Abstract

Fluorescence microscopy is a powerful method for producing high fidelity images with high spatial resolution, particularly in the biological sciences. We recently introduced coherent holographic image reconstruction by phase transfer (CHIRPT), a single-pixel imaging method that significantly improves the depth of field in fluorescence microscopy and enables holographic refocusing of fluorescent light. Here we demonstrate that by installing a confocal slit conjugate to the illuminating light sheets used in CHIRPT, out-of-focus light is rejected, thus improving lateral spatial resolution and rejecting noise from out-of-focus fluorescent light. Confocal CHIRPT is demonstrated and fully modeled. Finally, we explore the use of beam shaping and point-spread-function engineering to enable holographic single-lens light-sheet microscopy with single-pixel detection.

© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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Three-dimensional single-pixel imaging of incoherent light with spatiotemporally modulated illumination

Jeffrey J. Field, Keith A. Wernsing, Jeff A. Squier, and Randy A. Bartels
J. Opt. Soc. Am. A 35(8) 1438-1449 (2018)

Plane wave analysis of coherent holographic image reconstruction by phase transfer (CHIRPT)

Jeffrey J. Field, David G. Winters, and Randy A. Bartels
J. Opt. Soc. Am. A 32(11) 2156-2168 (2015)

References

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2018 (1)

2016 (3)

J. J. Field, D. G. Winters, and R. A. Bartels, “Single-pixel fluorescent imaging with temporally labeled illumination patterns,” Optica 3, 971–974 (2016).
[Crossref]

J. J. Field and R. A. Bartels, “Digital aberration correction of fluorescent images with coherent holographic image reconstruction by phase transfer (CHIRPT),” Proc. SPIE 9713, 97130B (2016).
[Crossref]

J. J. Field, K. A. Wernsing, S. R. Domingue, A. M. Allende Motz, K. F. DeLuca, D. H. Levi, J. G. DeLuca, M. D. Young, J. A. Squier, and R. A. Bartels, “Superresolved multiphoton microscopy with spatial frequency-modulated imaging,” Proc. Natl. Acad. Sci. 113, 6605–6610 (2016).
[Crossref] [PubMed]

2015 (1)

2014 (1)

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A.-C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346, 1257998 (2014).
[Crossref] [PubMed]

2013 (3)

D. R. Smith, D. G. Winters, and R. A. Bartels, “Submillisecond second harmonic holographic imaging of biological specimens in three dimensions,” Proc. Nat. Acad. Sci. 110, 18391–18396 (2013).
[Crossref] [PubMed]

E. D. Diebold, B. W. Buckley, D. R. Gossett, and B. Jalali, “Digitally synthesized beat frequency multiplexing for sub-millisecond fluorescence microscopy,” Nat. Photon. 7, 806–810 (2013).
[Crossref]

Y. Cotte, F. Toy, P. Jourdain, N. Pavillon, D. Boss, P. Magistretti, P. Marquet, and C. Depeursinge, “Marker-free phase nanoscopy,” Nat. Photon. 7, 1–5 (2013).

2012 (4)

D. J. Higley, D. G. Winters, G. L. Futia, and R. A. Bartels, “Theory of diffraction effects in spatial frequency-modulated imaging,” J. Opt. Soc. Am. A 29, 2579–2590 (2012).
[Crossref]

J. Miao, R. L. Sandberg, and C. Song, “Coherent X-Ray Diffraction Imaging,” IEEE J. Sel. Top. Quant. Elec. 18, 399–410 (2012).
[Crossref]

E. E. Hoover, J. J. Field, D. G. Winters, M. D. Young, E. V. Chandler, J. C. Speirs, J. T. Lapenna, S. M. Kim, S.-y. Ding, R. A. Bartels, J. W. Wang, and J. A. Squier, “Eliminating the scattering ambiguity in multifocal, multimodal, multiphoton imaging systems,” J. Biophoton. 5, 425–436 (2012).
[Crossref]

J. J. Field, K. E. Sheetz, E. V. Chandler, E. E. Hoover, M. D. Young, S.-Y. Ding, A. W. Sylvester, D. Kleinfeld, and J. A. Squier, “Differential Multiphoton Laser Scanning Microscopy,” Sel. Top. Quantum Electron. IEEE J. 18, 14–28 (2012).
[Crossref]

2011 (1)

G. Futia, P. Schlup, D. G. Winters, and R. A. Bartels, “Spatially-chirped modulation imaging of absorption and fluorescent objects onsingle-element optical detector,” Opt. Exp. 19, 1626–1640 (2011).
[Crossref]

2010 (2)

F. O. Fahrbach, P. Simon, and A. Rohrbach, “Microscopy with self-reconstructing beams,” Nat. Photonics 4, 1–6 (2010).

K. S. Raines, S. Salha, R. L. Sandberg, H. Jiang, J. A. Rodríguez, B. P. Fahimian, H. C. Kapteyn, J. Du, and J. Miao, “Three-dimensional structure determination from a single view,” Nature 463, 214–217 (2010).
[Crossref]

2009 (1)

J. Huisken and D. Y. R. Stainier, “Selective plane illumination microscopy techniques in developmental biology,” Development 136, 1963–1975 (2009).
[Crossref] [PubMed]

2007 (1)

G. A. Siviloglou, J. Broky, A. Dogariu, and D. N. Christodoulides, “Observation of Accelerating Airy Beams,” Phys. Rev. Lett. 99, 1–4 (2007).
[Crossref]

2006 (1)

P. Sarder and A. Nehorai, “Deconvolution methods for 3-d fluorescence microscopy images,” IEEE Signal Process. Mag. 23, 32–45 (2006).
[Crossref]

2003 (1)

W. R. Zipfel, R. M. Williams, and W. W. Webb, “Nonlinear magic: multiphoton microscopy in the biosciences,” Nat. Biotechnol. 21, 1369–1377 (2003).
[Crossref] [PubMed]

1998 (2)

Buist, Müller, Squier, and Brakenhoff, “Real time two-photon absorption microscopy using multi point excitation,” J. Microsc. 192, 217–226 (1998).
[Crossref]

J. Bewersdorf, R. Pick, and S. W. Hell, “Multifocal multiphoton microscopy,” Opt. Lett. 23, 655–657 (1998).
[Crossref]

1996 (1)

G. J. Brakenhoff, J. Squier, T. Norris, A. C. Bliton, M. H. Wade, and B. Athey, “Real-time two-photon confocal microscopy using a femtosecond, amplified ti:sapphire system,” J. Microsc. 181, 253–259 (1996).
[Crossref] [PubMed]

1990 (1)

W. Denk, J. Strickler, and W. Webb, “Two-photon laser scanning fluorescence microscopy,” Science 248, 73–76 (1990).
[Crossref] [PubMed]

1981 (1)

1979 (1)

M. V. Berry and N. L. Balazs, “Nonspreading wave packets,” Am. J. Phys. 47, 264–267 (1979).
[Crossref]

1971 (1)

1969 (1)

P. Davidovits and M. D. Egger, “Scanning laser microscope,” Nature 223, 831 (1969).
[Crossref] [PubMed]

1965 (1)

E. Leith and J. Upatnieks, “Wavefront Reconstruction Photography,” Phys. Today 18, 26 (1965).
[Crossref]

1948 (1)

D. Gabor, “A new microscopic principle,” Nature 161, 777 (1948).
[Crossref] [PubMed]

1902 (1)

H. Siedentopf and R. Zsigmondy, “Uber sichtbarmachung und größenbestimmung ultramikoskopischer teilchen, mit besonderer anwendung auf goldrubingläser,” Annalen der Physik 315, 1–39 (1902).
[Crossref]

Allende Motz, A. M.

J. J. Field, K. A. Wernsing, S. R. Domingue, A. M. Allende Motz, K. F. DeLuca, D. H. Levi, J. G. DeLuca, M. D. Young, J. A. Squier, and R. A. Bartels, “Superresolved multiphoton microscopy with spatial frequency-modulated imaging,” Proc. Natl. Acad. Sci. 113, 6605–6610 (2016).
[Crossref] [PubMed]

Athey, B.

G. J. Brakenhoff, J. Squier, T. Norris, A. C. Bliton, M. H. Wade, and B. Athey, “Real-time two-photon confocal microscopy using a femtosecond, amplified ti:sapphire system,” J. Microsc. 181, 253–259 (1996).
[Crossref] [PubMed]

Balazs, N. L.

M. V. Berry and N. L. Balazs, “Nonspreading wave packets,” Am. J. Phys. 47, 264–267 (1979).
[Crossref]

Bartels, R. A.

J. J. Field, K. A. Wernsing, J. A. Squier, and R. A. Bartels, “Three-dimensional single-pixel imaging of incoherent light with spatiotemporally modulated illumination,” J. Opt. Soc. Am. A 35, 1438–1449 (2018).
[Crossref]

J. J. Field and R. A. Bartels, “Digital aberration correction of fluorescent images with coherent holographic image reconstruction by phase transfer (CHIRPT),” Proc. SPIE 9713, 97130B (2016).
[Crossref]

J. J. Field, D. G. Winters, and R. A. Bartels, “Single-pixel fluorescent imaging with temporally labeled illumination patterns,” Optica 3, 971–974 (2016).
[Crossref]

J. J. Field, K. A. Wernsing, S. R. Domingue, A. M. Allende Motz, K. F. DeLuca, D. H. Levi, J. G. DeLuca, M. D. Young, J. A. Squier, and R. A. Bartels, “Superresolved multiphoton microscopy with spatial frequency-modulated imaging,” Proc. Natl. Acad. Sci. 113, 6605–6610 (2016).
[Crossref] [PubMed]

J. J. Field, D. G. Winters, and R. A. Bartels, “Plane wave analysis of coherent holographic image reconstruction by phase transfer (CHIRPT),” J. Opt. Soc. Am. A 32, 2156–2168 (2015).
[Crossref]

D. R. Smith, D. G. Winters, and R. A. Bartels, “Submillisecond second harmonic holographic imaging of biological specimens in three dimensions,” Proc. Nat. Acad. Sci. 110, 18391–18396 (2013).
[Crossref] [PubMed]

D. J. Higley, D. G. Winters, G. L. Futia, and R. A. Bartels, “Theory of diffraction effects in spatial frequency-modulated imaging,” J. Opt. Soc. Am. A 29, 2579–2590 (2012).
[Crossref]

E. E. Hoover, J. J. Field, D. G. Winters, M. D. Young, E. V. Chandler, J. C. Speirs, J. T. Lapenna, S. M. Kim, S.-y. Ding, R. A. Bartels, J. W. Wang, and J. A. Squier, “Eliminating the scattering ambiguity in multifocal, multimodal, multiphoton imaging systems,” J. Biophoton. 5, 425–436 (2012).
[Crossref]

G. Futia, P. Schlup, D. G. Winters, and R. A. Bartels, “Spatially-chirped modulation imaging of absorption and fluorescent objects onsingle-element optical detector,” Opt. Exp. 19, 1626–1640 (2011).
[Crossref]

Bembenek, J. N.

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A.-C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346, 1257998 (2014).
[Crossref] [PubMed]

Berry, M. V.

M. V. Berry and N. L. Balazs, “Nonspreading wave packets,” Am. J. Phys. 47, 264–267 (1979).
[Crossref]

Betzig, E.

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A.-C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346, 1257998 (2014).
[Crossref] [PubMed]

Bewersdorf, J.

Bliton, A. C.

G. J. Brakenhoff, J. Squier, T. Norris, A. C. Bliton, M. H. Wade, and B. Athey, “Real-time two-photon confocal microscopy using a femtosecond, amplified ti:sapphire system,” J. Microsc. 181, 253–259 (1996).
[Crossref] [PubMed]

Böhme, R.

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A.-C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346, 1257998 (2014).
[Crossref] [PubMed]

Born, M.

M. Born and E. Wolf, Principles of Optics: Electromagnetic Theory of Propagation, Interference and Diffraction of Light (Cambridge University Press, 1999), 7th ed.
[Crossref]

Boss, D.

Y. Cotte, F. Toy, P. Jourdain, N. Pavillon, D. Boss, P. Magistretti, P. Marquet, and C. Depeursinge, “Marker-free phase nanoscopy,” Nat. Photon. 7, 1–5 (2013).

Brakenhoff,

Buist, Müller, Squier, and Brakenhoff, “Real time two-photon absorption microscopy using multi point excitation,” J. Microsc. 192, 217–226 (1998).
[Crossref]

Brakenhoff, G. J.

G. J. Brakenhoff, J. Squier, T. Norris, A. C. Bliton, M. H. Wade, and B. Athey, “Real-time two-photon confocal microscopy using a femtosecond, amplified ti:sapphire system,” J. Microsc. 181, 253–259 (1996).
[Crossref] [PubMed]

Broky, J.

G. A. Siviloglou, J. Broky, A. Dogariu, and D. N. Christodoulides, “Observation of Accelerating Airy Beams,” Phys. Rev. Lett. 99, 1–4 (2007).
[Crossref]

Buckley, B. W.

E. D. Diebold, B. W. Buckley, D. R. Gossett, and B. Jalali, “Digitally synthesized beat frequency multiplexing for sub-millisecond fluorescence microscopy,” Nat. Photon. 7, 806–810 (2013).
[Crossref]

Buist,

Buist, Müller, Squier, and Brakenhoff, “Real time two-photon absorption microscopy using multi point excitation,” J. Microsc. 192, 217–226 (1998).
[Crossref]

Chandler, E. V.

E. E. Hoover, J. J. Field, D. G. Winters, M. D. Young, E. V. Chandler, J. C. Speirs, J. T. Lapenna, S. M. Kim, S.-y. Ding, R. A. Bartels, J. W. Wang, and J. A. Squier, “Eliminating the scattering ambiguity in multifocal, multimodal, multiphoton imaging systems,” J. Biophoton. 5, 425–436 (2012).
[Crossref]

J. J. Field, K. E. Sheetz, E. V. Chandler, E. E. Hoover, M. D. Young, S.-Y. Ding, A. W. Sylvester, D. Kleinfeld, and J. A. Squier, “Differential Multiphoton Laser Scanning Microscopy,” Sel. Top. Quantum Electron. IEEE J. 18, 14–28 (2012).
[Crossref]

Chen, B.-C.

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A.-C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346, 1257998 (2014).
[Crossref] [PubMed]

Christodoulides, D. N.

G. A. Siviloglou, J. Broky, A. Dogariu, and D. N. Christodoulides, “Observation of Accelerating Airy Beams,” Phys. Rev. Lett. 99, 1–4 (2007).
[Crossref]

Cotte, Y.

Y. Cotte, F. Toy, P. Jourdain, N. Pavillon, D. Boss, P. Magistretti, P. Marquet, and C. Depeursinge, “Marker-free phase nanoscopy,” Nat. Photon. 7, 1–5 (2013).

Davidovits, P.

Davidson, M. W.

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A.-C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346, 1257998 (2014).
[Crossref] [PubMed]

DeLuca, J. G.

J. J. Field, K. A. Wernsing, S. R. Domingue, A. M. Allende Motz, K. F. DeLuca, D. H. Levi, J. G. DeLuca, M. D. Young, J. A. Squier, and R. A. Bartels, “Superresolved multiphoton microscopy with spatial frequency-modulated imaging,” Proc. Natl. Acad. Sci. 113, 6605–6610 (2016).
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DeLuca, K. F.

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B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A.-C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346, 1257998 (2014).
[Crossref] [PubMed]

Shao, L.

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A.-C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346, 1257998 (2014).
[Crossref] [PubMed]

Sheetz, K. E.

J. J. Field, K. E. Sheetz, E. V. Chandler, E. E. Hoover, M. D. Young, S.-Y. Ding, A. W. Sylvester, D. Kleinfeld, and J. A. Squier, “Differential Multiphoton Laser Scanning Microscopy,” Sel. Top. Quantum Electron. IEEE J. 18, 14–28 (2012).
[Crossref]

Sheppard, C. J. R.

C. J. R. Sheppard, Scanning confocal microscopy (Marcel Dekker, 2003), vol. Encyclopedia of Optical Engineering: Las-Pho of Dekker Encyclopedias Series, pp. 2525–2544.

Siedentopf, H.

H. Siedentopf and R. Zsigmondy, “Uber sichtbarmachung und größenbestimmung ultramikoskopischer teilchen, mit besonderer anwendung auf goldrubingläser,” Annalen der Physik 315, 1–39 (1902).
[Crossref]

Simon, P.

F. O. Fahrbach, P. Simon, and A. Rohrbach, “Microscopy with self-reconstructing beams,” Nat. Photonics 4, 1–6 (2010).

Siviloglou, G. A.

G. A. Siviloglou, J. Broky, A. Dogariu, and D. N. Christodoulides, “Observation of Accelerating Airy Beams,” Phys. Rev. Lett. 99, 1–4 (2007).
[Crossref]

Smith, D. R.

D. R. Smith, D. G. Winters, and R. A. Bartels, “Submillisecond second harmonic holographic imaging of biological specimens in three dimensions,” Proc. Nat. Acad. Sci. 110, 18391–18396 (2013).
[Crossref] [PubMed]

Song, C.

J. Miao, R. L. Sandberg, and C. Song, “Coherent X-Ray Diffraction Imaging,” IEEE J. Sel. Top. Quant. Elec. 18, 399–410 (2012).
[Crossref]

Speirs, J. C.

E. E. Hoover, J. J. Field, D. G. Winters, M. D. Young, E. V. Chandler, J. C. Speirs, J. T. Lapenna, S. M. Kim, S.-y. Ding, R. A. Bartels, J. W. Wang, and J. A. Squier, “Eliminating the scattering ambiguity in multifocal, multimodal, multiphoton imaging systems,” J. Biophoton. 5, 425–436 (2012).
[Crossref]

Squier,

Buist, Müller, Squier, and Brakenhoff, “Real time two-photon absorption microscopy using multi point excitation,” J. Microsc. 192, 217–226 (1998).
[Crossref]

Squier, J.

G. J. Brakenhoff, J. Squier, T. Norris, A. C. Bliton, M. H. Wade, and B. Athey, “Real-time two-photon confocal microscopy using a femtosecond, amplified ti:sapphire system,” J. Microsc. 181, 253–259 (1996).
[Crossref] [PubMed]

Squier, J. A.

J. J. Field, K. A. Wernsing, J. A. Squier, and R. A. Bartels, “Three-dimensional single-pixel imaging of incoherent light with spatiotemporally modulated illumination,” J. Opt. Soc. Am. A 35, 1438–1449 (2018).
[Crossref]

J. J. Field, K. A. Wernsing, S. R. Domingue, A. M. Allende Motz, K. F. DeLuca, D. H. Levi, J. G. DeLuca, M. D. Young, J. A. Squier, and R. A. Bartels, “Superresolved multiphoton microscopy with spatial frequency-modulated imaging,” Proc. Natl. Acad. Sci. 113, 6605–6610 (2016).
[Crossref] [PubMed]

E. E. Hoover, J. J. Field, D. G. Winters, M. D. Young, E. V. Chandler, J. C. Speirs, J. T. Lapenna, S. M. Kim, S.-y. Ding, R. A. Bartels, J. W. Wang, and J. A. Squier, “Eliminating the scattering ambiguity in multifocal, multimodal, multiphoton imaging systems,” J. Biophoton. 5, 425–436 (2012).
[Crossref]

J. J. Field, K. E. Sheetz, E. V. Chandler, E. E. Hoover, M. D. Young, S.-Y. Ding, A. W. Sylvester, D. Kleinfeld, and J. A. Squier, “Differential Multiphoton Laser Scanning Microscopy,” Sel. Top. Quantum Electron. IEEE J. 18, 14–28 (2012).
[Crossref]

Stainier, D. Y. R.

J. Huisken and D. Y. R. Stainier, “Selective plane illumination microscopy techniques in developmental biology,” Development 136, 1963–1975 (2009).
[Crossref] [PubMed]

Strickler, J.

W. Denk, J. Strickler, and W. Webb, “Two-photon laser scanning fluorescence microscopy,” Science 248, 73–76 (1990).
[Crossref] [PubMed]

Swanson, G. J.

Sylvester, A. W.

J. J. Field, K. E. Sheetz, E. V. Chandler, E. E. Hoover, M. D. Young, S.-Y. Ding, A. W. Sylvester, D. Kleinfeld, and J. A. Squier, “Differential Multiphoton Laser Scanning Microscopy,” Sel. Top. Quantum Electron. IEEE J. 18, 14–28 (2012).
[Crossref]

Toy, F.

Y. Cotte, F. Toy, P. Jourdain, N. Pavillon, D. Boss, P. Magistretti, P. Marquet, and C. Depeursinge, “Marker-free phase nanoscopy,” Nat. Photon. 7, 1–5 (2013).

Tulu, U. S.

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A.-C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346, 1257998 (2014).
[Crossref] [PubMed]

Upatnieks, J.

E. Leith and J. Upatnieks, “Wavefront Reconstruction Photography,” Phys. Today 18, 26 (1965).
[Crossref]

Wade, M. H.

G. J. Brakenhoff, J. Squier, T. Norris, A. C. Bliton, M. H. Wade, and B. Athey, “Real-time two-photon confocal microscopy using a femtosecond, amplified ti:sapphire system,” J. Microsc. 181, 253–259 (1996).
[Crossref] [PubMed]

Wang, J. T.

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A.-C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346, 1257998 (2014).
[Crossref] [PubMed]

Wang, J. W.

E. E. Hoover, J. J. Field, D. G. Winters, M. D. Young, E. V. Chandler, J. C. Speirs, J. T. Lapenna, S. M. Kim, S.-y. Ding, R. A. Bartels, J. W. Wang, and J. A. Squier, “Eliminating the scattering ambiguity in multifocal, multimodal, multiphoton imaging systems,” J. Biophoton. 5, 425–436 (2012).
[Crossref]

Wang, K.

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A.-C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346, 1257998 (2014).
[Crossref] [PubMed]

Webb, W.

W. Denk, J. Strickler, and W. Webb, “Two-photon laser scanning fluorescence microscopy,” Science 248, 73–76 (1990).
[Crossref] [PubMed]

Webb, W. W.

W. R. Zipfel, R. M. Williams, and W. W. Webb, “Nonlinear magic: multiphoton microscopy in the biosciences,” Nat. Biotechnol. 21, 1369–1377 (2003).
[Crossref] [PubMed]

Wernsing, K. A.

J. J. Field, K. A. Wernsing, J. A. Squier, and R. A. Bartels, “Three-dimensional single-pixel imaging of incoherent light with spatiotemporally modulated illumination,” J. Opt. Soc. Am. A 35, 1438–1449 (2018).
[Crossref]

J. J. Field, K. A. Wernsing, S. R. Domingue, A. M. Allende Motz, K. F. DeLuca, D. H. Levi, J. G. DeLuca, M. D. Young, J. A. Squier, and R. A. Bartels, “Superresolved multiphoton microscopy with spatial frequency-modulated imaging,” Proc. Natl. Acad. Sci. 113, 6605–6610 (2016).
[Crossref] [PubMed]

Williams, R. M.

W. R. Zipfel, R. M. Williams, and W. W. Webb, “Nonlinear magic: multiphoton microscopy in the biosciences,” Nat. Biotechnol. 21, 1369–1377 (2003).
[Crossref] [PubMed]

Winters, D. G.

J. J. Field, D. G. Winters, and R. A. Bartels, “Single-pixel fluorescent imaging with temporally labeled illumination patterns,” Optica 3, 971–974 (2016).
[Crossref]

J. J. Field, D. G. Winters, and R. A. Bartels, “Plane wave analysis of coherent holographic image reconstruction by phase transfer (CHIRPT),” J. Opt. Soc. Am. A 32, 2156–2168 (2015).
[Crossref]

D. R. Smith, D. G. Winters, and R. A. Bartels, “Submillisecond second harmonic holographic imaging of biological specimens in three dimensions,” Proc. Nat. Acad. Sci. 110, 18391–18396 (2013).
[Crossref] [PubMed]

D. J. Higley, D. G. Winters, G. L. Futia, and R. A. Bartels, “Theory of diffraction effects in spatial frequency-modulated imaging,” J. Opt. Soc. Am. A 29, 2579–2590 (2012).
[Crossref]

E. E. Hoover, J. J. Field, D. G. Winters, M. D. Young, E. V. Chandler, J. C. Speirs, J. T. Lapenna, S. M. Kim, S.-y. Ding, R. A. Bartels, J. W. Wang, and J. A. Squier, “Eliminating the scattering ambiguity in multifocal, multimodal, multiphoton imaging systems,” J. Biophoton. 5, 425–436 (2012).
[Crossref]

G. Futia, P. Schlup, D. G. Winters, and R. A. Bartels, “Spatially-chirped modulation imaging of absorption and fluorescent objects onsingle-element optical detector,” Opt. Exp. 19, 1626–1640 (2011).
[Crossref]

Wolf, E.

M. Born and E. Wolf, Principles of Optics: Electromagnetic Theory of Propagation, Interference and Diffraction of Light (Cambridge University Press, 1999), 7th ed.
[Crossref]

Wu, X. S.

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A.-C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346, 1257998 (2014).
[Crossref] [PubMed]

Young, M. D.

J. J. Field, K. A. Wernsing, S. R. Domingue, A. M. Allende Motz, K. F. DeLuca, D. H. Levi, J. G. DeLuca, M. D. Young, J. A. Squier, and R. A. Bartels, “Superresolved multiphoton microscopy with spatial frequency-modulated imaging,” Proc. Natl. Acad. Sci. 113, 6605–6610 (2016).
[Crossref] [PubMed]

E. E. Hoover, J. J. Field, D. G. Winters, M. D. Young, E. V. Chandler, J. C. Speirs, J. T. Lapenna, S. M. Kim, S.-y. Ding, R. A. Bartels, J. W. Wang, and J. A. Squier, “Eliminating the scattering ambiguity in multifocal, multimodal, multiphoton imaging systems,” J. Biophoton. 5, 425–436 (2012).
[Crossref]

J. J. Field, K. E. Sheetz, E. V. Chandler, E. E. Hoover, M. D. Young, S.-Y. Ding, A. W. Sylvester, D. Kleinfeld, and J. A. Squier, “Differential Multiphoton Laser Scanning Microscopy,” Sel. Top. Quantum Electron. IEEE J. 18, 14–28 (2012).
[Crossref]

Zipfel, W. R.

W. R. Zipfel, R. M. Williams, and W. W. Webb, “Nonlinear magic: multiphoton microscopy in the biosciences,” Nat. Biotechnol. 21, 1369–1377 (2003).
[Crossref] [PubMed]

Zsigmondy, R.

H. Siedentopf and R. Zsigmondy, “Uber sichtbarmachung und größenbestimmung ultramikoskopischer teilchen, mit besonderer anwendung auf goldrubingläser,” Annalen der Physik 315, 1–39 (1902).
[Crossref]

Am. J. Phys. (1)

M. V. Berry and N. L. Balazs, “Nonspreading wave packets,” Am. J. Phys. 47, 264–267 (1979).
[Crossref]

Annalen der Physik (1)

H. Siedentopf and R. Zsigmondy, “Uber sichtbarmachung und größenbestimmung ultramikoskopischer teilchen, mit besonderer anwendung auf goldrubingläser,” Annalen der Physik 315, 1–39 (1902).
[Crossref]

Appl. Opt. (2)

Development (1)

J. Huisken and D. Y. R. Stainier, “Selective plane illumination microscopy techniques in developmental biology,” Development 136, 1963–1975 (2009).
[Crossref] [PubMed]

IEEE J. Sel. Top. Quant. Elec. (1)

J. Miao, R. L. Sandberg, and C. Song, “Coherent X-Ray Diffraction Imaging,” IEEE J. Sel. Top. Quant. Elec. 18, 399–410 (2012).
[Crossref]

IEEE Signal Process. Mag. (1)

P. Sarder and A. Nehorai, “Deconvolution methods for 3-d fluorescence microscopy images,” IEEE Signal Process. Mag. 23, 32–45 (2006).
[Crossref]

J. Biophoton. (1)

E. E. Hoover, J. J. Field, D. G. Winters, M. D. Young, E. V. Chandler, J. C. Speirs, J. T. Lapenna, S. M. Kim, S.-y. Ding, R. A. Bartels, J. W. Wang, and J. A. Squier, “Eliminating the scattering ambiguity in multifocal, multimodal, multiphoton imaging systems,” J. Biophoton. 5, 425–436 (2012).
[Crossref]

J. Microsc. (2)

Buist, Müller, Squier, and Brakenhoff, “Real time two-photon absorption microscopy using multi point excitation,” J. Microsc. 192, 217–226 (1998).
[Crossref]

G. J. Brakenhoff, J. Squier, T. Norris, A. C. Bliton, M. H. Wade, and B. Athey, “Real-time two-photon confocal microscopy using a femtosecond, amplified ti:sapphire system,” J. Microsc. 181, 253–259 (1996).
[Crossref] [PubMed]

J. Opt. Soc. Am. A (3)

Nat. Biotechnol. (1)

W. R. Zipfel, R. M. Williams, and W. W. Webb, “Nonlinear magic: multiphoton microscopy in the biosciences,” Nat. Biotechnol. 21, 1369–1377 (2003).
[Crossref] [PubMed]

Nat. Photon. (2)

E. D. Diebold, B. W. Buckley, D. R. Gossett, and B. Jalali, “Digitally synthesized beat frequency multiplexing for sub-millisecond fluorescence microscopy,” Nat. Photon. 7, 806–810 (2013).
[Crossref]

Y. Cotte, F. Toy, P. Jourdain, N. Pavillon, D. Boss, P. Magistretti, P. Marquet, and C. Depeursinge, “Marker-free phase nanoscopy,” Nat. Photon. 7, 1–5 (2013).

Nat. Photonics (1)

F. O. Fahrbach, P. Simon, and A. Rohrbach, “Microscopy with self-reconstructing beams,” Nat. Photonics 4, 1–6 (2010).

Nature (3)

P. Davidovits and M. D. Egger, “Scanning laser microscope,” Nature 223, 831 (1969).
[Crossref] [PubMed]

D. Gabor, “A new microscopic principle,” Nature 161, 777 (1948).
[Crossref] [PubMed]

K. S. Raines, S. Salha, R. L. Sandberg, H. Jiang, J. A. Rodríguez, B. P. Fahimian, H. C. Kapteyn, J. Du, and J. Miao, “Three-dimensional structure determination from a single view,” Nature 463, 214–217 (2010).
[Crossref]

Opt. Exp. (1)

G. Futia, P. Schlup, D. G. Winters, and R. A. Bartels, “Spatially-chirped modulation imaging of absorption and fluorescent objects onsingle-element optical detector,” Opt. Exp. 19, 1626–1640 (2011).
[Crossref]

Opt. Lett. (1)

Optica (1)

Phys. Rev. Lett. (1)

G. A. Siviloglou, J. Broky, A. Dogariu, and D. N. Christodoulides, “Observation of Accelerating Airy Beams,” Phys. Rev. Lett. 99, 1–4 (2007).
[Crossref]

Phys. Today (1)

E. Leith and J. Upatnieks, “Wavefront Reconstruction Photography,” Phys. Today 18, 26 (1965).
[Crossref]

Proc. Nat. Acad. Sci. (1)

D. R. Smith, D. G. Winters, and R. A. Bartels, “Submillisecond second harmonic holographic imaging of biological specimens in three dimensions,” Proc. Nat. Acad. Sci. 110, 18391–18396 (2013).
[Crossref] [PubMed]

Proc. Natl. Acad. Sci. (1)

J. J. Field, K. A. Wernsing, S. R. Domingue, A. M. Allende Motz, K. F. DeLuca, D. H. Levi, J. G. DeLuca, M. D. Young, J. A. Squier, and R. A. Bartels, “Superresolved multiphoton microscopy with spatial frequency-modulated imaging,” Proc. Natl. Acad. Sci. 113, 6605–6610 (2016).
[Crossref] [PubMed]

Proc. SPIE (1)

J. J. Field and R. A. Bartels, “Digital aberration correction of fluorescent images with coherent holographic image reconstruction by phase transfer (CHIRPT),” Proc. SPIE 9713, 97130B (2016).
[Crossref]

Science (2)

W. Denk, J. Strickler, and W. Webb, “Two-photon laser scanning fluorescence microscopy,” Science 248, 73–76 (1990).
[Crossref] [PubMed]

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A.-C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346, 1257998 (2014).
[Crossref] [PubMed]

Sel. Top. Quantum Electron. IEEE J. (1)

J. J. Field, K. E. Sheetz, E. V. Chandler, E. E. Hoover, M. D. Young, S.-Y. Ding, A. W. Sylvester, D. Kleinfeld, and J. A. Squier, “Differential Multiphoton Laser Scanning Microscopy,” Sel. Top. Quantum Electron. IEEE J. 18, 14–28 (2012).
[Crossref]

Other (3)

C. J. R. Sheppard, Scanning confocal microscopy (Marcel Dekker, 2003), vol. Encyclopedia of Optical Engineering: Las-Pho of Dekker Encyclopedias Series, pp. 2525–2544.

“Datasheet for focalcheck fluorescence microscope test slides,” https://www.thermofisher.com/order/catalog/product/F36909 (2018).

M. Born and E. Wolf, Principles of Optics: Electromagnetic Theory of Propagation, Interference and Diffraction of Light (Cambridge University Press, 1999), 7th ed.
[Crossref]

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Figures (9)

Fig. 1
Fig. 1 Schematic of the epi-fluorescent collection scheme in confocal CHIRPT. PMT: photomultiplier tube; CS: confocal slit; TL: tube lens; DM: dichroic mirror; WD: working distance.
Fig. 2
Fig. 2 Computed VGF created with a confocal slit. (a) Visualizations of the detection PSF (green) and the VGF (purple) resulting from a confocal slit. (b) The detection PSF at zo = 0. (c) The VGF at zo = 0. (d) The detection PSF at zo = −25 μm. (e) The VGF at zo = −25 μm. The multiplicative factors in (d) and (e) indicate that the distribution has been multiplied by that factor to bring the peak intensity to the same as the distributions in the focal plane for visualization. The PSF was computed for λem = 555 nm and detection NA of 0.8. Scale bars: 10 μm.
Fig. 3
Fig. 3 The VGF, ψ(r), and effective light sheet sectioning, Γeff(r), for a variety of slit sizes. A 2D slice through the VGF in the (y, z) plane, taken at x = 0, is shown for slit sizes of (a) 500 μm, (b) 200 μm, and (c) 5 μm. The corresponding effective light sheet sectioning for each slit size, Γeff(r), are shown in panels (d)–(f). The illuminating light sheet, Γ(r), was computed in each case with λex = 488 nm, fill factor of f0 = 1, and a numerical aperture of 1.1. Scale bars: 25 μm.
Fig. 4
Fig. 4 Experimental and simulated 2D images in the (x, z) plane at y =0 for various sizes of the confocal detection slit. Images were collected with slit sizes of (a) 5 mm (the size of the detection PMT aperture), (b) 200 μm, and (c) 75 μm. Corresponding simulated images for the same slit sizes are shown in panels (d)–(f).
Fig. 5
Fig. 5 Reciprocal space representations of the images shown in Fig. 4. Experimental data is shown in panels (a)–(c), while simulated data is displayed in panels (d)–(f). Note that the experimental data displays large DC-peaks that result from edge effects in computing the Fourier transform numerically with the FFT. In addition, the simulated data does not display the noise observed in the experimental data as we did not include noise in the simulation.
Fig. 6
Fig. 6 Simulated spatial envelopes for CHIRPT, computed with cubic pupil phase to create accelerating light sheets (i.e., 1D Airy beams). Slices in the (y, z)-plane are shown through (a) Γ(r), (b) ψ(r), and (c) the effective light sheet envelope, Γeff(r). Dashed lines indicate the approximate DOF for illumination and detection under the same conditions with a Gaussian-intensity light sheet and an unmodified detection PSF. Scale bar: 10 μm.
Fig. 7
Fig. 7 Simulated images comparing the use of a confocal slit and Airy light sheets in CHIRPT. (a)–(c) Images in the focal plane (z =0). (d)–(f) Images from ∼4 confocal parameters away from the focal plane (z =4 DOFy). (g)–(i) The defocused images propagated back to the focal plane with the angular spectrum propagator. Scale bar: 10 μm.
Fig. 8
Fig. 8 Scanned (left column) vs. propagated (right column) images with various CHIRPT configurations. In all cases, the 2D image corresponding to zero defocus (gray plane in the scanned images) was propagated to compute the 3D images in the right column. (a) Scanned image with Gaussian beam illumination and no confocal slit. (b) Propagated image computed from the 2D image at zero defocus in panel (a). (c) Scanned image with Gaussian illumination and a 3 μm slit. (d) Propagated image computed from the 2D image at zero defocus in panel (c). (e) Scanned image with Airy beam illumination using a 3 μm slit and an 1D Airy beam PSF in the detection optics. (f) Propagated image computed from the 2D image at zero defocus in panel (e).
Fig. 9
Fig. 9 Mean squared error (MSE) computed between scanned and propagated lateral images as the axial position is varied. Gaussian beam illumination without a confocal slit: blue dashed line. Gaussian beam illumination with a confocal slit: red dotted line. Airy beam illumination and detection: solid gold line.

Equations (7)

Equations on this page are rendered with MathJax. Learn more.

S ˜ t ( 1 ) = μ t Γ ( r ) e i Δ k t r c ( r ) r .
c ^ ( r ) = CSF ( r ) c ( r )
CSF ( r ) = μ t Γ ( r ) e i Δ k t r t .
S ˜ t ( 1 ) = μ t ψ ( r ) Γ ( r ) e i Δ k t r c ( r ) r
ψ ( r ) = ψ ( ρ , z ) d 2 ρ PSF ( ρ i M ρ , z ) D ( ρ i M ) .
CSF ( r ) = μ t Γ eff ( r ) e i Δ k t r t
CTF ( k ) = μ t [ Γ ˜ eff ( k ) δ ( k Δ k t ) ] k t

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