Abstract

We developed handheld photoacoustic microscopy (PAM) to detect melanoma and determine tumor depth in nude mice in vivo. Compared to our previous PAM system for melanoma imaging, a new light delivery mechanism is introduced to improve light penetration. We show that melanomas with 4.1 and 3.7 mm thicknesses can be successfully detected in phantom and in in vivo experiments, respectively. With its deep melanoma imaging ability and handheld design, this system can be tested for clinical melanoma diagnosis, prognosis, and surgical planning for patients at the bedside.

© 2014 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Toward in vivo biopsy of melanoma based on photoacoustic and ultrasound dual imaging with an integrated detector

Yating Wang, Dong Xu, Sihua Yang, and Da Xing
Biomed. Opt. Express 7(2) 279-286 (2016)

In vivo transrectal imaging of canine prostate with a sensitive and compact handheld transrectal array photoacoustic probe for early diagnosis of prostate cancer

Chengbo Liu, Muyue Xing, Bing Cong, Chen Qiu, Dong He, Congzhi Wang, Yang Xiao, Tinghui Yin, Min Shao, Weibao Qiu, Teng Ma, Xiaojing Gong, Xiong Chen, Hairong Zheng, Rongqin Zheng, and Liang Song
Biomed. Opt. Express 10(4) 1707-1717 (2019)

Real-time handheld optical-resolution photoacoustic microscopy

Parsin Hajireza, Wei Shi, and Roger J. Zemp
Opt. Express 19(21) 20097-20102 (2011)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (5)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription