

1986 (1)

A. Tripathi and E. R. Nadel, “Forearm skin and muscle vasoconstriction during lower body negative pressure,” J Appl Physiol (1985) 60, 1535– 1541 (1986).

Alam, H. B.

M. J. Duggan, A. Y. Mejaddam, J. Beagle, M. A. Demoya, G. C. Velmahosa, H. B. Alam, A. Rago, G. Zugates, R. Busold, T. Freyman, U. Sharma, and D. R. King, “Development of a lethal, closed-abdomen grade V hepato-portal injury model in non-coagulopathic swine,” J. Surg. Res. 182(1), 101–107 (2013).
[Crossref] [PubMed]

Andersson-Engels, S.

Angele, M. K.

M. K. Angele, C. P. Schneider, and I. H. Chaudry, “Bench-to-bedside review: latest results in hemorrhagic shock,” Crit. Care 12(4), 218 (2008).
[Crossref] [PubMed]

Baker, W. B.

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse Optics for Tissue Monitoring and Tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[Crossref] [PubMed]

Barbee, R. W.

K. R. Ward, R. R. Ivatury, R. W. Barbee, J. Terner, R. Pittman, I. P. Filho, and B. Spiess, “Near infrared spectroscopy for evaluation of the trauma patient: a technology review,” Resuscitation 68(1), 27–44 (2006).
[Crossref] [PubMed]

Bauer, C.

C. Hinojosa-Laborde, R. E. Shade, G. W. Muniz, C. Bauer, K. A. Goei, H. F. Pidcoke, K. K. Chung, A. P. Cap, and V. A. Convertino, “Validation of lower body negative pressure as an experimental model of hemorrhage,” J Appl Physiol (1985) 116, 406– 415 (2014).

Beagle, J.

M. P. Peev, A. Rago, J. O. Hwabejire, M. J. Duggan, J. Beagle, J. Marini, G. Zugates, R. Busold, T. Freyman, G. S. Velmahos, M. A. Demoya, D. D. Yeh, P. J. Fagenholz, U. Sharma, and D. R. King, “Self-expanding foam for prehospital treatment of severe intra-abdominal hemorrhage: dose finding study,” J. Trauma Acute Care Surg. 76(3), 619–624 (2014).
[Crossref]

M. J. Duggan, A. Y. Mejaddam, J. Beagle, M. A. Demoya, G. C. Velmahosa, H. B. Alam, A. Rago, G. Zugates, R. Busold, T. Freyman, U. Sharma, and D. R. King, “Development of a lethal, closed-abdomen grade V hepato-portal injury model in non-coagulopathic swine,” J. Surg. Res. 182(1), 101–107 (2013).
[Crossref] [PubMed]

M. Duggan, A. Rago, U. Sharma, G. Zugates, T. Freyman, R. Busold, J. Caulkins, Q. Pham, Y. Chang, A. Mejaddam, J. Beagle, G. Velmahos, M. deMoya, L. Zukerberg, T. F. Ng, and L. T. C. D. R. King, “Self-expanding polyurethane polymer improves survival in a model of noncompressible massive abdominal hemorrhage,” J. Trauma Acute Care Surg. 74(6), 1462–1467 (2013).
[Crossref]

Beilman, G. J.

J. H. Taylor, K. E. Mulier, D. E. Myers, and G. J. Beilman, “Use of near-infrared spectroscopy in early determination of irreversible hemorrhagic shock,” J. Trauma 58(6), 1119–1125 (2005).
[Crossref] [PubMed]

Bellomo, R.

M. Lipcsey, N. C. Woinarski, and R. Bellomo, “Near infrared spectroscopy (NIRS) of the thenar eminence in anesthesia and intensive care,” Ann. Intensive Care 2(1), 11 (2012).
[Crossref] [PubMed]

Birkhan, O. A.

A. Y. Mejaddam, O. A. Birkhan, A. C. Sideris, G. M. Van der Wilden, A. M. Imam, J. O. Hwabejire, Y. Chang, G. C. Velmahos, P. J. Fagenholz, D. D. Yeh, M. A. de Moya, and D. R. King, “Real-time heart rate entropy predicts the need for lifesaving interventions in trauma activation patients,” J. Trauma Acute Care Surg. 75(4), 607–612 (2013).
[Crossref] [PubMed]

Blackbourne, L. H.

B. J. Eastridge, R. L. Mabry, P. Seguin, J. Cantrell, T. Tops, P. Uribe, O. Mallett, T. Zubko, L. Oetjen-Gerdes, T. E. Rasmussen, F. K. Butler, R. S. Kotwal, J. B. Holcomb, C. Wade, H. Champion, M. Lawnick, L. Moores, and L. H. Blackbourne, “Death on the battlefield (2001-2011): implications for the future of combat casualty care,” J. Trauma Acute Care Surg. 73(6Suppl 5), S431–S437 (2012).
[Crossref] [PubMed]

Boas, D. A.

Brothers, R. M.

R. M. Brothers, J. E. Wingo, K. A. Hubing, and C. G. Crandall, “Methodological assessment of skin and limb blood flows in the human forearm during thermal and baroreceptor provocations,” J Appl Physiol (1985) 109, 895– 900 (2010).

Brown, J. Q.

J. Q. Brown, K. Vishwanath, G. M. Palmer, and N. Ramanujam, “Advances in quantitative UV-visible spectroscopy for clinical and pre-clinical application in cancer,” Curr. Opin. Biotechnol. 20(1), 119–131 (2009).
[Crossref] [PubMed]

Buckley, E. M.

V. Jain, E. M. Buckley, D. J. Licht, J. M. Lynch, P. J. Schwab, M. Y. Naim, N. A. Lavin, S. C. Nicolson, L. M. Montenegro, A. G. Yodh, and F. W. Wehrli, “Cerebral oxygen metabolism in neonates with congenital heart disease quantified by MRI and optics,” J. Cereb. Blood Flow Metab. 34(3), 380–388 (2014).
[Crossref] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Busold, R.

M. P. Peev, A. Rago, J. O. Hwabejire, M. J. Duggan, J. Beagle, J. Marini, G. Zugates, R. Busold, T. Freyman, G. S. Velmahos, M. A. Demoya, D. D. Yeh, P. J. Fagenholz, U. Sharma, and D. R. King, “Self-expanding foam for prehospital treatment of severe intra-abdominal hemorrhage: dose finding study,” J. Trauma Acute Care Surg. 76(3), 619–624 (2014).
[Crossref]

M. J. Duggan, A. Y. Mejaddam, J. Beagle, M. A. Demoya, G. C. Velmahosa, H. B. Alam, A. Rago, G. Zugates, R. Busold, T. Freyman, U. Sharma, and D. R. King, “Development of a lethal, closed-abdomen grade V hepato-portal injury model in non-coagulopathic swine,” J. Surg. Res. 182(1), 101–107 (2013).
[Crossref] [PubMed]

M. Duggan, A. Rago, U. Sharma, G. Zugates, T. Freyman, R. Busold, J. Caulkins, Q. Pham, Y. Chang, A. Mejaddam, J. Beagle, G. Velmahos, M. deMoya, L. Zukerberg, T. F. Ng, and L. T. C. D. R. King, “Self-expanding polyurethane polymer improves survival in a model of noncompressible massive abdominal hemorrhage,” J. Trauma Acute Care Surg. 74(6), 1462–1467 (2013).
[Crossref]

Butler, F. K.

