Abstract

Liquid-core waveguide-based optofluidic devices have proven to be valuable tools for analysis of biological samples in fluid. They have enabled single bioparticle sensitivity while maintaining in-plane detection via light-induced fluorescence. The incorporation of multi-spot excitation with multimode interference (MMI) waveguides has enabled spatially and spectrally multiplexed detection of single viruses on an oxide-based optofluidic platform. Here, we introduce a new way of MMI-based multiplexing where multiple analysis channels are placed within a single multi-spot pattern. This stacked channel design enables both velocity and spectral multiplexing of single particles. The principle is demonstrated with differentiated detection of single H3N2 and H1N1 viruses on a polydimethylsiloxane platform.

© 2018 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Optofluidic detection of Zika nucleic acid and protein biomarkers using multimode interference multiplexing

Alexandra Stambaugh, Joshua W. Parks, Matthew A. Stott, Gopikrishnan G. Meena, Aaron R. Hawkins, and Holger Schmidt
Biomed. Opt. Express 9(8) 3725-3730 (2018)

Multi-parameter analysis using photovoltaic cell-based optofluidic cytometer

Chien-Shun Yan and Yao-Nan Wang
Biomed. Opt. Express 7(9) 3585-3595 (2016)

Spectrally reconfigurable integrated multi-spot particle trap

Kaelyn D. Leake, Michael A. B. Olson, Damla Ozcelik, Aaron R. Hawkins, and Holger Schmidt
Opt. Lett. 40(23) 5435-5438 (2015)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (4)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (1)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription