Abstract

We report a silicon-on-insulator ring resonator biosensor array with one output port, using wavelength division multiplexing as the addressing scheme. With the use of on-chip referencing for environmental drift cancellation, simultaneous monitoring of multiplexed molecular bindings is demonstrated, with a resolution of 0.3pg/mm2 (40ag of total mass) for protein concentrations over 4 orders of magnitude down to 20pM. Reactions are measured over time periods as long as 3h with high stability.

© 2010

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