B. J. Eastridge, R. L. Mabry, P. Seguin, J. Cantrell, T. Tops, P. Uribe, O. Mallett, T. Zubko, L. Oetjen-Gerdes, T. E. Rasmussen, F. K. Butler, R. S. Kotwal, J. B. Holcomb, C. Wade, H. Champion, M. Lawnick, L. Moores, and L. H. Blackbourne, “Death on the battlefield (2001-2011): implications for the future of combat casualty care,” J. Trauma Acute Care Surg. 73(6Suppl 5), S431–S437 (2012).
[Crossref] [PubMed]

Cantrell, J.

B. J. Eastridge, R. L. Mabry, P. Seguin, J. Cantrell, T. Tops, P. Uribe, O. Mallett, T. Zubko, L. Oetjen-Gerdes, T. E. Rasmussen, F. K. Butler, R. S. Kotwal, J. B. Holcomb, C. Wade, H. Champion, M. Lawnick, L. Moores, and L. H. Blackbourne, “Death on the battlefield (2001-2011): implications for the future of combat casualty care,” J. Trauma Acute Care Surg. 73(6Suppl 5), S431–S437 (2012).
[Crossref] [PubMed]

Cap, A. P.

C. Hinojosa-Laborde, R. E. Shade, G. W. Muniz, C. Bauer, K. A. Goei, H. F. Pidcoke, K. K. Chung, A. P. Cap, and V. A. Convertino, “Validation of lower body negative pressure as an experimental model of hemorrhage,” J Appl Physiol (1985) 116, 406– 415 (2014).

Carp, S. A.

Caulkins, J.

M. Duggan, A. Rago, U. Sharma, G. Zugates, T. Freyman, R. Busold, J. Caulkins, Q. Pham, Y. Chang, A. Mejaddam, J. Beagle, G. Velmahos, M. deMoya, L. Zukerberg, T. F. Ng, and L. T. C. D. R. King, “Self-expanding polyurethane polymer improves survival in a model of noncompressible massive abdominal hemorrhage,” J. Trauma Acute Care Surg. 74(6), 1462–1467 (2013).
[Crossref]

Champion, H.

B. J. Eastridge, R. L. Mabry, P. Seguin, J. Cantrell, T. Tops, P. Uribe, O. Mallett, T. Zubko, L. Oetjen-Gerdes, T. E. Rasmussen, F. K. Butler, R. S. Kotwal, J. B. Holcomb, C. Wade, H. Champion, M. Lawnick, L. Moores, and L. H. Blackbourne, “Death on the battlefield (2001-2011): implications for the future of combat casualty care,” J. Trauma Acute Care Surg. 73(6Suppl 5), S431–S437 (2012).
[Crossref] [PubMed]

Chang, K.

Chang, V.

Chang, Y.

M. Duggan, A. Rago, U. Sharma, G. Zugates, T. Freyman, R. Busold, J. Caulkins, Q. Pham, Y. Chang, A. Mejaddam, J. Beagle, G. Velmahos, M. deMoya, L. Zukerberg, T. F. Ng, and L. T. C. D. R. King, “Self-expanding polyurethane polymer improves survival in a model of noncompressible massive abdominal hemorrhage,” J. Trauma Acute Care Surg. 74(6), 1462–1467 (2013).
[Crossref]

A. Y. Mejaddam, O. A. Birkhan, A. C. Sideris, G. M. Van der Wilden, A. M. Imam, J. O. Hwabejire, Y. Chang, G. C. Velmahos, P. J. Fagenholz, D. D. Yeh, M. A. de Moya, and D. R. King, “Real-time heart rate entropy predicts the need for lifesaving interventions in trauma activation patients,” J. Trauma Acute Care Surg. 75(4), 607–612 (2013).
[Crossref] [PubMed]

D. R. King, M. P. Ogilvie, B. M. Pereira, Y. Chang, R. J. Manning, J. A. Conner, C. I. Schulman, M. G. McKenney, and K. G. Proctor, “Heart rate variability as a triage tool in patients with trauma during prehospital helicopter transport,” J. Trauma 67(3), 436–440 (2009).
[Crossref] [PubMed]

Chaudry, I. H.

M. K. Angele, C. P. Schneider, and I. H. Chaudry, “Bench-to-bedside review: latest results in hemorrhagic shock,” Crit. Care 12(4), 218 (2008).
[Crossref] [PubMed]

Choe, R.

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse Optics for Tissue Monitoring and Tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[Crossref] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Chung, K. K.

C. Hinojosa-Laborde, R. E. Shade, G. W. Muniz, C. Bauer, K. A. Goei, H. F. Pidcoke, K. K. Chung, A. P. Cap, and V. A. Convertino, “Validation of lower body negative pressure as an experimental model of hemorrhage,” J Appl Physiol (1985) 116, 406– 415 (2014).

Conner, J. A.

D. R. King, M. P. Ogilvie, B. M. Pereira, Y. Chang, R. J. Manning, J. A. Conner, C. I. Schulman, M. G. McKenney, and K. G. Proctor, “Heart rate variability as a triage tool in patients with trauma during prehospital helicopter transport,” J. Trauma 67(3), 436–440 (2009).
[Crossref] [PubMed]

Convertino, V. A.

C. Hinojosa-Laborde, R. E. Shade, G. W. Muniz, C. Bauer, K. A. Goei, H. F. Pidcoke, K. K. Chung, A. P. Cap, and V. A. Convertino, “Validation of lower body negative pressure as an experimental model of hemorrhage,” J Appl Physiol (1985) 116, 406– 415 (2014).

K. R. Ward, M. H. Tiba, K. L. Ryan, I. P. Filho, C. A. Rickards, T. Witten, B. R. Soller, D. A. Ludwig, and V. A. Convertino, “Oxygen transport characterization of a human model of progressive hemorrhage,” Resuscitation 81(8), 987–993 (2010).
[Crossref] [PubMed]

Crandall, C. G.

D. Gagnon, R. Matthew Brothers, M. S. Ganio, J. L. Hastings, and C. G. Crandall, “Forehead versus forearm skin vascular responses at presyncope in humans,” Am. J. Physiol. Regul. Integr. Comp. Physiol. 307(7), R908–R913 (2014).
[Crossref] [PubMed]

R. M. Brothers, J. E. Wingo, K. A. Hubing, and C. G. Crandall, “Methodological assessment of skin and limb blood flows in the human forearm during thermal and baroreceptor provocations,” J Appl Physiol (1985) 109, 895– 900 (2010).

de Moya, M. A.

A. Y. Mejaddam, O. A. Birkhan, A. C. Sideris, G. M. Van der Wilden, A. M. Imam, J. O. Hwabejire, Y. Chang, G. C. Velmahos, P. J. Fagenholz, D. D. Yeh, M. A. de Moya, and D. R. King, “Real-time heart rate entropy predicts the need for lifesaving interventions in trauma activation patients,” J. Trauma Acute Care Surg. 75(4), 607–612 (2013).
[Crossref] [PubMed]

deMoya, M.

M. Duggan, A. Rago, U. Sharma, G. Zugates, T. Freyman, R. Busold, J. Caulkins, Q. Pham, Y. Chang, A. Mejaddam, J. Beagle, G. Velmahos, M. deMoya, L. Zukerberg, T. F. Ng, and L. T. C. D. R. King, “Self-expanding polyurethane polymer improves survival in a model of noncompressible massive abdominal hemorrhage,” J. Trauma Acute Care Surg. 74(6), 1462–1467 (2013).
[Crossref]

Demoya, M. A.

M. P. Peev, A. Rago, J. O. Hwabejire, M. J. Duggan, J. Beagle, J. Marini, G. Zugates, R. Busold, T. Freyman, G. S. Velmahos, M. A. Demoya, D. D. Yeh, P. J. Fagenholz, U. Sharma, and D. R. King, “Self-expanding foam for prehospital treatment of severe intra-abdominal hemorrhage: dose finding study,” J. Trauma Acute Care Surg. 76(3), 619–624 (2014).
[Crossref]

M. J. Duggan, A. Y. Mejaddam, J. Beagle, M. A. Demoya, G. C. Velmahosa, H. B. Alam, A. Rago, G. Zugates, R. Busold, T. Freyman, U. Sharma, and D. R. King, “Development of a lethal, closed-abdomen grade V hepato-portal injury model in non-coagulopathic swine,” J. Surg. Res. 182(1), 101–107 (2013).
[Crossref] [PubMed]

Deng, Y. F.

Detre, J. A.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Dodt, C.

P. Wellhöner, D. Rolle, P. Lönnroth, L. Strindberg, M. Elam, and C. Dodt, “Laser-Doppler flowmetry reveals rapid perfusion changes in adipose tissue of lean and obese females,” Am. J. Physiol. Endocrinol. Metab. 291(5), E1025–E1030 (2006).
[Crossref] [PubMed]

Duggan, M.

M. Duggan, A. Rago, U. Sharma, G. Zugates, T. Freyman, R. Busold, J. Caulkins, Q. Pham, Y. Chang, A. Mejaddam, J. Beagle, G. Velmahos, M. deMoya, L. Zukerberg, T. F. Ng, and L. T. C. D. R. King, “Self-expanding polyurethane polymer improves survival in a model of noncompressible massive abdominal hemorrhage,” J. Trauma Acute Care Surg. 74(6), 1462–1467 (2013).
[Crossref]

Duggan, M. J.

M. P. Peev, A. Rago, J. O. Hwabejire, M. J. Duggan, J. Beagle, J. Marini, G. Zugates, R. Busold, T. Freyman, G. S. Velmahos, M. A. Demoya, D. D. Yeh, P. J. Fagenholz, U. Sharma, and D. R. King, “Self-expanding foam for prehospital treatment of severe intra-abdominal hemorrhage: dose finding study,” J. Trauma Acute Care Surg. 76(3), 619–624 (2014).
[Crossref]

M. J. Duggan, A. Y. Mejaddam, J. Beagle, M. A. Demoya, G. C. Velmahosa, H. B. Alam, A. Rago, G. Zugates, R. Busold, T. Freyman, U. Sharma, and D. R. King, “Development of a lethal, closed-abdomen grade V hepato-portal injury model in non-coagulopathic swine,” J. Surg. Res. 182(1), 101–107 (2013).
[Crossref] [PubMed]

Duranteau, J.

G. Tachon, A. Harrois, S. Tanaka, H. Kato, O. Huet, J. Pottecher, E. Vicaut, and J. Duranteau, “Microcirculatory alterations in traumatic hemorrhagic shock,” Crit. Care Med. 42(6), 1433–1441 (2014).
[Crossref] [PubMed]

Durduran, T.

T. Durduran and A. G. Yodh, “Diffuse correlation spectroscopy for non-invasive, micro-vascular cerebral blood flow measurement,” Neuroimage 85(Pt 1), 51–63 (2014).
[Crossref] [PubMed]

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse Optics for Tissue Monitoring and Tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[Crossref] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Eastridge, B. J.

B. J. Eastridge, R. L. Mabry, P. Seguin, J. Cantrell, T. Tops, P. Uribe, O. Mallett, T. Zubko, L. Oetjen-Gerdes, T. E. Rasmussen, F. K. Butler, R. S. Kotwal, J. B. Holcomb, C. Wade, H. Champion, M. Lawnick, L. Moores, and L. H. Blackbourne, “Death on the battlefield (2001-2011): implications for the future of combat casualty care,” J. Trauma Acute Care Surg. 73(6Suppl 5), S431–S437 (2012).
[Crossref] [PubMed]

Edlow, B. L.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Elam, M.

P. Wellhöner, D. Rolle, P. Lönnroth, L. Strindberg, M. Elam, and C. Dodt, “Laser-Doppler flowmetry reveals rapid perfusion changes in adipose tissue of lean and obese females,” Am. J. Physiol. Endocrinol. Metab. 291(5), E1025–E1030 (2006).
[Crossref] [PubMed]

Ellerby, G. E.

B. Soller, C. Smith, F. Zou, G. E. Ellerby, M. D. Prince, and J. L. Sondeen, “Investigation of noninvasive muscle pH and oxygen saturation during uncontrolled hemorrhage and resuscitation in swine,” Shock 42(1), 44–51 (2014).
[Crossref] [PubMed]

Fagenholz, P. J.

M. P. Peev, A. Rago, J. O. Hwabejire, M. J. Duggan, J. Beagle, J. Marini, G. Zugates, R. Busold, T. Freyman, G. S. Velmahos, M. A. Demoya, D. D. Yeh, P. J. Fagenholz, U. Sharma, and D. R. King, “Self-expanding foam for prehospital treatment of severe intra-abdominal hemorrhage: dose finding study,” J. Trauma Acute Care Surg. 76(3), 619–624 (2014).
[Crossref]

A. Y. Mejaddam, O. A. Birkhan, A. C. Sideris, G. M. Van der Wilden, A. M. Imam, J. O. Hwabejire, Y. Chang, G. C. Velmahos, P. J. Fagenholz, D. D. Yeh, M. A. de Moya, and D. R. King, “Real-time heart rate entropy predicts the need for lifesaving interventions in trauma activation patients,” J. Trauma Acute Care Surg. 75(4), 607–612 (2013).
[Crossref] [PubMed]

Filho, I. P.

K. R. Ward, M. H. Tiba, K. L. Ryan, I. P. Filho, C. A. Rickards, T. Witten, B. R. Soller, D. A. Ludwig, and V. A. Convertino, “Oxygen transport characterization of a human model of progressive hemorrhage,” Resuscitation 81(8), 987–993 (2010).
[Crossref] [PubMed]

K. R. Ward, R. R. Ivatury, R. W. Barbee, J. Terner, R. Pittman, I. P. Filho, and B. Spiess, “Near infrared spectroscopy for evaluation of the trauma patient: a technology review,” Resuscitation 68(1), 27–44 (2006).
[Crossref] [PubMed]

Franceschini, M. A.

Frangos, S.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Freyman, T.

M. P. Peev, A. Rago, J. O. Hwabejire, M. J. Duggan, J. Beagle, J. Marini, G. Zugates, R. Busold, T. Freyman, G. S. Velmahos, M. A. Demoya, D. D. Yeh, P. J. Fagenholz, U. Sharma, and D. R. King, “Self-expanding foam for prehospital treatment of severe intra-abdominal hemorrhage: dose finding study,” J. Trauma Acute Care Surg. 76(3), 619–624 (2014).
[Crossref]

M. Duggan, A. Rago, U. Sharma, G. Zugates, T. Freyman, R. Busold, J. Caulkins, Q. Pham, Y. Chang, A. Mejaddam, J. Beagle, G. Velmahos, M. deMoya, L. Zukerberg, T. F. Ng, and L. T. C. D. R. King, “Self-expanding polyurethane polymer improves survival in a model of noncompressible massive abdominal hemorrhage,” J. Trauma Acute Care Surg. 74(6), 1462–1467 (2013).
[Crossref]

M. J. Duggan, A. Y. Mejaddam, J. Beagle, M. A. Demoya, G. C. Velmahosa, H. B. Alam, A. Rago, G. Zugates, R. Busold, T. Freyman, U. Sharma, and D. R. King, “Development of a lethal, closed-abdomen grade V hepato-portal injury model in non-coagulopathic swine,” J. Surg. Res. 182(1), 101–107 (2013).
[Crossref] [PubMed]

Gagnon, D.

D. Gagnon, R. Matthew Brothers, M. S. Ganio, J. L. Hastings, and C. G. Crandall, “Forehead versus forearm skin vascular responses at presyncope in humans,” Am. J. Physiol. Regul. Integr. Comp. Physiol. 307(7), R908–R913 (2014).
[Crossref] [PubMed]

Ganio, M. S.

D. Gagnon, R. Matthew Brothers, M. S. Ganio, J. L. Hastings, and C. G. Crandall, “Forehead versus forearm skin vascular responses at presyncope in humans,” Am. J. Physiol. Regul. Integr. Comp. Physiol. 307(7), R908–R913 (2014).
[Crossref] [PubMed]

Goei, K. A.

C. Hinojosa-Laborde, R. E. Shade, G. W. Muniz, C. Bauer, K. A. Goei, H. F. Pidcoke, K. K. Chung, A. P. Cap, and V. A. Convertino, “Validation of lower body negative pressure as an experimental model of hemorrhage,” J Appl Physiol (1985) 116, 406– 415 (2014).

Grady, M. S.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Green, M. S.

M. S. Green, S. Sehgal, and R. Tariq, “Near-Infrared Spectroscopy: The New Must Have Tool in the Intensive Care Unit?” Semin. Cardiothorac. Vasc. Anesth. 20(3), 213–224 (2016).
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D. R. King, M. P. Ogilvie, B. M. Pereira, Y. Chang, R. J. Manning, J. A. Conner, C. I. Schulman, M. G. McKenney, and K. G. Proctor, “Heart rate variability as a triage tool in patients with trauma during prehospital helicopter transport,” J. Trauma 67(3), 436–440 (2009).
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Pham, Q.

M. Duggan, A. Rago, U. Sharma, G. Zugates, T. Freyman, R. Busold, J. Caulkins, Q. Pham, Y. Chang, A. Mejaddam, J. Beagle, G. Velmahos, M. deMoya, L. Zukerberg, T. F. Ng, and L. T. C. D. R. King, “Self-expanding polyurethane polymer improves survival in a model of noncompressible massive abdominal hemorrhage,” J. Trauma Acute Care Surg. 74(6), 1462–1467 (2013).
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Phelps, J. E.

Pidcoke, H. F.

C. Hinojosa-Laborde, R. E. Shade, G. W. Muniz, C. Bauer, K. A. Goei, H. F. Pidcoke, K. K. Chung, A. P. Cap, and V. A. Convertino, “Validation of lower body negative pressure as an experimental model of hemorrhage,” J Appl Physiol (1985) 116, 406– 415 (2014).

Pifferi, A.

Pinsky, M. R.

R. Schlichtig, D. J. Kramer, and M. R. Pinsky, “Flow redistribution during progressive hemorrhage is a determinant of critical O2 delivery,” J. Appl. Physiol. 70(1), 169–178 (1991).
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Pittman, R.

K. R. Ward, R. R. Ivatury, R. W. Barbee, J. Terner, R. Pittman, I. P. Filho, and B. Spiess, “Near infrared spectroscopy for evaluation of the trauma patient: a technology review,” Resuscitation 68(1), 27–44 (2006).
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Pottecher, J.

G. Tachon, A. Harrois, S. Tanaka, H. Kato, O. Huet, J. Pottecher, E. Vicaut, and J. Duranteau, “Microcirculatory alterations in traumatic hemorrhagic shock,” Crit. Care Med. 42(6), 1433–1441 (2014).
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Prince, M. D.

B. Soller, C. Smith, F. Zou, G. E. Ellerby, M. D. Prince, and J. L. Sondeen, “Investigation of noninvasive muscle pH and oxygen saturation during uncontrolled hemorrhage and resuscitation in swine,” Shock 42(1), 44–51 (2014).
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Proctor, K. G.

D. R. King, M. P. Ogilvie, B. M. Pereira, Y. Chang, R. J. Manning, J. A. Conner, C. I. Schulman, M. G. McKenney, and K. G. Proctor, “Heart rate variability as a triage tool in patients with trauma during prehospital helicopter transport,” J. Trauma 67(3), 436–440 (2009).
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Rago, A.

M. P. Peev, A. Rago, J. O. Hwabejire, M. J. Duggan, J. Beagle, J. Marini, G. Zugates, R. Busold, T. Freyman, G. S. Velmahos, M. A. Demoya, D. D. Yeh, P. J. Fagenholz, U. Sharma, and D. R. King, “Self-expanding foam for prehospital treatment of severe intra-abdominal hemorrhage: dose finding study,” J. Trauma Acute Care Surg. 76(3), 619–624 (2014).
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M. Duggan, A. Rago, U. Sharma, G. Zugates, T. Freyman, R. Busold, J. Caulkins, Q. Pham, Y. Chang, A. Mejaddam, J. Beagle, G. Velmahos, M. deMoya, L. Zukerberg, T. F. Ng, and L. T. C. D. R. King, “Self-expanding polyurethane polymer improves survival in a model of noncompressible massive abdominal hemorrhage,” J. Trauma Acute Care Surg. 74(6), 1462–1467 (2013).
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M. J. Duggan, A. Y. Mejaddam, J. Beagle, M. A. Demoya, G. C. Velmahosa, H. B. Alam, A. Rago, G. Zugates, R. Busold, T. Freyman, U. Sharma, and D. R. King, “Development of a lethal, closed-abdomen grade V hepato-portal injury model in non-coagulopathic swine,” J. Surg. Res. 182(1), 101–107 (2013).
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Ramanujam, N.

Rasmussen, T. E.

B. J. Eastridge, R. L. Mabry, P. Seguin, J. Cantrell, T. Tops, P. Uribe, O. Mallett, T. Zubko, L. Oetjen-Gerdes, T. E. Rasmussen, F. K. Butler, R. S. Kotwal, J. B. Holcomb, C. Wade, H. Champion, M. Lawnick, L. Moores, and L. H. Blackbourne, “Death on the battlefield (2001-2011): implications for the future of combat casualty care,” J. Trauma Acute Care Surg. 73(6Suppl 5), S431–S437 (2012).
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Rickards, C. A.

J. D. Sprick, B. R. Soller, and C. A. Rickards, “The efficacy of novel anatomical sites for the assessment of muscle oxygenation during central hypovolemia,” Exp. Biol. Med. (Maywood) 241(17), 2007–2013 (2016).
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K. R. Ward, M. H. Tiba, K. L. Ryan, I. P. Filho, C. A. Rickards, T. Witten, B. R. Soller, D. A. Ludwig, and V. A. Convertino, “Oxygen transport characterization of a human model of progressive hemorrhage,” Resuscitation 81(8), 987–993 (2010).
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Roche-Labarbe, N.

Rolle, D.

P. Wellhöner, D. Rolle, P. Lönnroth, L. Strindberg, M. Elam, and C. Dodt, “Laser-Doppler flowmetry reveals rapid perfusion changes in adipose tissue of lean and obese females,” Am. J. Physiol. Endocrinol. Metab. 291(5), E1025–E1030 (2006).
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Ryan, K. L.

K. R. Ward, M. H. Tiba, K. L. Ryan, I. P. Filho, C. A. Rickards, T. Witten, B. R. Soller, D. A. Ludwig, and V. A. Convertino, “Oxygen transport characterization of a human model of progressive hemorrhage,” Resuscitation 81(8), 987–993 (2010).
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Sakadžic, S.

Salcedo, M. C.

M. C. Salcedo, K. Tart, and K. Hall, “A systematic review of human and veterinary applications of noninvasive tissue oxygen monitoring,” J. Vet Emerg Crit Care 26(3), 323–332 (2016).
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Sato, S.

T. Kurita, K. Morita, and S. Sato, “The Influence of Hypovolemia and Fluid Resuscitation During Hemorrhagic Shock on Apneic Oxygen Desaturation After Preoxygenation in a Swine Model,” Anesth. Analg. 121(6), 1555–1561 (2015).
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Schlichtig, R.

R. Schlichtig, D. J. Kramer, and M. R. Pinsky, “Flow redistribution during progressive hemorrhage is a determinant of critical O2 delivery,” J. Appl. Physiol. 70(1), 169–178 (1991).
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Schneider, C. P.

M. K. Angele, C. P. Schneider, and I. H. Chaudry, “Bench-to-bedside review: latest results in hemorrhagic shock,” Crit. Care 12(4), 218 (2008).
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Schulman, C. I.

D. R. King, M. P. Ogilvie, B. M. Pereira, Y. Chang, R. J. Manning, J. A. Conner, C. I. Schulman, M. G. McKenney, and K. G. Proctor, “Heart rate variability as a triage tool in patients with trauma during prehospital helicopter transport,” J. Trauma 67(3), 436–440 (2009).
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Schwab, P. J.

V. Jain, E. M. Buckley, D. J. Licht, J. M. Lynch, P. J. Schwab, M. Y. Naim, N. A. Lavin, S. C. Nicolson, L. M. Montenegro, A. G. Yodh, and F. W. Wehrli, “Cerebral oxygen metabolism in neonates with congenital heart disease quantified by MRI and optics,” J. Cereb. Blood Flow Metab. 34(3), 380–388 (2014).
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Seguin, P.

B. J. Eastridge, R. L. Mabry, P. Seguin, J. Cantrell, T. Tops, P. Uribe, O. Mallett, T. Zubko, L. Oetjen-Gerdes, T. E. Rasmussen, F. K. Butler, R. S. Kotwal, J. B. Holcomb, C. Wade, H. Champion, M. Lawnick, L. Moores, and L. H. Blackbourne, “Death on the battlefield (2001-2011): implications for the future of combat casualty care,” J. Trauma Acute Care Surg. 73(6Suppl 5), S431–S437 (2012).
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Sehgal, S.

M. S. Green, S. Sehgal, and R. Tariq, “Near-Infrared Spectroscopy: The New Must Have Tool in the Intensive Care Unit?” Semin. Cardiothorac. Vasc. Anesth. 20(3), 213–224 (2016).
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Shade, R. E.

C. Hinojosa-Laborde, R. E. Shade, G. W. Muniz, C. Bauer, K. A. Goei, H. F. Pidcoke, K. K. Chung, A. P. Cap, and V. A. Convertino, “Validation of lower body negative pressure as an experimental model of hemorrhage,” J Appl Physiol (1985) 116, 406– 415 (2014).

Shang, Y.

Y. Shang, T. Li, and G. Yu, “Clinical applications of near-infrared diffuse correlation spectroscopy and tomography for tissue blood flow monitoring and imaging,” Physiol. Meas. 38(4), R1–R26 (2017).
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M. P. Peev, A. Rago, J. O. Hwabejire, M. J. Duggan, J. Beagle, J. Marini, G. Zugates, R. Busold, T. Freyman, G. S. Velmahos, M. A. Demoya, D. D. Yeh, P. J. Fagenholz, U. Sharma, and D. R. King, “Self-expanding foam for prehospital treatment of severe intra-abdominal hemorrhage: dose finding study,” J. Trauma Acute Care Surg. 76(3), 619–624 (2014).
[Crossref]

M. J. Duggan, A. Y. Mejaddam, J. Beagle, M. A. Demoya, G. C. Velmahosa, H. B. Alam, A. Rago, G. Zugates, R. Busold, T. Freyman, U. Sharma, and D. R. King, “Development of a lethal, closed-abdomen grade V hepato-portal injury model in non-coagulopathic swine,” J. Surg. Res. 182(1), 101–107 (2013).
[Crossref] [PubMed]

M. Duggan, A. Rago, U. Sharma, G. Zugates, T. Freyman, R. Busold, J. Caulkins, Q. Pham, Y. Chang, A. Mejaddam, J. Beagle, G. Velmahos, M. deMoya, L. Zukerberg, T. F. Ng, and L. T. C. D. R. King, “Self-expanding polyurethane polymer improves survival in a model of noncompressible massive abdominal hemorrhage,” J. Trauma Acute Care Surg. 74(6), 1462–1467 (2013).
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A. Y. Mejaddam, O. A. Birkhan, A. C. Sideris, G. M. Van der Wilden, A. M. Imam, J. O. Hwabejire, Y. Chang, G. C. Velmahos, P. J. Fagenholz, D. D. Yeh, M. A. de Moya, and D. R. King, “Real-time heart rate entropy predicts the need for lifesaving interventions in trauma activation patients,” J. Trauma Acute Care Surg. 75(4), 607–612 (2013).
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B. Soller, C. Smith, F. Zou, G. E. Ellerby, M. D. Prince, and J. L. Sondeen, “Investigation of noninvasive muscle pH and oxygen saturation during uncontrolled hemorrhage and resuscitation in swine,” Shock 42(1), 44–51 (2014).
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B. Soller, C. Smith, F. Zou, G. E. Ellerby, M. D. Prince, and J. L. Sondeen, “Investigation of noninvasive muscle pH and oxygen saturation during uncontrolled hemorrhage and resuscitation in swine,” Shock 42(1), 44–51 (2014).
[Crossref] [PubMed]

Soller, B. R.

J. D. Sprick, B. R. Soller, and C. A. Rickards, “The efficacy of novel anatomical sites for the assessment of muscle oxygenation during central hypovolemia,” Exp. Biol. Med. (Maywood) 241(17), 2007–2013 (2016).
[Crossref] [PubMed]

K. R. Ward, M. H. Tiba, K. L. Ryan, I. P. Filho, C. A. Rickards, T. Witten, B. R. Soller, D. A. Ludwig, and V. A. Convertino, “Oxygen transport characterization of a human model of progressive hemorrhage,” Resuscitation 81(8), 987–993 (2010).
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B. Soller, C. Smith, F. Zou, G. E. Ellerby, M. D. Prince, and J. L. Sondeen, “Investigation of noninvasive muscle pH and oxygen saturation during uncontrolled hemorrhage and resuscitation in swine,” Shock 42(1), 44–51 (2014).
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Spiess, B.

K. R. Ward, R. R. Ivatury, R. W. Barbee, J. Terner, R. Pittman, I. P. Filho, and B. Spiess, “Near infrared spectroscopy for evaluation of the trauma patient: a technology review,” Resuscitation 68(1), 27–44 (2006).
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J. D. Sprick, B. R. Soller, and C. A. Rickards, “The efficacy of novel anatomical sites for the assessment of muscle oxygenation during central hypovolemia,” Exp. Biol. Med. (Maywood) 241(17), 2007–2013 (2016).
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Srinivasan, V. J.

Strindberg, L.

P. Wellhöner, D. Rolle, P. Lönnroth, L. Strindberg, M. Elam, and C. Dodt, “Laser-Doppler flowmetry reveals rapid perfusion changes in adipose tissue of lean and obese females,” Am. J. Physiol. Endocrinol. Metab. 291(5), E1025–E1030 (2006).
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G. Tachon, A. Harrois, S. Tanaka, H. Kato, O. Huet, J. Pottecher, E. Vicaut, and J. Duranteau, “Microcirculatory alterations in traumatic hemorrhagic shock,” Crit. Care Med. 42(6), 1433–1441 (2014).
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Tariq, R.

M. S. Green, S. Sehgal, and R. Tariq, “Near-Infrared Spectroscopy: The New Must Have Tool in the Intensive Care Unit?” Semin. Cardiothorac. Vasc. Anesth. 20(3), 213–224 (2016).
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Taroni, P.

Tart, K.

M. C. Salcedo, K. Tart, and K. Hall, “A systematic review of human and veterinary applications of noninvasive tissue oxygen monitoring,” J. Vet Emerg Crit Care 26(3), 323–332 (2016).
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K. R. Ward, M. H. Tiba, K. L. Ryan, I. P. Filho, C. A. Rickards, T. Witten, B. R. Soller, D. A. Ludwig, and V. A. Convertino, “Oxygen transport characterization of a human model of progressive hemorrhage,” Resuscitation 81(8), 987–993 (2010).
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M. Tivnan, R. Gurjar, D. E. Wolf, and K. Vishwanath, “High Frequency Sampling of TTL Pulses on a Raspberry Pi for Diffuse Correlation Spectroscopy Applications,” Sensors (Basel) 15(8), 19709–19722 (2015).
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B. J. Eastridge, R. L. Mabry, P. Seguin, J. Cantrell, T. Tops, P. Uribe, O. Mallett, T. Zubko, L. Oetjen-Gerdes, T. E. Rasmussen, F. K. Butler, R. S. Kotwal, J. B. Holcomb, C. Wade, H. Champion, M. Lawnick, L. Moores, and L. H. Blackbourne, “Death on the battlefield (2001-2011): implications for the future of combat casualty care,” J. Trauma Acute Care Surg. 73(6Suppl 5), S431–S437 (2012).
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V. V. Tuchin, S. R. Utz, and I. V. Yaroslavsky, “Tissue Optics, Light-Distribution, and Spectroscopy,” Opt. Eng. 33(10), 3178–3188 (1994).
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B. J. Eastridge, R. L. Mabry, P. Seguin, J. Cantrell, T. Tops, P. Uribe, O. Mallett, T. Zubko, L. Oetjen-Gerdes, T. E. Rasmussen, F. K. Butler, R. S. Kotwal, J. B. Holcomb, C. Wade, H. Champion, M. Lawnick, L. Moores, and L. H. Blackbourne, “Death on the battlefield (2001-2011): implications for the future of combat casualty care,” J. Trauma Acute Care Surg. 73(6Suppl 5), S431–S437 (2012).
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V. V. Tuchin, S. R. Utz, and I. V. Yaroslavsky, “Tissue Optics, Light-Distribution, and Spectroscopy,” Opt. Eng. 33(10), 3178–3188 (1994).
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Van der Wilden, G. M.

