Panelist: Zawadzki

Information Acquisition, Processing, and Display

  • Spotlight Summary by Robert J Zawadzki

    • Spectral fusing Gabor domain optical coherence microscopy based on FPGA processing
    • Easy to use, extended depth of field in high lateral resolution Gaussian beam illumination Optical Coherence Microscopy (OCM)? This hard to achieve, yet very necessary for broad implementation of OCM requirement, has...
    • Appl. Opt. 60(7) 2069-2076 (2021) View: Abstract | HTML | PDF

  • Spotlight Summary by Robert Zawadzki

    • Template free eye motion correction for scanning systems
    • Reference frame free correction of retinal motion artifacts present during in vivo retinal imaging. Yes, it is now possible with the application of a dual raster scanning imaging system, initially developed by the...
    • Opt. Lett. 46(4) 753-756 (2021) View: Abstract | HTML | PDF

  • Spotlight Summary by Robert J. Zawadzki

    • Multi-Megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second
    • In this latest paper from Robert Huber’s group, Wolfgang Wieser describes an optical coherence tomography (OCT) instrument with unprecedented acquisition speed—about 100 times faster than most other competing OCT...
    • Opt. Express 18(14) 14685-14704 (2010) View: Abstract | HTML | PDF

Light–Matter Interactions

  • Spotlight Summary by Robert J. Zawadzki

    • Lasing from Escherichia coli bacteria genetically programmed to express green fluorescent protein
    • A new class of bio-lasers using self-healing biological material as the active medium has been introduced with the demonstration of lasing from colonies of GFP-expressing Escherichia coli (E. coli)...
    • Opt. Lett. 36(16) 3299-3301 (2011) View: Abstract | HTML | PDF

  • Spotlight Summary by Robert J. Zawadzki

    • Characterizing the localized surface plasmon resonance behaviors of Au nanorings and tracking their diffusion in bio-tissue with optical coherence tomography
    • The wait for robust nanoparticles with high extinction cross sections in a 1300-nm window is over. The opportunity for new exciting biomedical applications in this wavelength range is now open—thanks to Cheng-Kuang Lee...
    • Biomed. Opt. Express 1(4) 1060-1074 (2010) View: Abstract | HTML | PDF

Optics in Biology and Medicine

  • Spotlight Summary by Robert Zawadzki

    • Measuring red blood cell shape in the human retina
    • In vivo observations of red blood cell deformations while traversing the individual retinal capillaries in the human eye becomes reality thanks to recent work published by Phillip Bedggood, Yifu Ding, and Andrew Metha....
    • Opt. Lett. 48(7) 1554-1557 (2023) View: Abstract | HTML | PDF

  • Spotlight Summary by Robert Zawadzki

    • 105° field of view non-contact handheld swept-source optical coherence tomography
    • The Ultra-widefield (UWF) handheld optical coherence tomography (OCT) systems are destined to transform the clinical retinal diagnostic landscape. However, many engineering challenges have been slowing down the progress...
    • Opt. Lett. 46(23) 5878-5881 (2021) View: Abstract | HTML | PDF

  • Spotlight Summary by Robert Zawadzki

    • Sensorless astigmatism correction using a variable cross-cylinder for high lateral resolution optical coherence tomography in a human retina
    • A simple yet elegant solution that removes one of the major barriers for translation of Adaptive Optics Optical Coherence Tomography (AO-OCT) to clinical retinal imaging has been proposed and validated in the latest...
    • Appl. Opt. 60(30) 9553-9559 (2021) View: Abstract | HTML | PDF

  • Spotlight Summary by Robert Zawadzki

    • Photobiomodulation of lymphatic drainage and clearance: perspective strategy for augmentation of meningeal lymphatic functions
    • Alzheimer's Disease (AD) is the most common cause of dementia, a general term for loss of memory and other cognitive abilities serious enough to interfere with daily life. In the U.S., approximately 5.5 million...
    • Biomed. Opt. Express 11(2) 725-734 (2020) View: Abstract | HTML | PDF

  • Spotlight Summary by Robert Zawadzki

    • Picometer scale vibrometry in the human middle ear using a surgical microscope based optical coherence tomography and vibrometry system
    • Despite the great potential of phase-sensitive Optical Coherence Tomography (OCT) for clinical studies of the middle ear volumetric morphology and function, there were no instruments available that would provide these...
    • Biomed. Opt. Express 10(9) 4395-4410 (2019) View: Abstract | HTML | PDF

  • Spotlight Summary by Robert J. Zawadzki

    • Compensating spatially dependent dispersion in visible light OCT
    • The prospect of visible light optical coherence tomography (VIS-OCT) has been capturing the imagination of the optical imaging community for years. This is because OCT imaging in the visible spectral band should offer...
    • Opt. Lett. 44(4) 775-778 (2019) View: Abstract | HTML | PDF

  • Spotlight Summary by Robert Zawadzki

    • Simple approach for aberration-corrected OCT imaging of the human retina
    • In the latest paper by Helge Sudkamp, the authors propose a very simple system allowing acquisition of retinal data with phase stability that is suitable for computational aberration correction (CAC). To achieve that,...
    • Opt. Lett. 43(17) 4224-4227 (2018) View: Abstract | HTML | PDF