A. Y. Mejaddam, O. A. Birkhan, A. C. Sideris, G. M. Van der Wilden, A. M. Imam, J. O. Hwabejire, Y. Chang, G. C. Velmahos, P. J. Fagenholz, D. D. Yeh, M. A. de Moya, and D. R. King, “Real-time heart rate entropy predicts the need for lifesaving interventions in trauma activation patients,” J. Trauma Acute Care Surg. 75(4), 607–612 (2013).
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M. Duggan, A. Rago, U. Sharma, G. Zugates, T. Freyman, R. Busold, J. Caulkins, Q. Pham, Y. Chang, A. Mejaddam, J. Beagle, G. Velmahos, M. deMoya, L. Zukerberg, T. F. Ng, and L. T. C. D. R. King, “Self-expanding polyurethane polymer improves survival in a model of noncompressible massive abdominal hemorrhage,” J. Trauma Acute Care Surg. 74(6), 1462–1467 (2013).
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A. Y. Mejaddam, O. A. Birkhan, A. C. Sideris, G. M. Van der Wilden, A. M. Imam, J. O. Hwabejire, Y. Chang, G. C. Velmahos, P. J. Fagenholz, D. D. Yeh, M. A. de Moya, and D. R. King, “Real-time heart rate entropy predicts the need for lifesaving interventions in trauma activation patients,” J. Trauma Acute Care Surg. 75(4), 607–612 (2013).
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M. P. Peev, A. Rago, J. O. Hwabejire, M. J. Duggan, J. Beagle, J. Marini, G. Zugates, R. Busold, T. Freyman, G. S. Velmahos, M. A. Demoya, D. D. Yeh, P. J. Fagenholz, U. Sharma, and D. R. King, “Self-expanding foam for prehospital treatment of severe intra-abdominal hemorrhage: dose finding study,” J. Trauma Acute Care Surg. 76(3), 619–624 (2014).
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M. J. Duggan, A. Y. Mejaddam, J. Beagle, M. A. Demoya, G. C. Velmahosa, H. B. Alam, A. Rago, G. Zugates, R. Busold, T. Freyman, U. Sharma, and D. R. King, “Development of a lethal, closed-abdomen grade V hepato-portal injury model in non-coagulopathic swine,” J. Surg. Res. 182(1), 101–107 (2013).
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G. Tachon, A. Harrois, S. Tanaka, H. Kato, O. Huet, J. Pottecher, E. Vicaut, and J. Duranteau, “Microcirculatory alterations in traumatic hemorrhagic shock,” Crit. Care Med. 42(6), 1433–1441 (2014).
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M. Tivnan, R. Gurjar, D. E. Wolf, and K. Vishwanath, “High Frequency Sampling of TTL Pulses on a Raspberry Pi for Diffuse Correlation Spectroscopy Applications,” Sensors (Basel) 15(8), 19709–19722 (2015).
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P. Wellhöner, D. Rolle, P. Lönnroth, L. Strindberg, M. Elam, and C. Dodt, “Laser-Doppler flowmetry reveals rapid perfusion changes in adipose tissue of lean and obese females,” Am. J. Physiol. Endocrinol. Metab. 291(5), E1025–E1030 (2006).
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K. R. Ward, M. H. Tiba, K. L. Ryan, I. P. Filho, C. A. Rickards, T. Witten, B. R. Soller, D. A. Ludwig, and V. A. Convertino, “Oxygen transport characterization of a human model of progressive hemorrhage,” Resuscitation 81(8), 987–993 (2010).
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M. Tivnan, R. Gurjar, D. E. Wolf, and K. Vishwanath, “High Frequency Sampling of TTL Pulses on a Raspberry Pi for Diffuse Correlation Spectroscopy Applications,” Sensors (Basel) 15(8), 19709–19722 (2015).
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M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
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Yeh, D. D.

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[Crossref] [PubMed]

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T. Durduran and A. G. Yodh, “Diffuse correlation spectroscopy for non-invasive, micro-vascular cerebral blood flow measurement,” Neuroimage 85(Pt 1), 51–63 (2014).
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M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
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B. Soller, C. Smith, F. Zou, G. E. Ellerby, M. D. Prince, and J. L. Sondeen, “Investigation of noninvasive muscle pH and oxygen saturation during uncontrolled hemorrhage and resuscitation in swine,” Shock 42(1), 44–51 (2014).
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M. J. Duggan, A. Y. Mejaddam, J. Beagle, M. A. Demoya, G. C. Velmahosa, H. B. Alam, A. Rago, G. Zugates, R. Busold, T. Freyman, U. Sharma, and D. R. King, “Development of a lethal, closed-abdomen grade V hepato-portal injury model in non-coagulopathic swine,” J. Surg. Res. 182(1), 101–107 (2013).
[Crossref] [PubMed]

M. Duggan, A. Rago, U. Sharma, G. Zugates, T. Freyman, R. Busold, J. Caulkins, Q. Pham, Y. Chang, A. Mejaddam, J. Beagle, G. Velmahos, M. deMoya, L. Zukerberg, T. F. Ng, and L. T. C. D. R. King, “Self-expanding polyurethane polymer improves survival in a model of noncompressible massive abdominal hemorrhage,” J. Trauma Acute Care Surg. 74(6), 1462–1467 (2013).
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M. Duggan, A. Rago, U. Sharma, G. Zugates, T. Freyman, R. Busold, J. Caulkins, Q. Pham, Y. Chang, A. Mejaddam, J. Beagle, G. Velmahos, M. deMoya, L. Zukerberg, T. F. Ng, and L. T. C. D. R. King, “Self-expanding polyurethane polymer improves survival in a model of noncompressible massive abdominal hemorrhage,” J. Trauma Acute Care Surg. 74(6), 1462–1467 (2013).
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T. Kurita, K. Morita, and S. Sato, “The Influence of Hypovolemia and Fluid Resuscitation During Hemorrhagic Shock on Apneic Oxygen Desaturation After Preoxygenation in a Swine Model,” Anesth. Analg. 121(6), 1555–1561 (2015).
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J. Q. Brown, K. Vishwanath, G. M. Palmer, and N. Ramanujam, “Advances in quantitative UV-visible spectroscopy for clinical and pre-clinical application in cancer,” Curr. Opin. Biotechnol. 20(1), 119–131 (2009).
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A. Lima, “Current status of tissue monitoring in the management of shock,” Curr. Opin. Crit. Care 22(3), 274–278 (2016).
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J. D. Sprick, B. R. Soller, and C. A. Rickards, “The efficacy of novel anatomical sites for the assessment of muscle oxygenation during central hypovolemia,” Exp. Biol. Med. (Maywood) 241(17), 2007–2013 (2016).
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J. Opt. Soc. Am. A (1)

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M. J. Duggan, A. Y. Mejaddam, J. Beagle, M. A. Demoya, G. C. Velmahosa, H. B. Alam, A. Rago, G. Zugates, R. Busold, T. Freyman, U. Sharma, and D. R. King, “Development of a lethal, closed-abdomen grade V hepato-portal injury model in non-coagulopathic swine,” J. Surg. Res. 182(1), 101–107 (2013).
[Crossref] [PubMed]

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J. Trauma Acute Care Surg. (4)

A. Y. Mejaddam, O. A. Birkhan, A. C. Sideris, G. M. Van der Wilden, A. M. Imam, J. O. Hwabejire, Y. Chang, G. C. Velmahos, P. J. Fagenholz, D. D. Yeh, M. A. de Moya, and D. R. King, “Real-time heart rate entropy predicts the need for lifesaving interventions in trauma activation patients,” J. Trauma Acute Care Surg. 75(4), 607–612 (2013).
[Crossref] [PubMed]

M. Duggan, A. Rago, U. Sharma, G. Zugates, T. Freyman, R. Busold, J. Caulkins, Q. Pham, Y. Chang, A. Mejaddam, J. Beagle, G. Velmahos, M. deMoya, L. Zukerberg, T. F. Ng, and L. T. C. D. R. King, “Self-expanding polyurethane polymer improves survival in a model of noncompressible massive abdominal hemorrhage,” J. Trauma Acute Care Surg. 74(6), 1462–1467 (2013).
[Crossref]

M. P. Peev, A. Rago, J. O. Hwabejire, M. J. Duggan, J. Beagle, J. Marini, G. Zugates, R. Busold, T. Freyman, G. S. Velmahos, M. A. Demoya, D. D. Yeh, P. J. Fagenholz, U. Sharma, and D. R. King, “Self-expanding foam for prehospital treatment of severe intra-abdominal hemorrhage: dose finding study,” J. Trauma Acute Care Surg. 76(3), 619–624 (2014).
[Crossref]

B. J. Eastridge, R. L. Mabry, P. Seguin, J. Cantrell, T. Tops, P. Uribe, O. Mallett, T. Zubko, L. Oetjen-Gerdes, T. E. Rasmussen, F. K. Butler, R. S. Kotwal, J. B. Holcomb, C. Wade, H. Champion, M. Lawnick, L. Moores, and L. H. Blackbourne, “Death on the battlefield (2001-2011): implications for the future of combat casualty care,” J. Trauma Acute Care Surg. 73(6Suppl 5), S431–S437 (2012).
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M. C. Salcedo, K. Tart, and K. Hall, “A systematic review of human and veterinary applications of noninvasive tissue oxygen monitoring,” J. Vet Emerg Crit Care 26(3), 323–332 (2016).
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Neurocrit. Care (1)

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Neuroimage (1)

T. Durduran and A. G. Yodh, “Diffuse correlation spectroscopy for non-invasive, micro-vascular cerebral blood flow measurement,” Neuroimage 85(Pt 1), 51–63 (2014).
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Physiol. Meas. (1)

Y. Shang, T. Li, and G. Yu, “Clinical applications of near-infrared diffuse correlation spectroscopy and tomography for tissue blood flow monitoring and imaging,” Physiol. Meas. 38(4), R1–R26 (2017).
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Rep. Prog. Phys. (1)

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse Optics for Tissue Monitoring and Tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
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K. R. Ward, R. R. Ivatury, R. W. Barbee, J. Terner, R. Pittman, I. P. Filho, and B. Spiess, “Near infrared spectroscopy for evaluation of the trauma patient: a technology review,” Resuscitation 68(1), 27–44 (2006).
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M. S. Green, S. Sehgal, and R. Tariq, “Near-Infrared Spectroscopy: The New Must Have Tool in the Intensive Care Unit?” Semin. Cardiothorac. Vasc. Anesth. 20(3), 213–224 (2016).
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M. Tivnan, R. Gurjar, D. E. Wolf, and K. Vishwanath, “High Frequency Sampling of TTL Pulses on a Raspberry Pi for Diffuse Correlation Spectroscopy Applications,” Sensors (Basel) 15(8), 19709–19722 (2015).
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Shock (1)

B. Soller, C. Smith, F. Zou, G. E. Ellerby, M. D. Prince, and J. L. Sondeen, “Investigation of noninvasive muscle pH and oxygen saturation during uncontrolled hemorrhage and resuscitation in swine,” Shock 42(1), 44–51 (2014).
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Other (3)

J. Malsan, R. Gurjar, D. Wolf, and K. Vishwanath, “Extracting optical properties of turbid media using radially and spectrally resolved diffuse reflectance,” in Design and Quality for Biomedical Technologies Vii, R. Raghavachari, and R. Liang, eds. (2014).

K. Vishwanath, R. Gurjar, S. Kuo, A. Fasi, R. Kim, S. Riccardi, S. E. Feinberg, and D. E. Wolf, “Sensing vascularization of ex-vivo produced oral mucosal equivalent (EVPOME) skin grafts in nude mice using optical spectroscopy,” in Photonic Therapeutics and Diagnostics X. B. Choi, N. Kollias, H. Zeng, H. W. Kang, B. J. F. Wong, J. F. Ilgner, G. J. Tearney, K. W. Gregory, L. Marcu, and A. Mandelis, eds. (2014).

R. S. Gurjar, S. L. Riccardi, B. D. Johnson, C. P. Johnson, N. A. Paradis, M. J. Joyner, and D. E. Wolf, “Point-of-care optical tool to detect early stage of hemorrhage and shock,” in SPIE BiOS(SPIE2014), p. 89510K.

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Figures (6)

Fig. 1
Fig. 1

Images of the animal preparation along with optical probes. Figure 1(a) shows the probes on the thighs of the animal while Fig. 1(b) shows the ear (transmission) DCS probe.

Fig. 2
Fig. 2

Representative DCS signal measured for the ear channel (Fig. 2(a)) and DRS spectra (Fig. 2(b)) acquired before injury (black curves - baseline) and 100s post injury (red curves - bleed) for one animal. Figure 2(a) illustrates how τ0.5 (see text) was computed for each trace. Figure 2(b) shows the corrected DRS spectra measured in the same animal, at nearly the same times as the DCS curves (symbols) and the corresponding MC fits (lines).

Fig. 3
Fig. 3

Representative DCS signal measured for the ear transmittance channel (Fig. 3(a)), the 1 cm reflectance channel (Fig. 3(b)) and the 0.2 cm channel (Fig. 3(c)). The two traces show points of baseline (in black) and bleed (in red) for the same times and animal as Fig. 2. The solid line shows the diffusion theory based fits.

Fig. 4
Fig. 4

Normalized longitudinal variations in flow index derived from DCS using both analytical strategies (see text). Symbols differentiate pre-injury (baseline: circles) from post-injury (bleed: triangles), while each color corresponds to a different animal. The vertical line at t = 0 indicates time of induced hemorrhage. Data in Fig. 4(a) and 4(d) are for the ear channel, for 4(b) and (e) are for the 1cm reflectance channel and 4(c) and 4(f) for the 0.2 cm reflectance channel, respectively.

Fig. 5
Fig. 5

Longitudinal changes in normalized SO2 (Fig. 5(a)) and [THb] (Fig. 5(b)) derived from DRS for each animal. Symbols mark pre-injury (baseline: circles) and post-injury (bleed: triangles), while each color corresponds to a different animal. The vertical line at t = 0 indicates time of induced hemorrhage.

Fig. 6
Fig. 6

Mean fractional change in flow index from diffusion theory fits (Fig. 6(a)) and DRS variables (Fig. 6(b)) across all four animals. Bars are average values obtained in each animal during baseline while the bleed values were obtained at 90s post injury. Whiskers indicate standard deviations.

Tables (1)

Tables Icon

Table 1 Systemic variables at baseline (pre) and following shock (post) for the 4 animals. Data for each variable are shown as the mean value with standard deviations in parentheses. The last column presents the averages for these data across all animals.