  • Spotlight Summary by Robert Zawadzki

    • Ultrahigh-resolution optical coherence elastography through a micro-endoscope: towards in vivo imaging of cellular-scale mechanics
    • Quantitative detection of mechanical properties of the living tissue is of great importance in clinical imaging as it promises to improve our understanding of disease processes and provides advanced diagnostic...
    • Biomed. Opt. Express 8(11) 5127-5138 (2017) View: Abstract | HTML | PDF

  • Spotlight Summary by Robert J. Zawadzki

    • The ecosystem that powered the translation of OCT from fundamental research to clinical and commercial impact [Invited]
    • This invited review by Eric A. Swanson and James G. Fujimoto, two of the original inventors of optical coherence tomography (OCT), on the history of OCT provides a unique perspective on the development of this technique...
    • Biomed. Opt. Express 8(3) 1638-1664 (2017) View: Abstract | HTML | PDF

  • Spotlight Summary by Robert Zawadzki

    • Dynamic imaging and quantitative analysis of cranial neural tube closure in the mouse embryo using optical coherence tomography
    • Optical coherence tomography (OCT) allows insight into the fascinating dynamics of neural tube closure during embryonic development. Neural tube closure is a critical feature of the central nervous system morphogenesis...
    • Biomed. Opt. Express 8(1) 407-419 (2017) View: Abstract | HTML | PDF

  • Spotlight Summary by Robert J. Zawadzki

    • Compartment-resolved imaging of cortical functional hyperemia with OCT angiography
    • Over the last decade OCT has become the leading technology for measuring in-vivo volumetric morphology of many biological tissues at micrometer resolution, with special focus on investigating neural tissues of the eye...
    • Biomed. Opt. Express 4(8) 1255-1268 (2013) View: Abstract | HTML | PDF

  • Spotlight Summary by Robert J. Zawadzki

    • Joint aperture detection for speckle reduction and increased collection efficiency in ophthalmic MHz OCT
    • In the latest paper from Robert Huber’s group, Thomas Klein presents the joined aperture OCT (JA-OCT) detection scheme, a novel parallel angle-resolved OCT technique, and demonstrates its application for speckle...
    • Biomed. Opt. Express 4(4) 619-634 (2013) View: Abstract | HTML | PDF

  • Spotlight Summary by Robert J. Zawadzki

    • High-resolution, lensless endoscope based on digital scanning through a multimode optical fiber
    • The field of micro-endoscopy might be on the verge of a small revolution thanks to the possibility of using lensless multimode fibers as a reliable medium for delivering tightly focused and scanned laser light at the...
    • Biomed. Opt. Express 4(2) 260-270 (2013) View: Abstract | HTML | PDF

  • Spotlight Summary by Robert J. Zawadzki

    • A 3D glass optrode array for optical neural stimulation
    • The ability to effectively deliver optical stimulation into deep tissue targets with sufficient spatio-temporal resolution is a prerequisite for successful translation of many exciting novel optical methods from optical...
    • Biomed. Opt. Express 3(12) 3087-3104 (2012) View: Abstract | HTML | PDF

  • Spotlight Summary by Robert J. Zawadzki

    • Simultaneous optically sectioned fluorescence and optical coherence microscopy with full-field illumination
    • In this paper Makhlouf, Perronet, Dupuis Levêque-Fort and Dubois introduce, in a very elegant way, a method to simultaneously acquire morphological information offered by Optical Coherence Microscopy (OCM) and...
    • Opt. Lett. 37(10) 1613-1615 (2012) View: Abstract | HTML | PDF

  • Spotlight Summary by Robert J. Zawadzki

    • Ultrahigh speed 1050nm swept source / Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second
    • In this paper Potsaid et al., introduce, in a very impressive way, cavity swept lasers to the field of ophthalmic imaging. This novel technology has the potential to change the landscape of commercial optical coherence...
    • Opt. Express 18(19) 20029-20048 (2010) View: Abstract | HTML | PDF

  • Spotlight Summary by Robert J. Zawadzki

    • High-speed optical coherence tomography: basics and applications
    • The introduction of Fourier-domain (Fd) detection to optical coherence tomography (OCT), just over a decade ago, revolutionized the field of imaging by drastically increasing acquisition speeds without reduction in...
    • Appl. Opt. 49(16) D30-D61 (2010) View: Abstract | HTML | PDF

Optoelectronics

  • Spotlight Summary by Robert J. Zawadzki

    • Lasing from Escherichia coli bacteria genetically programmed to express green fluorescent protein
    • A new class of bio-lasers using self-healing biological material as the active medium has been introduced with the demonstration of lasing from colonies of GFP-expressing Escherichia coli (E. coli)...
    • Opt. Lett. 36(16) 3299-3301 (2011) View: Abstract | HTML | PDF

Vision and Color

  • Spotlight Summary by Robert Zawadzki

    • Photoreceptor disc shedding in the living human eye
    • The discovery by Kocaoglu et al. of the optical signature associated with photoreceptor disc shedding in the living human eye is a remarkable technical achievement, since it clearly marks the transition of AO-OCT...
    • Biomed. Opt. Express 7(11) 4554-4568 (2016) View: Abstract | HTML | PDF

  • Spotlight Summary by Robert J. Zawadzki

    • Reflective afocal broadband adaptive optics scanning ophthalmoscope
    • In this paper, Dubra and Sulai present an adaptive optics (AO) scanning ophthalmoscope design that implements nonplanar folding of the telescopes to reduce pupil and image plane astigmatism. This relatively simple...
    • Biomed. Opt. Express 2(6) 1757-1768 (2011) View: Abstract | HTML | PDF

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